FR3138314A1 - Cosmetic composition comprising 2,4-diaminopyrimidine-3-N-oxide, piroctone olamine, caffeine, and an extract of Eperua falcata bark - Google Patents

Abstract

The present invention relates to a cosmetic composition comprising 2,4-diaminopyrimidine-3-N-oxide and/or one of its organic or mineral acid salts and/or one of its hydrates, piroctone olamine from caffeine, and an extract of Eperua falcata bark. The invention also relates to a method of cosmetic treatment of human keratin materials such as the skin, in particular the scalp, hair and/or human eyelashes, comprising at least the application of the cosmetic composition according to the present invention. The present invention also relates to the use of said cosmetic composition to treat hair loss, and/or promote the regrowth of keratin fibers.

Description

Cosmetic composition comprising 2,4-diaminopyrimidine-3-N-oxide, piroctone olamine, caffeine, and Eperua falcata bark extract

The present invention relates to a cosmetic composition comprising 2,4-diaminopyrimidine-3-N-oxide and/or one of its organic or mineral acid salts and/or one of its hydrates, piroctone olamine, caffeine, and tree bark extractEperua falcata.

The invention also relates to a method of cosmetic treatment of human keratin materials such as the skin, in particular the scalp, hair and/or human eyelashes, comprising at least the application of the cosmetic composition according to the present invention.

The present invention also relates to the use of said cosmetic composition to treat hair loss, and/or promote the regrowth of keratin fibers.

The present invention relates to the field of cosmetic treatment of human keratin materials, in particular human keratin fibers, such as human hair, eyebrows, eyelashes and/or body hair, in particular beard hair, mustache hair and body hair. pubic bones, and the skin, in particular the scalp and areas of the skin, in particular alopecic or non-alopecic areas, preferably alopecic, covered with keratin fibers as mentioned above. More particularly, the invention relates to the cosmetic treatment of human hair and/or eyelashes and/or skin, preferably hair and/or scalp.

Hair growth and renewal in humans are mainly determined by the activity of hair follicles and their dermo-epidermal environment. Their activity is cyclical and essentially has three phases, namely the anagen phase, the catagen phase and the telogen phase.

The anagen phase (corresponding to the active phase or growth phase), which lasts several years and during which the hair lengthens, is followed by a very short and transient catagen phase which lasts a few weeks. During this phase, the hair undergoes an evolution, the follicle atrophies and its dermal implantation appears higher and higher.

The terminal phase, which lasts a few months, corresponds to a resting phase, called the telogen phase. At the end of this rest period, the hair falls out and gives way to new hair follicles in the anagen phase so that another hair cycle begins again.

Hair is therefore constantly being renewed, and of the approximately 150,000 hairs that make up a head of hair, at any time, approximately 10% of them are at rest and will therefore be replaced in a few months.

Alopecia refers to the accelerated loss of hair, eyelashes, eyebrows and/or body hair from any part of the body. It generally occurs in genetically predisposed people and mainly affects men. We then speak of androgenetic or androgenic or androgenetic alopecia.

Alopecia is essentially due to a disruption in hair renewal which initially leads to an acceleration in the frequency of cycles at the expense of the quality of the hair and then its quantity. There is thus a progressive impoverishment of the hair by regression of so-called “terminal” hair to the down stage. Certain areas are preferentially affected; particularly in men, the temporal or frontal gulfs as well as the upper part of the occipital, while in women, we see rather a diffuse alopecia of the vertex.

Other causes can lead to significant temporary or permanent hair loss. This may involve loss and alteration of hair after pregnancy (or postpartum), during states of malnutrition or dietary imbalances or even states of asthenia or hormonal dysfunction as may be the case. cases during or after menopause. It may also be hair loss or damage linked to seasonal phenomena.

Alopecia can also affect eyelashes, eyebrows and/or hair on any part of the human body and can cause aesthetic discomfort in the same way as alopecia affecting one or more areas of the scalp.

People thus prone to alopecia are increasingly resorting to cosmetic treatments to eliminate and/or reduce the effect of alopecia, and in particular to reduce or delay the loss of hair, eyelashes and/or hair, as well as inducing or stimulating their growth.

Such treatments generally consist of daily applications on the different alopecic areas of the human body, in particular on the alopecic areas of the scalp, such as the temporal or frontal gulfs in men, or areas of the body devoid of hair, in particular on the face, in particular the beard, mustache and/or eyebrows, of cosmetic compositions comprising one or more anti-hair loss agents and/or capable of promoting regrowth.

For this purpose, we can in particular cite, as agents capable of reducing hair loss and/or promoting the regrowth of keratin fibers, agents such as minoxidil, finasteride, aminexil or even stemoxydine.

The duration of these treatments generally varies from several weeks to several months, or can even extend over years, and their long-term effectiveness most often depends on the diligence observed by the user in regularly applying the cosmetic compositions on the areas to be treated may be more or less extensive.

The implementation of treatments capable of reducing loss and/or promoting the regrowth of hair, eyelashes and/or body hair, may in particular last several weeks before being able to start seeing the desired effects, in particular slowing down alopecia. .

The use of these treatments must be daily to obtain pronounced effectiveness.

However, these compositions still too often present numerous drawbacks of use which can have a negative impact on the cosmetic treatment to be followed, possibly leading in particular to a more or less rapid abandonment of the treatment and, consequently, to poor results in terms of limitation or even elimination of alopecia.

In fact, many compositions include gelling agents to prevent the composition from flowing onto the face, into the eyes or into the neck. However, the use of gelling agents, particularly in the context of daily use, leads to an aggregation of keratin fibers, providing a sticky effect on the hair which is not acceptable for consumers.

In order to improve the effectiveness of these treatments, it may be necessary to increase the quantities of active ingredients, which can lead to difficulties in solubilizing the active ingredients and generate during use the formation of powders visible on the keratin fibers and on the scalp. This powdery effect is also not acceptable to consumers. Anti-hair loss lotions must be used daily to obtain pronounced effectiveness. Some consumers wash their hair every day, and in this case, products previously applied to the scalp are removed. Most consumers do not wash their hair every day, so the product applied on the second day is added to the product applied on the first day. We are talking about a cumulative effect. In this context of repeated application without washing the scalp, the appearance of powder can be present from the first day, and more often present on the second day. This appearance of powder results from the precipitation of the solid compounds of the formula, during the evaporation of the solvent.

As a result, the insufficient usability of these compositions may in the long run discourage users from diligently following cosmetic anti-hair loss and/or regrowth treatments, especially since the effectiveness of these treatments is mainly linked to the daily regularity of the implementation of the compositions described above on the areas to be treated for several weeks, or even several months.

In other words, a lack of adherence or too rapid abandonment of treatment most of the time leads to poor results in terms of anti-hair loss effectiveness and/or regrowth and, consequently, to dissatisfaction. This reinforces disappointment among consumers who do not have the time to observe the progress and/or long-term effectiveness of these treatments.

