FR3037810A1 - ULTRAPORTABLE METHOD AND DEVICE FOR COSMETIC ANTI-WRINKLE TREATMENT AND ANTI-REDNESS SKIN BY IOPHORESIS PHOTOMODULATION AND MICROVIBRATIONS - Google Patents

Abstract

The present invention relates to a cosmetic treatment method for preventing and / or treating wrinkles and redness of the skin, consisting of a step of exposing said area of the skin to be treated to a light source (20) emitting light at a wavelength between 590 and 598 nm for a luminous intensity of between 8000 and 12000 mcd; a step of exposing said area of the skin to be treated to a light source (20) emitting light at a wavelength of between 630 and 660 nm, for a luminous intensity of between 8000 and 12000 mcd; a step of exposing said area of the skin to be treated to ion therapy; a step of exposing said area of the skin to be treated to micro-vibrations. The present invention also relates to a device (1) for a cosmetic treatment for preventing and / or treating wrinkles and redness of a skin zone consisting of a housing and being characterized in that it comprises a light source (20). ), simultaneously emitting light in a wavelength range between 590 and 598 nm, with a luminous intensity of between 8000 and 12000 mcd, and light in a wavelength spectrum of between 630 and 660 nm, with a light intensity of between 8000 and 12000 mcd, an iontophoresis device and microvibration device.

Description

Ultraportable process and device for cosmetic treatment anti-wrinkle and anti-redness of the skin by photomodulation iontophoresis and microvibrations.

The present invention relates to a method of cosmetic anti-aging treatment (wrinkles, redness) of the skin by photomodulation, iontophoresis and vibration and a device for carrying out such a cosmetic treatment of the skin. Maintaining a youthful appearance is a constant concern today. Over time, and particularly chronological and / or photoinduced aging, the skin undergoes numerous modifications and degradations that are reflected, at the tissue level, by a disorganization of the architecture of the epidermis, of the dermal junction. epidermal, dermis, as well as blood supply systems and innervation, and a slowing down or dysregulation of different cellular metabolisms, such as those put into play in the balance of the barrier function or involved in melanogenesis. At the cellular level, aging thus results in an alteration of the physiology or metabolism of the main cell types such as dermal fibroblasts, epidermal keratinocytes, and also melanocytes. Skin aging results from two separate and independent processes that involve intrinsic or extrinsic factors. Intrinsic or chrono-biological aging corresponds to age-related normal or physiological aging. The intrinsic aging results in a slowing down of the renewal of the cells of the epidermis and the appearance of fine lines or wrinkles. At the level of the dermis, the biosynthesis of macromolecules such as collagen decreases with age, changing the mechanical properties of the dermis, hence slackening of the skin, one of the clinical signs of aging. Extrinsic aging corresponds to aging caused in general by the environment and corresponds more particularly to the photo-aging due to exposure to the sun. Photo-induced skin aging, that is to say, caused following exposure to the sun is still called photo-aging or heliodermia. Photo-aging is the result, at the level of the dermis, of the degradation of the collagen fibers resulting in particular in clinical alterations such as thick wrinkles and the formation of a soft and tanned skin. The aging of the skin is accelerated by chronic UV exposure.

