FR3076703A1 - BODY MONITORING SYSTEM WITH ADHESIVE - Google Patents

Abstract

The invention provides a body monitoring device, comprising at least one needle (25), at least one sensor (24) of a physical body fluid magnitude, the sensor being configured to measure a physical quantity of the fluid, wherein: the needle (25) and the sensor (24) are part of a capsule (3) configured to engage with a housing (2) removably, - the device further comprises an adhesive (80) configured to adhere the capsule (3) to the body.

Description

Body monitoring system with adhesive

GENERAL TECHNICAL AREA

The present invention relates to microfluidics. More specifically, it relates to a body monitoring system via analysis of body fluid, typically interstitial.

STATE OF THE ART

Certain pathologies such as diabetes require daily monitoring of biochemical parameters of the human body, i.e. concentrations of certain compounds (blood sugar in the example of glucose).

For this, it is common to prick a point on the skin so as to make a drop of blood pearl, and to analyze this drop either reactively (for example with a strip) or electronically (for example by less than one analytical sensor), so as to estimate the target parameter (s).

Today we know much less invasive advanced systems that simply analyze the interstitial fluid, that is to say the fluid that fills the space between blood capillaries and cells. It has an ionic composition close to that of blood plasma.

These advanced systems thus make it possible to monitor the desired biochemical parameters transcutaneously, that is to say without the need to regularly pierce the skin and take a sample.

In particular, a device worn on the wrist called GlucoWatch has been proposed, implementing a phenomenon called iontophoresis (or iontophoresis) in which an electric field makes it possible to "attract" the interstitial fluid through the skin to a sensor on the device wall. However, this concept was quickly abandoned because only 6% of patients endured the pain of electrical extraction. In addition, the measurement results were unreliable.

Transcutaneous probes have been proposed alternately, taking the form of a self-adhesive patch plating a "needle sensor" just under the skin, so as to put the sensor in permanent fluid communication with the interstitial fluid, for continuous monitoring.

Some of these transcutaneous patch type probes include wireless communications means making it possible to trace the measurements on the interstitial fluid, for example to a mobile terminal, for storage and processing (verification of thresholds and variations, production of statistics, triggering of alerts if necessary, etc.). Examples include sugarBEAT ™ or FreeStyle Libre systems.

Such systems are satisfactory (the patches are much more reliable and less painful than iontophoresis devices), but prove to be restrictive and expensive because of the single-use patch which must be changed regularly. In addition, the patches tend to peel off, tear off when you change your clothes or make sudden movements, and are very visible: the wearer can be stigmatized as "sick".

It would be desirable to have an alternative portable electronic system which avoids the frequent use of patches, painlessly, and without there being the slightest hygienic risk. Finally, it is important to find a system that minimizes inconvenience to the user in their daily life.

PRESENTATION OF THE INVENTION

The present invention therefore relates to a body monitoring device, comprising at least one needle, at least one sensor for a physical quantity of body fluid, the sensor being configured to measure a physical quantity of the fluid, in which:

- the needle and the sensor are part of a capsule configured to engage with a housing in a removable manner,

- The device further comprises an adhesive configured to adhere the capsule to the body.

Body fluid can be interstitial fluid or blood, for example.

The device can include the following characteristics, taken alone or in combination:

the needle or needles are means for transcutaneous sampling of body fluid and the device comprises a fluid circuit comprising the needles,

- The adhesive is placed on the capsule,

- The device further comprises a patch, said patch being removably attachable with the capsule, the adhesive being placed on the patch,

- the removability of the patch is allowed thanks to at least one lug clip on the patch which engages with an edge of the capsule,

- the patch is annular or U-shaped, inside which pass the needle (s),

- the patch is made of a rigid or semi-rigid material, such as plastic, or flexible, such as rubber,

- the patch has a maximum dimension less than or equal to 50mm, preferably 40mm,

- The capsule has a contact face, preferably flat, on which the needle (s) are located, and in which the patch can extend beyond the contact face and covers part of the housing by engaging in a case of the case,

- the sensor is located at the end of the needle (s) configured (s) to be inserted (s) in the body,

- The sensor is in the form of a coating placed on the needle (s), and the latter are preferably full.