There is therefore a real need to overcome the disadvantages mentioned above, in particular by implementing a composition capable of cosmetically and effectively treating the loss of human keratin fibers such as human hair, body hair and/or eyelashes, and/or promote their regrowth, having improved qualities of use while ensuring in particular a satisfactory visual result, in particular without greasy effect and without residue. This composition must also allow repeated application, that is to say allow daily use of the composition.

This aim is achieved by the present invention which relates in particular to a cosmetic composition comprising:
i) 2,4-diaminopyrimidine-3-N-oxide and/or one of its organic or mineral acid salts and/or one of its hydrates,
ii) piroctone olamine,
iii) caffeine, and
iv) an extract of Eperua falcata bark.

The cosmetic composition according to the invention has improved qualities of use by making it possible to avoid the powdery effect and/or aggregation of keratin fibers, in particular in the context of repeated application necessary for frequent use.

The cosmetic composition according to the invention also gives complete satisfaction in terms of anti-hair loss effectiveness and/or regrowth of keratin fibers. It also has a beneficial effect on increasing the diameter of keratin fibers and strengthening the fibers against breakage.

In addition, the composition according to the invention makes it possible to provide the keratin fibers with good cosmetic properties, in particular conditioning properties, particularly in terms of flexibility, looseness, and smoothness to the touch. It also allows for easier detangling.

The invention also relates to a method of cosmetic treatment of human keratin materials such as the skin, in particular the scalp, hair and/or human eyelashes, comprising at least the application of the cosmetic composition according to the present invention.

The present invention also relates to the use of said cosmetic composition to treat hair loss, and/or promote the regrowth of keratin fibers.

The present invention also relates to the use of said cosmetic composition for increasing the diameter of keratin fibers and/or reinforcing keratin fibers against breakage.

Other objects, characteristics, aspects and advantages of the invention will appear even more clearly on reading the description and the example which follows.

In what follows, and unless otherwise indicated, the limits of a domain of values are included in this domain, in particular in the expressions “between” and “ranging from… to…”.

Furthermore, the expression “at least one” used in this description is equivalent to the expression “one or more”.

i) 2,4-diaminopyrimidine-3-N-oxide
The cosmetic composition according to the invention comprises 2,4-diaminopyrimidine-3-N-oxide and/or one of its organic or mineral acid salts and/or one of its hydrates.

2,4-diaminopyrimidine-3-N-oxide has the following formula:

Among the usable organic or mineral acid salts, mention may be made in particular of hydrochlorides, sulfates, citrates and acetates. As a hydrate, mention may be made in particular of the monohydrate.

Preferably, the non-salified compound is used in the form of monohydrate.

Preferably, the total content of 2,4-diaminopyrimidine-3-N-oxide and/or one of its organic or mineral acid salts and/or one of its hydrates ranges from 0.05 to 8%. by weight, better from 0.1 to 5%, even better from 0.2 to 4%, then from 0.5 to 3%, and preferably from 1 to 2% by weight, relative to the total weight of the composition.

Preferably, the content of 2,4-diaminopyrimidine-3-N-oxide and/or one of its hydrates, in particular monohydrate, ranges from 0.05 to 8% by weight, better still from 0.1 to 5%, even better from 0.2 to 4%, from 0.5 to 3% and preferably from 1 to 2% by weight, relative to the total weight of the composition.

ii) Piroctone Olamine
The cosmetic composition according to the invention also comprises piroctone olamine.

Piroctone olamine is a monoethanolamine salt of 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone.

Preferably, the total piroctone olamine content ranges from 0.05 to 2% by weight, better still from 0.1 to 1%, preferably from 0.1 to 0.5% by weight, relative to the total weight of the composition. .

iii) Caffeine
The cosmetic composition according to the invention further comprises caffeine.

Preferably, the total caffeine content ranges from 0.1 to 10%, more preferably 0.5 to 5%, more preferably 1 to 4% by weight, and preferably 1.5 to 3% by weight, relative to the total weight. of the composition.

iv) Eperua falcata bark extract
The cosmetic composition according to the invention further comprises an extract of Eperua falcata bark (INCI name: EPERUA FALCATA BARK EXTRACT).

The Eperua falcata bark extract is preferably an aqueous extract obtained from ground bark. It can be absorbed onto a neutral support such as dextrin to produce a powder when drying.

An extract of Eperua falcata bark which can be used according to the invention is in particular that marketed under the name Eperuline ^® (PW LS 9627 by the company BASF).

The total content of Eperua falcata bark extract preferably ranges from 0.02 to 0.2% by weight, more preferably from 0.05 to 0.1% by weight, relative to the total weight of the composition.

v) Hydroxyl compounds
The cosmetic composition according to the invention may optionally also comprise one or more hydroxyl compounds v) having a melting temperature lower than 25°C at atmospheric pressure (1.013.10 ⁵ Pa) (eg they are liquid at 25°C and atmospheric pressure) and a boiling temperature greater than or equal to 170°C.

Preferably, said hydroxyl compounds consist of a C2-C8 hydrocarbon chain optionally interrupted by an oxygen atom and comprising 1 to 2 free hydroxyl groups (-OH) carried by different carbon atoms.

These compounds can be cyclic or acyclic, linear or branched, saturated or unsaturated.

Preferably, the hydroxylated compound(s) are chosen from linear C2-C8 diols, better C2-C6, or aromatic C6-C8 monoalcohols, better C7-C8, and mixtures thereof. More preferably, the hydroxylated compound(s) are chosen from linear C2-C8, better still C2-C6, diols.

Mention may in particular be made of propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, 1,3-propane diol, benzyl alcohol, phenetyl alcohol (phenylethyl alcohol), dipropylene glycol.

Even more preferably, the hydroxylated compound v) is propylene glycol.

The total content of hydroxylated compounds v), when present in the composition according to the invention, is greater than or equal to 0.5% by weight, relative to the total weight of the composition, preferably greater than or equal to 1 % by weight, relative to the total weight of the composition.

Preferably, the total content of hydroxylated compounds, when they are present in the composition according to the invention, ranges from 0.5 to 15% by weight, better still from 1 to 10%, more preferably from 1.5 to 8%. by weight, more preferably still from 2 to 6% by weight, relative to the total weight of the composition.

Preferably, the total content of hydroxylated compounds chosen from linear C2-C8 diols is greater than or equal to 0.5% by weight, better is 0.5 to 15%, preferably ranges from 1 to 10% by weight, more preferably from 1.5 to 8% by weight, more preferably from 2 to 6% by weight, or even from 2 to 4% by weight relative to the total weight of the composition.

