FR2858322B1 - SYNTHETIC INTERMEDIATES OF FLUORINATED INHIBITORS OF APARTICAL PROTEASES - Google Patents

SYNTHETIC INTERMEDIATES OF FLUORINATED INHIBITORS OF APARTICAL PROTEASES

Info

Publication number
FR2858322B1
FR2858322B1 FR0309458A FR0309458A FR2858322B1 FR 2858322 B1 FR2858322 B1 FR 2858322B1 FR 0309458 A FR0309458 A FR 0309458A FR 0309458 A FR0309458 A FR 0309458A FR 2858322 B1 FR2858322 B1 FR 2858322B1
Authority
FR
France
Prior art keywords
apartical
proteases
fluorinated
inhibitors
synthetic intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0309458A
Other languages
French (fr)
Other versions
FR2858322A1 (en
Inventor
Delpon Daniele Bonnet
Jean Pierre Begue
Benoit Crousse
Guillaume Magueur
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Universite Paris Sud Paris 11
Original Assignee
Centre National de la Recherche Scientifique CNRS
Universite Paris Sud Paris 11
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, Universite Paris Sud Paris 11 filed Critical Centre National de la Recherche Scientifique CNRS
Priority to FR0309458A priority Critical patent/FR2858322B1/en
Priority to PCT/FR2004/002049 priority patent/WO2005012276A2/en
Publication of FR2858322A1 publication Critical patent/FR2858322A1/en
Application granted granted Critical
Publication of FR2858322B1 publication Critical patent/FR2858322B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FR0309458A 2003-07-31 2003-07-31 SYNTHETIC INTERMEDIATES OF FLUORINATED INHIBITORS OF APARTICAL PROTEASES Expired - Fee Related FR2858322B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR0309458A FR2858322B1 (en) 2003-07-31 2003-07-31 SYNTHETIC INTERMEDIATES OF FLUORINATED INHIBITORS OF APARTICAL PROTEASES
PCT/FR2004/002049 WO2005012276A2 (en) 2003-07-31 2004-07-30 Intermediate products of the synthesis of fluorized inhibitors of aspartic proteases

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0309458A FR2858322B1 (en) 2003-07-31 2003-07-31 SYNTHETIC INTERMEDIATES OF FLUORINATED INHIBITORS OF APARTICAL PROTEASES

Publications (2)

Publication Number Publication Date
FR2858322A1 FR2858322A1 (en) 2005-02-04
FR2858322B1 true FR2858322B1 (en) 2005-09-30

Family

ID=34043709

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0309458A Expired - Fee Related FR2858322B1 (en) 2003-07-31 2003-07-31 SYNTHETIC INTERMEDIATES OF FLUORINATED INHIBITORS OF APARTICAL PROTEASES

Country Status (2)

Country Link
FR (1) FR2858322B1 (en)
WO (1) WO2005012276A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013151452A (en) * 2012-01-25 2013-08-08 Tosoh F-Tech Inc Imine derivative containing optically activity trifluoromethyl group, method of manufacturing the same, and method of manufacturing optical activity amine derivative containing trifluoromethyl group using the same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000509717A (en) * 1996-05-07 2000-08-02 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド Preparation method of oxiranemethanamine derivatives
SE9701245D0 (en) * 1997-04-04 1997-04-04 Bjoern Classon antivirals

Also Published As

Publication number Publication date
WO2005012276A3 (en) 2005-06-09
FR2858322A1 (en) 2005-02-04
WO2005012276A2 (en) 2005-02-10

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20070330