3037810 2 There is thus a large number of so-called "anti-aging" cosmetic treatments intended to prevent and / or treat aging, in particular photo-aging and their signs, in particular to prevent the appearance of wrinkles and to reduce visibly already present wrinkles, but also to attenuate or eliminate senescence tasks (due to age). Among these cosmetic treatments include, for example, the regular application of so-called anti-wrinkle lotions or creams, "peels" for removing one or more superficial layers of the skin, the injection of collagen or other agent of skin filling, dermabrasion, botulinum toxin injection or surgical methods such as "facelift". Recently, methods of treating the skin with light have appeared. Such methods use, for example, a laser or a source of intense pulsed light. The concept of photorejuvenation developed a few years ago aims to improve the heliodermia by non-ablative means, that is without removing the superficial layers of the skin and therefore without annoying side effects. Dr. Mac Daniel first showed that by using cold light sources such as LEDs (emitting from 0.01 to 2 Joules / cm2) one could regulate the fibroblast activity and induce the formation of procollagen (collagen type I) . At the same time, there was a significant reduction in Metalloproteinases type 1 (MMP1 or collagenase). This concept has been confirmed by NASA's Dr. Wheland team. Intense Pulse Light (IPL) is also a technology widely used in aesthetic care. It complements the action of lasers in the treatment of signs of aging such as photo-depigmentation and wrinkles. Flash lamps are high-intensity discharge lamps filled with a rare gas, xenon, for example. They work by converting stored electrical energy into intense bursts of radiant energy. The light emitted covers the ultraviolet, visible and infrared light spectrum regions, i.e. from about 350 nm to about 1200 nm. Unlike lasers, flash lamps are therefore polychromatic. This broad spectrum of the lamp allows to act simultaneously on different types of skin problem. Indeed, it has been determined that a given range of wavelengths can have a particular beneficial effect on the skin. It is then necessary to use filters allowing the selection of the desired wavelength depending on the treatment envisaged. This particularity of flash lamps explains that their manipulation must be reserved for experienced practitioners. Another disadvantage of flash lamps, as well as lasers, is the relatively large size of these devices.

Alternatively to the use of lasers or flashlamps, technology has developed around the use of light-emitting diodes (LEDs) for the cosmetic and therapeutic treatment of the skin. Light-emitting diodes are electronic components that, when traversed by an electric current, emit low-frequency light. It emits a light that is considered cold because it does not produce heat. This characteristic is due to a lack of resistance present in other bulbs. LEDs fall into the category of LLLTs (Low Level Laser Therapy). They have the advantage of being inexpensive in comparison with lasers or flashlamps and, because of their lower light intensity, do not present any danger of burns or other injuries to the skin if the exposure is not exposed. not properly performed. Light-emitting diodes emit light in a spectrum that extends from visible to infrared. Some are said to be monochromatic but emit light whose wavelength is within a small spectrum corresponding to a given color of light. Others, such as white diodes, are polychromatic. It is therefore possible to use light-emitting diodes for the cosmetic treatment of the skin and to select them according to the result that it is desired to obtain. One of the targets in the cosmetic treatment of wrinkles, as well as in the prevention of the appearance of wrinkles, is collagen. Collagen is a fibrous protein secreted by the connective tissue fibroblasts This protein ensures the connective tissue cohesion The appearance of the wrinkles is due, in large part, to the deterioration of the connective tissue and the decrease with the age of the connective tissue. the synthesis of collagen by fibroblasts. It is now known that exposure of the skin to light can stimulate collagen synthesis or even prevent the deterioration of collagen present in the connective tissue. This is the case, for example, of light which corresponds substantially to the yellow light of the visible spectrum of light. One possible explanation is that at this wavelength range, the light flow can inactivate collagenase, an enzyme that degrades collagen.

But if the choice of a range of wavelengths is important for a treatment given by the light, it is also important to select the adequate light intensity and the duration of exposure of the zone to be treated which will allow, in combination, to obtain a satisfactory result.

