FR2896123A1 - Use of a combination of pentylene glycol and sorbic acid as a preservative, in a dermatological or cosmetic composition for the skin or superficial body growths - Google Patents
Use of a combination of pentylene glycol and sorbic acid as a preservative, in a dermatological or cosmetic composition for the skin or superficial body growths Download PDFInfo
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- FR2896123A1 FR2896123A1 FR0700742A FR0700742A FR2896123A1 FR 2896123 A1 FR2896123 A1 FR 2896123A1 FR 0700742 A FR0700742 A FR 0700742A FR 0700742 A FR0700742 A FR 0700742A FR 2896123 A1 FR2896123 A1 FR 2896123A1
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- sorbic acid
- pentylene glycol
- skin
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- 239000000203 mixture Substances 0.000 title claims abstract description 37
- 239000002537 cosmetic Substances 0.000 title claims abstract description 32
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 title claims abstract description 22
- 235000010199 sorbic acid Nutrition 0.000 title claims abstract description 22
- 239000004334 sorbic acid Substances 0.000 title claims abstract description 22
- 229940075582 sorbic acid Drugs 0.000 title claims abstract description 22
- 229940043375 1,5-pentanediol Drugs 0.000 title claims abstract description 21
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 title claims abstract description 21
- 239000003755 preservative agent Substances 0.000 title claims abstract description 12
- 230000002335 preservative effect Effects 0.000 title claims abstract description 4
- 230000021332 multicellular organism growth Effects 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 claims abstract description 17
- 230000000845 anti-microbial effect Effects 0.000 claims abstract description 4
- 238000011109 contamination Methods 0.000 claims description 10
- 230000000813 microbial effect Effects 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- 239000004599 antimicrobial Substances 0.000 abstract description 2
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 6
- 244000005700 microbiome Species 0.000 description 6
- 235000010241 potassium sorbate Nutrition 0.000 description 6
- 239000004302 potassium sorbate Substances 0.000 description 6
- 229940069338 potassium sorbate Drugs 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 239000002054 inoculum Substances 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000006071 cream Substances 0.000 description 4
- 239000000839 emulsion Substances 0.000 description 4
- 239000006210 lotion Substances 0.000 description 4
- 241000228212 Aspergillus Species 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 239000013543 active substance Substances 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000002538 fungal effect Effects 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000002906 microbiologic effect Effects 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 239000002304 perfume Substances 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- -1 softeners Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- 239000004283 Sodium sorbate Substances 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229960000250 adipic acid Drugs 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 1
- MCFVRESNTICQSJ-RJNTXXOISA-L calcium sorbate Chemical compound [Ca+2].C\C=C\C=C\C([O-])=O.C\C=C\C=C\C([O-])=O MCFVRESNTICQSJ-RJNTXXOISA-L 0.000 description 1
- 235000010244 calcium sorbate Nutrition 0.000 description 1
- 239000004303 calcium sorbate Substances 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000001332 colony forming effect Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000008029 eradication Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000006916 nutrient agar Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229940113124 polysorbate 60 Drugs 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- LROWVYNUWKVTCU-STWYSWDKSA-M sodium sorbate Chemical compound [Na+].C\C=C\C=C\C([O-])=O LROWVYNUWKVTCU-STWYSWDKSA-M 0.000 description 1
- 235000019250 sodium sorbate Nutrition 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cosmetics (AREA)
Abstract
Description
1 SYSTÈME CONSERVATEUR D'UNE COMPOSITION COSMÉTIQUE1 SYSTEM CONSERVATING A COSMETIC COMPOSITION
La présente invention concerne le domaine cosmétique, et en particulier des agents conservateurs. The present invention relates to the cosmetic field, and in particular to preservatives.
