FR3088077B1 - Methode de diagnostic d'un cancer et kit associe - Google Patents

Methode de diagnostic d'un cancer et kit associe Download PDF

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Publication number
FR3088077B1
FR3088077B1 FR1860174A FR1860174A FR3088077B1 FR 3088077 B1 FR3088077 B1 FR 3088077B1 FR 1860174 A FR1860174 A FR 1860174A FR 1860174 A FR1860174 A FR 1860174A FR 3088077 B1 FR3088077 B1 FR 3088077B1
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France
Prior art keywords
probes
diagnostic method
cancer diagnostic
associated kit
subject
Prior art date
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Active
Application number
FR1860174A
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English (en)
Other versions
FR3088077A1 (fr
Inventor
Philippe Ruminy
Vinciane Marchand
Sater Ahmad Abdel
Pierre-Julien Viailly
Marie Delphine Lanic
Fabrice Jardin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Sante et de la Recherche Medicale INSERM
Universite de Rouen Normandie
Centre Henri Becquerel
Original Assignee
Institut National de la Sante et de la Recherche Medicale INSERM
Universite de Rouen Normandie
Centre Henri Becquerel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority to FR1860174A priority Critical patent/FR3088077B1/fr
Application filed by Institut National de la Sante et de la Recherche Medicale INSERM, Universite de Rouen Normandie, Centre Henri Becquerel filed Critical Institut National de la Sante et de la Recherche Medicale INSERM
Priority to CA3117898A priority patent/CA3117898A1/fr
Priority to JP2021524332A priority patent/JP2022506752A/ja
Priority to AU2019375136A priority patent/AU2019375136A1/en
Priority to EP19818215.6A priority patent/EP3877545A1/fr
Priority to US17/291,407 priority patent/US20220290242A1/en
Priority to PCT/FR2019/052617 priority patent/WO2020094970A1/fr
Publication of FR3088077A1 publication Critical patent/FR3088077A1/fr
Application granted granted Critical
Publication of FR3088077B1 publication Critical patent/FR3088077B1/fr
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne une méthode de diagnostic d'un cancer chez un sujet, comprenant une étape de RT-MLPA sur un échantillon biologique obtenu à partir dudit sujet, dans laquelle l'étape de RT-MLPA est réalisée à l'aide d'au moins un couple de sondes comprenant au moins une sonde choisie parmi les sondes SEQ ID NO : 1 à 13, et/ou les sondes SEQ ID NO : 96 à 99, chacune des sondes étant fusionnée, à au moins une extrémité, avec une séquence d'amorçage, et au moins une des sondes dudit couple comprenant une séquence de barcode moléculaire.
FR1860174A 2018-11-05 2018-11-05 Methode de diagnostic d'un cancer et kit associe Active FR3088077B1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
FR1860174A FR3088077B1 (fr) 2018-11-05 2018-11-05 Methode de diagnostic d'un cancer et kit associe
JP2021524332A JP2022506752A (ja) 2018-11-05 2019-11-05 がんを診断するための方法及び関連するキット
AU2019375136A AU2019375136A1 (en) 2018-11-05 2019-11-05 Method for diagnosing a cancer and associated kit
EP19818215.6A EP3877545A1 (fr) 2018-11-05 2019-11-05 Methode de diagnostic d'un cancer et kit associe
CA3117898A CA3117898A1 (fr) 2018-11-05 2019-11-05 Methode de diagnostic d'un cancer et kit associe
US17/291,407 US20220290242A1 (en) 2018-11-05 2019-11-05 Method for diagnosing a cancer and associated kit
PCT/FR2019/052617 WO2020094970A1 (fr) 2018-11-05 2019-11-05 Methode de diagnostic d'un cancer et kit associe

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1860174A FR3088077B1 (fr) 2018-11-05 2018-11-05 Methode de diagnostic d'un cancer et kit associe

Publications (2)

Publication Number Publication Date
FR3088077A1 FR3088077A1 (fr) 2020-05-08
FR3088077B1 true FR3088077B1 (fr) 2023-04-21

Family

ID=66542288

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1860174A Active FR3088077B1 (fr) 2018-11-05 2018-11-05 Methode de diagnostic d'un cancer et kit associe

Country Status (1)

Country Link
FR (1) FR3088077B1 (fr)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1130113A1 (fr) 2000-02-15 2001-09-05 Johannes Petrus Schouten Méthode d'amplification dépendant de ligatures multiples
US10072298B2 (en) * 2013-04-17 2018-09-11 Life Technologies Corporation Gene fusions and gene variants associated with cancer
WO2014193229A2 (fr) * 2013-05-27 2014-12-04 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Nouvelles translocations dans le cancer du poumon
FR3010530B1 (fr) * 2013-09-11 2015-10-09 Univ Rouen Methode de diagnostic des hemopathies malignes et kit associe
US20190185913A1 (en) * 2016-07-01 2019-06-20 Natera, Inc. Compositions and methods for detection of nucleic acid mutations
CA3060553A1 (fr) * 2017-04-19 2018-10-25 Singlera Genomics, Inc. Compositions et procedes de detection de variance genomique et du statut de methylation de l'adn

Also Published As

Publication number Publication date
FR3088077A1 (fr) 2020-05-08

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