FR2923717B1 - COMPOSITIONS OF STILBENIC POLYPHENOLIC DERIVATIVES AND THEIR APPLICATIONS FOR COMBATING PATHOLOGIES AND ENHANCING LIVING ORGANISMS - Google Patents

COMPOSITIONS OF STILBENIC POLYPHENOLIC DERIVATIVES AND THEIR APPLICATIONS FOR COMBATING PATHOLOGIES AND ENHANCING LIVING ORGANISMS

Info

Publication number
FR2923717B1
FR2923717B1 FR0708020A FR0708020A FR2923717B1 FR 2923717 B1 FR2923717 B1 FR 2923717B1 FR 0708020 A FR0708020 A FR 0708020A FR 0708020 A FR0708020 A FR 0708020A FR 2923717 B1 FR2923717 B1 FR 2923717B1
Authority
FR
France
Prior art keywords
nucleus
compositions
stilbenic
applications
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0708020A
Other languages
French (fr)
Other versions
FR2923717A1 (en
Inventor
Joseph Vercauteren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Caudalie
Original Assignee
Caudalie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0708020A priority Critical patent/FR2923717B1/en
Application filed by Caudalie filed Critical Caudalie
Priority to CN2008801235030A priority patent/CN101977601A/en
Priority to JP2010533714A priority patent/JP2011504467A/en
Priority to EP08850928.6A priority patent/EP2222294B1/en
Priority to ES08850928.6T priority patent/ES2482115T3/en
Priority to CA2705840A priority patent/CA2705840A1/en
Priority to PL08850928T priority patent/PL2222294T3/en
Priority to US12/734,677 priority patent/US20100310615A1/en
Priority to PCT/IB2008/054818 priority patent/WO2009063440A1/en
Priority to PT88509286T priority patent/PT2222294E/en
Priority to RU2010123790/15A priority patent/RU2491063C2/en
Publication of FR2923717A1 publication Critical patent/FR2923717A1/en
Application granted granted Critical
Publication of FR2923717B1 publication Critical patent/FR2923717B1/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/231—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having one or two double bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/91—Injection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Confectionery (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Furan Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

L'invention a pour objet des compositions de dérivés de polyphénols, caractérisées en ce que lesdits polyphénols renferment des monomères, des oligomères ou des polymères d'unités répondant à la formule (I) : ces unités étant caractérisées par la présence simultanée d'un noyau de type résorcinol (noyau A) et d'un noyau de type para-phénol (noyau B), reliés entre eux par un lien carboné C, lesdits dérivés étant suractivés, en ce qui concerne leur pouvoir nucléophile, par alkylation d'au moins une fonction phénolique de chaque unité et stabilisés par estérification par des mélanges d'acides gras insaturés (AGI) de toutes les autres.Application notamment en cosmétique, diététique et thérapeutique.The subject of the invention is compositions of polyphenol derivatives, characterized in that said polyphenols contain monomers, oligomers or polymers of units corresponding to formula (I): these units being characterized by the simultaneous presence of a nucleus of resorcinol type (nucleus A) and of a nucleus of para-phenol type (nucleus B), linked together by a carbon bond C, said derivatives being overactivated, with regard to their nucleophilic power, by alkylation of at less one phenolic function of each unit and stabilized by esterification with mixtures of unsaturated fatty acids (AGI) of all the others. Application in particular in cosmetics, dietetics and therapy.

