FR3125704A1 - Combination product to relieve symptoms of sore throats - Google Patents

Abstract

The present invention relates to a combination product comprising, as active substances, at least honey, eucalyptus and marshmallow to help relieve the symptoms of sore throats. The invention finally relates to the use of a combination product as previously defined for the treatment of sore throats.

Description

Combination product to relieve symptoms of sore throats

The present invention relates to a combination product comprising, as active substances, at least honey, eucalyptus and marshmallow to help relieve the symptoms of sore throats. The invention finally relates to the use of a combination product as previously defined for the treatment of sore throats.

Sore throat is a frequent reason for consultation. It is a symptom rather than a disease in itself. It can be diffuse or localized to the tonsils, pharynx or larynx.

• les pharyngites : il s'agit d'une inflammation des tissus de la gorge (pharynx). Avaler, parler ou même respirer peut devenir douloureux.
• dans les atteintes amygdaliennes (amygdalites) la douleur est plus localisée et siège au niveau d'une ou des deux amygdales, et provoque des difficultés importantes à avaler. La douleur peut aussi irradier dans l'oreille.
• l'épiglottite est une inflammation de l’épiglotte (petite langue cartilagineuse fermant le larynx lors de la déglutition). Elle est rare mais potentiellement grave car responsable de difficultés respiratoires

Locations of sore throat

• pharyngitis: this is an inflammation of the tissues of the throat (pharynx). Swallowing, talking or even breathing can become painful.
• in amygdala attacks (tonsillitis) the pain is more localized and sits at the level of one or both tonsils, and causes significant difficulty in swallowing. The pain may also radiate into the ear.
• epiglottitis is an inflammation of the epiglottis (small cartilaginous tongue closing the larynx during swallowing). It is rare but potentially serious because responsible for breathing difficulties

Sore throat results in tingling, pain or burning sensations, and is sometimes associated with difficulty swallowing or speaking as well as other symptoms depending on the location and cause of the disease.

In 80% to 90% of cases, sore throat is caused by a virus. In 10 to 15% of cases, angina is due to infection with bacteria.

Sore throat of viral origin:

It can be a pharyngitis or the beginning of a viral nasopharyngitis which is then completed by coughing, sneezing and nasal obstruction as in the flu for example.

Viral angina is generally accompanied by a moderate fever (between 38 and 39°). They can be due to many common viruses, but also to mononucleosis or herpes, measles, chicken pox...

Sore throat of bacterial origin:

Several types of bacteria can infect the throat.

Strep throat is caused by type A streptococcus (more rarely B or C). It is accompanied by fever, swelling of a tonsil, which may be red or dotted with white spots; in the neck, there is often a swollen and painful ganglion on the side of the affected tonsil. This angina can be serious when the streptococcus is group A because it can have repercussions on the whole body, the kidney and the heart in particular. It must therefore be treated quickly with antibiotics.

Tonsillitis:

We speak of chronic tonsillitis in front of an inflammation of the tonsils generally occurring after repetitive angina, responsible for pain or discomfort when swallowing, which is not very significant but which can increase during reheating flare-ups. The tonsillar "crypts" can fill with hard whitish secretions, the caseum, with a fetid odor.

Epiglottitis:

Epiglottitis is usually caused by the bacterium that causes pneumonia and meningitis, Haemophilus influenzae type B (Hib). This disease has become exceptional since the generalization of vaccination against Haemophilusinfluenzae in children.

• Une réaction allergique aux poils d’animaux, aux moisissures ou au pollen.
• L’air sec, surtout en hiver lorsque les maisons sont chauffées ou en été à cause de la climatisation.
• La pollution ou des irritants chimiques comme la fumée de tabac ou l'évaporation de produits comme les colles, les peintures, les produits ménagers….
• Une inflammation pharyngolaryngée après surmenage vocal.
• Un reflux gastro-œsophagien provoquant des pharyngites du fait de la remontée du liquide acide de l'estomac vers la gorge.
• Un mal de gorge qui persiste plus de 1 semaine peut être le signe d’un problème plus sérieux :
• Une infection au VIH, une infection à gonocoques.
• La présence d’une tumeur du pharynx ou du larynx.

Sore throats can also be due to:

• An allergic reaction to animal hair, mold or pollen.
• Dry air, especially in winter when houses are heated or in summer due to air conditioning.
• Pollution or chemical irritants such as tobacco smoke or the evaporation of products such as glues, paints, household products….
• Pharyngolaryngeal inflammation after vocal overstrain.
• Gastroesophageal reflux causing pharyngitis due to the rise of acidic liquid from the stomach to the throat.
• A sore throat that persists for more than 1 week may be a sign of a more serious problem:
• HIV infection, gonococcal infection.
• The presence of a tumor of the pharynx or larynx.

Possible complications:

Most sore throats, although uncomfortable, will get better on their own within 5-7 days. A bacterial sore throat can lead to certain complications.

In order to relieve sore throats, there are various products on the market. These products generally contain paracetamol, local anesthetics, such as lidocaine or tetracaine, corticosteroids, such as for example tixocortole, antibacterials, such as for example chlorhexidine, hexamidine, antiseptics such as biclotymol, benzalkonium, amylmetacresol, cetylpyridinium. Such products are marketed by URGO Laboratories under the trade name HUMEX® sore throat biclotymol or HUMEX® sore throat lidocaine or HUMEX sore throat lidocaine/benzalkonium, or by Sanofi-Aventis under the trade name SOLUTRICINE MAUX DE GORGE TETRACAINE, or ANGISPRAY MAL DE GORGE CHLORHEXIDINE/LIDOCAINE by P&G Health Laboratories. These compositions, due to the presence of active molecules such as paracetamol, lidocaine, tetracaine, tixocortole, chlorhexidine, hexamidine, biclotymol, benzalkonium, amylmetacresol or cetylpyridinium have the disadvantage of not cannot be used by the general population. Indeed, some products should not be used by children under 12 or by pregnant or breastfeeding women and may have undesirable effects.