The Applicant has already been able to demonstrate in patent FR2917299 that a cosmetic treatment of the skin with a device allowing the delivery of a light source emitting light in a wavelength spectrum of between 590 and 598 nm, for a luminous intensity of between 8000 and 12000 millicandelas (mcd), a frequency of the light pulses of about 5 Hz and a duration of each light pulse of about 1 ms allowed an action of prevention and reduction of wrinkles. Today the Applicant continues to innovate in this field of cosmetic skin treatment in the anti-aging having designed a cosmetic treatment process combining 2 ranges of wavelength and a range of luminous intensity which, in combination, allow the prevention and reduction of wrinkles by stimulating the synthesis of collagen by fibroblasts, but also the reduction of redness of the skin. This cosmetic treatment also includes treatment with iontophoresis and micro-vibrations. The Applicant also proposes an ultraportable device weighing less than 30 g without a battery, and less than 55 g with a battery, preferably weighing approximately 25 g without a battery, and approximately 50 g with a battery, thus making a mobile product, easily transportable in a pocket or handbag, and allowing an application on the surface of the skin to be treated throughout the day and allowing the implementation of this cosmetic treatment. In addition this small device with a treatment surface between 2 and 5 cm 2, preferably 3 cm 2, allows targeted treatment of an area of the skin and is particularly suitable for difficult areas of access of the face such as the contour eye, especially crow's feet and eyelid, and nasolabial folds. The present invention thus relates to a method of cosmetic anti-aging treatment (wrinkles, redness) of the skin by photomodulation, iontophoresis and vibration as well as an ultraportable device for carrying out such a cosmetic treatment of the skin. Thus, according to a first aspect, the invention relates to a cosmetic treatment method for preventing and / or treating wrinkles and redness of the skin, characterized in that it comprises concomitantly and for a given period of time: 3037810 5 a . a step of exposing said zone of the skin to be treated to a light source emitting light in a wavelength spectrum of between 590 and 598 nm, preferably 596 nm, for a light intensity of between 8000 and 12000 millicandelas (mcd) and for a defined period, advantageously between 30 sec and 3 min, preferably 1 minute; b. a step of exposing said area of the skin to be treated to a light source emitting light in a wavelength spectrum of between 630 and 660 nm, preferably 630 nm for a light intensity of between 8000 and 12000 millicandelas (mcd) and for a determined period, advantageously between 30 sec and 3 min, preferably 1 minute; vs. a step of exposing said area of the skin to be treated to ion therapy; 15 d. a step of exposing said zone of the skin to be treated to micro-vibrations. The applicants have observed, surprisingly, that the step of the cosmetic light treatment according to the invention in a wavelength spectrum of between 590 and 598 nm, preferably 596 nm, was used to stimulate the synthesis of collagen. by the fibroblasts of the skin in a big way. This is the result of combining the range of wavelengths and the intensity of the emitted light used. As mentioned above, stimulating collagen synthesis helps reduce skin wrinkles and prevent them from appearing.

Applicants have also observed, surprisingly, that the step of the cosmetic light treatment according to the invention in a wavelength spectrum of between 630 and 660 nm, preferably 630 nm, made it possible to reduce the production of pro-inflammatory cytokines and therefore reduce redness. Applicants have also observed, surprisingly, that the cosmetic ionotherapy treatment step according to the invention makes it possible to increase the skin permeability in a temporary and controlled manner. As mentioned above, this increase in skin permeability makes it possible to promote the penetration of skincare active ingredients, in particular anti-aging active ingredients and thus to increase and / or accelerate their effect on the skin. These anti-aging active agents may be anti-wrinkle, anti-redness or any anti-aging active ingredient known to those skilled in the art. Thus, advantageously, the cosmetic treatment method according to the invention comprises a step prior to the application of a topical composition comprising an anti-wrinkle or anti-redness active agent or any anti-aging active ingredient known to man of the job. Applicants have also observed, surprisingly, that the cosmetic microvalent treatment step according to the invention makes it possible to help restart the local microcirculation. As mentioned above, this makes it possible to improve intercellular communication, and in the case where an anti-wrinkle or anti-redness active agent, or more generally an anti-aging active agent is applied beforehand to the skin, this makes it possible, in particular in combination with ionotherapy, to increase and / or accelerate its effect on the skin.

Finally, the applicants observed that the exposure treatment step of said skin area to be treated with a light source (20) emitting light at two specific wavelengths, one between 590 and 598 nm , preferably 596 nm, the other 630 and 660 nm, preferably 630 nm for a light intensity of between 8000 and 12000 mcd, associated with an ion therapy step and a microvibration step made it possible to obtain, surprisingly, results particularly interesting. Within the meaning of the invention, the term "skin" refers to the entire epidermis of the human body. More particularly, the skin considered in the present invention is preferably the skin of the face, décolleté, back, and preferably the skin of the face. By "prevention" or "prevention" is meant according to the invention the fact of reducing the risk of occurrence or slowing down the occurrence of a given phenomenon, namely, according to the present invention, skin disorders and / or skin imperfections associated with aging skin.