FR0708020A 2007-11-15 2007-11-15 COMPOSITIONS OF STILBENIC POLYPHENOLIC DERIVATIVES AND THEIR APPLICATIONS FOR COMBATING PATHOLOGIES AND ENHANCING LIVING ORGANISMS Expired - Fee Related FR2923717B1 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
FR0708020A FR2923717B1 (en) 2007-11-15 2007-11-15 COMPOSITIONS OF STILBENIC POLYPHENOLIC DERIVATIVES AND THEIR APPLICATIONS FOR COMBATING PATHOLOGIES AND ENHANCING LIVING ORGANISMS
PCT/IB2008/054818 WO2009063440A1 (en) 2007-11-15 2008-11-17 Compositions comprising stilbene polyphenol derivatives and use thereof for combating the ageing of living organisms and diseases affecting same
EP08850928.6A EP2222294B1 (en) 2007-11-15 2008-11-17 Compositions comprising stilbene polyphenol derivatives and use thereof for combating the ageing of living organisms and diseases affecting same
ES08850928.6T ES2482115T3 (en) 2007-11-15 2008-11-17 Compositions of stylogenic polyphenolic derivatives and their applications to fight against the pathologies and aging of living organisms
CA2705840A CA2705840A1 (en) 2007-11-15 2008-11-17 Compositions comprising stilbene polyphenol derivatives and use thereof for combating the ageing of living organisms and diseases affecting same
PL08850928T PL2222294T3 (en) 2007-11-15 2008-11-17 Compositions comprising stilbene polyphenol derivatives and use thereof for combating the ageing of living organisms and diseases affecting same
CN2008801235030A CN101977601A (en) 2007-11-15 2008-11-17 Compositions comprising stilbene polyphenol derivatives and use thereof for combating the ageing of living organisms and diseases affecting same
JP2010533714A JP2011504467A (en) 2007-11-15 2008-11-17 Compositions containing stilbene polyphenol derivatives and their use to combat aging and diseases affecting aging
PT88509286T PT2222294E (en) 2007-11-15 2008-11-17 Compositions comprising stilbene polyphenol derivatives and use thereof for combating the ageing of living organisms and diseases affecting same
RU2010123790/15A RU2491063C2 (en) 2007-11-15 2008-11-17 Stilbene polyphenol derivative formulations and using them for controlling pathologies and living body ageing
US12/734,677 US20100310615A1 (en) 2007-11-15 2008-11-17 Compositions comprising stilbene polyphenol derivatives and use thereof for combating the ageing of living organisms and diseases affecting same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0708020A FR2923717B1 (en) 2007-11-15 2007-11-15 COMPOSITIONS OF STILBENIC POLYPHENOLIC DERIVATIVES AND THEIR APPLICATIONS FOR COMBATING PATHOLOGIES AND ENHANCING LIVING ORGANISMS

Publications (2)

Publication Number Publication Date
FR2923717A1 FR2923717A1 (en) 2009-05-22
FR2923717B1 true FR2923717B1 (en) 2015-01-16

Family

ID=39277024

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0708020A Expired - Fee Related FR2923717B1 (en) 2007-11-15 2007-11-15 COMPOSITIONS OF STILBENIC POLYPHENOLIC DERIVATIVES AND THEIR APPLICATIONS FOR COMBATING PATHOLOGIES AND ENHANCING LIVING ORGANISMS

Country Status (11)