The invention also provides a body monitoring system, comprising

- a box, comprising an electrical connection or a wireless link,

- a device as described above, in which the capsule is configured to engage with the housing in a removable manner.

The system can include the following features, taken alone or in combination:

- the housing is detachable from the capsule, even when the system is worn, that is to say detachable without touching the capsule and / or without accessing a contact surface,

the housing comprises data processing means configured to process measurements acquired by said sensor,

- The housing includes means for attaching to the reusable body.

The invention also provides a kit comprising a system as described above, and comprising at least one other patch, the two patches each having an adhesive with different adhesive strengths.

PRESENTATION OF THE FIGURES

Other characteristics and advantages of the present invention will appear on reading the following description of a preferred embodiment. This description will be given with reference to the appended drawings in which:

FIG. 1 illustrates a diagram representing a system comprising a capsule, a housing and a patch disposed on the capsule,

- Figures 2a to 2c show three-dimensional views of the engagement of the capsule in the housing,

FIGS. 3a to 3c represent a three-dimensional view of the patch, and of the capsule and of the patch,

FIG. 4 represents the housing alone,

FIG. 5 represents the housing, the capsule and the patch,

- Figure 6 illustrates a sectional view of the housing and the capsule.

DETAILED DESCRIPTION

General architecture

Two general system architectures can be used in particular in the context of the invention.

Referring to Figure 1, and Figures 2a, 2b and 2c, which show a general diagram, the present invention relates to an electronic body monitoring system 1 according to a first embodiment.

A second embodiment will also be presented (but not illustrated).

By bodily monitoring is meant the verification of biochemical constants of a person carrying system 1, typically the concentration of a protein, a hormone, a marker, oxygen, nutrients, etc., in the interstitial fluid of the person. We will cite the example of blood sugar. The person skilled in the art will be able to monitor other physical physical quantities such as temperature, hydration, etc. if necessary.

The description will be illustrated with interstitial fluid but applies to other body fluids such as blood.

As will be explained below, the system 1 is separated in particular into two modules: a box 2 and a capsule 3. The term device will be used for what concerns in particular the capsule 3.

The system 1 thus comprises at least one sensor 24 of a physical quantity of the interstitial liquid, in particular a sensor of “biochemical” nature, that is to say allowing the analysis of the interstitial liquid in particular by detecting a compound for example by with several electrodes in contact with the interstitial liquid, and advantageously at least one second sensor such as a temperature sensor making it possible to adjust the analysis of the interstitial liquid sampled (taking into account the viscosity of the fluid as a function of the temperature).

The system 1 also comprises data processing means 11 (in particular a processor or a microcontroller) configured to process measurements acquired by the sensor 24, and where appropriate data storage means 12 (in particular a memory, in particular of the flash type, and / or the memory of the microcontroller) making it possible for example to store these measurements, and / or a date of the first use of each sensor 24 to calculate an expiration date of the sensor (s) 24 (the biochemical sensors have a limited life). The data processing means 11 also serve to generate instructions to different components. Within the framework of this description, these various functions are provided by the same unit. However, it is possible to provide dedicated processors. The system 1 also comprises a battery for the electrical supply of the components, advantageously rechargeable, for example via port 10 (which it is understood that it can also be used to connect the system 1 for example to a computer to download the acquired data and / or processed).

Preferably, the system 1 can comprise wireless connection means (in particular of the WiFi type, but also Bluetooth, or even 3G / 4G) for connection to a network, in particular the internet, and a user interface such as a screen, possibly touch to display the monitoring results to the user.

It will be understood that a person skilled in the art knows algorithms for processing sensor measurements 24 and associated interfaces, and will know how to implement them in the present system 1.

- First embodiment

The system 1 comprises pumping means 21 A, 21 B. These advantageously form part of the device. They will be detailed later.

