FR3078701A3 - USE OF A COMPOSITION COMPRISING 1.3 PROPANEDIOL AND CANNABIDIOL AS A LIQUID FOR ELECTRONIC CIGARETTE. - Google Patents

Abstract

The present invention relates to the use of an electronic cigarette liquid composition comprising propanediol 1.3 as well as Cannabidiol (CBD).

Description

TECHNICAL AREA

The present invention relates to the use of an electronic cigarette liquid composition comprising propanediol 1.3 as well as Cannabidiol (CBD). It also relates to an electronic cigarette liquid composition comprising 1.3 propanediol and Cannabidiol and at least one of the following components among the flavors, terpenes, nicotine and an electronic cigarette containing this composition.

STATE OF THE PRIOR ART

The electronic cigarette is an existing market and democratized since 2010 in France and in the world. Now it is a regulated market and supervised under the tobacco directive despite the fact that its use is based on an alternative to tobacco linked to a healthier and less harmful consumption than that of conventional tobacco, as has been demonstrated in numerous studies . (Link to the study in question http://helveticvape.ch/the-report-of-public-heal th-england /).

Its operation is simple, an electronic cigarette is an electromechanical or electronic device generating an aerosol to be inhaled. It produces a "vapor" or "artificial smoke" visually resembling the smoke produced by burning tobacco. This steam can be flavored with different kinds of flavors: blond tobacco, brown, fruit, mint, gourmet flavors, etc ... and contain or not nicotine. Unlike the smoke produced by a traditional cigarette, this vapor (gaseous state) does not have the smell of burnt tobacco and according to the first scientific studies, contains much lower or even no quantities of particles and carcinogenic or toxic substances than the traditional cigarette.

The operation of an electronic cigarette is made possible by two tools that are the electronic cigarette and the e-liquid that will be vaporized.

The electronic cigarette is composed of three main elements:

A battery or battery

An atomizer containing resistance

A reservoir containing the liquid (e-liquid) that will be vaporized The operation of these three elements is to vaporize the e-liquid by heating the resistance by actuating or not a button.

The battery is the largest part of an electronic cigarette. It contains a battery (commonly called accumulator - conventional short - circuit battery in the middle of the electronic cigarette). The atomizer is the part that will be used to heat the e-liquid in the tank to turn it into steam. The atomizers contain a resistive wire that surrounds a wick, the wick has the function of storing the liquid and bringing it by capillarity to the resistance for it to be heated and vaporized.

The reservoir is the part that contains the e-liquid, it is usually cylindrical (polyethylene, glass or stainless metal), it can also be in the form of a cartridge. The tank has two openings: an air inlet and an outlet for steam. The outlet is usually equipped with an interchangeable mouthpiece (commonly called drip tip in English).

The composition of the e-liquid that is used in electronic cigarettes most often includes the following elements:

Propylene glycol (PG) for 50% to 80% of the vegetable glycerine e-liquid for 20% to 50% of the nicotine e-liquid ranging from a concentration of Omg / ml to 20mg / ml of a flavor : ranging from 5% to 20% Water and / or alcohol: ranging from 0% to 10%

Currently the market favors the compositions with an equivalent proportion between propylene glycol and vegetable glycerin, ie 50% of one and 50% of the other. Propylene glycol favoring the rendering of the aroma and fluidifying the liquid allowing a better vaporization of the latter. Propylene glycol brings a hit in throat (tingling sensation in the throat reminding contraction made during the passage in the throat of the smoke of the tobacco cigarette). But when there is too much propylene glycol this can hinder and irritate the throat when inhaling the e-liquid. Vegetable glycerin meanwhile will allow to have a more round vape in the mouth, lessen this irritation during inhalation, with a strong visible vapor emerging during the expiration, reminiscent of the classic cigarette. Since glycerine is viscous, it does not favor the rendering of the aroma and gives rise to certain difficulties during the spraying when it is used in large quantities, necessitating use of the electronic cigarette at higher temperatures to allow the product to vaporize. this promotes during the degradation of the product the appearance of undesirable by-products such as acrolein. An equivalent use in proportion between propylene glycol and vegetable glycerine is then preferred.