Preferably, the total propylene glycol content is greater than or equal to 0.5% by weight, preferably 0.5 to 15%, preferably 1 to 10% by weight, more preferably 1.5 to 8%. by weight, more preferably still from 2 to 6% by weight, or even from 2 to 4% by weight relative to the total weight of the composition.

vi) Yeast extract of the genus Pichia minuta
The cosmetic composition according to the invention may optionally also comprise a yeast extract of the genus Pichia minuta .

By yeast of the genus Pichia minuta, we mean any yeast of the Saccharomycetaceae family, of the Ogataea genus and of the Pichia minuta species. Pichia minuta can in particular be isolated from the azalea flower Rhododendron indicum.

The yeast extract of the Pichia minuta genus is preferably in the form of hydrolyzate. Such an extract is described in particular in patent application FR3061656.

A yeast extract of the genus Pichia minuta which can be used according to the invention is notably marketed under the name ^Hairgenyl® by the company Silab.

When present in the composition according to the invention, the total content of yeast extract of the genus Pichia minuta preferably ranges from 0.02 to 0.2% by weight, more preferably from 0.03 to 0.1%. by weight, relative to the total weight of the composition.

vii) Thickening polymers
The composition according to the invention may optionally comprise one or more thickening polymers.

By “thickening polymer” is meant according to the present invention polymers which increase, by their presence at a concentration of 0.05% by weight, the viscosity of the cosmetic compositions into which they are introduced by at least 20 cps (20 mPa .s), preferably at least 50 cps (50 mPa.s), at room temperature (25°C), at atmospheric pressure and at a shear rate of 1s ^-1 (viscosity can be measured using using a cone/plane viscometer, Haake R600 rheometer or similar).

The thickening polymer(s) which can be used in the process according to the invention are preferably chosen from non-associative thickening polymers with sugar units, non-associative thickening polymers without sugar units, associative thickening polymers, and mixtures thereof.

For the purposes of the present invention, the term “sugar unit” means an oxygenated hydrocarbon compound which has several alcohol functions, with or without an aldehyde or ketone function, and which contains at least 4 carbon atoms.

The sugar units can possibly be modified by substitution, and/or by oxidation and/or by dehydration.

The sugar units of the thickening polymers are preferably derived from the following sugars: glucose; galactose; arabinose; rhamnosis; mannose; xylose; fucose; anhydrogalactose; galacturonic acid; glucuronic acid; mannuronic acid; galactose sulfate; anhydrogalactose sulfate and fructose.

According to the invention, polymers with sugar units are also called polysaccharides.

Mention may in particular be made, as non-associative thickening polymers with sugar units, of native gums such as:

a) exudates from trees or shrubs including:

• gum arabic (branched polymer of galactose, arabinose, rhamnose and glucuronic acid);
• ghatti gum (polymer from arabinose, galactose, mannose, xylose and glucuronic acid);
• karaya gum (polymer made from galacturonic acid, galactose, rhamnose and glucuronic acid);
• tragacanth (or tragacanth) gum (polymer of galacturonic acid, galactose, fucose, xylose and arabinose);

b) gums from algae including:

• agar (polymer derived from galactose and anhydrogalactose);
• alginates (polymers of mannuronic acid and glucuronic acid);
• carrageenans and furcellerans (polymers of galactose sulfate and anhydrogalactose sulfate);

c) gums from seeds or tubers including:

• guar gum (polymer of mannose and galactose);
• locust bean gum (mannose and galactose polymer);
• fenugreek gum (mannose and galactose polymer);
• tamarind gum (polymer of galactose, xylose and glucose);
• konjac gum (glucose and mannose polymer);

d) microbial gums including:

• xanthan gum (polymer of glucose, mannose acetate, mannose/pyruvic acid and glucuronic acid);
• gellan gum (polymer of partially acylated glucose, rhamnose and glucuronic acid);
• scleroglucan gum (glucose polymer);

e) plant extracts including:

• cellulose (glucose polymer);
• starch (glucose polymer) and
• inulin.

These polymers can be modified physically or chemically. As a physical treatment, we can cite in particular temperature.

As chemical treatments we can cite esterification, etherification, amidification and oxidation reactions. These treatments make it possible to produce polymers which may in particular be non-ionic, anionic or amphoteric.

Preferably, these chemical or physical treatments are applied to guar gums, locust bean gums, starches and celluloses.

The non-ionic guar gums which can be used according to the invention can be modified by C ₁ -C ₆ (poly)hydroxylakyl groups.

Among the C ₁ -C ₆ (poly)hydroxyalkyl groups, we can mention by way of example, the hydroxymethyl, hydroxyethyl, hydroxypropyl and hydroxybutyl groups.

These guar gums are well known from the state of the art and can for example be prepared by reacting corresponding alkene oxides such as for example propylene oxides with guar gum so as to obtain a guar gum. modified by hydroxypropyl groups.

The hydroxyalkylation rate preferably varies from 0.4 to 1.2 and corresponds to the number of alkylene oxide molecules consumed by the number of free hydroxyl functions present on the guar gum.

Such non-ionic guar gums possibly modified by hydroxyalkyl groups are for example sold under the trade names JAGUAR HP8, JAGUAR HP60 and JAGUAR HP120 by the company RHODIA CHIMIE.

The starch molecules which can be used in the present invention may have cereals or even tubers as botanical origins. Thus, the starches are for example chosen from corn, rice, cassava, barley, potato, wheat, sorghum and pea starches.

Starches can be modified chemically or physically: in particular by one or more of the following reactions: pregelatinization, oxidation, crosslinking, esterification, etherification, amidification, heat treatments.

Distarch phosphates or compounds rich in distarch phosphate will preferably be used, such as the product offered under the references PREJEL VA-70-T AGGL (gelatinized hydroxypropyl cassava distarch phosphate) or PREJEL TK1 (gelatinized cassava distarch phosphate) or PREJEL 200 (gelatinized acetylated cassava distarch phosphate) by the company AVEBE or STRUCTURE ZEA from NATIONAL STARCH (gelatinized corn distarch phosphate).

According to the invention, it is also possible to use amphoteric starches, these amphoteric starches comprise one or more anionic groups and one or more cationic groups. The anionic and cationic groups can be linked to the same reactive site of the starch molecule or to different reactive sites; preferably they are linked to the same reactive site. The anionic groups can be of the carboxylic, phosphate or sulfate type and preferably carboxylic. The cationic groups can be of the primary, secondary, tertiary or quaternary amine type.

Starch molecules can come from all plant sources of starch such as corn, potatoes, oats, rice, tapioca, sorghum, barley or wheat. The hydrolysates of the starches mentioned above can also be used. The starch preferably comes from potatoes.

The non-associative thickening polymers of the invention may be cellulosic polymers not comprising a C ₁₀ -C ₃₀ fatty chain in their structure.

