FR3132026A1 - System for processing an anatomical zone of a living being - Google Patents

Abstract

Treatment system (1) of an anatomical area of a living being, the anatomical area being covered by a layer of skin, the treatment system (1) comprising:- an electroporation device (15),- a device iontophoresis (20),- a body (2) configured to be held in the hand of a practitioner, the body (2) having a treatment surface (4) configured to be placed in contact with the skin layer of the area anatomy, wherein the treatment surface (4) has first and second distinct treatment zones, a set of electroporation electrodes is arranged in the first treatment zone, and first and second iontophoresis electrodes are arranged outside of the first treatment zone, at least the first iontophoresis electrode being arranged in the second treatment zone. Abstract Figure: Figure 2

Description

System for treating an anatomical area of a living being

The present disclosure relates to the field of systems for treating an anatomical area of a living being.

The present disclosure relates more precisely to the treatment of an anatomical area of a living being implementing in a local and superficial manner one or more electrical signals on a layer of skin covering the anatomical area.

Such electrical signals can be used in conjunction with formulations containing in particular appropriate active ingredients to obtain one or more desired effects, whether for example a feeling of well-being or an aesthetic, cosmetic, analgesic, therapeutic or other effect.

These electrical signals include in particular electroporation electrical signals producing an electric field suitable for carrying out electroporation. Electroporation makes it possible to limit locally and reversibly, that is to say transiently over time, the barrier properties of the skin layer to allow the active ingredients to pass through the skin layer.

The aforementioned electrical signals also include electrical iontophoresis signals based on an electric current adapted to carry out iontophoresis. Iontophoresis makes it possible to migrate the active ingredients by carrying them in a flow generated by the electric current. Among other phonemes possibly involved in the generation of the flow, we can cite a phenomenon of electromigration, also called electro-repulsion, for the ionized active ingredients repelled by an iontophoresis electrode in contact with the skin layer and having the same sign of polarity as the active ingredients. We can also cite a phenomenon of electro-osmosis for any type of active principle driven by convection by the electric current circulating between two iontophoresis electrodes.

The electrical electroporation and iontophoresis signals can therefore be used alone or in combination to promote penetration of active ingredients of one or more formulations through the skin layer and into the anatomical area so as to achieve targeted treatment and effective.

Whether with the formulations mentioned above or independently of them, the aforementioned electrical signals and, in particular, those dedicated to electroporation and iontophoresis also make it possible to obtain other effects, particularly of a metabolic and physiological nature. on the anatomical area. These electrical signals can in fact induce transdermal vascular stimulation (TEVS for Trans - Epidermic V ascular Stimulation in English) which promotes microcirculation of the skin and thus, irrigation of the epidermis of the skin layer .

In view of the benefits they provide, there is particular interest in the development and dissemination of treatment systems using electrical signals from electroporation and iontophoresis.

However, the implementation of electrical signals on an anatomical area can prove difficult to master to obtain the desired effect without generating discomfort or even pain during the treatment.

These difficulties are first of a technical nature in generating electrical signals for electroporation and iontophoresis with the appropriate characteristics. These technical difficulties are all the more important when we wish to combine the benefits of electroporation and iontophoresis. Indeed, interference of the electrical electroporation and iontophoresis signals can occur not only with each other but also with the electroporation and iontophoresis electrodes involved in the application of these signals.

The difficulties are also practical, with discomfort and even pain resulting from inappropriate handling of the treatment system by a practitioner during treatment.

All of these difficulties make known processing systems complex to produce and use. In particular, they require a certain amount of experience to handle them safely and while respecting the comfort of the user. They are also generally heavy and bulky.

Summary

This disclosure improves the situation.

According to one aspect of the disclosure, a system is proposed for treating an anatomical area of a living being, the anatomical area being covered by a layer of skin, the treatment system comprising:
- an electroporation device comprising an electroporation generator configured to generate an electrical electroporation signal, and a set of electroporation electrodes comprising at least two electroporation electrodes and configured to deliver the electrical electroporation signal,
- an iontophoresis device comprising an iontophoresis generator configured to generate an electrical iontophoresis signal, and at least first and second iontophoresis electrodes configured to deliver the electrical iontophoresis signal,
- a body configured to be held in the hand by a practitioner, the body having a treatment surface configured to be placed in contact with the skin layer of the anatomical area,
in which the treatment surface has first and second distinct treatment zones, the set of electroporation electrodes is arranged in the first treatment zone, and the first and second iontophoresis electrodes are arranged outside the first zone treatment, at least the first iontophoresis electrode being arranged in the second treatment zone.