The system 1 comprises needles, in the form of transcutaneous sampling means 25, configured for sampling the interstitial fluid under the skin of the user. The needles are then hollow.

The system 1 comprises a fluid circuit 20 on which the transcutaneous sampling means 25 of interstitial liquid are disposed, said sensor

24, an absorbent foam 21B called measurement foam, which stores the liquid for analysis by the sensor 24 and which can serve as pumping means and optionally an intermediate foam 21 A, located between the transcutaneous sampling means 25 and the measurement foam 21 B, to pump. In one embodiment, the absorbent foam 21 A, 21B acts as a pump for aspirating the interstitial liquid by the transcutaneous sampling means

25.

It is also possible to provide an evacuation foam, downstream, which has the function of emptying the measurement foam 21 B, with controllable hydrophilicity (for example by means of heating means such as a resistor). The French patent application in the name of the same applicant filed concomitantly with this application, entitled "Body monitoring system with double foam" describes such a system (with a reference 21C for the evacuation foam). The other reference numbers are identical.

Said transcutaneous interstitial fluid sampling means 25 advantageously consist of a network of micro-needles in contact with the skin when the device is placed on the body of a person (see how later). Microneedles allow painless removal of interstitial fluid from the dermis without bleeding.

Preferably, said transcutaneous sampling means 25 comprise between four and sixteen or twenty-five micro-needles (in particular four, nine or sixteen in the form of a square), substantially pyramidal, with spikes of a height between 0.3mm and 0.9 mm, each with a hole with a diameter between 0.04 and 0.22mm. Each of these advantageous characteristics of micro-needles can be taken separately or in combination with the others.

The absorbent foam 21A or 21B causes the transcutaneous extraction (through the epidermis) via the transcutaneous removal of interstitial fluid from the body (the dermis under the epidermis), its circulation through the circuit 20 to its arrived at the level of the absorbent foam 21B thus making it possible to store it. Finally, this foam is brought into contact with the sensor 24 which will analyze the interstitial liquid. The liquid is evacuated from the foam by evaporation (the foam is advantageously in exchange with the atmosphere, in particular through a fabric which is porous to gases, so as to allow this evaporation, but advantageously impermeable to liquids (for example at polytetrafluoroethylene base) so as to avoid the penetration of liquids such as sweat from the outside).

The system 1 can also comprise a set of electrodes 40, comprising an electrode 41 and an electrode 42 (combined with one or more needles of the transcutaneous sampling means 25) for measuring the conductivity of the skin and / or causing electrophoresis under the skin in order to accumulate interstitial fluid at the level of the transcutaneous sampling means 25. The French patent application in the name of the same applicant filed concomitantly with the present application, entitled “Body monitoring system with electrophoresis” describes such a system. The numerical references are identical.

The system 1 can also include a conductivity meter 44, which makes it possible to know whether the foams 21A or 21B are soaked with liquid. In particular, the conductimetry of the foam 21B is measured (which can be mobile, not illustrated here: see the French patent application entitled “Body monitoring system with mobile foam”, filed concurrently with the present application by the same applicant. numerical references are identical).

- Second embodiment

In another embodiment, the device comprises at least one needle (preferably a plurality), which act as means of piercing the skin. On the needle or needles, one or more sensors are positioned, typically in the form of a coating (chemical sensor) at the end of the needle which is inserted into the body.

In this embodiment, there is therefore no transcutaneous fluid sample. The measurement obtained by the sensor is then collected and processed. The document by Yoon et al. (“Fabrication of a Microneedle / CNT Hierarchical Micro / Nano Surface Electrochemical Sensor and Its In-Vitro Glucose Sensing Characterization”, in Sensors 2013, 13 (12), 16672-16681; doi: 10.3390 / s131216672) describes a type of sensor- needle.

The electrophoresis mechanism can be applied here, by providing needles intended for electrophoresis (see the aforementioned patent application: "Body monitoring system with electrophoresis").

The needles are then usually full, but they can also be hollow.