Ionotherapy is intended to denote according to the invention a cosmetic treatment which relies on the use of a low intensity electric current to penetrate molecules, preferably hydrophilic in the skin, according to two mechanisms (Morrow et al. (2007) Innovative strategies for enhancing topical and transdermal drug delivery.The 5 Open Drug Delivery Journal, 1; TEAIMA (2012) Electrically-assisted Transdermal Delivery of Escin.International Journal of Pharmacy and Pharmaceutical Sciences, 4.) - Electro-repulsion (Morrow et al.): principle of transport of charged molecules. A charged molecule (for example positively) is repelled by an electrode of the same polarity (in our positively charged example) when applying an electric current (very low). And conversely for negative charges. - electro-osmosis (TEAIMA, 2012) principle of the transport of uncharged molecules. The skin is negatively charged: the positively charged ions (eg Na +), circulate better in the skin, and thus create a flow, which induces an osmotic flow of water, when applying an electric current ( very weak). It is this flow of water that will facilitate the penetration of neutral molecules. Ionotherapy therefore makes it possible to promote the penetration of active agents into the skin, whatever their polarity, thanks to electro-osmosis, but even better by the combined action of electro-osmosis and electro-repulsion. in the case where it is chosen to apply to the skin prior to the ionotherapy step at least one anti-wrinkle, anti-redness, or more generally anti-aging active having the same charge as the electrode used for the application low intensity electric current.

According to the present invention, said low intensity electric current is between 400 and 1000 μL, preferably 700 μL. By microvibration is meant according to the present invention vibrations of between 700 and 950 Hz on the skin, preferably 843 Hz. The ion therapy device and the microvibration device must be placed in contact with the skin so that the steps Ionotherapy and microvibrations of the method according to the invention may have an effect on said skin to be treated.

According to one characteristic of the invention, said light source is composed of a plurality of light-emitting diodes. In a preferred manner according to the invention, said light source comprises at least 5, preferably between 5 and 15 electroluminescent diodes. Even more preferentially, said light source is composed of 10 light-emitting diodes. More particularly preferably, said light source is composed of 5 light-emitting diodes capable of emitting in a wavelength spectrum of between 630 and 660 nm, preferably 630 nm, and 5 light-emitting diodes capable of emitting in a wavelength range between 590 and 598 nm, preferably 596 nm. More preferably, these light-emitting diodes have a power of 0.018W. In a preferred manner according to the invention, said light whose wavelength spectrum is between 590 and 598 nm is emitted in the form of bursts of light pulses. More preferably, the frequency of said pulses is about 5 Hz and the duration of said pulses is about 1 ms. In a preferred manner according to the invention, the four steps a) b) c) and d) are simultaneous and of a given period of between 1 minute and 3 minutes in total, preferably 1 minute. Advantageously, said exposure step is repeated two to three times a day. Advantageously, said exposure step is repeated two to three times daily, either as a spot treatment for 2 to 5 days, or for a chronic treatment for at least 28 days. Advantageously, the light source is disposed in contact with the zone to be treated, without it being necessary. According to a second object, the present invention relates to a device for implementing the cosmetic treatment method for preventing and / or treating wrinkles. and redness of the skin, as just described. Such a device according to the invention comprises, preferably consists of, a housing comprising a light source (20), characterized in that said light source (20) 3037810 9 simultaneously emits light in a spectrum of wavelengths between 590 and 598 nm, preferably 596 nm, with a luminous intensity of between 8000 and 12000 mcd, a light in a wavelength spectrum of between 630 and 660 nm, preferably 630 nm, with a luminous intensity of between 8000 and and 12000 mcd, an iontophoresis device (I) and a microvibration device (U). According to one characteristic of the invention, said light source comprises a plurality of light-emitting diodes, advantageously arranged in a matrix. More preferably, the light source represents an area of 2 to 5 cm 2, preferably 3 cm 2. According to one characteristic of the invention, said light source is composed of a plurality of light-emitting diodes. In a preferred manner according to the invention, said light source comprises at least 5 light-emitting diodes, more preferably between 5 and 15 light-emitting diodes and particularly preferably 5 light emitting diodes whose wavelength spectrum is between 630 and 660 nm, preferably 630 nm and 5 light emitting diodes whose wavelength spectrum is between 590 and 598 nm, preferably 596 nm, a total of 10 light emitting diodes.