By “cellulosic” polymer is meant according to the invention any polysaccharide compound having in its structure sequences of glucose residues united by β-1,4 bonds; in addition to unsubstituted celluloses, cellulose derivatives can be anionic, cationic, amphoteric or non-ionic.

Thus, the cellulose polymers which can be used according to the invention can be chosen from unsubstituted celluloses, including in a microcrystalline form, and cellulose ethers.

Among these cellulose polymers, we distinguish cellulose ethers, cellulose esters and cellulose ether esters.

Among the cellulose esters, we find inorganic cellulose esters (cellulose nitrates, sulfates or phosphates, etc.), organic cellulose esters (cellulose monoacetates, triacetates, amidopropionates, acetatebutyrates, acetatepropionates or acetatetrimellitates, etc.) and mixed esters. organic/inorganic cellulose such as acetatebutyratesulfates and cellulose acetatepropionatesulfates. Among the ether esters of cellulose, we can cite hydroxypropylmethylcellulose phthalates and ethylcellulose sulfates.

Among the non-ionic cellulose ethers without a C ₁₀ -C ₃₀ fatty chain, ie "non-associative", we can cite (C ₁ -C ₄ ) alkylcelluloses such as methylcelluloses and ethylcelluloses (for example Ethocel standard 100 Premium from DOW CHEMICAL); (poly)hydroxy(C ₁ -C ₄ )alkylcelluloses such as hydroxymethylcelluloses, hydroxyethylcelluloses (for example Natrosol 250 HHR offered by AQUALON) and hydroxypropylcelluloses (for example Klucel EF from AQUALON); mixed (poly)hydroxy(C ₁ -C ₄ )alkyl-(C ₁ -C ₄ )alkylcelluloses such as hydroxypropyl-methylcelluloses (for example Methocel E4M from DOW CHEMICAL), hydroxyethyl-methylcelluloses, hydroxyethyl-ethylcelluloses ( for example Bermocoll E 481 FQ from AKZO NOBEL) and hydroxybutyl-methylcelluloses.

Among the anionic cellulose ethers without a fatty chain, mention may be made of (poly) carboxy(C ₁ -C ₄ ) alkylcelluloses and their salts. By way of example, mention may be made of carboxymethylcelluloses, carboxymethylmethylcelluloses (for example Blanose 7M from the company AQUALON) and carboxymethylhydroxyethylcelluloses and their sodium salts.

Among the cationic cellulose ethers without a fatty chain, mention may be made of cationic cellulose derivatives such as cellulose copolymers or cellulose derivatives grafted with a water-soluble quaternary ammonium monomer, and described in particular in US patent 4,131,576, such as (poly)hydroxy(C ₁ -C ₄ )alkyl celluloses, such as hydroxymethyl-, hydroxyethyl- or hydroxypropyl celluloses grafted in particular with a salt of methacryloylethyl trimethylammonium, of methacrylmidopropyl trimethylammonium, of dimethyl-diallylammonium. The products marketed meeting this definition are more particularly the products sold under the name “Celquat ^® L 200” and “Celquat ^® H 100” by the National Starch Company.

Among the non-associative thickening polymers without sugar units which can be used according to the invention, mention may be made of cross-linked homopolymers or copolymers of acrylic or methacrylic acid, cross-linked homopolymers of 2-acrylamido-2-methyl-propane sulfonic acid and their cross-linked copolymers of acrylamide, ammonium acrylate homopolymers or copolymers of ammonium acrylate and acrylamide alone or in mixtures.

A first family of suitable non-associative thickening polymers is represented by crosslinked acrylic acid homopolymers.

Among the homopolymers of this type, we can cite those crosslinked with an allylic ether of alcohol of the sugar series, such as for example the products sold under the names CARBOPOLS 980, 981, 954, 2984 and 5984 by the company NOVEON or the products sold under the names SYNTHALEN M and SYNTHALEN K by the company 3 VSA. These polymers have the name INCI Carbomer.

The non-associative thickening polymers can also be crosslinked (meth)acrylic acid copolymers such as the polymer sold under the name AQUA SF1 by the company NOVEON.

The non-associative thickening polymers can be chosen from crosslinked homopolymers of 2-acrylamido-2-methylpropane sulfonic acid and their crosslinked acrylamide copolymers.

Among the crosslinked copolymers of 2-acrylamido-2-methyl-propane sulfonic acid and partially or totally neutralized acrylamide, we can cite in particular the product described in Example 1 of document EP 503 853 and we can refer to refer to this document for what concerns these polymers.

The composition according to the invention may also comprise, as non-associative thickening polymers, ammonium acrylate homopolymers or ammonium acrylate and acrylamide copolymers.

As examples of ammonium acrylate homopolymers, we can cite the product sold under the name MICROSAP PAS 5193 by the company HOECHST. Among the copolymers of ammonium acrylate and acrylamide, we can cite the product sold under the name BOZEPOL C NOUVEAU or the product PAS 5193 sold by the company HOECHST. Reference may in particular be made to documents FR 2 416 723, US 2798053 and US 2923692 for what relates to the description and preparation of such compounds.

Cationic thickening polymers of the acrylic type can also be used.

Among the thickening polymers, mention may also be made of associative polymers well known to those skilled in the art and in particular of a non-ionic, anionic, cationic or amphoteric, preferably anionic, nature.

It is recalled that “associative polymers” are polymers capable, in an aqueous medium, of reversibly associating with each other or with other molecules.

Their chemical structure more particularly comprises at least one hydrophilic zone and at least one hydrophobic zone.

By “hydrophobic group” is meant a radical or polymer with a hydrocarbon chain, saturated or not, linear or branched, comprising at least 10 carbon atoms, preferably from 10 to 30 carbon atoms, in particular from 12 to 30 carbon atoms. carbon and more preferably from 18 to 30 carbon atoms.

Preferably, the hydrocarbon group comes from a monofunctional compound. For example, the hydrophobic group can come from a fatty alcohol such as stearyl alcohol, dodecyl alcohol, decyl alcohol. It can also designate a hydrocarbon polymer such as for example polybutadiene.

Among the associative polymers of the anionic type, we can cite:

- (a) those comprising at least one hydrophilic unit, and at least one fatty chain allyl ether unit, more particularly those whose hydrophilic unit is constituted by an ethylenically unsaturated anionic monomer, more particularly still by a vinyl carboxylic acid and very particularly by an acrylic acid or a methacrylic acid or mixtures thereof.

Among these anionic associative polymers, the polymers formed from 20 to 60% by weight of acrylic acid and/or methacrylic acid, from 5 to 60% by weight of (meth)acrylates are particularly preferred according to the invention. lower alkyls, 2 to 50% by weight of fatty chain allyl ether, and 0 to 1% by weight of a crosslinking agent which is a well-known copolymerizable polyethylenic unsaturated monomer, such as diallyl phthalate , allyl (meth)acrylate, divinylbenzene, (poly)ethylene glycol dimethacrylate, and methylene-bis-acrylamide.