Thus the invention proposes to bring together the electroporation and iontophoresis electrodes on the same treatment surface of a handpiece, by achieving spatial decoupling of these electroporation and iontophoresis electrodes. These arrangements make it possible to simplify the production of the treatment system as well as its handling, and to improve its compactness. With such a treatment system, it is possible to perform electroporation and iontophoresis in a simple, effective way without pain or even discomfort, even when combined.

The second treatment zone can extend at least partly around the first treatment zone.

The treatment surface may have an outer edge, the second treatment zone extending over at least part of the outer edge.

The electroporation electrodes may respectively have point contact surfaces distributed discretely over part of the first treatment zone, and the first iontophoresis electrode may have an extended contact surface extending continuously over at least one part of the second treatment zone, a surface ratio of the extended contact surface of the first iontophoresis electrode to the point contact surface of each electroporation electrode being preferably greater than 20, in particular greater than 50, in particular greater than 100, for example between 150 and 300.

An area ratio of the first treatment zone to the second treatment zone can be between 0.5 and 1.5, in particular between 0.8 and 1.2, a sum of the point contact surfaces of the electroporation electrodes covering at most 25%, preferably at most 15%, of the first treatment zone and the extended contact surface of the first iontophoresis electrode covering at least 50%, preferably at least 75%, of the second treatment zone .

Each electroporation electrode can be cylindrical around a central axis, the point contact surface of each electroporation electrode being between 1 mm² and 3 mm² and the electroporation electrodes being arranged on the first treatment zone with a center distance between 2 mm and 6 mm.

The extended contact surface of the first iontophoresis electrode can be between 2 cm² and 4 cm².

The point contact surfaces of the electroporation electrodes may be arranged at a distance from the treatment surface greater than 5% to 20% of a distance from the extended contact surface of the first iontophoresis electrode.

The second iontophoresis electrode can be arranged at a distance from the treatment surface.

The second iontophoresis electrode can thus be offset. In particular, it can be offset so that the practitioner holding the body of the treatment system and the user to whom the treatment is applied close the circuit between the first and second iontophoresis electrodes.

The body can thus comprise a head comprising the treatment surface, and a handle arranged opposite the treatment surface and configured to be held in the hand by the practitioner, the second iontophoresis electrode being arranged on the handle.

In particular, the handle may comprise a side wall extending from the head along a longitudinal axis, the second iontophoresis electrode extending on the side wall around the longitudinal axis.

During iontophoresis, the practitioner can then hold the handle with a first hand so as to be in contact with the second iontophoresis electrode, and place part of the second hand in contact with an area of skin opposite the layer of skin. of the anatomical area, facing the treatment surface.

The body may internally include a housing receiving the electroporation and iontophoresis generators.

The treatment system may include a self-contained energy supply source disposed in the body housing and to which the electroporation and iontophoresis generators are connected.

The electroporation electrical signal may comprise trains of electrical pulses, two successive trains of electrical pulses being separated by a time interval, and the electrical iontophoresis signal may comprise direct electric current bursts, the processing system comprising a control unit configured to jointly control the electroporation and iontophoresis generators to generate the electroporation and iontophoresis electrical signals in a synchronized manner such that each DC electric current slot of the iontophoresis electrical signal is generated in the time interval between two successive trains of electrical pulses after a time delay has elapsed.

The treatment system according to the invention can therefore combine temporal decoupling of the electrical electroporation and iontophoresis signals with spatial decoupling of the electroporation and iontophoresis electrodes to simplify its production and handling while improving the effectiveness of the treatment. and this, without generating discomfort or pain.

The electroporation generator may be a voltage generator configured to generate trains of electrical pulses at a frequency F between 0.5 Hz and 5 Hz, each train of electrical pulses comprising a number N, an integer greater than or equal to to 4, bipolar electrical pulses each having a voltage between 25 V and 300 V and a duration d _E of between 1 µs and 25 µs from an initial instant, the number N and the duration d _E being such that 10 ^-6 .1/F ≤ N* d _E ≤ 10 ^-2 .1/F. The time delay can have a duration d _T such that 0.25.1/F ≤ d _T ≤ 0.75.1/F from the initial instant. The iontophoresis generator may be an electric current generator configured to generate the direct electric current slots at the frequency F, each direct electric current slot having a voltage of between 5 V and 30 V, an intensity of 0.2 mA .cm ^-2 and 1 mA.cm ^-2 and a duration d _i such that 0 < d _i ≤ 1/F - d _T .

The control unit can further be configured to:
- control the electroporation generator alone so that said electroporation generator generates the electrical electroporation signal,
- control the iontophoresis generator alone so that said iontophoresis generator generates the electrical iontophoresis signal.

