FR3025200B1 - Derives de n-aryl-tricyclopyrimidine-2-amine polyethers macrocycliques - Google Patents
Derives de n-aryl-tricyclopyrimidine-2-amine polyethers macrocycliquesInfo
- Publication number
- FR3025200B1 FR3025200B1 FR1458204A FR1458204A FR3025200B1 FR 3025200 B1 FR3025200 B1 FR 3025200B1 FR 1458204 A FR1458204 A FR 1458204A FR 1458204 A FR1458204 A FR 1458204A FR 3025200 B1 FR3025200 B1 FR 3025200B1
- Authority
- FR
- France
- Prior art keywords
- tricyclopyrimidine
- aryl
- amine derivatives
- macrocyclic polyethers
- macrocyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1458204A FR3025200B1 (fr) | 2014-09-02 | 2014-09-02 | Derives de n-aryl-tricyclopyrimidine-2-amine polyethers macrocycliques |
RU2017108937A RU2017108937A (ru) | 2014-09-02 | 2015-09-02 | Производные макроциклических полиэфиров n-арил-трициклопиримидин-2-амина в качестве ингибиторов ftl3 и jak |
BR112017003880A BR112017003880A2 (pt) | 2014-09-02 | 2015-09-02 | derivados de poliéteres de n-aril-triciclopirimidina-2-amina macrocíclicos como inibidores de ftl3 e jak |
CN201580053646.9A CN106715445B (zh) | 2014-09-02 | 2015-09-02 | 作为ftl3和jak抑制剂的大环n-芳基-三环嘧啶-2-胺聚醚的衍生物 |
JP2017511996A JP2017525733A (ja) | 2014-09-02 | 2015-09-02 | Ftl3およびjakの阻害剤としての大環状n−アリール−トリシクロピリミジン−2−アミンポリエーテルの誘導体 |
PCT/EP2015/070072 WO2016034637A1 (fr) | 2014-09-02 | 2015-09-02 | Derives de n-aryl-tricyclopyrimidine-2-amine polyethers macrocycliques comme inhibiteurs de la ftl3 et jak |
US15/508,014 US10323043B2 (en) | 2014-09-02 | 2015-09-02 | Derivatives of macrocyclic N-aryl-tricyclopyrimidine-2-amine polyethers as inhibitors of FTL3 and JAK |
MX2017002747A MX2017002747A (es) | 2014-09-02 | 2015-09-02 | Derivados de polieteres macrociclicos de n-aril-triciclopirimidin- 2-amino como inhibidores de ftl3 y jak. |
EP15757491.4A EP3189061A1 (fr) | 2014-09-02 | 2015-09-02 | Derives de n-aryl-tricyclopyrimidine-2-amine polyethers macrocycliques comme inhibiteurs de la ftl3 et jak |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1458204A FR3025200B1 (fr) | 2014-09-02 | 2014-09-02 | Derives de n-aryl-tricyclopyrimidine-2-amine polyethers macrocycliques |
Publications (2)
Publication Number | Publication Date |
---|---|
FR3025200A1 FR3025200A1 (fr) | 2016-03-04 |
FR3025200B1 true FR3025200B1 (fr) | 2016-09-23 |
Family
ID=51842565
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR1458204A Expired - Fee Related FR3025200B1 (fr) | 2014-09-02 | 2014-09-02 | Derives de n-aryl-tricyclopyrimidine-2-amine polyethers macrocycliques |
Country Status (9)
Country | Link |
---|---|
US (1) | US10323043B2 (zh) |
EP (1) | EP3189061A1 (zh) |
JP (1) | JP2017525733A (zh) |
CN (1) | CN106715445B (zh) |
BR (1) | BR112017003880A2 (zh) |
FR (1) | FR3025200B1 (zh) |
MX (1) | MX2017002747A (zh) |
RU (1) | RU2017108937A (zh) |
WO (1) | WO2016034637A1 (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113735856A (zh) * | 2020-05-29 | 2021-12-03 | 百极弘烨(南通)医药科技有限公司 | 大环jak抑制剂及其应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1897950A (zh) * | 2003-10-14 | 2007-01-17 | 惠氏公司 | 稠合芳基和杂芳基衍生物及其使用方法 |
WO2007058627A1 (en) * | 2005-11-16 | 2007-05-24 | S*Bio Pte Ltd | Oxygen linked pyrimidine derivatives |
-
2014
- 2014-09-02 FR FR1458204A patent/FR3025200B1/fr not_active Expired - Fee Related
-
2015
- 2015-09-02 EP EP15757491.4A patent/EP3189061A1/fr not_active Withdrawn
- 2015-09-02 US US15/508,014 patent/US10323043B2/en not_active Expired - Fee Related
- 2015-09-02 BR BR112017003880A patent/BR112017003880A2/pt not_active IP Right Cessation
- 2015-09-02 CN CN201580053646.9A patent/CN106715445B/zh not_active Expired - Fee Related
- 2015-09-02 RU RU2017108937A patent/RU2017108937A/ru not_active Application Discontinuation
- 2015-09-02 WO PCT/EP2015/070072 patent/WO2016034637A1/fr active Application Filing
- 2015-09-02 JP JP2017511996A patent/JP2017525733A/ja active Pending
- 2015-09-02 MX MX2017002747A patent/MX2017002747A/es unknown
Also Published As
Publication number | Publication date |
---|---|
MX2017002747A (es) | 2017-10-20 |
RU2017108937A3 (zh) | 2019-02-25 |
US10323043B2 (en) | 2019-06-18 |
WO2016034637A1 (fr) | 2016-03-10 |
FR3025200A1 (fr) | 2016-03-04 |
US20170283432A1 (en) | 2017-10-05 |
EP3189061A1 (fr) | 2017-07-12 |
RU2017108937A (ru) | 2018-10-04 |
CN106715445A (zh) | 2017-05-24 |
CN106715445B (zh) | 2019-05-31 |
BR112017003880A2 (pt) | 2017-12-05 |
JP2017525733A (ja) | 2017-09-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PLFP | Fee payment |
Year of fee payment: 2 |
|
PLSC | Search report ready |
Effective date: 20160304 |
|
PLFP | Fee payment |
Year of fee payment: 3 |
|
PLFP | Fee payment |
Year of fee payment: 4 |
|
PLFP | Fee payment |
Year of fee payment: 5 |
|
ST | Notification of lapse |
Effective date: 20200910 |