Il est usuel d'ajouter à une composition cosmétique, notamment comprenant de l'eau et ou des nutriments, des conservateurs en particulier destinés à combattre la prolifération des micro-organismes. En effet la contamination microbienne peut survenir à deux étapes de la vie du produit cosmétique : soit pendant sa fabrication, on parle alors de contamination primaire ; soit au cours de son utilisation, il s'agit dans ce cas de contamination secondaire. Contrairement aux denrées alimentaires un produit cosmétique n'est généralement pas réfrigéré après ouverture, mais conservé dans un environnement chaud et humide, donc favorable au développement microbien, tel que la salle de bain. Il peut également rester ouvert entre deux utilisations, être dilué par le consommateur avec de l'eau ou bien être utilisé par plusieurs personnes. La contamination microbienne d'un produit cosmétique provoque généralement des modifications telles que le consommateur les remarque, par exemple changement de couleur du produit, production de gaz pouvant se manifester par l'apparition de bulles ou gonflement de l'article de conditionnement, modification de la texture d'un produit homogène qui peut devenir hétérogène, développement d'une odeur désagréable, de plus des moisissures peuvent apparaitre à la surface d'un produit conditionné en pot. Il est donc souhaitable de se prémunir contre ces problèmes, par exemple en tentant de maitriser le risque de contamination microbienne. 2 Un produit cosmétique contaminé par des micro-organismes pourrait exposer le consommateur à un risque d'infection. Ce risque est plus important lorsque le consommateur visé est une personne âgée ou un enfant en bas âge, ou encore, lorsque la zone d'application du produit concerne les muqueuses. L'utilisation de conservateurs est donc le plus souvent nécessaire pour maintenir une bonne qualité microbiologique du produit au cours de son utilisation et protéger le consommateur des risques. Néanmoins il s'agit fréquemment de substances biologiquement actives qui ne sont pas spécifiques des cellules microbiennes. Il convient donc de trouver un équilibre entre le risque microbiologique et le risque d'apparition de réaction d'intolérance (irritation, allergie) en utilisant la quantité de conservateurs nécessaire et suffisante. Les conservateurs connus en cosmétiques présentent fréquemment des efficacités insuffisantes, un faible spectre d'activité, une tolérance cutanée insuffisante, une certaine difficulté d'utilisation, une odeur et/ou une couleur susceptible d'être gênante dans le cadre d'une formulation cosmétique, et/ou ne pas être neutre vis-à-vis des autres matières premières, ainsi que du conditionnement. It is usual to add to a cosmetic composition, in particular comprising water and or nutrients, preservatives in particular intended to combat the proliferation of microorganisms. Indeed, microbial contamination can occur at two stages of the life of the cosmetic product: during its manufacture, it is called primary contamination; either during its use, it is in this case secondary contamination. Unlike foodstuffs a cosmetic product is generally not refrigerated after opening, but kept in a warm and humid environment, thus favorable to microbial growth, such as the bathroom. It can also remain open between uses, be diluted by the consumer with water or be used by several people. The microbial contamination of a cosmetic product generally causes changes such as the consumer notices them, for example color change of the product, production of gas may be manifested by the appearance of bubbles or swelling of the packaging article, modification of the texture of a homogeneous product that can become heterogeneous, development of an unpleasant smell, more mold can appear on the surface of a product packaged in a pot. It is therefore desirable to guard against these problems, for example by trying to control the risk of microbial contamination. 2 A cosmetic product contaminated with micro-organisms could expose the consumer to a risk of infection. This risk is greater when the intended consumer is an elderly person or a young child, or when the area of application of the product is for the mucous membranes. The use of preservatives is therefore most often necessary to maintain a good microbiological quality of the product during its use and to protect the consumer from risks. Nevertheless, these are frequently biologically active substances that are not specific for microbial cells. It is therefore necessary to find a balance between the microbiological risk and the risk of appearance of intolerance reaction (irritation, allergy) by using the amount of preservatives necessary and sufficient. Preservatives known in cosmetics frequently have insufficient efficacies, a low spectrum of activity, insufficient skin tolerance, a certain difficulty of use, an odor and / or a color that may be inconvenient in the context of a cosmetic formulation , and / or not be neutral with respect to other raw materials, as well as packaging.
Il subsiste donc un besoin pour un système conservateur permettant de résoudre en tout ou partie les problèmes évoqués ci-dessus, en particulier efficace mais ne présentant pas ou peu d'effets secondaires pour protéger les compositions cosmétiques destinées à la peau ou aux phanères de la contamination microbienne. La demanderesse a trouvé que de manière surprenante l'association de pentylène glycol et de l'acide sorbique et/ou ses sels protégeait une composition 3 cosmétique, en particulier contre la prolifération microbienne et ceci avec un minimum d'effets secondaires, voire sans effets secondaires, pour le consommateur. Cette association peut en outre permettre d'éviter la contamination fongique des compositions cosmétiques. Il est généralement plus difficile de combattre une contamination fongique, en effet les moisissures sont plus résistantes aux conservateurs habituellement utilisés. There is therefore still a need for a conservative system that makes it possible to solve all or part of the problems mentioned above, in particular being effective but having no or few side effects to protect the cosmetic compositions intended for the skin or integuments of the skin. microbial contamination. The Applicant has surprisingly found that the combination of pentylene glycol and sorbic acid and / or its salts protects a cosmetic composition 3, in particular against microbial proliferation and this with a minimum of side effects, or even without effects. secondary, for the consumer. This combination can furthermore make it possible to avoid fungal contamination of the cosmetic compositions. It is generally more difficult to combat fungal contamination, because molds are more resistant to the preservatives usually used.