The control unit can be offset relative to the body, the treatment system further comprising a communication interface between the control unit and the electroporation and iontophoresis generators.

According to another aspect of the disclosure, an installation is proposed for treating an anatomical zone of a living being, the anatomical zone being covered by a layer of skin, comprising:
- a processing system as defined previously,
- a radio frequency treatment device comprising a radio frequency generator configured to generate a radio frequency signal, a set of radio frequency electrodes comprising at least two radio frequency electrodes and configured to deliver the radio frequency signal, and an additional body configured to be held by hand by a practitioner, the additional body having a radiofrequency treatment surface configured to be placed in contact with the skin layer of the anatomical area, the set of radiofrequency electrodes being arranged on the radiofrequency treatment surface radio frequency.

The additional body may comprise a head comprising the radiofrequency treatment surface, and a handle arranged opposite the radiofrequency treatment surface and configured to be held in the hand by the practitioner, the additional body internally comprising a housing receiving the radio frequency generator.

The radio frequency treatment device may be bipolar, the radio frequency signal having a frequency between 3 kHz and 300 MHz and an energy between 10 J.cm ^-3 and 100 J.cm ^-3 .

The treatment installation may further comprise a phototherapy device comprising a light source configured to emit phototherapy light and a support having an application surface configured to be placed facing the layer of skin of the anatomical zone, said at least one light source being arranged on the application surface.

The support may constitute a mask configured to be worn on at least one part of the face as an anatomical zone.

The light source may comprise at least one group of light-emitting diodes chosen from:
- monochromatic light-emitting diodes whose phototherapy light has a wavelength of between 620 nm and 660 nm and a power of between 2 mW/cm² and 5 mW/cm² at 1 cm from the skin layer,
- monochromatic light-emitting diodes whose phototherapy light has a wavelength of between 820 nm and 840 nm and a power of between 1.5 mW/cm² and 3 mW/cm² at 1 cm from the skin layer.

According to another aspect of the disclosure, a method of treating an anatomical area of a living being is proposed, the anatomical area being covered by a layer of skin, the treatment method implementing the treatment system such as defined previously, the treatment process providing:
- to place the treatment surface in contact with the skin layer of the anatomical area,
- to apply at least one treatment chosen from electroporation and iontophoresis, the electroporation being applied by generating the electrical electroporation signal by the electroporation generator and by delivering the electrical electroporation signal by the set of electroporation electrodes on the skin layer, and the iontophoresis being applied by generating the iontophoresis electrical signal through the iontophoresis generator and outputting the iontophoresis electrical signal through the first and second iontophoresis electrodes on the skin layer.

The treatment method may include moving the treatment surface onto the skin layer of the anatomical area.

The treatment method may provide for jointly applying electroporation and iontophoresis, the electroporation and iontophoresis electrical signals being delivered in a synchronized manner such that each continuous electric current slot of the iontophoresis electrical signal is generated in the time interval between two successive trains of electrical pulses after a time delay has elapsed.

The treatment method may provide for holding the handle with a first hand of the practitioner, the first hand being in contact with the second iontophoresis electrode, and placing part of the second hand of the practitioner in contact with an area of skin opposite to the skin layer of the anatomical area, facing the treatment surface.

Other characteristics, details and advantages will appear on reading the detailed description below, and on analyzing the attached drawings, in which:

– Figures 1 and 2 represent views in elevation and in longitudinal section of a system for treating an anatomical area of a living being according to one embodiment, the treatment system comprising an electroporation device and a device of iontophoresis integrated into a body,

- there is a plan representation of a head of the body of the treatment system of the , illustrating an arrangement of electroporation electrodes of the electroporation device and a first iontophoresis electrode of the iontophoresis device,

- there is an enlarged representation of the detail referenced IV on the ,

- there is a representation of an example of an electroporation signal delivered by the electroporation device of the treatment system of the ,

- there is a representation of an example of an iontophoresis signal delivered by the iontophoresis device of the iontophoresis treatment system. ,

– Figures 7 and 8 represent views in elevation and in longitudinal section of a radiofrequency treatment device belonging to a treatment installation according to one embodiment,

– Figures 9 and 10 represent back and front perspective views of a mask of a phototherapy device of the treatment installation according to one embodiment,

- there represent a perspective view of a base and a control unit of the processing installation according to one embodiment, the base receiving the data processing system and 2, the radio frequency treatment device of Figures 7 and 8 and the mask of Figures 9 and 10, the control unit controlling the treatment system, the radio frequency treatment device and the mask.

Figures 1 and 2 represent an embodiment of a treatment system 1 of an anatomical area of a living being covered by a layer of skin.