However, propylene glycol is derived from petrochemicals with all the disadvantages that result in particular from the environmental footprint, resulting in high energy consumption and a large production of volatile organic components and waste. It has been proven in previous studies that after the purification of propylene glycol minor organic impurities as well as propylene glycol oxide appeared, hence the importance of limiting exposure to this product. Another disturbing aspect of propylene glycol is that it has been proven that some users are allergic to this product with an irritation beyond normal during inhalation.

To overcome the disadvantages of synthetic propylene glycol some have opted for the use of plant propylene glycol obtained by the catalytic hydrogenation of sorbitol itself derived from corn.

However, the use of vegetable propylene glycol, despite the fact that it overcomes the various disadvantages of the abovementioned synthetic propylene glycol, combined with vegetable glycerin, does not make it possible to obtain the best aromatic yield or a volume of vapor required by many vapers and consistently foul the material.

To replace synthetic or vegetable propylene glycol the use of propanediol (FIG. 1) has been favored. It has been highlighted during in-depth studies of the product placed on the market the - VEGETOL - (Link to the website http://www.vegetol.fr/le-vegetol/) that the 1.3 propanediol in use alone or accompanied by vegetable glycerin allowed a strengthening of the aromatic power, an improvement of the aspiration of the steam, a more dense vapor, a sensation of tingling in throat (the hit) more important without irritation i as well as an improvement of the bioavailability nicotine and consistently delivering it.

The proven performance of 1.3 propanediol when used in an electronic cigarette liquid composition can be extended with the association with other components to meet certain constraints such as those currently encountered with cannabidiol (CBD FIG. 2) recently. used in electronic cigarette liquids.

Cannabidiol (CBD) is a cannabinoid, one of the molecules extracted from the cannabis plant Sativa (This molecule and one of the most studied with that of THC). Its many therapeutic virtues have been proven as well as its non-psychoactive effect. It is currently used in various forms (cf CBD France https://www.cbd-ffance.fr/) such as oil, in foods, creams, crystals and now via e-liquids containing CBD and sprayed with electronic cigarettes. However we will note that the cannabidiol (CBD) for which we make and will be references in this invention can be represented only in the form of pure crystals derived from varieties and part of authorized plants and allowing to exclude any trace of delta -9 tetrahydrocannabinol (THC) in the finished product thus meeting the French legislation currently in force (Cf note of the Interministerial Mission of fight against drugs and addictive behaviors "MILDECA" (http://www.drogues.gouv.fr / news / cannabidiol-cbd-colon-law)

Figure 1 1.3 Propanediol

The current composition of e-liquids containing CBD is as follows:

Cannabidiol of Omg at 1000 mg for 10 ml in oil or in the form of pure crystals: pure crystals are preferred in this form because they are free of THC and of any other compound that is potentially difficult to assimilate by inhalation, a form that we prefer in our invention

Propylene glycol 80% up to 100%

Vegetable glycerin 0% to 20%

Terpenes or not

Aroma 5% to 20%

No nicotine

CBD has been shown to be more bioavailable when CBD was inhaled (20% bioavailability) versus 8% by ingestion (see Vaping site post https: //en.vapingpost.coni/e-liquide-cbd/). The optimized release of the CBD makes it possible to accentuate its effects thanks to a diffusion of the product in the body in greater proportion.

However, it has been proved that pure CBD crystals are hardly soluble in vegetable glycerin because they are too viscous, which pushes manufacturers to use a composition of 80% propylene glycol and 20% vegetable glycerine so as to dissolve the

CBD crystals. As it was found previously propylene glycol has a more fluid basic solution than that of vegetable glycerin and allows better dissolution and fixation of aromas and also CBD.

CBD is a so-called hydrophobic and lipophilic apolar molecule, which is insoluble in water and more soluble in fats. It needs an apolar solvent in order to be dissolved as best as possible however it can be dissolved by an organic solvent, such as propylene glycol in which the CBD crystals are currently the best dissolved. Indeed, the solubility of a compound such as CBD in a solvent generally depends on the interactions that may exist between the solvent and the CBD molecule and the latter interacts well with propylene glycol.