La demanderesse a mis en évidence l'effet potentialisateur du pentylène glycol sur l'acide sorbique et/ou ses sels, antifongique déjà utilisé. En effet, utilisé seul, l'acide sorbique et/ou ses sels permettent une réduction progressive du nombre de micro-organismes dans une composition cosmétique. L'addition de pentylène glycol peut permettre non seulement une réduction plus rapide du nombre de micro organismes, mais aussi une totale éradication des germes. The Applicant has highlighted the potentiating effect of pentylene glycol on sorbic acid and / or its salts, antifungal already used. Indeed, used alone, sorbic acid and / or its salts allow a gradual reduction in the number of microorganisms in a cosmetic composition. The addition of pentylene glycol can not only allow a faster reduction of the number of microorganisms, but also a total eradication of germs.
La présente invention concerne donc l'utilisation de l'association pentylène glycol et acide sorbique et/ou ses sels comme agent conservateur, dans une composition cosmétique ou dermatologique, en particulier destinée à la peau ou aux phanères. The present invention therefore relates to the use of the pentylene glycol and sorbic acid combination and / or its salts as a preservative, in a cosmetic or dermatological composition, in particular intended for the skin or integuments.
Le pentylène glycol aussi nommé pentanediol-1,2 répond à la formule chimique CH3CH2CH2CHOHCH2OH. Il peut s'agir d'un liquide visqueux d'odeur caractéristique, incolore, son poids moléculaire est de 104 g/mol. La teneur en pentylène glycol peut aller de 0,1 à 15 % en poids, particulièrement de 1 à 8 % en poids et tout particulièrement de 1 à 5 % en poids par rapport au poids total de la composition. On utilise selon la présente invention de l'acide sorbique et /ou ses sels. On entend par sels de 4 l'acide sorbique , au sens de la présente invention les sels de cet acide communément utilisés en cosmétique, comme le sorbate de potassium, le sorbate de sodium ou le sorbate de calcium. En particulier, on utilise le sorbate de potassium. L'acide sorbique aussi appelé acide hexanedioïque-2,4 a la formule chimique CH3CHCHCHCHCOOH. Il peut s'agir d'une poudre cristalline blanche à jaune pouvant être légèrement odorante, son poids moléculaire est de 112,1 g/mol. Le sorbate de potassium a pour formule CH3CHCHCHCHCOOK. Il s'agit de granulés blancs à jaunes d'odeur faible, son poids moléculaire est de 150,22 g/mol. Pentylene glycol also named pentanediol-1,2 has the chemical formula CH3CH2CH2CHOHCH2OH. It may be a viscous liquid of characteristic odor, colorless, its molecular weight is 104 g / mol. The pentylene glycol content may range from 0.1 to 15% by weight, particularly from 1 to 8% by weight and more particularly from 1 to 5% by weight relative to the total weight of the composition. According to the present invention, sorbic acid and / or its salts are used. The term "salts of 4" means sorbic acid, within the meaning of the present invention, the salts of this acid commonly used in cosmetics, such as potassium sorbate, sodium sorbate or calcium sorbate. In particular, potassium sorbate is used. Sorbic acid also called 2,4-hexanedioic acid has the chemical formula CH3CHCHCHCHCOOH. It can be a white to yellow crystalline powder that can be slightly odorous, its molecular weight is 112.1 g / mol. Potassium sorbate has the formula CH3CHCHCHCHCOOK. It is white to yellow granules of low odor, its molecular weight is 150.22 g / mol.