The treatment system 1 is used to make it possible to carry out a treatment making it possible to obtain one or more desired effects chosen for example from a sensation of well-being, an aesthetic effect, a cosmetic effect, an analgesic effect, a metabolic effect, a physiological effect, a therapeutic effect or other.

To do this, the treatment system 1 is configured to carry out electroporation and iontophoresis making it possible to promote penetration of active ingredients of one or more formulations through the skin layer and into the anatomical area so as to carry out a treatment. targeted and effective.

The treatment system 1 is configured in the form of a handpiece comprising a body 2 which extends along a longitudinal axis L. The body 2 comprises a head 3 arranged at a first end of the body 2, and a handle 6 which extends from the head 3 along the longitudinal axis L to a second end of the body 2.

The head 3 comprises a treatment surface 4 which extends transversely, in particular perpendicularly, relative to the longitudinal axis L and which is configured to be placed in contact with the layer of skin of the anatomical area to be treated. In the embodiment shown, the treatment surface 4 has a circular outer edge 5.

The handle 6, arranged opposite the treatment surface 4, is configured to be held by the hand by the practitioner. It comprises a side wall 7 which extends around the longitudinal axis L by internally delimiting a housing 8. The side wall 7 has an exterior surface shaped to improve the ergonomics and the grip of the handle 6. In particular , the exterior surface has a concave zone 9 adjoining the head 3 and a convex zone 10 comprising the second end of the body 2. A flat 11 extending parallel to the longitudinal axis L is provided on the convex zone 10.

To carry out the electroporation, the treatment system 1 comprises an electroporation device 15.

The electroporation device 15 comprises an electroporation generator 16 configured to generate an electrical electroporation signal SE described later in relation to the . The electroporation generator 15 is placed in the housing 8 of the handle 6 and supplied with energy by an independent energy supply source 17 also placed in the housing 8.

The electroporation device 15 also comprises a set of electroporation electrodes 18 configured to deliver the electrical electroporation signal SE generated by the electroporation generator 16.

In Figures 3 and 4, each electroporation electrode 18 is cylindrical around a central axis and has a point contact surface 18a at a free end arranged to come into contact with the layer of skin.

The electroporation electrodes 18 are distributed in a discrete manner exclusively over part of a first treatment zone 4a of the treatment surface 4. The first treatment zone 4a is central, centered on the longitudinal axis L and in the immediate vicinity of it. The number of electroporation electrodes 18 and the point contact surface 18a of each of them are chosen so that a sum of the point contact surfaces 18a of the electroporation electrodes 18 covers at most 25%, preferably at most 15%, of the first treatment zone 4a. In the embodiment shown, the set of electroporation electrodes 18 comprises twelve electroporation electrodes 18 grouped in pairs of electroporation electrodes, and arranged on the first treatment zone 4a with a center distance of between 2 mm and 6mm. The point contact surface 18a of each electroporation electrode 18 may in particular be between 1 mm² and 3 mm². Alternatively, the set of electroporation electrodes 18 could comprise any other number of electroporation electrodes 18 greater than or equal to two, the point contact surface 18a of each of them being adapted accordingly.

To carry out iontophoresis, the treatment system 1 comprises an iontophoresis device 20.

The iontophoresis device 20 comprises an iontophoresis generator 21 configured to generate an electrical iontophoresis signal SI described later in relation to the . The iontophoresis generator 21 is arranged in the housing 8 of the handle 6 and supplied with energy by the autonomous energy supply source 17.

The iontophoresis device 20 also comprises first 22 and second 23 iontophoresis electrodes configured to deliver the electrical iontophoresis signal SI generated by the iontophoresis generator 21.

The first 22 and second 23 iontophoresis electrodes are arranged outside the first treatment zone 4a.

In particular, the first iontophoresis electrode 22 is arranged in a second treatment zone 4b of the treatment surface 4, distinct from the first treatment zone 4a. In the embodiment shown, the second treatment zone 4b is centered on the longitudinal axis L of the body 2, at a distance therefrom and peripheral to the first treatment zone 4a. Thus, the second treatment zone 4b extends around the first treatment zone 4a and in particular along the outer edge 5 of the treatment surface 4. Alternatively, the second treatment zone 4b could only extend partly around the first treatment zone 4a, along a part of the outer edge 5 of the treatment surface 4. An area ratio of the first treatment zone 4a to the second treatment zone 4b can be between 0.5 and 1.5, especially between 0.8 and 1.2.

