FR3056226B1 - BIOPRODUCTION OF ACETALDEHYDE BY REORIENTATION OF THE FERMENTAL METABOLISM OF S. CEREVISIAE - Google Patents

BIOPRODUCTION OF ACETALDEHYDE BY REORIENTATION OF THE FERMENTAL METABOLISM OF S. CEREVISIAE Download PDF

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Publication number
FR3056226B1
FR3056226B1 FR1658932A FR1658932A FR3056226B1 FR 3056226 B1 FR3056226 B1 FR 3056226B1 FR 1658932 A FR1658932 A FR 1658932A FR 1658932 A FR1658932 A FR 1658932A FR 3056226 B1 FR3056226 B1 FR 3056226B1
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Prior art keywords
acetaldehyde
strain
bioproduction
cerevisiae
fermental
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FR1658932A
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French (fr)
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FR3056226A1 (en
Inventor
Pierre Guichebard
Sabine Cognies
Abdelkader Belarbi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ecole Superieure De Chimie Organique Et Minerale
Universite de Technologie de Compiegne
Universite de Technologie de Compiegne UTC
Universite de Reims Champagne Ardenne URCA
Weylchem Lamotte SAS
Original Assignee
Ecole Superieure De Chimie Organique Et Minerale
Universite de Technologie de Compiegne
Universite de Technologie de Compiegne UTC
Universite de Reims Champagne Ardenne URCA
Weylchem Lamotte SAS
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Application filed by Ecole Superieure De Chimie Organique Et Minerale, Universite de Technologie de Compiegne, Universite de Technologie de Compiegne UTC, Universite de Reims Champagne Ardenne URCA, Weylchem Lamotte SAS filed Critical Ecole Superieure De Chimie Organique Et Minerale
Priority to FR1658932A priority Critical patent/FR3056226B1/en
Priority to PCT/FR2017/052557 priority patent/WO2018055308A1/en
Publication of FR3056226A1 publication Critical patent/FR3056226A1/en
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La présente invention concerne une souche de levure génétiquement modifiée, ainsi qu'un procédé de bioproduction d'acétaldéhyde utilisant cette souche. Plus particulièrement, l'invention concerne une souche de S. cerevisiae exprimant une NADH oxydase exogène et dans laquelle le gène ADH1 est inactivé. Mise en culture dans un milieu comprenant environ 5% de sucres et en présence d'un bullage permettant l'extraction en continu de l'acétaldéhyde produit, cette souche permet une production aisée d'acétaldéhyde.The present invention relates to a genetically modified strain of yeast, as well as a process for the bioproduction of acetaldehyde using this strain. More particularly, the invention relates to a strain of S. cerevisiae expressing an exogenous NADH oxidase and in which the ADH1 gene is inactivated. Cultured in a medium comprising approximately 5% of sugars and in the presence of bubbling allowing the continuous extraction of the acetaldehyde produced, this strain allows easy production of acetaldehyde.

FR1658932A 2016-09-22 2016-09-22 BIOPRODUCTION OF ACETALDEHYDE BY REORIENTATION OF THE FERMENTAL METABOLISM OF S. CEREVISIAE Active FR3056226B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR1658932A FR3056226B1 (en) 2016-09-22 2016-09-22 BIOPRODUCTION OF ACETALDEHYDE BY REORIENTATION OF THE FERMENTAL METABOLISM OF S. CEREVISIAE
PCT/FR2017/052557 WO2018055308A1 (en) 2016-09-22 2017-09-22 Bioproduction of acetaldehyde by reorientation of the fermentation metabolism of s. cerevisiae

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1658932 2016-09-22
FR1658932A FR3056226B1 (en) 2016-09-22 2016-09-22 BIOPRODUCTION OF ACETALDEHYDE BY REORIENTATION OF THE FERMENTAL METABOLISM OF S. CEREVISIAE

Publications (2)

Publication Number Publication Date
FR3056226A1 FR3056226A1 (en) 2018-03-23
FR3056226B1 true FR3056226B1 (en) 2021-02-12

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
FR1658932A Active FR3056226B1 (en) 2016-09-22 2016-09-22 BIOPRODUCTION OF ACETALDEHYDE BY REORIENTATION OF THE FERMENTAL METABOLISM OF S. CEREVISIAE

Country Status (2)

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FR (1) FR3056226B1 (en)
WO (1) WO2018055308A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111783315B (en) * 2020-07-21 2024-02-23 华东理工大学 Early stopping method of fuel ethanol fermentation tank based on data driving

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4481292A (en) 1980-07-01 1984-11-06 The Coca-Cola Company Process for the generation of acetaldehyde from ethanol
US4720457A (en) 1984-12-20 1988-01-19 Canadian Patents And Development Ltd. Selective production of ethyl acetate and acetaldehyde by microorganisms
US4900670A (en) * 1988-02-23 1990-02-13 Cornell Research Foundation, Inc. Microbiological production of acetaldeyde
US20090246841A1 (en) 2008-03-26 2009-10-01 Jamieson Andrew C Methods and compositions for production of acetaldehyde
WO2016122107A1 (en) * 2015-01-29 2016-08-04 서울대학교 산학협력단 Genetically modified yeast cell having 2,3-butanediol or acetoin productivity and method for producing 2,3-butanediol or acetoin by using same

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Publication number Publication date
WO2018055308A1 (en) 2018-03-29
FR3056226A1 (en) 2018-03-23

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