Country Link
US (1) US20100310615A1 (en)
EP (1) EP2222294B1 (en)
JP (1) JP2011504467A (en)
CN (1) CN101977601A (en)
CA (1) CA2705840A1 (en)
ES (1) ES2482115T3 (en)
FR (1) FR2923717B1 (en)
PL (1) PL2222294T3 (en)
PT (1) PT2222294E (en)
RU (1) RU2491063C2 (en)
WO (1) WO2009063440A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20091940A1 (en) 2009-11-05 2011-05-06 Functional Point S R L COMPOSITION INCLUDING RESVERATROL AND AT LEAST ONE RED WINE POLYPHENOL AND ITS USES.
CN102173983A (en) * 2011-03-17 2011-09-07 中南大学 Method for synthesizing trans-3,4',5-trimethoxytoluylene
CN102408893A (en) * 2011-09-21 2012-04-11 浙江大学 Preparation method of mulberry twig antioxidant
CN103826596B (en) * 2011-09-26 2017-05-24 帝斯曼知识产权资产管理有限公司 Fluid compositions
CN103826597B (en) * 2011-09-26 2016-08-17 帝斯曼知识产权资产管理有限公司 Topical composition
BR112014013667A2 (en) 2011-12-06 2017-06-13 Unilever Nv anti aging skin makeup
FR2989270B1 (en) * 2012-04-12 2016-12-30 Soc La Biochimie Appliquee ANTI-AGE SKIN COSMETIC COMPOSITION CONTAINING ACTIVATORS OF MITOCHONDRIAL ACONITASE
CN103275044B (en) 2013-06-14 2015-01-14 中国药科大学 R type resveratrol oligomer as well as preparation method and blood sugar decreasing application thereof
ES2881360T3 (en) 2015-06-05 2021-11-29 Tomcat International Ltd Procedure and composition to stimulate the synthesis of hyaluronic acid
US9738581B2 (en) 2015-06-16 2017-08-22 Hong Kong Baptist University Method of using dihydro-resveratrol or its stilbenoid derivatives and/or chemical variants in treatments of fibrotic and diabetic conditions
WO2017011318A1 (en) 2015-07-10 2017-01-19 University Of Miami Methods for treating mucopolysaccharidosis
JP7051843B2 (en) 2016-11-15 2022-04-11 ホンコン バプテスト ユニバーシティ Skin protection composition containing dendrobium-based material
CA3062067A1 (en) * 2017-06-05 2018-12-13 Flagship Pioneering Innovations V, Inc. Multibiotic agents and methods of using the same
EP3801496A4 (en) 2018-06-05 2022-07-06 Flagship Pioneering Innovations V, Inc. Active agents and methods of their use for the treatment of metabolic disorders and nonalcoholic fatty liver disease
EP4167935A1 (en) 2020-06-19 2023-04-26 Tomcat International Limited Association of natural actives ingredients to fight skin aging
WO2023144120A1 (en) 2022-01-25 2023-08-03 Planbio Cosmetics Srl Composition containing nero di troia pomace extract

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6976191A (en) * 1989-12-22 1991-07-24 Smithkline Beecham Corporation Anti-viral compositions
JPH08217721A (en) * 1995-02-16 1996-08-27 Lion Corp Production of phenol derivative ester
FR2766176B1 (en) * 1997-07-15 1999-10-29 Caudalie COMPOSITIONS BASED ON RESVERATROL DERIVATIVES
FR2772613B1 (en) * 1997-12-19 2003-05-09 Oreal USE OF PHLOROGLUCINOL IN A COSMETIC COMPOSITION
JP2000344622A (en) * 1999-03-31 2000-12-12 Sunstar Inc Stabilization of stilbenic compound and plant extract containing the same, and food, medicine, cosmetic or oral cavity preparation stably compounded with stilbenic compound and plant extract containing the same
ITNA20000037A1 (en) * 2000-06-02 2001-12-02 Dev Biotechnological Proces Se INNOVATIVE MULTIFUNCTION SOLAR FILTER.
JP2006510738A (en) * 2002-12-18 2006-03-30 ロレアル Use of alkyl stilbene alkyl ethers for the treatment of dry skin
JP2005112764A (en) * 2003-10-07 2005-04-28 Toagosei Co Ltd Method for producing aromatic ester
EP1976505A1 (en) * 2005-11-14 2008-10-08 Abraxis BioScience, Inc. Combretastatin derivatives and related therapeutic methods
US20090035236A1 (en) * 2007-07-31 2009-02-05 Maes Daniel H Emulsion Cosmetic Compositions Containing Resveratrol Derivatives And An Oil Phase Structuring Agent
US8409376B2 (en) * 2008-10-31 2013-04-02 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
PL3210591T3 (en) * 2010-08-27 2019-08-30 Sienna Biopharmaceuticals, Inc. Compositions and methods for targeted thermomodulation

Also Published As

Publication number Publication date
PL2222294T3 (en) 2014-09-30
RU2010123790A (en) 2013-01-20
CN101977601A (en) 2011-02-16
EP2222294A1 (en) 2010-09-01
ES2482115T3 (en) 2014-08-01
US20100310615A1 (en) 2010-12-09
RU2491063C2 (en) 2013-08-27
JP2011504467A (en) 2011-02-10
FR2923717A1 (en) 2009-05-22
WO2009063440A1 (en) 2009-05-22
PT2222294E (en) 2014-08-22
EP2222294B1 (en) 2014-05-07
CA2705840A1 (en) 2009-05-22

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