La teneur en d'acide sorbique et/ou ses sels peut aller de 0,01 à 1 % en poids, particulièrement de 0,05 à 0,5 % en poids et tout particulièrement de 0,05 à 0,2 % en poids par rapport au poids total de la composition. The content of sorbic acid and / or its salts may range from 0.01 to 1% by weight, particularly from 0.05 to 0.5% by weight and more particularly from 0.05 to 0.2% by weight. relative to the total weight of the composition.
En particulier, la composition comprend le pentylène glycol et l'acide sorbique en un rapport allant de 10 à 100, notamment de 15 à 50, en particulier de 20 à 40, voire de 25 à 35, et tout particulièrement de 30. In particular, the composition comprises pentylene glycol and sorbic acid in a ratio ranging from 10 to 100, in particular from 15 to 50, in particular from 20 to 40, even from 25 to 35, and most particularly from 30.
La composition cosmétique peut constituer notamment une composition de protection, de traitement, de nettoyage ou de soin cosmétique ou dermatologique pour le visage, pour le cou, pour les mains ou pour le corps, par exemple, crèmes de jour, crèmes de nuit, lotions pour le visage, gels nettoyants moussants, crèmes solaires, laits corporels, une composition capillaire (par exemple lotion capillaire), une composition de maquillage (par exemple fond de teint) ou une composition auto bronzante. The cosmetic composition may constitute in particular a composition for the protection, treatment, cleaning or cosmetic or dermatological treatment for the face, neck, hands or body, for example, day creams, night creams, lotions for the face, foaming cleansing gels, sun creams, body milks, a hair composition (for example a hair lotion), a make-up composition (for example a foundation) or a self-tanning composition.
La composition cosmétique peut contenir un ou 5 plusieurs autres composants connus de l'homme du métier, comme des agents de formulation ou additifs d'usage connu et classique dans les compositions cosmétiques. À titre d'exemple et de façon non limitative, de tels agents de formulation et additifs peuvent être des gélifiants hydrophiles ou lipophiles, des adoucissants, des colorants, des agents solubilisants, des agents de texture, des parfums, des charges, des absorbeurs d'odeur, des actifs filmogènes, des tensio-actifs, des émulsionnants, des huiles, des vitamines, des filtres solaires,.... Grâce à ses connaissances en matière de cosmétiques, l'homme du métier saura quels agents de formulation ajouter à la composition cosmétique selon l'invention et en quelles quantités en fonction des propriétés recherchées. The cosmetic composition may contain one or more other components known to those skilled in the art, such as formulating agents or additives of known and conventional use in cosmetic compositions. By way of example and in a nonlimiting manner, such formulating agents and additives may be hydrophilic or lipophilic gelling agents, softeners, colorants, solubilizing agents, texturizing agents, perfumes, fillers odor, film-forming active agents, surfactants, emulsifiers, oils, vitamins, sunscreens, .... Thanks to his knowledge of cosmetics, the skilled person will know which formulating agents to add to the cosmetic composition according to the invention and in what quantities according to the desired properties.
De plus, la composition cosmétique peut se présenter sous toute forme connue de l'homme du métier dans le domaine de la cosmétique sans aucune autre restriction galénique particulière que celle pour l'application sur la peau ou les phanères. Ainsi, la composition cosmétique selon l'invention peut avoir la forme d'une solution ou suspension aqueuse, alcoolique ou d'une solution ou d'une dispersion de type lotion ou sérum, d'une émulsion de consistance liquide ou semiliquide de type lait, obtenues par dispersion d'une phase grasse dans une phase aqueuse (émulsion Huile dans Eau : H/E) ou inversement (Eau dans Huile : E/H), ou d'une émulsion du type crème H/E ou E/H ou d'un gel, d'une lotion, d'un masque. On peut également envisager les formulations cosmétiques sous la forme d'une mousse 6 ou encore sous forme de compositions pour aérosol comprenant également un agent propulseur sous pression. In addition, the cosmetic composition may be in any form known to those skilled in the field of cosmetics without any other particular pharmaceutical restriction than that for application to the skin or integuments. Thus, the cosmetic composition according to the invention can have the form of an aqueous solution, or an alcoholic solution or a dispersion of the lotion or serum type, of a emulsion of liquid or semiliquid consistency of the milk type. obtained by dispersion of a fatty phase in an aqueous phase (oil in water: O / W emulsion) or conversely (water in oil: W / O), or of an O / W or W / O cream type emulsion. or a gel, a lotion, a mask. It is also possible to envisage the cosmetic formulations in the form of a foam 6 or in the form of aerosol compositions also comprising a propellant under pressure.