In a preferred manner according to the invention, said light emitting diodes emitting a light whose wavelength spectrum is between 590 and 598 nm emit preferably at 596 nm and have a power of 0.018 w.

In a preferred manner according to the invention, said light emitting diodes emitting a light whose wavelength spectrum is between 630 and 660 nm preferably emit at 630 nm and have a power of 0.018 w. According to yet another characteristic of the invention, said device comprises an iontophoresis device (I) (making it possible to perform ion therapy). The person skilled in the art knows from his general knowledge the devices that can be used to generate a current of low intensity according to the invention. For example, a donor electrode assembly, a counter-electrode assembly and an electric current generator may be associated. In particular, it is possible to use a device that creates a non-sinusoidal sawtooth wave.

According to yet another feature of the invention, said device comprises a microvibration device (U) which advantageously consists of a motor for creating micro-vibrations. It is preferably a motor running at 800 rpm.

According to yet another characteristic of the invention, said device advantageously comprises a detector (D) enabling it to automatically switch on the skin the treatment steps by phototherapy ionotherapy and by microvibration. Preferably, the detector (D) is a micro-current contactor. According to a preferred embodiment of the invention, the light source (20), the ion therapy device (I), the microvibration device (U) and the detector (D) are present in the same device and can be contact of the skin simultaneously thanks to the same zone of contact with the skin (Z). Said contact zone (Z) represents an area of 2 to 5 cm 2, preferably 3 cm 2 allowing targeted treatment, which can even be task by task. In addition this small device with a contact area (Z) between 2 and 5 cm 2, preferably 3 cm 2, is particularly suitable for areas difficult to access such as areas of the face. According to yet another characteristic of the invention, said device comprises a timer provided to control the duration of each step.

According to yet another characteristic of the invention, said device comprises a timer provided for switching off the device after one minute of non-use. According to yet another characteristic of the invention, said device comprises a timer associated with the detector (D) provided for stopping the treatment steps after 1.5 seconds of non-contact of the device with the skin.

Advantageously, said power source consists of a rechargeable battery or battery, preferably an LR06 battery. The characteristics of the invention mentioned above, as well as others, will emerge more clearly on reading the following description and examples of embodiment, said description being given in relation to the attached drawings, among which: FIG. . 1 is a front view of a device for the cosmetic anti-wrinkle and anti-perspirant treatment according to the invention. Fig. 2 is a side view of a device for the cosmetic anti-wrinkle and anti-redness treatment according to the invention. The device for the cosmetic treatment of the skin 3037810 11 according to the invention shown in FIG. 1 comprises a housing 10 comprising a light source 20. The light source 20 is composed of a plurality of light emitting diodes, such as the diode 210 and the diode 220. These are assembled into a matrix 21, preferably of oval shape. The matrix 21 may advantageously comprise 5 diodes 210 and 5 diodes 220. Each diode 210 of the light source 20 emits a light in the visible spectrum, of yellow-orange color, whose wavelengths are between 590 and 598 mu, preferably 596 nm and whose intensity is between 8000 and 12000 mcd, and each diode 220 of the light source 20 emits a light in the visible spectrum, of red color, whose wavelengths are between 630 and 660 nm, preferably 630 nm and whose intensity is between 8000 and 12000 mcd. Advantageously, the light source 20, when it emits a light in the visible spectrum, yellow-orange in color, whose wavelengths are between 590 and 598 nm, emits light pulses. To do this, the device of the invention comprises an electrical pulse generating means 50 supplying the diodes 210, with a pulse frequency of about 5 Hz and a duration of 1 ms. As can be seen in FIG. 1, the device of the invention further comprises a timer 60 connected, via the pulse generator 50, 20 to the matrix of diodes 21. It controls the pulse generator 50 for a predetermined duration for issuing bursts of light pulses with a frequency of approximately 5 Hz during said duration, for example between 30 seconds and 3 minutes, preferably 1 minute. Said device further comprises a battery pack 40 (battery or rechargeable battery or battery) for the general power supply of the device 1, that is to say the timer 60, and the matrix of diodes 20 and the generator of 50. A start button M present on the housing 10 is also connected to the battery 40 to allow the user to respectively turn on.