The first iontophoresis electrode 22 has an extended contact surface 22a extending continuously over at least part of the second treatment zone 4b. The extended contact surface 22a of the first iontophoresis electrode 22 is chosen to cover at least 50%, preferably at least 75%, of the second treatment zone 4b. The extended contact surface 22a of the first iontophoresis electrode 22 may in particular be between 2 cm² and 4 cm².

The extended contact surface 22a of the first iontophoresis electrode 22 and the point contact surface 18a of each electroporation electrode 18 have a significant difference in extent. For example, a surface ratio of the extended contact surface 22a of the first iontophoresis electrode 22 to the point contact surface 18a of each electroporation electrode 18 is greater than 20, in particular greater than 50, in particular greater than 100 , for example between 150 and 300.

In addition to the difference in extent, the extended contact surface 22a of the first iontophoresis electrode 22 and the point contact surface 18 of each electroporation electrode 18a have a height difference relative to the treatment surface of the body 4 along the longitudinal axis. For example, the point contact surfaces 18a of the electroporation electrodes 18 are arranged at a distance relative to the treatment surface 4 greater than 5% to 20% of a distance from the extended contact surface 22a of the first electrode. of iontophoresis 22.

The second iontophoresis electrode 23 of the iontophoresis device 20 is arranged at a distance from the treatment surface 4. In the embodiment shown, the second iontophoresis electrode 23 is arranged on the handle 6. In particular, the second iontophoresis electrode 23 is annular around the longitudinal axis L and extends on the exterior surface of the side wall 7, at the level of a hollow in the concave zone 9.

Figure 5 represents an example of an electric electroporation signal SE making it possible to produce an electric field suitable for carrying out electroporation. In particular, the electric field produced by the electric electroporation signal SE reduces locally and reversibly, that is to say transiently over time, the barrier properties of the skin layer to allow the active ingredients to pass through. the skin layer.

The electroporation generator 16 is, for example, a voltage generator configured to generate the electroporation electrical signal SE in the form of trains of electrical pulses T _SE such that two successive trains of electrical pulses T _SE are separated by a time interval. To obtain the appropriate electric field, the electroporation electric signal SE has a frequency F between 0.5 Hz to 5 Hz corresponding to the frequency at which the electric pulse trains T _SE are generated. Each train of electrical pulses T _SE comprises a number N, integer greater than or equal to 4, of bipolar electrical pulses I _SE each having a voltage between 25 V and 300 V and a duration d _E between 1 µs and 25 µs from an initial moment. The number N of electrical pulses I _SE and the duration d _E of each electrical pulse are chosen for: 10 ^-6.1 /F ≤ N* d _E ≤ 10 ^-2.1 /F. Thus, the total duration of the train of electrical pulses T _SE only represents between one hundredth and one millionth of a period of the electrical electroporation signal SE.

There represents an example of an electrical iontophoresis signal SI based on an electric current adapted to carry out iontophoresis. Formulations can then be planned with ionized active ingredients exhibiting a sign of polarity. During iontophoresis, the first iontophoresis electrode 22 having the same polarity sign is brought into contact with the formulation so as to cause the ionized active ingredients to migrate according to a phenomenon of electromigration or electro-repulsion. The active ingredients can also be entrained by convection by the electric current circulating between the first 22 and second 23 iontophoresis electrodes by a phenomenon of electro-osmosis.

The iontophoresis generator 21 can be an electric current generator configured to generate the electric iontophoresis signal SI in the form of direct electric current slots C. The direct electric current slots C are generated at the same frequency F as the trains d electrical pulses T _SE of the electroporation electrical signal SE. Each wave of direct electric current C has a voltage between 5 V and 30 V, an intensity between 0.2 mA.cm ^-2 and 1 mA.cm ^-2 and a duration d _i .

The processing system 1 includes a control unit 25 configured to:
- control the electroporation generator 16 alone so that it generates the electrical electroporation signal SE,
- control the iontophoresis generator 21 alone so that it generates the electrical iontophoresis signal SI,
- jointly control the electroporation 16 and iontophoresis 21 generators to generate the electroporation SE and iontophoresis electrical signals SI in a synchronized manner.

In the latter case, synchronization is provided in such a way that each continuous electrical current slot C of the electrical iontophoresis signal SI is generated in the time interval between two successive trains of electrical pulses T _SE after a time delay T has passed. In particular, the time delay T can have a duration d _T such that 0.25.1/F ≤ d _T ≤ 0.75.1/F from the initial instant, that is to say between a quarter and three quarters of the period of the electrical signals of electroporation SE and iontophoresis SI. The duration d _i of the direct electric current slot C of the electrical iontophoresis signal SI is such that 0 < d _i ≤ 1/F - d _T , that is to say it is non-zero and corresponds to all or part of the remaining part of the period of the electrical signals of electroporation SE and iontophoresis SI after the time delay T.