Among the latter, crosslinked terpolymers of methacrylic acid, ethyl acrylate, polyethylene glycol (10 EO) and stearyl alcohol ether (Steareth 10) are particularly preferred, in particular those sold by the company CIBA under the names SALCARE SC80 ^® and SALCARE SC90 ^® which are 30% aqueous emulsions of a crosslinked terpolymer of methacrylic acid, ethyl acrylate and steareth-10-allyl ether (40/50/10).

- (b) those comprising i) at least one hydrophilic unit of the olefinic unsaturated carboxylic acid type, and ii) at least one hydrophobic unit of the (C ₁₀ -C ₃₀ ) alkyl ester type of unsaturated carboxylic acid.

Alkyl esters (C ₁₀ -C ₃₀ ) of unsaturated carboxylic acids useful in the invention include, for example, lauryl acrylate, stearyl acrylate, decyl acrylate, isodecyl acrylate , dodecyl acrylate, and the corresponding methacrylates, lauryl methacrylate, stearyl methacrylate, decyl methacrylate, isodecyl methacrylate, and dodecyl methacrylate.

Anionic polymers of this type are for example described and prepared, according to patents US-3,915,921 and 4,509,949.

Among this type of anionic associative polymers, those consisting of 60 to 95% by weight of acrylic acid (hydrophilic unit), 4 to 40% by weight of C 10 -C 30 alkyl acrylate (C ₁₀ -C ₃₀ unit) will be used more particularly. hydrophobic), and 0 to 6% by weight of crosslinking polymerizable monomer, or those consisting of 96 to 98% by weight of acrylic acid (hydrophilic unit), 1 to 4% by weight of C ₁₀ alkyl acrylate -C ₃₀ (hydrophobic unit), and 0.1 to 0.6% by weight of crosslinking polymerizable monomer such as those described above.

Among said polymers above, according to the present invention, the products sold by the company GOODRICH under the trade names PEMULEN TR1 ^® , PEMULEN TR2 ^® , CARBOPOL 1382 ^® , and even more preferably PEMULEN TR1 ^® , and the product sold by the company SEPPIC under the name COATEX SX ^® .

We can also cite the acrylic acid/lauryl methacrylate/vinylpyrrolidone terpolymer marketed under the name Acrylidone LM by the Company ISP.

- (c) maleic anhydride/C ₃₀ -C ₃₈ α-olefin/alkyl maleate terpolymers such as the product (maleic anhydride/C ₃₀ -C ₃₈ α-olefin/isopropyl maleate copolymer) sold under the name PERFORMA V 1608 ^® by the company NEWPHASE TECHNOLOGIES.

- (d) acrylic terpolymers comprising:

i) approximately 20 to 70% by weight of an α,β-monoethylenically unsaturated carboxylic acid [A],

ii) approximately 20 to 80% by weight of a non-surfactant α,β-monoethylenically unsaturated monomer different from [A],

iii) approximately 0.5 to 60% by weight of a non-ionic mono-urethane which is the reaction product of a monohydric surfactant with a monoethylenically unsaturated monoisocyanate,

such as those described in patent application EP-A-0173109 and more particularly that described in Example 3, namely, a methacrylic acid/methyl acrylate/dimethyl metaisopropenyl benzyl isocyanate ethoxylated behenyl alcohol terpolymer (40OE) in 25% aqueous dispersion.

- (e) copolymers comprising among their monomers an α,β-monoethylenically unsaturated carboxylic acid and an ester of an α,β-monoethylenically unsaturated carboxylic acid and an oxyalkylenated fatty alcohol.

Preferably these compounds also comprise as monomer an ester of carboxylic acid with α, β-monoethylenic unsaturation and of C ₁ -C ₄ alcohol.

As an example of this type of compound, we can cite ACULYN 22 ^® sold by the company ROHM and HAAS, which is a methacrylic acid/ethyl acrylate/oxyalkylenated stearyl methacrylate terpolymer as well as ACULYN 88 also sold by the company ROHM and HAAS.

- (f) Amphiphilic polymers comprising at least one ethylenically unsaturated monomer with a sulfonic group, in free or partially or totally neutralized form and comprising at least one hydrophobic part. These polymers can be crosslinked or non-crosslinked. They are preferably crosslinked.

The ethylenically unsaturated monomers with a sulfonic group are chosen in particular from vinylsulfonic acid, styrenesulfonic acid, (meth)acrylamido(C ₁ -C ₂₂ )alkylsulfonic acids, N-(C ₁ -C ₂₂ )alkyl( meth)acrylamido-(C ₁ -C ₂₂ ) alkylsulfonic acids such as undecyl-acrylamido-methane-sulfonic acid as well as their partially or totally neutralized forms.

More preferably, (meth)acrylamido(C ₁ -C ₂₂ ) alkylsulfonic acids will be used such as for example acrylamido-methane-sulfonic acid, acrylamido-ethane-sulfonic acid, acrylamido-propane-sulfonic acid, 2-acrylamido-2-methylpropanesulfonic acid, methacrylamido-2-methylpropanesulfonic acid, 2-acrylamido-n-butane-sulfonic acid, 2-acrylamido-2,4,4- acid trimethylpentane-sulfonic acid, 2-methacrylamido-dodecyl-sulfonic acid, 2-acrylamido-2,6-dimethyl-3-heptane-sulfonic acid as well as their partially or totally neutralized forms.

More particularly, we will use 2-acrylamido-2-methylpropanesulfonic acid (AMPS) as well as its partially or completely neutralized forms.

The polymers of this family can in particular be chosen from random amphiphilic polymers of AMPS modified by reaction with an n-monoalkylamine or a di-n-C ₆ -C ₂₂ alkylamine, and such as those described in the patent application WO 00/31154 (forming an integral part of the content of the description). These polymers may also contain other hydrophilic ethylenically unsaturated monomers chosen for example from (meth)acrylic acids, their β-substituted alkyl derivatives or their esters obtained with monoalcohols or mono- or poly-alkylene glycols, (meth)acrylamides. , vinylpyrrolidone, maleic anhydride, itaconic acid or maleic acid or mixtures of these compounds.

The preferred polymers of this family are chosen from amphiphilic copolymers of AMPS and at least one hydrophobic monomer with ethylenic unsaturation.

These same copolymers may also contain one or more ethylenically unsaturated monomers not comprising a fatty chain such as (meth)acrylic acids, their β-substituted alkyl derivatives or their esters obtained with monoalcohols or mono- or poly-alkylene glycols, (meth)acrylamides, vinylpyrrolidone, maleic anhydride, itaconic acid or maleic acid or mixtures of these compounds.