The housing 10 has a weight and dimensions enabling it to be portable and can advantageously be held in one hand. Advantageously, the device measures less than 15 cm long and less than 3 cm wide, preferably 13 cm long and 2.5 cm wide.

Advantageously the device weighs less than 50g, preferably less than 30g, without battery or battery and / or less than 55g with battery or battery. More preferably the device weighs about 25g without battery or battery and / or about 50g with battery or battery.

Advantageously, the device according to the invention comprises a magnet at its base enabling it to be fixed to a metal surface, for example to be kept standing on a metal surface such as a desk or a display stand. The device 1 according to the invention can be used in a cosmetic anti-wrinkle and anti-redness treatment of an area of the skin.

Such a method comprises a step during which the user can first apply a cosmetic composition, preferably anti-wrinkle and anti-redness, and put the device in contact with the skin to initiate the steps of ionotherapy phototherapy and microvibrations , simultaneous. For this the user grasps the device 1 in his hand and then presses the start button M and then places the device against the skin to be treated. The detector D makes it possible to start the phototherapy, ionotherapy and microvibration steps in contact with the skin. The timer 60 allows the device 1 to operate for a light exposure period of between 1 minute and 4 minutes, preferably 1 minute. During this step, the light source 20 emits a light whose wavelength spectrum is between 590 and 598 nm, preferably 596 nm and the light intensity is between 8000 and 12000 mcd, as well as a light whose wavelength spectrum is between 630 and 660 nm, preferably 630 nm and the light intensity is between 8000 and 12000 mcd and simultaneously dispenses the steps of treatment with ion therapy and by microvibrations, preferably for 1 minute. The user then presses the M button to turn off the device. If the user moves the device away and the device is no longer in contact with the skin for 1.5 seconds, the treatment steps automatically stop.

If the user does not use the device for 1 minute (i.e. the device is not in contact with the skin for 1 minute), the device automatically turns off. The Applicant has shown that the preferred embodiment, making it possible to solve the technical problem as efficiently as possible, combines in a device 3037810 13 a number of light-emitting diodes, with a certain power, and a spectrum in wavelengths (5). 0.018W light-emitting diodes having a wavelength spectrum of 590 nm to 598 nm, preferably 596 nm, and 5 light emitting 0.018W diodes having a wavelength spectrum in the range of 630 to 660 nm nm, preferably 630 nm), an ionotherapy and microvibration device and a specific treatment protocol (device placed in contact with the skin to be treated, treatment for one to three minutes 2 to 3 times per day, or punctual treatment for 2 to 5 days, ie for chronic treatment for at least 28 days).

Very good results were obtained with a repeated exposure period of one to two minutes twice daily for 28 days. The selection and combination of a wavelength of between 590 and 598 nm, preferably 596 nm and a wavelength of between 630 and 660 nm, preferably 630 nm, and of an appropriate light intensity provides a surprising result, as evidenced by the analyzes described in the following. Finally ionotherapy, optionally preceded by an application of a cosmetic anti-wrinkle or anti-redness composition, and the micro-vibrations associated with the light exposure at the wavelength of 596 nm and 630 nm according to a protocol of one minute morning and evening for 28 days allow to obtain even more interesting results.