Except as it was previously seen this composition of 80% propylene glycol and 20% vegetable glycerin generates many genes in inhalation with irritation in the throat and also slight impurities and propylene oxide potentially harmful to the user final. Added to this is a difficulty of use of the liquid for those being allergic to propylene glycol and an earlier fouling of the equipment. Knowing that for the CBD to be even better dissolved it would have to be in 100% PG, which is already the case for some products put on the market. But these products can not be inhaled directly, they must be mixed with existing (e-liquid) compositions containing propylene glycol but also vegetable glycerin so that the product can be inhaled with less irritation or inhalation remains currently impossible for any vaper. But in this case the concentration in the milliliter is reduced with a loss of bioavailability of CBD and a loss of efficiency. The combination of 1,3 propanediol with cannabidiol allows to overcome these difficulties. 1.3 propanediol being very fluid, more fluid than propylene glycol, it is also an organic solvent that allows better dissolution of CBD and those at high concentrations up to a concentration of 1500 mg per 10 ml. With 1.3 propanediol, the CBD can be dissolved in a base composed of 100% propanediol and 1.3 free of any other product. The dissolution of the CBD is then greater with a higher milliliter concentration thus improving the bioavailability of the product by inhalation. The composition can then be inhaled as it is. The use of 1,3-propanediol combined with CBD allows a reduction in the fouling of resistances and equipment, a recurring problem when using CBD with propylene glycol and vegetable glycerine. A composition based on 1.3 propanediol with little vegetable glycerin of the order of 1% to 20% or better without vegetable glycerin allows an increase in the bioavailability of CBD by inhalation, beyond 20%, inducing an increase in effects. for a decrease of the catch. To this is added a better deliverability of the CBD at constant rate given a vaporization at the same temperature between the 1.3 propanediol molecules and the CBD, that is to say around 190 °.

We have a completely natural composition, without waste after degradation of the product related to heating, even at high temperature because neither 1.3 propanediol nor CBD have a degradation of their molecule even at high temperature of heating. This addition of 1.3 propanediol and CBD improves the hit, even without nicotine as 1.3 propanediol has been shown to bring out a natural hit without nicotine and CBD also brings a natural hit, the combination of both allowing for an increase in hit without adding nicotine or any other product wanting to simulate this effect (example Flavor Art's "Flash" flavor). This composition mixing CBD via propanediol 1.3 is the possibility of relief of smoking cessation and a palliative nicotine through the stimulation of certain CB1 and CB2 receptors (Link to blog website https://elixinol.com / en / blog / how-does-cannabidiol-cbd-work /) as studies have already been able to prove by reconsolidating the memory of the smoker. This reduces the harmful effects of smoking cessation such as anxiety, insomnia, nervousness and concentration disorder related to a lack of nicotine addiction.

The 1,3 propanediol of plant origin is produced industrially by fermentation of glucose. Today we find its use in several sectors such as food, cosmetics, pharmaceuticals, perfumes, natural extracts and personal and household hygiene products. It is also used in many industrial products, such as composite materials, adhesives, film coatings, coatings, moldings, aliphatic polyesters or co-polyesters. It will then serve as humectant, emollient, solvent, antifreeze and preservative.

Currently there is no publication or other evidence, study or archiving that informs about the use of 1.3 propanediol of plant origin or synthetic associated as a basis for cannabidiol (CBD) allowing it to improve its dissolution to obtain the highest bioavailability by inhalation (greater than 20%) and thus improve the effects related to CBD. No other composition comprising this mixture of 1.3 propanediol and CBD associated or not with one of the following compounds: propylene glycol, vegetable glycerin, flavors, terpenes, water, alcohol, nicotine has been identified to date.

The combination of 1.3 propanediol and CBD is all the more effective because it does not contain vegetable glycerin or propylene glycol.

