FR3011248B1 - PROCESS FOR OBTAINING BIOACTIVE OLIGOSACCHARIDES CLIVES, MICRO-ORGANISM FOR ITS IMPLEMENTATION, OLIGOSACCHARIDES OBTAINED AND THEIR COSMETIC USE - Google Patents
PROCESS FOR OBTAINING BIOACTIVE OLIGOSACCHARIDES CLIVES, MICRO-ORGANISM FOR ITS IMPLEMENTATION, OLIGOSACCHARIDES OBTAINED AND THEIR COSMETIC USE Download PDFInfo
- Publication number
- FR3011248B1 FR3011248B1 FR1359354A FR1359354A FR3011248B1 FR 3011248 B1 FR3011248 B1 FR 3011248B1 FR 1359354 A FR1359354 A FR 1359354A FR 1359354 A FR1359354 A FR 1359354A FR 3011248 B1 FR3011248 B1 FR 3011248B1
- Authority
- FR
- France
- Prior art keywords
- oligosaccharides
- strain
- clives
- organism
- micro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 229920001542 oligosaccharide Polymers 0.000 title abstract 4
- 150000002482 oligosaccharides Chemical class 0.000 title abstract 4
- 244000005700 microbiome Species 0.000 title abstract 3
- 230000000975 bioactive effect Effects 0.000 title abstract 2
- 239000002537 cosmetic Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 102000008186 Collagen Human genes 0.000 abstract 2
- 108010035532 Collagen Proteins 0.000 abstract 2
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 abstract 2
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 abstract 2
- 238000003776 cleavage reaction Methods 0.000 abstract 2
- 229920001436 collagen Polymers 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 210000002744 extracellular matrix Anatomy 0.000 abstract 2
- 230000007017 scission Effects 0.000 abstract 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000195628 Chlorophyta Species 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000016359 Fibronectins Human genes 0.000 abstract 1
- 108010067306 Fibronectins Proteins 0.000 abstract 1
- 241000244332 Flavobacteriaceae Species 0.000 abstract 1
- 241000056221 Flavobacteriaceae bacterium Species 0.000 abstract 1
- 241000993141 Gaetbulibacter marinus Species 0.000 abstract 1
- 241000346880 Jejuia pallidilutea Species 0.000 abstract 1
- 102000004317 Lyases Human genes 0.000 abstract 1
- 108090000856 Lyases Proteins 0.000 abstract 1
- 241000196252 Ulva Species 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000002225 anti-radical effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000002500 effect on skin Effects 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 abstract 1
- 229920002674 hyaluronan Polymers 0.000 abstract 1
- 229960003160 hyaluronic acid Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- LWGJTAZLEJHCPA-UHFFFAOYSA-N n-(2-chloroethyl)-n-nitrosomorpholine-4-carboxamide Chemical compound ClCCN(N=O)C(=O)N1CCOCC1 LWGJTAZLEJHCPA-UHFFFAOYSA-N 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/12—Disaccharides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
Le procédé consiste à fournir un micro-organisme apte à produire au moins une enzyme lyase de clivage osidique, à mettre en contact des polysaccharides d'algue verte, de préférence du genre Ulva, avec ladite enzyme de manière à provoquer ledit clivage, et à récupérer lesdits oligosaccharides bioactifs clivés. Selon l'invention, le micro-organisme est choisi parmi le groupe de bactéries de la famille des Flavobacteriaceae comprenant la souche Jejuia pallidilutea, la souche Flavobacteriaceae bacterium, la souche Gaetbulibacter marinus et la souche référencée CNCM I-4797. Le mélange d'oligosaccharides clivés obtenus présente une activité cosmétique sur les cellules de la peau, notamment des effets anti-inflammatoires, anti-radicalaires, dé-pigmentant, sur des molécules de la matrice extracellulaire dermique (comme le collagène 1, collagène 4 et la fibronectine), sur des molécules de la matrice extracellulaire épidermique (l'acide hyaluronique).The method consists of providing a microorganism capable of producing at least one osidic cleavage lyase enzyme, of bringing green algae polysaccharides, preferably of the genus Ulva, into contact with said enzyme so as to cause said cleavage, and of recovering said cleaved bioactive oligosaccharides. According to the invention, the microorganism is chosen from the group of bacteria of the Flavobacteriaceae family comprising the strain Jejuia pallidilutea, the strain Flavobacteriaceae bacterium, the strain Gaetbulibacter marinus and the strain referenced CNCM I-4797. The mixture of cleaved oligosaccharides obtained exhibits cosmetic activity on the cells of the skin, in particular anti-inflammatory, anti-radical, de-pigmenting effects on molecules of the dermal extracellular matrix (such as collagen 1, collagen 4 and fibronectin), on molecules of the epidermal extracellular matrix (hyaluronic acid).