La présente invention concerne également un procédé de protection antimicrobien d'une composition cosmétique ou dermatologique pour la peau ou les phanères comprenant l'adjonction d'une association pentylène glycol et acide sorbique et/ou ses sels. La présente invention concerne aussi l'utilisation de l'association pentylène glycol et acide sorbique et/ou ses sels pour la préparation d'une composition dermatologique pour la protéger d'une contamination microbienne. The present invention also relates to a method for the antimicrobial protection of a cosmetic or dermatological composition for the skin or integuments comprising the addition of a combination of pentylene glycol and sorbic acid and / or its salts. The present invention also relates to the use of the combination pentylene glycol and sorbic acid and / or its salts for the preparation of a dermatological composition to protect it from microbial contamination.
Les exemples ci-après mettent en évidence l'activité de l'association pentylène glycol et acide sorbique et/ou ses sels sur les micro-organismes. Le test est réalisé d'après le CTFA Microbiology Guidelines 2005 `Determination of preservation adequacy of water miscible cosmetic and toiletry formulations'. Les étapes pour réaliser ce test sont les suivantes . 1. Culture du micro-organisme: Aspergillus piger (moisissure). La souche est préparée dans le milieu de culture de tryptone-sel. 2. Préparation de l'inoculum : L'inoculum est constitué d'une culture de 7 jours d'Aspergillus piger sur une gélose au malt (milieu nutritif gélosé approprié). The examples below demonstrate the activity of the combination pentylene glycol and sorbic acid and / or its salts on microorganisms. The test is carried out according to the CTFA Microbiology Guidelines 2005 'Determination of preservation of water miscible cosmetic and toiletry formulations'. The steps to perform this test are as follows. 1. Culture of the microorganism: Aspergillus piger (mold). The strain is prepared in the tryptone-salt culture medium. 2. Preparation of Inoculum: The inoculum consists of a 7-day-old culture of Aspergillus on a malt agar (appropriate nutrient agar medium).
Cet inoculum est dilué plusieurs fois au 1/10 de façon à obtenir une suspension contenant 104 à 105 UfC (unité formant colonies)/ml. 3. Préparation de l'échantillon : On dépose dans 1 pot en polypropylène 20 g du produit à tester. 7 4. Inoculation : on introduit 0,2 ml d'inoculum de la souche dans le pot, le mélange est ensuite homogénéisé mécaniquement. Ce pot sera conservé dans une étuve à 22.5 C à l'abri de la lumière pendant toute la durée du test (28 jours). 5. Prélèvements et dénombrements : Des dénombrements de la quantité de germes sont effectués à différents temps : 8 jours, 13 jours et 30 jours après inoculation. Pour se faire 1 g de produit est prélevé. Puis des dilutions décimales sont effectuées dans un diluant renfermant des inhibiteurs de conservateurs qui vont stopper l'action des conservateurs. Ces dilutions sont déposées dans des boîtes de Pétri gélosées dans lesquelles on coulera un milieu de culture. Ces boites seront mises ensuite à incuber à 22,5 C pendant 5 jours. Les colonies apparues sont alors dénombrées en tenant compte des dilutions. This inoculum is diluted several times to 1/10 so as to obtain a suspension containing 104 to 105 cfu (colony-forming unit) / ml. 3. Preparation of the sample: 20 g of the product to be tested are deposited in a polypropylene jar. 4. Inoculation: 0.2 ml of inoculum of the strain is introduced into the pot, the mixture is then mechanically homogenized. This pot will be kept in an oven at 22.5 C in the dark for the duration of the test (28 days). 5. Sampling and counting: Countings of the amount of sprouts are done at different times: 8 days, 13 days and 30 days after inoculation. To make 1 g of product is taken. Then decimal dilutions are made in a diluent containing inhibitors of preservatives which will stop the action of the preservatives. These dilutions are deposited in agri-culture plates in which a culture medium will flow. These boxes will then be incubated at 22.5 C for 5 days. The colonies appearing are then counted taking into account the dilutions.