These copolymers are described in particular in patent application EP-A-750899, patent US 5089578 and in the following publications by Yotaro Morishima:

- “Self-assembly amphiphilic polyelectrolytes and their nanostructures - Chinese Journal of Polymer Science Vol. 18, No. 40, (2000), 323-336. » ;

- “Miscelle formation of random copolymers of sodium 2-(acrylamido)-2-methylpropanesulfonate and a non-ionic surfactant macromonomer in water as studied by fluorescence and dynamic light scattering - Macromolecules, Vol. 33, No. 10 (2000), 3694-3704”;

- “Solution properties of miscelle networks formed by non-ionic moieties covalently bound to an polyelectrolyte: salt effects on rheological behavior - Langmuir, , Vol. 16, No. 12, (2000) 5324-5332”;

- “Stimuli responsive amphiphilic copolymers of sodium 2-(acrylamido)-2-methylpropanesulfonate and associative macromonomers - Polym. Preprint, Div. Polym. Chem., 40(2), (1999), 220-221”.

Among these polymers, we can cite:

- crosslinked or non-crosslinked copolymers, neutralized or not, comprising from 15 to 60% by weight of AMPS units and from 40 to 85% by weight of (C ₈ -C ₁₆ )alkyl(meth)acrylamide units or (C) units ₈ -C ₁₆ )alkyl(meth)acrylate relative to the polymer, such as those described in application EP-A750 899;

- terpolymers comprising from 10 to 90 mole% of acrylamide units, from 0.1 to 10 mole% of AMPS units and from 5 to 80 mole% of n-(C ₆ -C ₁₈ ) alkylacrylamide units, such as those described in patent US-5089578.

We can also cite the copolymers of totally neutralized AMPS and dodecyl methacrylate as well as the copolymers of AMPS and non-crosslinked and crosslinked n-dodecylmethacrylamide, such as those described in the Morishima articles cited above.

Among the cationic associative polymers we can cite:

(a) cationic associative polyurethanes;

(b) the compound marketed by the company NOVEON under the name AQUA CC and which corresponds to the INCI name POLYACRYLATE-1 CROSSPOLYMER.

POLYACRYLATE-1 CROSSPOLYMER is the product of the polymerization of a mixture of monomers comprising:

• a di(C ₁ -C ₄ alkyl)amino(C ₁ -C ₆ alkyl) methacrylate,
• one or more C ₁ -C ₃₀ alkyl esters and (meth)acrylic acid,
• a polyethoxylated C ₁₀ -C ₃₀ alkyl methacrylate (20-25 moles of ethylene oxide unit),
• a 30/5 polyethylene glycol/polypropylene glycol allyl ether,
• a hydroxy(C ₂ -C ₆ alkyl) methacrylate, and
• an ethylene glycol dimethacrylate.

(c) quaternized (poly)hydroxyethylcelluloses modified by groups comprising at least one fatty chain, such as alkyl, arylalkyl, alkylaryl groups comprising at least 8 carbon atoms, or mixtures thereof. The alkyl radicals carried by the quaternized celluloses or hydroxyethylcelluloses above preferably contain from 8 to 30 carbon atoms. Aryl radicals preferably designate phenyl, benzyl, naphthyl or anthryl groups. We can indicate as examples of quaternized alkylhydroxyethyl celluloses with C ₈ -C ₃₀ fatty chains, such as the products QUATRISOFT LM 200 ^® , QUATRISOFT LM-X 529-18-A ^® , QUATRISOFT LM-X 529-18-B ® (C ₁₂ alkyl) and QUATRISOFT LM-X 529-8 ^® (C ₁₈ alkyl) sold by the company AQUALON, the products CRODACEL QM ^® , CRODACEL QL ^® (C ₁₂ alkyl) and CRODACEL QS ^® (C 12 alkyl) C ₁₈ ) sold by the company CRODA and the product SOFTCAT SL 100 ^® sold by the company AQUALON.

(d) cationic polyvinyllactam polymers.

Such polymers are for example described in patent application WO-00/68282.

As cationic poly(vinyllactam) polymers according to the invention, the vinylpyrrolidone/dimethylaminopropylmethacrylamide/dodecyldimethylmethacrylamidopropylammonium tosylate terpolymers, the vinylpyrrolidone/dimethylaminopropylmethacrylamide/cocoyldimethyl-methacrylamidopropylammonium tosylate terpolymers, the vinylpyrrolidone/dimethylaminopropylmethacrylamide/cocoyldimethyl-methacrylamidopropylammonium tosylate terpolymers, the vinylpyrrolidone/dimethylaminopropylmethacrylamide terpolymers are used as cationic poly(vinyllactam) polymers according to the invention. acrylamide/tosylate or lauryldimethylmethacrylamido chloride -propylammonium.

The amphoteric associative polymers are preferably chosen from those comprising at least one non-cyclic cationic unit. Even more particularly, we prefer those prepared from or comprising 1 to 20 mole% of monomer comprising a fatty chain, and preferably 1.5 to 15 mole% and even more particularly 1.5 to 6 mole%, relative to the number total moles of monomers.

Amphoteric associative polymers according to the invention are for example described and prepared in patent application WO 9844012.

Among the amphoteric associative polymers according to the invention, acrylic acid/(meth)acrylamidopropyl trimethyl ammonium chloride/stearyl methacrylate terpolymers are preferred.

The associative polymers of non-ionic type which can be used according to the invention are preferably chosen from:

(a) copolymers of vinyl pyrrolidone and hydrophobic fatty chain monomers of which we can cite by way of example:

- ANTARON V216 ^® or GANEX V216 ^® products (vinylpyrrolidone/hexadecene copolymer) sold by the company ISP

- ANTARON V220 ^® or GANEX V220 ^® products (vinylpyrrolidone/eicosene copolymer) sold by the company ISP

(b) copolymers of methacrylates or C ₁ -C ₆ alkyl acrylates and amphiphilic monomers comprising at least one fatty chain such as for example the methyl acrylate/oxyethylenated stearyl acrylate copolymer sold by the company GOLDSCHMIDT under the name ANTIL 208 ^® .

(c) copolymers of methacrylates or hydrophilic acrylates and hydrophobic monomers comprising at least one fatty chain such as for example the polyethylene glycol methacrylate/lauryl methacrylate copolymer.

(d) polyurethane polyethers comprising in their chain, both hydrophilic sequences of a most often polyoxyethylenated nature and hydrophobic sequences which can be aliphatic chains alone and/or cycloaliphatic and/or aromatic chains.

(e) polymers with an ether aminoplast skeleton having at least one fatty chain, such as the PURE THIX ^® compounds offered by the company SUD-CHEMIE.