Example 1: Clinical evaluation on 25 subjects of an anti-aging cosmetic treatment using a device emitting light at the wavelength of 630 nm. Treatment with a device emitting light at wavelengths of 630 25 nm was performed on one half-face on 25 healthy subjects (Caucasian women aged 23 to 68 years with a mean of age of 49.40 + 10.64 years). a) Realization of a model of erythema in the face after mesotherapy 30 Realization of a mesotherapy session using a roller with needles 1 mm long associated with the application of a polyrevitalisante solution . This roller allows the stimulation of skin cells in response to the mechanical aggression of the needles and creation of micro-channels optimizing the penetration of active ingredients.

3037810 14 In the immediate after-effects and generally continuing 30 minutes after the session of mesotherapy, an important erythema in the cheeks and extending on the chin and the forehead is observed. B) Performing the light application session at 630 nm on the right half-face To enable quantification of the anti-redness effect, each treatment session was performed with a device emitting continuous red light. 630 nm for 3 minutes on the right half face. Chromametric evaluations associated with dermatologic scoring have been used to measure the modulation of redness of the skin. 3D photographs illustrate the effect of the device according to the invention. C) Analyzes at TO, after completion of mesotherapy, 30 minutes and 1 hour after the session with the device according to the invention * Dermatological analysis, using a scoring (0 to 5) carried out from photographs made with the LifeViz II device by selecting the option to visualize the red components of the skin (erythema, rosacea, vascular disease ...). * Chromametric analysis of skin color using Konica Minolta Chromameter CR / DP-400® parameter a: red. The decrease in parameter (a) correlates with the decrease in erythema. * 3D photographs (profile) using the LifeViz II device to visualize the modulation of erythema after treatment. d) RESULTS This model of mesotherapy significantly increased the erythema in both cheeks with an average score of 2.88 versus 0.37 (p = 4.66x10-9) for the right cheek. and 2.76 versus 0.24 for the untreated left cheek (p = 3.14x10-9).

The erythema observed at the level of the right cheek treated by the device according to the invention emitting light at 630 nm is significantly decreased compared to the untreated left cheek with an average score of 1.36 versus 2. , 08 (p = 0.00076).

The anti-redness effect obtained by the device according to the invention emitting light at 630 nm is 52%. CONCLUSION In this clinical trial carried out on 25 subjects, using a cutaneous erythema model induced by mesotherapy, a statistically significant reduction in redness was obtained by dermatological and chromameric evaluation after treatment with the device according to the invention light at 630 nm. The anti-redness effect of the device according to the invention emitting light at 630 nm is 52% after mesotherapy. It can probably be extended to other inflammatory conditions of the skin, such as sunburn and skin irritations in sensitive skin. The cutaneous tolerance after use of the device according to the invention emitting light at 630 nm was excellent for all subjects.

The device according to the invention for carrying out the cosmetic treatment method according to the invention thus makes it possible to reduce the redness of a zone of the skin in a significant manner.

Example 2: Clinical evaluation on 30 subjects of an anti-aging cosmetic treatment using a device emitting light at the wavelength of 590 nm The clinical study involved a total of 30 elderly women from 35 to 60, the average age is 45 (37 to 59). A) Performing the 590 nm light application session on the pigmented lesions at the crow's feet or in the orbital region.

The device was used daily, preferably at the same time during the day (45-second session in pulsed mode) in the fine lines of crow's feet or in the orbital region for four weeks. Two visits were planned: at OJ for inclusion and at D28 (closing visit).