Aside from the fluid circuit and the elements which form it which are no longer present, the rest of the measurement system 1 is applicable to this embodiment (processing means, connectivity, etc.).

Capsule and case

The rest of the description is made for the first embodiment, but is immediately applicable to the second embodiment mentioned above.

Unlike known systems, system 1 is integral. This means that there is not a main module such as a mobile terminal connected wirelessly to a bulky and expensive secondary module (due to the need to equip it with a battery, wireless communication means , etc.) taking the form of a patch stuck to the skin. System 1 is thus autonomous.

To be used, it is either pressed against the skin if necessary by the user for a few seconds (it is in this case devoid of any means of attachment to the body), or directly worn on the body, in particular on a limb, and preferably on the wrist. The system 1 then takes for example the shape of a watch, with a face F against the skin of the arm, and an opposite face accommodating for example a screen.

As such, it advantageously comprises means for attaching to the reusable body, typically consisting of a strap or bracelet configured to surround the member (and not a sticky element), in particular a watch strap. "Reusable" means here as opposed to "single use" as was the case with patches, which cannot be reused after being peeled off and must be discarded. A bracelet can be opened and closed many times.

The system 1 is configured so that when it is placed on the skin (ie when the attachment means fix it to the body) the transcutaneous sampling means 25 are held against the skin (or at least in the immediate vicinity) to allow the sample.

In all cases, as illustrated in FIGS. 2a, 2b and 2c, the system 1 contains two subsets:

- the housing 2 in which are arranged at least the data processing means 11 (as well as the main components such as the battery, the memory, the possible user interface, etc.);

- the capsule 3 in which the fluid circuit 20, the sensor 24, the foams 21 A, 21B are arranged (as explained preferentially in exchange with the atmosphere to promote the evaporation of the fluid and thus limit its stagnation, if necessary via a window 26 through the capsule 3), the transcutaneous sampling means 25, the electrodes 41, 42, the conductivity meter 44, etc.

The capsule 3 is configured to engage with the housing 2 in a removable manner. The capsule 3 preferably engages in a cavity C of the housing 2 located on its face F intended to be in contact with the skin.

In other words, and as can be seen in FIG. 1 and FIGS. 2a2c which represent a preferred embodiment, the system 1 is composed of two modules 2, 3 but the latter are not physically separated as could be be the case in the prior art and are even in direct, mechanical connection.

The housing 2 and the capsule 3 respectively comprise, for this, transmission means for transmitting electrical signals, such as wireless links (transmitter / receiver) without contact or electrical connectors 12a and 12b (contacts) which are seen. particularly in FIGS. 2a and 2b, configured so that when the capsule 3 is engaged with the housing 2, said electrical connectors 12a, 12b provide a connection between the data processing means 11 and the sensor 24 (for raising the measurement data ).

The capsule 3 thus constitutes an interchangeable sub-assembly of the system 1 which can be chosen according to the type of monitoring desired. Indeed, insofar as the capsule contains the sensor (s) 24, changing the capsule makes it possible to change sensors 24 if they are at the end of their life or if one wishes to change the physical quantity measured, in a simple manipulation , fast and safe, without having to throw away other parts (in particular the box 2). It is noted in this respect that the capsule 3 very effectively preserves the sensors 24, and needs to be changed less often than a patch (the same capsule can be used for a month).

And since capsule 3 contains neither a "pump" (in the traditional sense of the term), nor advanced electronic equipment such as a battery or wireless communication means, it is significantly less expensive than a patch.

The present system is therefore much more practical than the systems known from the prior art, but above all much less expensive to use, without there being the slightest hygienic risk, and without pain due to the insertion of a needle or strong electricity.

Advantageously, the capsule 3 is the only part of the system 1 which can be in contact with interstitial liquid, since it contains the pumping means in the form of absorbent foam 21B (beyond which the withdrawn fluid cannot rise). Thus, the removable capsule prevents contamination of the housing 2 and makes it possible to be able to replace the capsule 3 at the end of the life of the sensors 24 or change the type of capsule 3 in a simple, rapid and safe handling, without having to throw away other parts.