(f) celluloses or their derivatives, modified by groups comprising at least one fatty chain such as alkyl, arylalkyl, alkylaryl groups or their mixtures where the alkyl groups are C ₈ - and in particular:

* non-ionic alkylhydroxyethylcelluloses such as the products NATROSOL PLUS GRADE 330 CS and POLYSURF 67 (C ₁₆ alkyl) sold by the company AQUALON

* non-ionic nonoxynylhydroxyethylcelluloses such as the product AMERCELL HM-1500 sold by the company AMERCHOL;

* non-ionic alkylcelluloses such as the product BERMOCOLL EHM 100 sold by the company BEROL NOBEL;

(g) associative guar derivatives such as hydroxypropyl guars modified by a fatty chain such as the product ESAFLOR HM 22 (modified by a C ₂₂ alkyl chain) sold by the company LAMBERTI; _the product _MIRACARE

Preferably, the polyethers polyurethanes comprise at least two lipophilic hydrocarbon chains, having from 6 to 30 carbon atoms, separated by a hydrophilic sequence, the hydrocarbon chains possibly being pendant chains or chains at the end of the hydrophilic sequence. In particular, it is possible that one or more pendant chains are provided. In addition, the polymer may comprise a hydrocarbon chain at one end or at both ends of a hydrophilic sequence.

Polyurethane polyethers can be multiblocked, particularly in triblock form. The hydrophobic blocks can be at each end of the chain (for example: triblock copolymer with a hydrophilic central block) or distributed both at the ends and in the chain (multiblock copolymer for example). These same polymers can also be grafts or stars.

The nonionic polyurethane polyethers with a fatty chain can be triblock copolymers whose hydrophilic sequence is a polyoxyethylenated chain comprising from 50 to 1000 oxyethylenated groups. Non-ionic polyurethane polyethers have a urethane bond between the hydrophilic sequences, hence the origin of the name.

By extension, non-ionic polyurethane polyethers with a fatty chain also include those whose hydrophilic sequences are linked to the lipophilic sequences by other chemical bonds.

As examples of non-ionic polyurethane polyethers with a fatty chain which can be used in the invention, one can also use Rhéolate 205 ^® with a urea function sold by the company RHEOX or even Rhéolates ^® 208, 204 or 212, as well as Acrysol RM 184 ^® .

We can also cite the product ELFACOS T210 ^® with a C ₁₂ - ₁₄ alkyl chain and the product ELFACOS T212 ® with a C ₁₈ alkyl chain from AKZO.

The product DW 1206B ^® from ROHM & HAAS with a C ₂₀ alkyl chain and a urethane bond, offered at 20% dry matter in water, can also be used.

It is also possible to use solutions or dispersions of these polymers, particularly in water or in a hydroalcoholic medium. By way of example, such polymers include RHEOLATE ^® 255, RHEOLATE ^® 278 and RHEOLATE ^® 244 sold by the company RHEOX. You can also use the product DW 1206F and DW 1206J offered by the company ROHM & HAAS.

The polyurethane polyethers which can be used according to the invention are in particular those described in the article by G. Fonnum, J. Bakke and Fk. Hansen - Colloid Polym. Sci 271, 380,389 (1993).

Even more particularly, it is preferred to use a polyether polyurethane capable of being obtained by polycondensation of at least three compounds comprising (i) at least one polyethylene glycol comprising from 150 to 180 moles of ethylene oxide, (ii) stearyl alcohol or decyl alcohol and (iii) at least one diisocyanate.

Such polyether polyurethanes are sold in particular by the company ROHM & HAAS under the names ACULYN 46 ^® and ACULYN 44 ^® [ACULYN 46 ^® is a polyethylene glycol polycondensate containing 150 or 180 moles of ethylene oxide, stearyl alcohol and methylene bis(4-cyclohexyl-isocyanate) (SMDI), at 15% by weight in a matrix of maltodextrin (4%) and water (81%); ACULYN 44 ^® is a polyethylene glycol polycondensate containing 150 or 180 moles of ethylene oxide, decyl alcohol and methylene bis(4-cyclohexylisocyanate) (SMDI), at 35% by weight in a mixture of propylene glycol ( 39%) and water (26%)].

Preferably, the composition comprises one or more thickening polymers; preferably chosen from non-associative thickening polymers without sugar units, anionic associative thickening polymers, in particular anionic associative acrylic polymers, and mixtures thereof.

Preferably, when the thickening polymer(s) are present in the composition according to the invention, the total content of thickening polymer(s) is included in the range going from 0.05 to 4% by weight, more preferably from 0.1 to 2% by weight, more preferably still 0.2 to 1% by weight, and even better 0.3 to 0.8% by weight, relative to the total weight of the composition.

viii) Organic solvents
The composition according to the invention may optionally comprise one or more organic solvents, different from the hydroxylated compounds v) previously described.

These organic solvents are preferably chosen from C1-C5, preferably C2-C4, monoalcohols. Particularly preferably, ethanol will be used.

Preferably, the composition comprises one or more organic solvents different from the hydroxylated compounds v) previously described, preferably one or more C2-C4 monoalcohols, better still ethanol.

When it(ies) are(are) present, the total content of organic solvents different from the hydroxylated compounds v) preferably ranges from 1 to 60% by weight, preferably from 5 to 50% by weight, more preferably from 10 to 40% by weight, better still from 20 to 35% by weight relative to the total weight of the composition.

When the composition comprises ethanol, the ethanol content preferably ranges from 1 to 60% by weight, preferably from 5 to 50% by weight, more preferably from 10 to 40% by weight, better still from 20 to 35% by weight. weight relative to the total weight of the composition.

The composition is preferably aqueous. More preferably, the total water content of the composition according to the invention is included in the range going from 10 to 90% by weight, even more preferably from 20 to 80% by weight, and even better from 40 to 70% by weight. relative to the total weight of the composition.

Additives
The composition may optionally also comprise one or more additives different from the compounds previously described such as those chosen from cationic, anionic, amphoteric or zwitterionic surfactants and their mixtures, cationic, anionic, non-ionic, amphoteric polymers, different from thickening polymers. previously described, or their mixtures, anti-dandruff agents, anti-seborrheic agents, vitamins and pro-vitamins including panthenol, sun filters, sequestering agents, plasticizing agents, solubilizing agents, acidifying agents, opacifying or pearlizing agents , anti-oxidant agents, hydroxy acids, perfumes, preservatives and ceramides.

Of course, those skilled in the art will take care to choose this or these possible complementary compounds in such a way that the advantageous properties intrinsically attached to the composition according to the invention are not, or substantially not, altered by the addition(s) envisaged. .

The above additives can generally be present in a quantity comprised for each of them between 0 and 20% by weight, relative to the total weight of the composition.

Process
The invention also relates to a method of cosmetic treatment of human keratin materials such as the skin, in particular the scalp, hair and/or human eyelashes, comprising at least the application to said keratin materials of the cosmetic composition as defined previously.

The composition according to the present invention is preferably applied topically, in particular to the scalp and/or hair. Advantageously, the composition according to the invention comprises a cosmetically acceptable medium suitable for topical application.