The treatment system 1 described above can be implemented in a treatment process during which a formulation is applied to the skin layer of the anatomical area to be treated. The formulation contains in particular active ingredients, where appropriate ionized, and texturizing and stabilizing agents, preferably neutral, to stabilize it.

The treatment surface of the treatment system 1 is placed in contact with the skin layer and moved over the skin layer.

At least one of electroporation and iontophoresis is applied.

As indicated previously, electroporation can be applied alone, by generating the electrical electroporation signal SE by the electroporation generator 16 and by delivering the electrical electroporation signal SE by the set of electroporation electrodes 18 on the skin layer.

Likewise, iontophoresis can be applied alone by generating the electrical iontophoresis signal SI by the iontophoresis generator 21 and by delivering the electrical iontophoresis signal SI by the first 22 and second 23 iontophoresis electrodes on the skin layer.

Finally, electroporation and iontophoresis can be applied jointly, the electrical electroporation signals SE and iontophoresis SI being delivered in a synchronized manner by the electroporation 16 and iontophoresis 21 generators controlled by the control unit 25 in such a way that each continuous electric current slot C of the electrical iontophoresis signal SI is generated in the time interval between two successive trains of electrical pulses T _SE after the time delay T has elapsed.

As explained previously, electroporation makes it possible to transiently permeabilize the skin layer in order to allow the active ingredients of the formulation to pass through. Iontophoresis allows the active ingredients to penetrate into the anatomical area to be treated.

During iontophoresis, the practitioner holds the handle 6 of the body 2 of the treatment system 1 with a first hand of the practitioner, in contact with the second iontophoresis electrode 23. The practitioner places part of his second hand in contact with a area of skin opposite the layer of skin of the anatomical area, facing the treatment surface 4. The practitioner and the user to whom the treatment is applied close a circuit between the first 22 and second 23 iontophoresis electrodes. In doing so, the electric current can flow perpendicular to the skin layer to effectively migrate the active ingredients through the skin.

In addition to the penetration of active ingredients through the skin layer and into the anatomical area to be treated, the electrical signals of electroporation SE and iontophoresis SI can also induce transdermal vascular stimulation (TEVS for Trans- Epidermic Vascular Stimulation in English) which promotes microcirculation of the skin and thus, irrigation of the epidermis of the skin layer.

The treatment system 1 described above can be integrated into a treatment installation combining electroporation and iontophoresis with other treatment techniques.

In addition to the treatment system 1, the treatment installation in particular a radiofrequency treatment device 30 shown in Figures 7 and 9.

The radiofrequency treatment device 30 comprises an additional body 32 configured to be held in the hand by the practitioner and having a radiofrequency treatment surface 34 configured to be placed in contact with the skin layer of the anatomical area. The additional body 32 is shaped similarly to the body of the treatment system. It comprises a head 33 comprising the radiofrequency treatment surface 34, and a handle 36 arranged opposite the radiofrequency treatment surface 34. The handle 36 is configured to be held in the hand by the practitioner and internally comprises a accommodation 38.

The radio frequency processing device 30 also includes a radio frequency generator 41 received in the housing 38 of the handle 36 of the body 32 and configured to generate a radio frequency signal. It also includes a set of radio frequency electrodes 42 arranged on the radio frequency processing surface 34 and configured to deliver the radio frequency signal. The radio frequency electrode assembly 42 includes two or more radio frequency electrodes 42.

For example, the radiofrequency treatment device 30 may be bipolar. The radio frequency signal can then have a frequency between 3 kHz and 300 MHz. And an energy between 10 J.cm ^-3 and 100 J.cm ^-3 .

The treatment installation may further comprise a phototherapy device 50 shown in Figures 9 and 10.

The phototherapy device 50 includes a light source 51 configured to emit phototherapy light. The light source may comprise at least one group of light-emitting diodes 52 chosen from:
- monochromatic light-emitting diodes whose phototherapy light has a wavelength of between 620 nm and 660 nm and a power of between 2 mW/cm² and 5 mW/cm² at 1 cm from the skin layer,
- monochromatic light-emitting diodes whose phototherapy light has a wavelength of between 820 nm and 840 nm and a power of between 1.5 mW/cm² and 3 mW/cm² at 1 cm from the skin layer.

The phototherapy device 50 also includes a support having an application surface configured to be placed facing the layer of skin of the anatomical area. In the embodiment shown, the support constitutes a mask 55 configured to be worn on at least one part of the face as an anatomical zone. The group or groups of light-emitting diodes 52 are arranged on an interior surface 56 of the mask 55 constituting the application surface. An exterior surface 57 of the mask 55 can be covered by a removable cover 58, for example by being pivotally mounted on the mask 55.