1.3 Propanediol and CBD are two molecules that are used in different sectors, their approximation not being implicit. The CBD has just been popularized in the world of e-cigarettes, vaping and we highlight for the first time its association with 1.3 propanediol to improve its bioavailability by inhalation to improve the effects of CBD and consider among other things, a pathway to a nicotine withdrawal line.

SUMMARY OF THE INVENTION

The subject of the present invention is therefore the use of a composition containing 1.3 plant or synthetic propanediol mixed with cannabidiol (CBD), the CBD being able to be presented only in the form of pure crystals derived from varieties and from part of authorized plants and allowing to exclude any trace of delta-9 tetrahydrocannabinol (THC) in the finished product, composition comprising or not at least one of the following additives namely vegetable glycerin, propylene glycol, aroma, terpenes , water, alcohol and nicotine or a nicotine substitute, as an electronic cigarette liquid.

It also relates to an electronic cigarette containing this composition.

It also relates to the use of 1.3 propanediol with cannabidiol (CBD) in the form of pure crystals derived from authorized varieties and parts of plants and making it possible to exclude all traces of delta-9 tetrahydrocannabinol (THC) in the finished product, with or without vegetable glycerin to improve the bioavailability of CBD by inhalation and maximize effects related to CBD.

It also relates to the use of 1.3 propanediol with cannabidiol in the form of pure crystals derived from varieties and part of authorized plants and to exclude any trace of delta-9 tetrahydrocannabinol (THC) in the finished product in the presence or absence of nicotine to improve the throat hit, tingling sensation in the throat felt by a vaper and / or ease the aspiration of the composition representing the liquid for electronic cigarette.

It also relates to the use of 1.3 propanediol and cannabidiol in the form of pure crystals derived from authorized varieties and parts of plants and making it possible to exclude all traces of delta-9 tetrahydrocannabinol (THC) in the finished product. without nicotine as an electronic cigarette liquid for smoking cessation and nicotine thanks to the improved effects of the CBD present in said composition.

It also relates to the use of 1.3 propanediol with cannabidiol in the form of pure crystals derived from varieties and part of authorized plants and to exclude any trace of delta-9 tetrahydrocannabinol (THC) in the finished product allowing less clogging of the material.

It also relates to the use of propanediol with cannabidiol in the form of pure crystals derived from varieties and part of authorized plants and to exclude any trace of delta-9 tetrahydrocannabinol (THC) in the finished product and with or without vegetable glycerin as an electronic cigarette liquid to enhance delivery of cannabidiol.

It also relates to the use of 1.3 propanediol and cannabidiol in the form of pure crystals derived from authorized varieties and parts of plants and making it possible to exclude all traces of delta-9 tetrahydrocannabinol (THC) in the finished product. with or without vegetable glycerin in the presence of aroma and / or terpene as an electronic cigarette liquid to enhance the aromatic power.

It also relates to the use of 1.3 propanediol and cannabidiol in the form of pure crystals derived from authorized varieties and parts of plants and making it possible to exclude all traces of delta-9 tetrahydrocannabinol (THC) in the finished product. without vegetable glycerine nor propylene glycol to eliminate all dangerous impurities by inhalation related to the degradation of these molecules and remove any irritations related to propylene glycol potentially qualified as allergen for some vapers.

Said composition may or may not be accompanied by at least one of the additives such as vegetable glycerin, propylene glycol, nicotine, flavoring, terpenes, water, alcohol and nicotine nicotine or a nicotine substitute.

It also relates to an electronic cigarette containing said composition without or with at least one of the additives mentioned above.

DETAILED DESCRIPTION OF EMBODIMENTS

In the present application we refer to the term "electronic cigarette" any electromechanical or electronic device generating an aerosol to be inhaled producing a "vapor" or "artificial smoke" visually reminiscent of the smoke associated with burning tobacco. This definition therefore encompasses all personal vaporizer models, as well as nicotine delivery devices called "ENDS" for

Electronic Nicotine Deliver System or "ENDD" for Electronic Nicotine Delivery Device as well as heated tobacco cigarettes.