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1359354A FR3011248B1 (en) | 2013-09-27 | 2013-09-27 | PROCESS FOR OBTAINING BIOACTIVE OLIGOSACCHARIDES CLIVES, MICRO-ORGANISM FOR ITS IMPLEMENTATION, OLIGOSACCHARIDES OBTAINED AND THEIR COSMETIC USE |
| PCT/IB2014/064830 WO2015044892A1 (en) | 2013-09-27 | 2014-09-25 | Method for preparing cleaved bioactive oligosaccharides, micro-organism for its implementation, prepared oligosaccharides and cosmetic use thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1359354A FR3011248B1 (en) | 2013-09-27 | 2013-09-27 | PROCESS FOR OBTAINING BIOACTIVE OLIGOSACCHARIDES CLIVES, MICRO-ORGANISM FOR ITS IMPLEMENTATION, OLIGOSACCHARIDES OBTAINED AND THEIR COSMETIC USE |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR3011248A1 FR3011248A1 (en) | 2015-04-03 |
| FR3011248B1 true FR3011248B1 (en) | 2021-05-21 |
Family
ID=49753383
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR1359354A Active FR3011248B1 (en) | 2013-09-27 | 2013-09-27 | PROCESS FOR OBTAINING BIOACTIVE OLIGOSACCHARIDES CLIVES, MICRO-ORGANISM FOR ITS IMPLEMENTATION, OLIGOSACCHARIDES OBTAINED AND THEIR COSMETIC USE |
Country Status (2)
| Country | Link |
|---|---|
| FR (1) | FR3011248B1 (en) |
| WO (1) | WO2015044892A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3055903B1 (en) * | 2016-09-13 | 2020-10-16 | Centre Nat Rech Scient | NEW ULVANE LYASE AND ITS USE TO CLIVIDE POLYSACCHARIDES |
| FR3075644B1 (en) * | 2017-12-27 | 2020-08-28 | Oreal | SULPHATED OLIGOSACCHARIDES AND THEIR COSMETIC USES |
| CN115572318B (en) * | 2022-10-23 | 2024-09-17 | 爱生泽(上海)生物科技有限公司 | Preparation method of rhizoma anemarrhenae oligosaccharide and application of rhizoma anemarrhenae oligosaccharide in cosmetics |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2917750B1 (en) * | 2007-06-22 | 2013-02-08 | Univ Picardie | PROCESS FOR ENZYMATIC CLEAVAGE OF POLYSACCHARIDES FROM ALGAE |
| EP2593546A4 (en) | 2010-07-16 | 2014-01-01 | Valorisation Recherche Ltd Partnership | Affinity purification of rna under native conditions based on the lambda boxb/n peptide interaction |
| FR2988606B1 (en) * | 2012-03-30 | 2014-08-08 | Sederma Sa | TOPICAL COMPOSITION COMPRISING BIOACTIVE SULPHATE OLIGOSACCHARIDES AND COSMETIC USES |
-
2013
- 2013-09-27 FR FR1359354A patent/FR3011248B1/en active Active
-
2014
- 2014-09-25 WO PCT/IB2014/064830 patent/WO2015044892A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015044892A1 (en) | 2015-04-02 |
| FR3011248A1 (en) | 2015-04-03 |
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