There represents a base 60 receiving the treatment system 1, the radiofrequency treatment device 30 and the phototherapy device 50. A cover 61 cooperating with the base 60 to close it comprises the control unit 25 of the treatment system 1, for example further adapted to control the radiofrequency treatment device 30 and the phototherapy device 50 of the treatment installation. The control unit 25 being offset relative to the body 2 of the treatment system 1, to the additional body 32 of the radiofrequency treatment device 30 and to the phototherapy device 50, the treatment system 25 further comprises a communication interface 65 between the control unit 25, on the one hand, and the electroporation 16, iontophoresis 21 and radio frequency 41 generators and the light source 51 on the other hand. The communication interface 65 includes for example a touch screen on the cover 61 of the base 60 and a wireless information exchange system, according to any appropriate protocol, or wired.

As a purely illustrative, non-limiting example, the processing system was implemented with the following parameters:
Electroporation:
- 12 electroporation electrodes of 1.6 mm diameter arranged with a center distance of 3.5 mm,
- electroporation signal consisting of trains of bipolar electrical pulses between 100V and 300V (minimum one train of bipolar pulses of 4 bipolar electrical pulses) with a duration of between 1 µs and 25 µs per bipolar electrical pulse (i.e. between 4 µs and 100 µs per train of bipolar electrical pulses) at 2 Hz via a voltage generator,
Iontophoresis:
- extended contact surface of the first iontophoresis electrode of 2.52 cm²,
- iontophoresis signal from a direct current between 5 and 30V, for an intensity of 0.5mA.

The radiofrequency treatment device 30 was implemented with the following parameters:
- bipolar,
- frequency between 3 kHz and 300 MHz,
- energy between 10 J.cm ^{- 3} and 100 J.cm ^{- 3} .

Furthermore, the phototherapy device was implemented by emitting simultaneously at two following wavelengths:
- Monochromatic LED λ=632 nm (Red)
Power at 1cm from the skin: 4.2 mW/cm² (equivalent in power to a panel 5 cm from the skin of 105 mW/cm²),
Energy: 130 J/cm² for 20 minutes,
- Monochromatic LED λ=830 nm (Near IR)
Power at 1cm from the skin: 2.2 mW/cm² (equivalent in power to a panel 5 cm from the skin of 55 mW/cm²),
Energy: 70 J/cm² for 20 minutes.

Claims (16)