As indicated above, the invention relates to the use of a composition containing 1,3 propanediol vegetable or synthetic with cannadidiol (CBD) in the form of pure crystals derived from varieties and part of authorized plants and to exclude any trace of delta-9 tetrahydrocannabinol (THC) in the finished product, such as electronic cigarette e-liquid. It will therefore be preferred for the invention a composition containing 1.3 propanediol of plant origin combined with isolated cannabidiol in the form of pure crystals, as an electronic cigarette liquid.

Propanediol 1.3 is derived from plant raw materials, it can be obtained by fermentation of glucose via an environmentally friendly biological process (cf sited 'information https://www.boursier.com/actions/actualites/news/metabolic- explore-the-process-book-of-production-of-pdo-is-valid-391929.html).

1.3 propanediol may represent by weight from 10% to 99%, preferably from 60% to 99%, and preferably from 80% to 99% relative to the total weight of the composition.

The invention solicits the use of cannabidiol (CBD). This molecule may be derived from the cannabis plant Sativa (study report https://dumas.ccsd.cnrs.fr/dumas-00983072/document), or from hemp, a derivative of the plant with a very low THC or Hops. In this invention it will be preferred the use of CBD in the form of pure crystals derived from varieties and part of authorized plants and to exclude any trace of delta-9 tetrahydrocannabinol (THC) in the finished product and responding to legal requirements in France.

CBD cannabidiol is not classified as a narcotic in France if two cumulative conditions are met: only seeds and fibers can be used from authorized hemp varieties with a content of less than 0.2% THC and the finished product after processing must be free of any traces of THC (see the report of the Interministerial Mission for the Fight against Drugs and Addictive Conduct "MILDECA" http://www.drogues.gouv.fr/aetualites/cannabidiol-cbd- point-legislation; Interview of the prosecutor of Dijon in a specialized site https://leeannabiste.com/eric-mathais-procureur-de-diion-exelusivite-on-the-cannabiste-loi-and-cbd/)

CBD can be used in various forms such as pure crystals of CBD, powder or oil. For the invention the use of pure crystals of CBD will be preferred because it guarantees to exclude all traces of THC according to the French legislation for a composition which once diluted in 1.3 propanediol allows inhalation via a personal vaporizer of a 100% vegetable composition free of any impurity after the degradation of the two molecules even after heating at high temperature. Containing no trace of pesticides or heavy metals, these crystals are made from European organic hemp, authorized varieties of plants that are regulated and listed in the French Public Health Code under the French legislation, and proposed in this form. following the crystallization of pure hemp extract, to obtain a 99.5% pure product.

For the present invention, the CBD will come from a totally biological culture. Cannabidiol (CBD) may represent, by weight, from 1% to 30%, preferably from 1% to 20% and preferably from 1% to 15% by weight of the total weight of said composition.

The composition used may or may not contain propylene glycol, whether synthetic or of plant origin, that is to say obtained from vegetable raw materials. Propylene glycol is obtained from the reaction of propylene oxide with water to form monopropylene glycol (MPG), its production can also be vegetable through monopropylene glycol bio-sourced.

The propylene glycol of synthetic origin or of vegetable origin may represent from 0% to 50% by total weight of the composition, preferably from 0% to 20% and preferentially less than 5%.

For this invention it is preferred that the composition be free of propylene glycol, whether synthetic or vegetable origin. As mentioned above, synthetic propylene glycol is very irritating and its use in the composition due to the need to be able to dissolve cannabidiol (CBD) makes it suitable for its use as e-liquid. of electronic cigarette. Plant propylene glycol meanwhile, even if it avoids the aforementioned disadvantages concerning synthetic propylene glycol, it is not as fluid as 1.3 propanediol and does not allow a proportional use of propylene glycol. 100% of the composition, it would remain too dry during the throat and would not provide a better bioavailability of CBD.