A contact face FC is defined at the capsule 3, this is the face which is free to be on the side of the skin, when the capsule 3 is engaged in the housing 2. The contact face FC partially comprises the means 25. The contact face FC of the capsule 3 and the face F of the housing are generally substantially level (apart from the patch - see below) and generally form a flat surface (with the exception of the transcutaneous collection means 25 ).

The adhesive

The device comprises an adhesive 80 on the side of the contact face FC of the capsule (FIG. 1 and not visible in the other figures). This adhesive 80 keeps the capsule 3 in place on the wrist, even in the absence of the case 2.

Thanks to this, it is possible, when the system 1 is worn, to detach the housing 2 without removing the capsule 3 and keeping it pressed against the body. Such a configuration makes it possible to avoid removing the capsule 3 for certain tasks which only involves the housing 2: recharging the battery, repairing, replacing, extracting data to a computer, etc.

Thus, the needles are kept pressed in when the casing 2 is removed, which eliminates the need to clean them and reinsert them each time the adhesive is removed.

The adhesive 80 is hypoallergenic and known per se, as used on the existing patches described in the prior art.

The patch

In a preferred embodiment, the device comprises a patch 90, that is to say a plate or a piece of generally flat shape which is fixed at the level of the contact face FC of the capsule 3 in a removable manner (FIGS. 3a, 3b and 3c). The term patch used here is to be distinguished from the term patch used for the description of the prior art.

The adhesive 80 is then positioned on the patch 90: one face of the patch 90 is attached to the contact face FC of the capsule 3 and an opposite face of the patch 90 is at least partially covered with adhesive 80.

Thanks to this, it is also possible to remove the capsule 3 without having to tear off a sticky element from the skin, since the patch 90 is not necessarily removed.

A modularity is thus obtained which improves the practicality of using the system according to the different situations of daily life. To charge the housing 2, the user keeps the capsule 3 glued with the patch 90 and the adhesive 80. To bathe in the sea or in a swimming pool, the user can only keep the patch 90 and remove the capsule 3 and box 2. Alternatively, it can also remove patch 90.

In addition, patch 90 allows the user to keep the same location on the skin for the insertion of the transcutaneous sampling means 25. It thus serves as a positioning guide.

In order to allow the transcutaneous sampling means 25 to be on the skin, the patch 90 comprises a central through opening 91: in this way, the patch 90 can still surround said means 25 (FIG. 4).

The patch 90 can be removably mounted on the capsule 3 in different ways.

In a variant, the patch 90 comprises a tongue 92, in the form of an elongated protuberance which cooperates with a recess 36, in the form of a groove 36 of substantially complementary shape present on the contact face FC of the capsule 3. The tongue 92 can have a closed or open shape.

Alternatively, the tongue 92 is a point projection, and the recess 36 is in the form of a blind hole. A plurality of tongues 92 and recess 36 are then provided.

In these cases, the engagement is done simply by forcing slightly.

In a variant, the patch 90 comprises one or more clipping lugs 94 which clip, by deformation of elastic elements, to the contact face FC of the capsule (FIGS. 3a, 3b).

In a variant, the patch 90 is screwed.

The patch 90 advantageously has the shape of a ring (of circular or square shape, generally depending on the shape of the capsule 3) or of a torus or of a U, with therefore the central recess 91 to allow the passage of the transcutaneous sampling means 25 and, where appropriate, of the electrodes 41, 42.

In one embodiment, the capsule 3 comprises a protrusion 37 configured to extend in the center of the patch 90 in the form of a ring. This configuration is convenient if the thickness of the patch 90 is greater than the free length (that is to say outside of the capsule 3) of the transcutaneous sampling means 25. By definition, the contact face FC then does not include not this protuberance 37.

The patch 90 preferably extends, in the plane, beyond the contact face FC of the capsule 3 (as illustrated in FIGS. 3c and 5).