La matrice utilisée est une émulsion de structure ci-dessous historiquement difficile à conserver dans laquelle sont introduit différents systèmes anti microbien. Matière première % en poids OCTYL DODECANOL 10,50 POLYSORBATE 60 1,50 TRIGLYCERIDES C 8 C 10 14,00 CETEARYL GLUCOSIDE 0,50 CARBOMER 0,45 TRIETHANOLAMINE 0,50 PARFUM 0,05 EAU DEMINERALISEE qsp Les systèmes testés ont la composition suivante : Constituants Système 1 0,1% sorbate de Potassium Système 2 0,1% acide sorbique Système 3 3% pentylène glycol Système 4 0,1% acide sorbique + 3~ pentylène glycol Système 5 0,1% sorbate de Potassium +3% pentylène glycol Les résultats obtenus sont rassemblés dans le tableau suivant exprimés en germes survivants en ufc/g Inoculum 7 jours 13 jours 30 jours Système 1 2, 9 104 2, 7 104 4, 5 104 4, 9 103 Système 2 2, 9 109 2, 8 109 4, 5 104 4, 5 104 Système 3 2, 9 104 3, 5 109 6, 7 103 1, 8 103 Système 4 2, 9 104 8, 2 103 1, 6 103 <10* Système 5 2, 9 109 3, 2 103 4, 0 103 <10* * seuil de sensibilité de la méthode The matrix used is a structure emulsion below that is historically difficult to maintain, in which various anti-microbial systems are introduced. Raw material% by weight OCTYL DODECANOL 10.50 POLYSORBATE 60 1.50 TRIGLYCERIDES C 8 C 10 14.00 CETEARYL GLUCOSIDE 0.50 CARBOMER 0.45 TRIETHANOLAMINE 0.50 PERFUME 0.05 DEMINERALIZED WATER qs The systems tested have the following composition : Constituents System 1 0.1% Potassium Sorbate System 2 0.1% Sorbic Acid System 3 3% Pentylene Glycol System 4 0.1% Sorbic Acid + 3 ~ Pentylene Glycol System 5 0.1% Potassium Sorbate + 3% pentylene glycol The results obtained are summarized in the following table expressed as surviving germs in cfu / g Inoculum 7 days 13 days 30 days System 1 2, 9 104 2, 7 104 4, 5 104 4, 9 103 System 2 2, 9 109 2, 8 109 4, 5 104 4, 5 104 System 3 2, 9 104 3, 5 109 6, 7 103 1, 8 103 System 4 2, 9 104 8, 2 103 1, 6 103 <10 * System 5 2 , 9 109 3, 2 103 4, 0 103 <10 * * sensitivity threshold of the method
Les résultats montrent pour les systèmes 4 et 5 une diminution d'au moins 1 log de l'Aspergillus piger à 13 15 jours ce qui représente la quantité satisfaisante. Par ailleurs il y a potentialisation de l'action de l'acide sorbique et du sorbate de Potassium par l'adjonction de pentylène glycol. 10 20 The results show for systems 4 and 5 a decrease of at least 1 log of Aspergillus piger at 13 days which represents the satisfactory amount. In addition, the action of sorbic acid and potassium sorbate is potentiated by the addition of pentylene glycol. 10 20
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| Publication number | Priority date | Publication date | Assignee | Title |
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| DE202005007363U1 (en) * | 2005-05-04 | 2005-07-14 | Anton Hübner GmbH & Co. KG | Pharmaceutical or cosmetic preparations for alleviating herpes blisters, especially on the lips, containing silicic acid, humectant, skin care agent(s), preservative, stabilizer and pH regulator |
| WO2005102276A1 (en) * | 2004-04-08 | 2005-11-03 | Isp Investments Inc. | Antimicrobial compositions |
| WO2006045743A1 (en) * | 2004-10-22 | 2006-05-04 | Symrise Gmbh & Co. Kg | Synergistic mixtures of 1,2-hexanediol and 1,2-octanediol and also a further preservative |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2005102276A1 (en) * | 2004-04-08 | 2005-11-03 | Isp Investments Inc. | Antimicrobial compositions |
| WO2006045743A1 (en) * | 2004-10-22 | 2006-05-04 | Symrise Gmbh & Co. Kg | Synergistic mixtures of 1,2-hexanediol and 1,2-octanediol and also a further preservative |
| DE202005007363U1 (en) * | 2005-05-04 | 2005-07-14 | Anton Hübner GmbH & Co. KG | Pharmaceutical or cosmetic preparations for alleviating herpes blisters, especially on the lips, containing silicic acid, humectant, skin care agent(s), preservative, stabilizer and pH regulator |
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