The composition may or may not contain vegetable glycerin, however for the invention we prefer that the composition contains no or little vegetable glycerin. As indicated above, the viscosity of vegetable glycerine hinders the dissolution of cannabidiol (CBD) and will thereby reduce its bioavailability and therefore its effects. The viscosity of the vegetable glycerin will also require a higher heating temperature which, during the degradation of the product, may lead to the appearance of an impurity that is not suitable for inhalation, such as acrolein, which is toxic. The heating temperature of the vegetable glycerin being 288 °, it is clearly greater than the heating temperature of the CBD (about 190 °) which will cause too much heating of the composition to get to vaporize the vegetable glycerine and which of this will degrade the CBD molecule. Vegetable glycerin also fouls the material and the fact that it is completely free of the composition would improve the bioavailability of cannabidiol (CBD). The use of glycerin may therefore represent from 0% to 20% by weight of the total composition, preferably from 0% to 10%, preferably from 0% to 5%.

Beyond the aforementioned components, the composition may also contain aromas and / or terpenes to give an aromatic note to the composition.

The flavors can be synthetic or natural flavors such as those approved in the food and / or pharmaceutical fields, in particular those listed in the EU Regulation 872/2012 of October 1, 2012 and in the US (USP) and European (EU) pharmacopoeias in force. . The concentration of aroma and / or terpene may be from 0% to 20% by weight, preferably from 0% to 15% by weight, more preferably from 0% to 10% by weight relative to the total weight of the composition. . As indicated above terpenes can bring a surrounding effect and thus improve the effects of CBD, phenomenon accentuated with a greater bioavailability due to its association with 1.3 propanediol.

The composition may also contain nicotine or a nicotine substitute. The nicotine can be of synthetic origin, plant or it can also be nicotine salt and must meet the purity criteria described in the US Pharmacopoeia (USP) and European (EU) in force. Nicotine can be extracted from tobacco leaves or obtained by chemical or biological synthesis. The concentration may range from 0 ml / ml to 50 ml / ml, preferably from 0 ml / ml to 20 mg / ml.

As indicated above, the composition containing 1,3-propanediol and cannadidiol allows smoking and nicotine withdrawal assistance, it is therefore preferable that the nicotine be free of the composition except that the combination of CBD and Nicotine may help with the daily relief of some people with Parkinson's disease who may be prescribed nicotine. (Cf study site news http://www.parismatch.com/Actu/Sante/Parkinson-des-malades-denoncent-l- abandonment-d-une-therapie-effective-1363304).

The composition used may or may not contain ethanol (alcohol) and / or water and / or at least one dye. The alcohol may represent from 0% to 20% by weight, preferably from 0% to 10% by weight, more preferably from 0% to 5% by weight relative to the total weight of the composition. The water may represent from 0% to 10% by weight, preferably from 0% to 5% by weight relative to the total weight of the composition. The dyes may be of synthetic or plant origin, such as those approved in the food and / or pharmaceutical fields and in particular those listed in the EU Regulation No. 1331/2008 and in the American (USP) and European (EU) pharmacopoeias. force.

According to said invention, however, it will be preferable for the composition to contain neither ethanol (alcohol) nor water. The fluidity of 1.3 propanediol is sufficient to avoid adding a concentration of water that can promote the development of pathogenic microorganisms of microbial origin and its use generally requires the use of preservatives or the realization of a sterilizing microfiltration. Especially since CBD is not soluble in water, in the absence of water and ethanol the combination 1.3 propanediol and CBD will be more effective and healthier by inhalation. The invention also relates to an electronic cigarette containing said composition as described above.

It also relates to the use of 1.3 propanediol with cannabidiol (CBD) in the form of pure crystals derived from authorized varieties and parts of plants and making it possible to exclude all traces of delta-9 tetrahydrocannabinol (THC) in the finished product, with or without vegetable glycerin to improve the bioavailability of CBD by inhalation and maximize the effects of CBD. A composition with a base of 100% 1.3 propanediol and CBD in pure crystals will be preferred.

