FR2884831B1 - Methode de criblage de composes inhibiteurs de la mtp - Google Patents

Methode de criblage de composes inhibiteurs de la mtp

Info

Publication number
FR2884831B1
FR2884831B1 FR0504060A FR0504060A FR2884831B1 FR 2884831 B1 FR2884831 B1 FR 2884831B1 FR 0504060 A FR0504060 A FR 0504060A FR 0504060 A FR0504060 A FR 0504060A FR 2884831 B1 FR2884831 B1 FR 2884831B1
Authority
FR
France
Prior art keywords
screening
inhibitory compounds
mtp inhibitory
mtp
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0504060A
Other languages
English (en)
Other versions
FR2884831A1 (fr
Inventor
Olivier Chevreuil
Herve Dupont
Daniel Guerrier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sante SAS
Original Assignee
Merck Sante SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0504060A priority Critical patent/FR2884831B1/fr
Application filed by Merck Sante SAS filed Critical Merck Sante SAS
Priority to CA002605491A priority patent/CA2605491A1/fr
Priority to ES06723639T priority patent/ES2328065T3/es
Priority to JP2008506949A priority patent/JP2008538413A/ja
Priority to US11/912,052 priority patent/US20090220421A1/en
Priority to EP06723639A priority patent/EP1871895B1/fr
Priority to PCT/EP2006/002647 priority patent/WO2006111238A1/fr
Priority to AT06723639T priority patent/ATE433497T1/de
Priority to AU2006237044A priority patent/AU2006237044B2/en
Priority to DE602006007225T priority patent/DE602006007225D1/de
Priority to ARP060101574A priority patent/AR053365A1/es
Publication of FR2884831A1 publication Critical patent/FR2884831A1/fr
Application granted granted Critical
Publication of FR2884831B1 publication Critical patent/FR2884831B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/60—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving cholesterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/61—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving triglycerides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
FR0504060A 2005-04-22 2005-04-22 Methode de criblage de composes inhibiteurs de la mtp Expired - Fee Related FR2884831B1 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
FR0504060A FR2884831B1 (fr) 2005-04-22 2005-04-22 Methode de criblage de composes inhibiteurs de la mtp
AU2006237044A AU2006237044B2 (en) 2005-04-22 2006-04-12 Method for screening MTP-inhibiting compounds
JP2008506949A JP2008538413A (ja) 2005-04-22 2006-04-12 Ｍｔｐ阻害化合物をスクリーニングするための方法
US11/912,052 US20090220421A1 (en) 2005-04-22 2006-04-12 Method for screening mtp-inhibiting compounds
EP06723639A EP1871895B1 (fr) 2005-04-22 2006-04-12 Methode de criblage de composes d'inhibition d'une proteine de transfert de triglyceride microsomale (mtp)
PCT/EP2006/002647 WO2006111238A1 (fr) 2005-04-22 2006-04-12 Methode de criblage de composes d'inhibition d'une proteine de transfert de triglyceride microsomale (mtp)
CA002605491A CA2605491A1 (fr) 2005-04-22 2006-04-12 Methode de criblage de composes d'inhibition d'une proteine de transfert de triglyceride microsomale (mtp)
ES06723639T ES2328065T3 (es) 2005-04-22 2006-04-12 Metodo para seleccion de compuestos inhibidores de mtp.
DE602006007225T DE602006007225D1 (de) 2005-04-22 2006-04-12 Verfahren zum screening mtp hemmender verbindungen
AT06723639T ATE433497T1 (de) 2005-04-22 2006-04-12 Verfahren zum screening mtp hemmender verbindungen
ARP060101574A AR053365A1 (es) 2005-04-22 2006-04-21 Metodo para el cribado de compuestos inhibidores de la mtp

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0504060A FR2884831B1 (fr) 2005-04-22 2005-04-22 Methode de criblage de composes inhibiteurs de la mtp

Publications (2)

Publication Number Publication Date
FR2884831A1 FR2884831A1 (fr) 2006-10-27
FR2884831B1 true FR2884831B1 (fr) 2007-08-10

Family

ID=35478603

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0504060A Expired - Fee Related FR2884831B1 (fr) 2005-04-22 2005-04-22 Methode de criblage de composes inhibiteurs de la mtp

Country Status (11)

Country Link
US (1) US20090220421A1 (fr)
EP (1) EP1871895B1 (fr)
JP (1) JP2008538413A (fr)
AR (1) AR053365A1 (fr)
AT (1) ATE433497T1 (fr)
AU (1) AU2006237044B2 (fr)
CA (1) CA2605491A1 (fr)
DE (1) DE602006007225D1 (fr)
ES (1) ES2328065T3 (fr)
FR (1) FR2884831B1 (fr)
WO (1) WO2006111238A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS52825B2 (sr) 2004-03-05 2018-03-30 Univ Pennsylvania Postupci za lečenje poremećaja ili bolesti povezanih sa hiperlipidemijom i hiperholesterolemijom uz minimizaciju sporednih efekata

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5595872A (en) * 1992-03-06 1997-01-21 Bristol-Myers Squibb Company Nucleic acids encoding microsomal trigyceride transfer protein
DE19929065A1 (de) * 1999-06-25 2000-12-28 Bayer Ag Kombination von MTP-Inhibitoren und HMG-CoA-Reduktase-Inhibitoren und ihre Verwendung in Arzneimitteln
CA2325358C (fr) * 1999-11-10 2005-08-02 Pfizer Products Inc. Amides de l'acide 7-¬(4'-trifluoromethylbiphenyl-2-carbonyl)amino|-quinoleine-3-carboxylique et methodes pour inhiber la secretion d'apolipoproteine b
FR2816940A1 (fr) * 2000-11-23 2002-05-24 Lipha Derives de 4-(biphenylcarbonylamino)-piperidine, compositions les contenant et leur utilisation
EP1369128A1 (fr) * 2002-06-07 2003-12-10 Procorde GmbH Inhibiteurs de glycoprotéine VI et leur utilisation thérapeutique

Also Published As

Publication number Publication date
AU2006237044A1 (en) 2006-10-26
WO2006111238A1 (fr) 2006-10-26
FR2884831A1 (fr) 2006-10-27
EP1871895B1 (fr) 2009-06-10
ES2328065T3 (es) 2009-11-06
AR053365A1 (es) 2007-05-02
CA2605491A1 (fr) 2006-10-26
AU2006237044B2 (en) 2011-05-26
ATE433497T1 (de) 2009-06-15
US20090220421A1 (en) 2009-09-03
DE602006007225D1 (de) 2009-07-23
EP1871895A1 (fr) 2008-01-02
JP2008538413A (ja) 2008-10-23

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20141231