In addition, consumers are increasingly opting for natural solutions and are reluctant to use active ingredients such as those described above.

Among the existing natural solutions, we can cite for example Lehning Swiss paste Propolis and honey, Oropolis soothes the throat liquid heart from the Mediflor Laboratory based on propolis, Activox mint eucalyptus from Arkopharma based on erysimum and matricaria, Pranarom Aromaforce Honey Lemon Gums based on essential oils of Lemon, Globular Eucalyptus, Thyme, Mandarin and Lemongrass.

None of the products offered contains the combination that is the subject of the present invention.

The Applicant has developed, and this is the subject of the present invention, a combination product comprising, as active substances, at least honey, eucalyptus and marshmallow to help relieve the symptoms of sore throats.

Preferably, the honey of the combination product according to the invention is a Manuka honey.

By “relieving the symptoms of sore throats”, is meant in the context of the present invention, a product which makes it possible to soften the throat, relieve tingling, pain or burning sensations, and reduce difficulty in swallowing.

Such a product therefore makes it possible to relieve the symptoms of sore throats with products of natural origin and to treat a greater number of people.

The product according to the present invention also has the advantage of preferably not containing any artificial coloring or allergens and of being, preferably, lactose or gluten free.

The product of the present invention has a galenic suitable for adults and children over 6 years old, preferably in the form of a lozenge to be sucked.

The product according to the present invention, although containing products of natural origin, has a pleasant taste and smell.

The pastille according to the invention advantageously has a solid shell and a melting heart, the two textures being perceptible after suction.

Preferably, the pastille according to the invention has a very good taste of honey, is soft and pleasant in the mouth when it is sucked.

Advantageously, the pellet according to the invention does not stick to the fingers when it is taken in hand.

Once in the mouth, advantageously, the pastille according to the invention does not stick either to the tongue or to the palate and the hard bark does not injure the palate.

The release of the melting heart brings a lining effect in the throat, thus allowing to relieve the symptoms of sore throats, in particular by reducing the pain during swallowing.

Summary

The present invention relates to a combination product, comprising as active substances, at least honey, eucalyptus and marshmallow to help relieve the symptoms of sore throats.

The present invention also relates to a combination product, comprising as active substances, at least honey, eucalyptus, and marshmallow for its use in the treatment of sore throats.

• Des plantes ou extraits de plantes, tels que par exemple le coquelicot
• Des vitamines et minéraux, tels que par exemple la vitamine C,

In certain embodiments, the combination product according to the invention comprises, in addition to honey, eucalyptus and marshmallow, as active substances:

• Plants or plant extracts, such as for example the poppy
• Vitamins and minerals, such as vitamin C,

• (i) 50 à 500 mg, de préférence 100 à 400 mg de miel
• (ii) 1 à 10 mg, de préférence 2 à 5 mg d’eucalyptus, de préférence d’E ucalyptus globulus
• (iii) 5 à 200 mg, de préférence 10 à 100 mg de guimauve

In certain embodiments, the combination product of the invention is characterized in that it is in the form of a single composition comprising at least:

• (i) 50-500mg, preferably 100-400mg of honey
• (ii) 1 to 10 mg, preferably 2 to 5 mg of eucalyptus, preferably Eucalyptus globulus
• (iii) 5 to 200 mg, preferably 10 to 100 mg of marshmallow

Eucalyptus may be present as ingredient (ii) in a combination product of the invention in more or less purified form, in particular in the form of essential oil.

The marshmallow may be present as ingredient (iii) in a combination product of the invention in more or less purified form, in particular in the form of a plant extract.

The honey is preferably Manuka honey.

According to a particular embodiment of the invention, the combination product is characterized in that the active ingredients (i), (ii) and (iii) are in a medium suitable for oral administration. Preferably, the suitable medium is a solid medium. Preferably, the combination product is in the form of a tablet.

The various embodiments of the invention are particularly described in the detailed description below. These embodiments can be taken separately or in combination with each other.

Claims (10)

Combination product comprising, as active substances, at least honey, eucalyptus and marshmallow to help relieve the symptoms of sore throats Combination product according to Claim 1, characterized in that it is in the form of a single composition in a physiologically acceptable medium comprising at least:

• (i) 50 to 500 mg, preferably 100 to 400 mg of honey
• (ii) 1 to 10 mg, preferably 2 to 5 mg of eucalyptus, preferably Eucalyptus globulus
• (iii) 5 to 200 mg, preferably 10 to 100 mg of marshmallow

Combination product according to one of the preceding claims, characterized in that the honey is Manuka honey. Combination product according to one of the preceding claims, characterized in that the physiologically acceptable medium is suitable for oral administration. Combination product according to one of the preceding claims, characterized in that it is in the form of a pellet. Combination product according to one of the preceding claims, characterized in that it is in the form of a pellet having a hard shell and a melting heart. Combination product according to one of the preceding claims, characterized in that the eucalyptus is in the form of an essential oil. Combination product according to one of the preceding claims, characterized in that the marshmallow is in the form of a plant extract. Combination product according to one of the preceding claims, characterized in that it contains a sweetening agent chosen from glucose syrup, sucrose, glucose, fructose, invert sugar, honey, maltose, polyol, preferably glucose syrup and sucrose. Combination product according to at least one of the preceding claims, for its use in the treatment of sore throats.