At each visit, a dermatological clinical examination of the tone of the skin (analysis by touch) and wrinkles or fine lines was done (semi-quantitative scores). Macrophotographies (subject not made up, standard poses) were taken. Measurements of the surface of the wrinkles, their depth and the roughness of the skin were made at OJ and 10 D28 with a measuring device (Skin Station). An assessment of tolerance and cosmetic comfort as well as that of the effectiveness of the product was collected. b) Results 15 - The average clinical score of skin tone was 1.93 at OJ. It is 1.57 to D28, corresponding to a statistically significant 18% improvement in skin tone - The average clinical score for fine lines and wrinkles was 2.13 at OJ. It is 1.73 to D28, 20 a statistically significant decrease of 19% - The average percentage of area occupied by fine lines and wrinkles, calculated by the Skin Station, was 5.76% at OJ. It was 3.66% at D28, a statistically significant decrease of 36.4% - The average roughness of the crow's foot and periorbital zone, calculated by the Skin 25 Station, was 0.479 at OJ . It is 0.391 to D28, a statistically significant decrease of 18.4% - The average volume of fine lines and wrinkles (V / mm), calculated by the Skin Station, was 57.5 at OJ. It is 40.2 to D28, a statistically significant decrease of 30%. The largest decrease in the volume of fine lines and wrinkles was 72% and the lowest 30 among responders was 15%. The tolerance was excellent and no adverse effects were noted. c) Conclusion 3037810 17 Clinical improvement after treatment with the device was observed in 27 of the 30 subjects. The results of the open clinical study on 30 women who daily applied the device to the crow's foot and the suborbital region for 28 days show an improvement in the clinical scores of the tone of the skin and the appearance of wrinkles respectively 18 and 19% on average. The surface of wrinkles and fine lines is reduced by 36.4% and their volume by 30% (measured by the Skin Station).

The tolerance of the product was excellent and the cosmetological appreciation overall very good. The device according to the invention for the implementation of the cosmetic treatment method according to the invention thus makes it possible to reduce the wrinkles of the skin significantly. 15

Claims (9)

REVENDICATIONS1. Cosmetic treatment method for preventing and / or treating wrinkles and redness of the skin, in particular the skin of the eye contour and in particular the crow's feet, characterized in that it consists, concomitantly and for a given period of time , to: a. a step of exposing said zone of the skin to be treated to a light source (20) emitting light at a wavelength of between 590 and 598 nm, preferably 596 nm, for a luminous intensity of between 8000 and 12000 mcd; b. a step of exposing said zone of the skin to be treated to a light source (20) emitting light at a wavelength of between 630 and 660 nm, preferably 630 nm, for a luminous intensity of between 8000 and 12000 mcd; vs. a step of exposing said area of the skin to be treated to ion therapy; d. a step of exposing said zone of the skin to be treated to micro-vibrations. 2. Cosmetic treatment process according to claim 1, characterized in that it comprises a step prior to a) application of a topical composition comprising an anti-wrinkle or anti-redness active. 3. Cosmetic treatment method according to claim 1 or 2, characterized in that said step c) of ion therapy is performed by the application on said area of the skin to be treated with an electric current of 700uA; 4. Cosmetic treatment method according to one of the preceding claims, characterized in that the 4 steps a), b) c) and d) are simultaneous and a specified period of between 1 minute and 3 minutes in total. 5. Cosmetic treatment method according to one of the preceding claims, characterized in that said exposure step is repeated two to three times a day either in point treatment for 2 to 5 days, or for chronic treatment for at least 28 days. days. 3037810 19 6. Device (1) for a cosmetic treatment for preventing and / or treating wrinkles and redness of a skin area according to the method according to one of claims 1 to 5, said device consisting of a housing and being characterized in that it comprises a light source (20), simultaneously emitting light in a wavelength spectrum of between 590 and 598 nm, preferably 596 nm with a light intensity of between 8000 and 12000 mcd, and a light in a wavelength spectrum of between 630 and 660 nm, preferably 630 nm with a light intensity of between 8000 and 12000 mcd, an iontophoresis device and a microvibration device. 10 7. Device (1) according to claim 6, characterized in that said light source (20) comprises 5 light-emitting diodes (210) emitting a light whose wavelength spectrum is between 590 and 598 nm, preferably 596 and 5 light-emitting diodes (220) whose wavelength spectrum is between 630 and 660 nm, preferably 630 nm. 15 8. Device (1) according to one of claims 6 or 7, characterized in that the light source is an area of 2 to 5 cm2, preferably 3 cm2. 9. Device (1) according to one of claims 7 to 8, characterized in that it measures less than 15cm long and less than 3cm wide