The application of the composition may or may not be followed by rinsing after a possible exposure time.

Preferably, the application of the composition according to the invention is not followed by rinsing.

Preferably, the cosmetic treatment process is a hair and/or scalp care process.

The present invention also relates to the use of a cosmetic composition as defined above to treat loss, and/or promote regrowth, of keratin fibers.

The present invention also relates to the use of a cosmetic composition as defined above to increase the diameter of the keratin fibers and/or to reinforce the keratin fibers against breakage.

The following examples serve to illustrate the invention without, however, being limiting in nature.

Examples
In the examples which follow, all quantities are indicated as a percentage by weight of active ingredient (%ma) relative to the total weight of the composition (unless otherwise stated).

a) Compositions
Compositions A according to the invention and B comparative (reference) were prepared from the ingredients whose contents are indicated in the table below:

Composition A Composition B Caffeine 2 2 Diaminopyrimidine oxide 1.5 1.5 Piroctone olamine 0.25 0.25 Eperua falcata bark extract
(Eperuline PWLS 9627 from BASF) 0.08 (%my) - Acrylates/Beheneth-25 Methacrylate Copolymer 0.38 0.38 Glycerol 2 2 Propylene glycol 2.5 2.5 PEG-40 Hydrogenated Castor Oil 0.1 0.1 Ethanol 27 27 Water Qsp 100 Qsp 100

b) Protocol
The compositions were tested on 2.7g strands of natural hair of Caucasian origin.

• Cleaning the locks before applying the compositions:
The hair strands were previously cleaned with DOP shampoo at a rate of 0.4 g per gram of hair. The locks are kneaded then rinsed 10 times. They are then wrung out twice between 2 fingers then combed.

• Application of the compositions to damp hair:
The compositions were applied at a rate of 0.4g of composition for a 2.7g lock.

The strands are then combed to separate the fibers and distribute the product evenly across the fibers. The locks are finally straightened by hand
The strands were then dried with a hairdryer at moderate temperature.

c) Evaluation

The locks were evaluated blindly by experts for 3 criteria: cosmeticity, suppleness and detangling (looser hair).

The notes are positioned in relation to composition B which serves as a reference (note 0). Ratings range from +3 (very good effect) to -3 (very bad effect).

Detangling:

Definition of detangling : the comb passes easily through the strand

Detangling of the lock is assessed by making 1 pass with the small teeth of the comb from the root to the tip of the lock.

Evaluation protocol:

The wick is hung on a rack and held with one hand by its top. The comb (fine teeth) is placed at 45° to the root of the lock, then the comb is slid to the tip.
If the comb (fine teeth) blocks, perform the same gestures with the comb (large teeth). If the comb does not work, start detangling at the tip of the strand and repeat the process, gradually going up along the strand to the root.

Result: Detangling is easier for the lock having been treated with composition A according to the invention.

Flexibility:

Definition of flexibility : the wick allows itself to be bent without resistance, it is not hardened.

Evaluation protocol:

The wick is hung on a rack and held with one hand by its top. With the other hand, the wick is folded in the palm of the palm and tightened 3 times, 1 second per tightening.

Result: The wick having been treated with composition A according to the invention has improved flexibility compared to the wick treated with the comparative reference composition B.

Cosmetics:

Definition of cosmeticity : cosmeticity is evaluated on the criteria of smooth and regular touch.

Results: The lock having been treated with composition A according to the invention has improved cosmeticity compared to the lock treated with the comparative reference composition B.

The following table 2 summarizes the different results obtained: Expert 1 Expert 2 Composition HAS B HAS B Cosmetics +1.5 0 +2 0 Detangling +2 0 +2 0 Flexibility +1 0 +1 0

The table shows that composition A according to the invention leads to better detangling of hair (untied hair), improved suppleness and better cosmeticity than comparative composition B.

Claims (12)

Cosmetic composition comprising:
i) 2,4-diaminopyrimidine-3-N-oxide and/or one of its organic or mineral acid salts and/or one of its hydrates,
ii) piroctone olamine,
iii) caffeine, and
iv) an extract of Eperua falcata bark. Composition according to the preceding claim, characterized in that the total content of 2,4-diaminopyrimidine-3-N-oxide and/or one of its organic or mineral acid salts and/or one of its hydrates, ranges from 0.05 to 8% by weight, preferably from 0.1 to 5% by weight, preferably from 0.2 to 4% by weight, more preferably from 0.5 to 3% by weight, and better still from 1 at 2% by weight, relative to the total weight of the composition. Composition according to any one of the preceding claims, characterized in that the total content of piroctone olamine ranges from 0.05 to 2% by weight, preferably from 0.1 to 1% by weight, preferably from 0.1 to 0 .5% by weight, relative to the total weight of the composition. Composition according to any one of the preceding claims, characterized in that the total caffeine content ranges from 0.1 to 10% by weight, preferably from 0.5 to 5% by weight, preferably from 1 to 4% by weight , and more preferably from 1.5 to 3% by weight, relative to the total weight of the composition. Composition according to any one of the preceding claims, characterized in that the total content of Eperua falcata bark extract ranges from 0.02 to 0.2% by weight, preferably from 0.05 to 0.1%. by weight, relative to the total weight of the composition. Composition according to any one of the preceding claims, characterized in that it further comprises v) one or more hydroxylated compounds having a melting temperature lower than 25°C and a boiling temperature greater than or equal to 170°C, at atmospheric pressure; preferably chosen from linear C2-C8 diols or aromatic C6-C8 monoalcohols, and mixtures thereof; more preferably among linear diols in C2-C8, better C2-C6; even more preferably propylene glycol. Composition according to the preceding claim, characterized in that the total content of the hydroxyl compound(s) v) ranges from 0.5 to 15% by weight, preferably from 1 to 10%, preferably from 1.5 to 8% by weight, more preferably from 2 to 6% by weight, relative to the total weight of the composition. Composition according to any one of the preceding claims, characterized in that it further comprises an extract of yeasts of the genus Pichia minuta , preferably in a total content ranging from 0.02 to 0.2% by weight, more preferably 0 .03 to 0.1% by weight, relative to the total weight of the composition. Composition according to any one of the preceding claims, characterized in that it further comprises one or more thickening polymers, preferably chosen from non-associative thickening polymers without sugar units, anionic associative thickening polymers, in particular anionic associative acrylic polymers. , and their mixtures. Process for the cosmetic treatment of human keratin materials such as the skin, in particular the scalp, hair and/or eyelashes, comprising the application to said keratin materials of a composition as defined in any one of the preceding claims . Use of a composition as defined in any one of claims 1 to 9 to treat loss and/or promote regrowth of keratin fibers. Use of a composition as defined in any one of claims 1 to 9 to increase the diameter of keratin fibers and/or reinforce keratin fibers against breakage.