Likewise, the patch 90 preferably covers the entire contact face FC of the capsule 3 (and also, as indicated above, only the contact face FC), with the exception of the zones where needles or electrodes are present. , like the transcutaneous sampling means 25 or the electrodes 41,42.

Patch 90 can be removed from the wrist by tearing off. This step is painful but it is much less frequent than on existing technologies since the capsule 3 can be changed without having to remove the patch 90.

Patch 90 is reusable and a new layer of adhesive 80 must then be re-applied. For this, an adhesive film 80 of size similar to that of the face of the patch 90 in contact with the skin is deposited.

It is also possible to simply change everything, which is the easiest option for the user: just install a new patch that already includes the adhesive. Such a patch thus makes it possible to directly manipulate the housing 2 to remove the glue and / or put it back.

In these two cases, the strength of the adhesive can be chosen by the user.

A kit is thus defined, which comprises at least two adhesives with different adhesive properties (for example an adhesive more resistant to very humid environments, for a trip, etc.).

In order to be able to be worn on the wrist, the patch 90 has a maximum dimension less than or equal to 50mm (generally on the side, because the patch has a substantially square or rectangular shape, for example square 50x50mm or round with a diameter of 50mm), or even 40mm, for a thickness less than 6mm, preferably 4mm.

Due to the small thickness of the patch 90, the face F of the housing 2 can be level with the capsule 3 (see figure 1 upper part) or else with the patch 90 (see figure 1 lower part), or else between the two (see figure 1 intermediate part). In the latter case, the patch 90 partially extends inside the cavity C.

The preferred embodiment is that in which the housing 2 is level with the patch 90, as shown in FIGS. 1, 4 and 5. In this case, the housing 2 comprises an imprint 2a of a shape complementary to that of the patch 90. The cavity C is therefore housed in the cavity 2a.

Patch 90 is preferably rigid or semi-rigid because it is preferable that it does not deform. Plastic may be suitable. However, rubber or any other flexible material may be suitable.

Removing the capsule without accessing the FC contact face

In order to be able to remove the housing 2 without removing the device, it is provided that the capsule can be detached without the need to access the side F of the housing 2, since the latter is pressed against the skin.

To this end, the device comprises a release mechanism 29 accessible when the system 1 is worn, typically using a button located on a side wall of the housing 2.

Capsule change

The capsule 3 engages with the housing 2 in two successive translational movements T1 and T2 (Figures 2a to 2c). The reverse movement makes it possible to disengage the capsule 3. The first movement T1 consists in bringing the capsule 3 towards the housing 2 to attach the electrical connectors 12a / b and the second movement T2 consists in sliding the capsule 3 along the housing 2 to engage the mechanical connection 70. The electrical connections 12a / b are flexible (with spring for example).

Thanks to one or more stops 3a (FIGS. 3b and 3c), once the translation T2 has been carried out, the capsule 2 is blocked in the direction of the translation T1. These stops 3a are wedged between the bottom of the cavity C and a rail 2b (Figure 2a). The rail 2b comprises one or more openings 3b to authorize the translation T1, by letting pass the stop or stops 3a. At the end of the translation T2, as indicated above, the stops 3a are jammed and prevent movement in the direction of the translation T1.

The disengaging mechanism 29 comprises in this embodiment a movable stop (FIG. 4), movably mounted on the housing 2, which makes it possible to lock the movement of the capsule 3 according to the translation T2. During insertion, the capsule 3 presses on the mobile stop 29 which is not stressed in its blocking position. Once the translations T1 and T2 have been completed, the stop 29 passes into the blocking position (by translation in the direction of the translation T1), either by action of the user, or by return means (not shown). The stop 29 in the engaged position is visible in Figure 2c.

To unlock the system, the user moves the movable stop 29, for example with the index finger, and with the thumb he pushes the housing 2 to perform a translation -T2 (reverse of the translation T2). Then just pull the box away from the wrist to perform the translation -T1 (reverse of the translation T1).