System for treatment (1) of an anatomical zone of a living being, the anatomical zone being covered by a layer of skin, the treatment system (1) comprising:
- an electroporation device (15) comprising an electroporation generator (16) configured to generate an electrical electroporation signal (SE), and a set of electroporation electrodes (18) comprising at least two electroporation electrodes (18) electroporation (18) and configured to deliver the electroporation electrical signal (SE),
- an iontophoresis device (20) comprising an iontophoresis generator (21) configured to generate an electrical iontophoresis signal (SI), and at least first (22) and second (23) iontophoresis electrodes configured to deliver the electrical signal iontophoresis (SI),
- a body (2) configured to be held in the hand by a practitioner, the body (2) having a treatment surface (4) configured to be placed in contact with the skin layer of the anatomical area,
in which the treatment surface (4) has first (4a) and second (4b) distinct treatment zones, the set of electroporation electrodes (18) is arranged in the first treatment zone (4a), and the first (22) and second (23) iontophoresis electrodes are arranged outside the first treatment zone (4a), at least the first iontophoresis electrode (23) being arranged in the second treatment zone (4b). Treatment system (1) according to claim 1, in which the second treatment zone (4b) extends at least partly around the first treatment zone (4a). Treatment system (1) according to claim 2, in which the treatment surface (4) has an outer edge (5), the second treatment zone (4b) extending over at least part of the outer edge (5) . Treatment system (1) according to any one of claims 1 to 3, in which the electroporation electrodes (18) respectively have point contact surfaces (18a) distributed discreetly over a part of the first treatment zone (4a), and the first iontophoresis electrode (22) has an extended contact surface (22a) extending continuously over at least part of the second treatment zone (4b), an area ratio of the surface extended contact surface (22a) of the first iontophoresis electrode (22) on the point contact surface (18a) of each electroporation electrode (18) being preferably greater than 20, in particular greater than 50, in particular greater than 100 , for example between 150 and 300. Treatment system (1) according to claim 4, in which an area ratio of the first treatment zone (4a) to the second treatment zone (4b) is between 0.5 and 1.5, in particular between 0, 8 and 1.2, a sum of the point contact surfaces (18a) of the electroporation electrodes (18) covering at most 25%, preferably at most 15%, of the first treatment zone (4a) and the surface of extended contact (22a) of the first iontophoresis electrode (22) covering at least 50%, preferably at least 75%, of the second treatment zone (4b). Treatment system (1) according to any one of claims 4 and 5, in which each electroporation electrode (18) is cylindrical around a central axis, the point contact surface (18a) of each electroporation electrode (18) being between 1 mm² and 3 mm² and the electroporation electrodes (18) being arranged on the first treatment zone (4a) with a center distance of between 2 mm and 6 mm. Treatment system (1) according to any one of claims 4 to 6, wherein the extended contact surface (22a) of the first iontophoresis electrode (22) is between 2 cm² and 4 cm². Treatment system (1) according to any one of claims 4 to 7, wherein the point contact surfaces (18a) of the electroporation electrodes (18) are arranged at a distance from the upper treatment surface of 5 % to 20% of a distance from the extended contact surface (22a) of the first iontophoresis electrode (22). Treatment system (1) according to any one of claims 1 to 8, wherein the second iontophoresis electrode (23) is arranged at a distance from the treatment surface (4). Treatment system (1) according to claim 9, wherein the body (2) comprises a head (3) comprising the treatment surface (4), and a handle (6) arranged opposite the treatment surface ( 4) and configured to be held by the hand by the practitioner, the second iontophoresis electrode (23) being arranged on the handle (6). Treatment system (1) according to any one of claims 1 to 10, in which the body (2) internally comprises a housing (8) receiving the electroporation (16) and iontophoresis (21) generators. Treatment system (1) according to any one of claims 1 to 11, in which the electrical electroporation signal (SE) comprises trains of electrical pulses (T _SE ), two trains of electrical pulses (T _SE ) successive being separated by a time interval, and the electrical iontophoresis signal (SI) comprises direct electric current slots (C), the processing system (1) comprising a control unit (25) configured to jointly control the generators electroporation (16) and iontophoresis (21) for generating the electroporation (SE) and iontophoresis (SI) electrical signals in a synchronized manner such that each direct electric current slot (C) of the iontophoresis electrical signal (SI) is generated in the time interval between two successive trains of electrical pulses (T _SE ) after a time delay (T) has elapsed. Treatment system (1) according to claim 12, in which the electroporation generator (16) is a voltage generator configured to generate trains of electrical pulses (T _SE ) at a frequency F between 0.5 Hz at 5 Hz, each train of electrical pulses (T _SE ) comprising a number N, integer greater than or equal to 4, of bipolar electrical pulses (I _SE ) each having a voltage between 25 V and 300 V and a duration d _E between 1 µs and 25 µs from an initial instant, the number N and the duration d _E being such that 10 ^-6.1 /F ≤ N* d _E ≤ 10 ^-2.1 /F,
in which the time delay (T) has a duration d _T such that 0.25.1/F ≤ d _T ≤ 0.75.1/F from the initial instant, and
in which the iontophoresis generator (21) is an electric current generator configured to generate the direct electric current slots (C) at the frequency F, each direct electric current slot (C) having a voltage between 5 V and 30 V, an intensity comprised of 0.2 mA.cm ^-2 and 1 mA.cm ^-2 and a duration d _i such that 0 < d _i ≤ 1/F - d _T . Processing system (1) according to any one of claims 12 and 13, in which the control unit (25) is further configured to:
- control the electroporation generator (16) alone so that said electroporation generator (16) generates the electrical electroporation signal (SE),
- control the iontophoresis generator (17) alone so that said iontophoresis generator (17) generates the electrical iontophoresis signal (SI). Installation for treating an anatomical area of a living being, the anatomical area being covered by a layer of skin, comprising:
- a treatment system (1) according to any one of claims 1 to 14,
- a radio frequency treatment device (30) comprising a radio frequency generator (41) configured to generate a radio frequency signal, a set of radio frequency electrodes (42) comprising at least two radio frequency electrodes (42) and configured to deliver the radio frequency signal, and an additional body (32) configured to be held in the hand by a practitioner, the additional body (32) having a radio frequency treatment surface (34) configured to be placed in contact with the skin layer of the anatomical area, the set of radiofrequency electrodes (42) being arranged on the radiofrequency treatment surface (34). Treatment installation according to claim 15, further comprising a phototherapy device (50) comprising a light source (51) configured to emit phototherapy light and a support having an application surface configured to be placed facing the layer skin of the anatomical area, said at least one light source (51) being arranged on the application surface.