It also relates to the use of 1.3 propanediol with cannabidiol in the form of pure crystals derived from varieties and part of authorized plants and to exclude any trace of delta-9 tetrahydrocannabinol (THC) in the finished product , in the presence or absence of nicotine to improve the throat hit, tingling sensation in the throat felt by a vaper and / or ease the aspiration of the composition representing the liquid for an electronic cigarette.

It also relates to the use of 1.3 propanediol and cannabidiol in the form of pure crystals derived from authorized varieties and parts of plants and making it possible to exclude all traces of delta-9 tetrahydrocannabinol (THC) in the finished product. , without nicotine as an electronic cigarette liquid for smoking cessation and nicotinic thanks to the improved effects of the CBD present in said composition.

It also relates to the use of 1.3 propanediol with cannabidiol in the form of pure crystals derived from varieties and part of authorized plants and to exclude any trace of delta-9 tetrahydrocannabinol (THC) in the finished product , allowing less clogging of the material.

It also relates to the use of propanediol with cannabidiol in the form of pure crystals derived from varieties and part of authorized plants and to exclude any trace of delta-9 tetrahydrocannabinol (THC) in the finished product and with or without vegetable glycerin as an electronic cigarette liquid to enhance delivery of cannabidiol.

It also relates to the use of 1.3 propanediol and cannabidiol in the form of pure crystals derived from authorized varieties and parts of plants and making it possible to exclude all traces of delta-9 tetrahydrocannabinol (THC) in the finished product. , with or without vegetable glycerin in the presence of aroma and / or terpene as an electronic cigarette liquid to enhance the aromatic power.

It also relates to the use of 1.3 propanediol and cannabidiol in the form of pure crystals derived from authorized varieties and parts of plants and making it possible to exclude all traces of delta-9 tetrahydrocannabinol (THC) in the finished product. , without vegetable glycerine nor propylene glycol to eliminate any harmful impurity by inhalation related to the degradation of these molecules and remove any irritations related to propylene glycol may be potentially allergenic for some vapers.

Said composition may or may not be accompanied by at least one of the additives such as vegetable glycerin, propylene glycol, nicotine, flavoring, terpenes, water, alcohol and nicotine nicotine or a nicotine substitute.

It also relates to an electronic cigarette containing said composition without or with at least one of the additives mentioned above.

Claims (10)

An electronic cigarette liquid composition comprising 1,3 propanediol and Cannabidiol (CBD) mixed alone or with at least one of: aroma, terpene and / or nicotine. 2. Composition according to claim 1, characterized in that 1,3 propanediol is obtained from vegetable raw materials. 3. Composition according to any one of claims 1 to 2, characterized in that it is free of glycerine. 4. Composition according to any one of claims 1 to 3, characterized in that it does not contain propylene glycol. 5. Composition according to any one of claims 1 to 4, characterized in that it does not contain water and / or ethanol. 6. Composition according to any one of claims 1 to 5 characterized in that the cannabidiol (CBD) can be presented in the form of pure crystals derived from varieties and part of authorized plants and to exclude any trace of delta-9 tetrahydrocannabinol (THC) in the finished product. An electronic cigarette containing a composition of any one of claims 1 to 6. 8. Use of 1.3 propanediol with Cannabidiol (CBD) in the form of pure crystals derived from authorized varieties and parts of plants and making it possible to exclude all traces of delta-9 tetrahydrocannabinol (THC) in the finished product, in an electronic cigarette liquid to improve the dissolution and bioavailability of Cannabidiol (CBD) and maximize its effects by inhalation. 9. Use of 1.3 propanediol with Cannabidiol (CBD) in the form of pure crystals derived from authorized varieties and parts of plants and making it possible to exclude all traces of delta-9 tetrahydrocannabinol (THC) in the finished product, in an electronic cigarette liquid to consistently deliver Cannabidiol (CBD). 10. Use of 1,3-propanediol with Cannabidiol (CBD) in the form of pure crystals derived from authorized varieties and parts of plants, to exclude all traces of delta-9 tetrahydrocannabinol (THC) in the finished product , optionally in the presence of vegetable glycerin to replace nicotine for a nicotine withdrawal aid.