During this operation, the adhesive may be particularly stressed, which can damage it. Thus, the patch 90 may include a tongue 96 which extends in the plane outside the housing 2. This means that when the system is worn on the wrist, the tongue 96 is visible on the skin. The tongue 96 is preferably located on the side opposite to the movable stop 29.

When the user performs the translation-T1, he can press the tongue 96 at the same time to press the patch 90 against the skin (for example with the thumb) and avoid over-stressing the adhesive.

This provides a reliable, fast and uncomplicated system for assembling a housing 2 and a capsule 3 without accessing the contact face of the system (in other words, instead of putting a capsule in the housing, the housing is placed on the capsule).

In this engagement or disengagement procedure, the capsule 3 5 is fixed and the housing 2 is mobile (in a fixed wrist reference frame).

Claims (17)

1. Body monitoring device, comprising at least one needle (25), at least one sensor (24) of a physical quantity of body fluid, the sensor being configured to measure a physical quantity of the fluid, in which: - the needle (25) and the sensor (24) are part of a capsule (3) configured to engage with a housing (2) in a removable manner, - The device further comprises an adhesive (80) configured to adhere the capsule (3) to the body. 2. Device according to claim 1, in which the adhesive (80) is disposed on the capsule (3). 3. Device according to any one of the preceding claims, further comprising a patch (90), said patch (90) being removably attachable with the capsule (3), the adhesive (80) being disposed on the patch ( 90). 4. Device according to claim 3, in which the removability of the patch (90) is permitted by virtue of at least one lug which can be clipped onto the patch (90) which engages with the capsule (3). 5. Device according to any one of claims 3 to 4, wherein the patch (90) is annular or U-shaped, inside which pass the needle (s) (25). 6. Device according to any one of claims 3 to 5, wherein the patch has a maximum dimension less than or equal to 50mm, preferably 40mm. 7. Device according to any one of claims 3 to 6, in which the capsule (3) has a contact face (FC), preferably planar, on which the needle (s) are (25), and in which the patch (90) extends beyond the contact face (FC) and is configured to cover part of the housing by engaging in a recess (2a) of the housing (2). 8. Device according to any one of the preceding claims, in which the needle (s) (25) are means for transcutaneous sampling of body fluid and the device comprises a fluid circuit (20) comprising the needle (s) (25), and / or the sensor (24) is in the form of a coating disposed on the needle (s) (25), and the latter are preferably full. 9. Body monitoring system (1), comprising - a box (2), comprising an electrical connection (12a) or a wireless link, - a device according to any one of the preceding claims, in which the capsule (3) is configured to engage with the housing (2) in a removable manner. 10. System (1) according to claim 9, wherein the capsule (3) can be engaged with the housing (2) by means of two successive translations, preferably orthogonal to each other. 11. System (1) according to claim 10, comprising a movable stop (29) disposed on an external face of the system (1) and configured to block the capsule (3) in the housing (2) in the direction of the second translation. (T2). 12. System (1) according to claim 10 or 11, in which the housing (2) comprises at least one rail (2a) with an opening (3b), and the capsule (3) comprises at least one stop (3a), in which the opening (3b) is configured to allow passage of the stop according to the first translation (T1) and in which the stop (3a) is blocked in the direction of the first translation (T1) by the rail (2a) once the second translation (T2) has been carried out. 13. System (1) according to any one of claims 9 to 12, wherein the housing (2) is detachable from the capsule (3) including when the system is worn, that is to say detachable without touching to the capsule (3) and / or without accessing a contact surface (FC). 14. System (1) according to any one of claims 10 to 13, in combination with claim 3, wherein the patch (90) comprises a tongue (96) extending beyond the housing in the plane of the patch (90). 15. System (1) according to any one of claims 10 to 13, in which the housing (2) comprises data processing means (11) configured to process measurements acquired by said sensor. 16. System (1) according to any one of claims 10 to 14, wherein the housing (2) comprises means for attaching to the reusable body. 17. Kit comprising a system (1) according to any one of claims 9 to 16, in combination with claim 3, and comprising at least one other patch, the two patches each having an adhesive with different adhesive strengths.