FR3059903B1 - ORAL MEDICINE COMPRISING AN OSMOTIC LAXATIVE INCORPORATED IN A MATRIX BASED ON VEGETABLE FATS - Google Patents
ORAL MEDICINE COMPRISING AN OSMOTIC LAXATIVE INCORPORATED IN A MATRIX BASED ON VEGETABLE FATS Download PDFInfo
- Publication number
- FR3059903B1 FR3059903B1 FR1662128A FR1662128A FR3059903B1 FR 3059903 B1 FR3059903 B1 FR 3059903B1 FR 1662128 A FR1662128 A FR 1662128A FR 1662128 A FR1662128 A FR 1662128A FR 3059903 B1 FR3059903 B1 FR 3059903B1
- Authority
- FR
- France
- Prior art keywords
- incorporated
- vegetable fats
- matrix based
- pharmaceutical composition
- laxative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000008141 laxative Substances 0.000 title abstract 3
- 230000002475 laxative effect Effects 0.000 title abstract 3
- 230000003204 osmotic effect Effects 0.000 title abstract 3
- 239000011159 matrix material Substances 0.000 title abstract 2
- 235000019871 vegetable fat Nutrition 0.000 title abstract 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 2
- 229960003511 macrogol Drugs 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 239000003981 vehicle Substances 0.000 abstract 2
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 239000008203 oral pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/77—Polymers containing oxygen of oxiranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Médicament oral comprenant un laxatif osmotique incorporé dans une matrice à base de matières grasses végétales La présente invention se rapporte à une composition pharmaceutique orale comprenant : - entre 30 et 55% en poids de ladite composition pharmaceutique de macro gol micronisé et anhydre ; et - entre 45 et 70% en poids de la composition pharmaceutique d'un véhicule constitué d'un enrobage lipidique anhydre et hydrophobe à base de composé gras d'origine végétale ayant un point de fusion compris entre 36 et 38°C, et à son utilisation comme laxatif. Ledit véhicule protège le macrogol de la diminution de la pression osmotique provenant de l'humidité du tractus digestif.Oral medicament comprising an osmotic laxative incorporated in a matrix based on vegetable fats The present invention relates to an oral pharmaceutical composition comprising: between 30 and 55% by weight of said pharmaceutical composition of micronized and anhydrous macro gol; and - between 45 and 70% by weight of the pharmaceutical composition of a vehicle consisting of an anhydrous and hydrophobic lipid coating based on a fatty compound of plant origin having a melting point of between 36 and 38 ° C, and at its use as a laxative. Said vehicle protects the macrogol from the decrease in osmotic pressure from moisture in the digestive tract.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1662128A FR3059903B1 (en) | 2016-12-08 | 2016-12-08 | ORAL MEDICINE COMPRISING AN OSMOTIC LAXATIVE INCORPORATED IN A MATRIX BASED ON VEGETABLE FATS |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1662128A FR3059903B1 (en) | 2016-12-08 | 2016-12-08 | ORAL MEDICINE COMPRISING AN OSMOTIC LAXATIVE INCORPORATED IN A MATRIX BASED ON VEGETABLE FATS |
FR1662128 | 2016-12-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
FR3059903A1 FR3059903A1 (en) | 2018-06-15 |
FR3059903B1 true FR3059903B1 (en) | 2019-03-22 |
Family
ID=58401716
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR1662128A Active FR3059903B1 (en) | 2016-12-08 | 2016-12-08 | ORAL MEDICINE COMPRISING AN OSMOTIC LAXATIVE INCORPORATED IN A MATRIX BASED ON VEGETABLE FATS |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR3059903B1 (en) |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL53462A (en) * | 1976-11-26 | 1980-12-31 | Pennwalt Corp | Prolonged release pharmaceutical preparations containing ion exchange drug complexes |
CA2250010C (en) * | 1996-04-10 | 2008-06-10 | Warner-Lambert Company | Denaturants for sympathomimetic amine salts |
FR2769839B1 (en) * | 1997-10-21 | 1999-12-17 | Odette Mercedes Salsarulo | LACTULOSE-BASED ANHYDROUS COMPOSITION |
FR2852843B1 (en) * | 2003-03-24 | 2008-05-23 | Karim Ioualalen | GALENIC SYSTEM FOR MASKING TASTE |
US20090053304A1 (en) * | 2007-08-23 | 2009-02-26 | Jinling Chen | Composition and method of producing a taste masking formulation of laxatives for bowel cleaning preparation prior to colonoscopy |
WO2013044085A1 (en) * | 2011-09-23 | 2013-03-28 | Subramanian Veerappan Sellappan | A solid, edible, chewable laxative composition |
WO2014189933A1 (en) * | 2013-05-22 | 2014-11-27 | Empire Technology Development Llc | Long delayed release laxative |
-
2016
- 2016-12-08 FR FR1662128A patent/FR3059903B1/en active Active
Also Published As
Publication number | Publication date |
---|---|
FR3059903A1 (en) | 2018-06-15 |
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