FR2836827A1 - DIETETIC AND COSMETIC COMPOSITION BASED ON CROSSLINKED NATURAL POLYMERS IMMOBILIZING ACTIVE INGREDIENTS - Google Patents
DIETETIC AND COSMETIC COMPOSITION BASED ON CROSSLINKED NATURAL POLYMERS IMMOBILIZING ACTIVE INGREDIENTS Download PDFInfo
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- FR2836827A1 FR2836827A1 FR0202864A FR0202864A FR2836827A1 FR 2836827 A1 FR2836827 A1 FR 2836827A1 FR 0202864 A FR0202864 A FR 0202864A FR 0202864 A FR0202864 A FR 0202864A FR 2836827 A1 FR2836827 A1 FR 2836827A1
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- dietetic
- cosmetic composition
- composition according
- crosslinking
- cosmetic
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- 239000000203 mixture Substances 0.000 title claims abstract description 27
- 239000002537 cosmetic Substances 0.000 title claims abstract description 17
- 235000005911 diet Nutrition 0.000 title claims abstract description 16
- 230000000378 dietary effect Effects 0.000 title claims abstract description 16
- 239000004480 active ingredient Substances 0.000 title claims description 9
- 229920005615 natural polymer Polymers 0.000 title description 3
- 230000003100 immobilizing effect Effects 0.000 title description 2
- 229920000642 polymer Polymers 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 9
- 238000004132 cross linking Methods 0.000 claims abstract description 8
- 230000000994 depressogenic effect Effects 0.000 claims abstract description 5
- 238000002156 mixing Methods 0.000 claims abstract description 5
- 102000004190 Enzymes Human genes 0.000 claims description 7
- 108090000790 Enzymes Proteins 0.000 claims description 7
- 239000000126 substance Substances 0.000 claims description 7
- 230000000694 effects Effects 0.000 claims description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 4
- 239000003431 cross linking reagent Substances 0.000 claims description 4
- 239000008121 dextrose Substances 0.000 claims description 4
- 239000002245 particle Substances 0.000 claims description 4
- 238000001223 reverse osmosis Methods 0.000 claims description 4
- 102000016938 Catalase Human genes 0.000 claims description 3
- 108010053835 Catalase Proteins 0.000 claims description 3
- 102000003992 Peroxidases Human genes 0.000 claims description 3
- 238000009472 formulation Methods 0.000 claims description 3
- 150000004676 glycans Chemical class 0.000 claims description 3
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- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
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- 239000003814 drug Substances 0.000 claims 1
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- 235000013305 food Nutrition 0.000 abstract description 5
- 239000000499 gel Substances 0.000 description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 239000000843 powder Substances 0.000 description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 241000196324 Embryophyta Species 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 239000013543 active substance Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 2
- 241000282472 Canis lupus familiaris Species 0.000 description 2
- 108010082495 Dietary Plant Proteins Proteins 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 108060006613 prolamin Proteins 0.000 description 2
- XXRYFVCIMARHRS-UHFFFAOYSA-N propan-2-yl n-dimethoxyphosphorylcarbamate Chemical compound COP(=O)(OC)NC(=O)OC(C)C XXRYFVCIMARHRS-UHFFFAOYSA-N 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000018832 Cytochromes Human genes 0.000 description 1
- 108010052832 Cytochromes Proteins 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 241000206672 Gelidium Species 0.000 description 1
- 108010061711 Gliadin Proteins 0.000 description 1
- 102000000340 Glucosyltransferases Human genes 0.000 description 1
- 108010055629 Glucosyltransferases Proteins 0.000 description 1
- 108010068370 Glutens Proteins 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 229920002488 Hemicellulose Polymers 0.000 description 1
- 241000219745 Lupinus Species 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 229920000057 Mannan Polymers 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 102000004357 Transferases Human genes 0.000 description 1
- 108090000992 Transferases Proteins 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- GZCGUPFRVQAUEE-SLPGGIOYSA-N aldehydo-D-glucose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-SLPGGIOYSA-N 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- AEMOLEFTQBMNLQ-BKBMJHBISA-N alpha-D-galacturonic acid Chemical compound O[C@H]1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-BKBMJHBISA-N 0.000 description 1
- 229940089206 anhydrous dextrose Drugs 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229940059329 chondroitin sulfate Drugs 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000008139 complexing agent Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000008271 cosmetic emulsion Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 229940097362 cyclodextrins Drugs 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000021312 gluten Nutrition 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 230000007124 immune defense Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000011872 intimate mixture Substances 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 239000002417 nutraceutical Substances 0.000 description 1
- 235000021436 nutraceutical agent Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 229920002414 procyanidin Polymers 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Toxicology (AREA)
- Organic Chemistry (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cosmetics (AREA)
Abstract
Composition à usage diététique et cosmétique à base d'au moins un polymère naturel alimentaire contenant des principes actifs immobilisés susceptible d'être obtenue en réticulant le dit polymère et en le mélangeant à des produits dépresseurs ou osmoseurs, procédé d'obtention d'une telle composition.Composition for dietetic and cosmetic use based on at least one natural food polymer containing immobilized active principles capable of being obtained by crosslinking said polymer and by mixing it with depressant or osmosis products, process for obtaining such a composition.
Description
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COMPOSITION DIETETIQUE ET COSMETIQUE A BASE DE POLYMERES NATURELS RETICULES IMMOBILISANT DES ACTIFS. DIETETIC AND COSMETIC COMPOSITION BASED ON CROSSLINKED NATURAL POLYMERS IMMOBILIZING ACTIVE INGREDIENTS.
Domaine technique
L'invention concerne une composition diététique et cosmétique à base de polymères naturels alimentaires réticulés afin de mieux libérer les principes actifs qu'ils enferment, son mode d'obtention et les principales applications de la composition. Technical area
The invention relates to a dietary and cosmetic composition based on cross-linked natural food polymers in order to better release the active principles which they contain, its method of production and the main applications of the composition.
Etat de la technique
Une des difficultés que rencontre le formulateur dans l'utilisation de certains actifs réside dans leur bonne délivrance afin que ces derniers remplissent leurs rôles bénéfiques. State of the art
One of the difficulties encountered by the formulator in the use of certain active ingredients lies in their good delivery so that the latter fulfill their beneficial roles.
Ces problèmes de bio-disponibilité sont résolus de différentes et nombreuses manières suivant la nature de l'actif. Le technicien ou homme de l'art parle généralement de vectorisation par le biais de capsules, de liposomes, de bio-vecteurs, de complexants comme certains polysaccharides, des structures qui piègent par enfermement comme les cyclo-dextrines ou encore des prolamines végétales. These bio-availability problems are solved in many different ways depending on the nature of the asset. The technician or skilled in the art generally speaks of vectorization by means of capsules, liposomes, bio-vectors, complexing agents such as certain polysaccharides, structures which trap by confinement such as cyclo-dextrins or plant prolamins.
Une partie de ces techniques fait appel à des polymères naturels végétaux ou animaux. Il y a ceux de structure comme la cellulose, ceux de fonction comme l'amidon. Assez récemment les polymères végétaux comme les prolamines ont fait l'objet de développements. Mais ils sont d'emploi lourd et délicat. C'est le cas du brevet US 5,271, 961. Part of these techniques uses natural plant or animal polymers. There are those of structure like cellulose, those of function like starch. Quite recently, plant polymers such as prolamines have been the subject of development. But they are heavy and delicate to use. This is the case of US Patent 5,271,961.
Dans le brevet PCT/FR 96/00055 on réalise des gels ou films polymériques à partir de gliadine ou prolamine de blé en leur rajoutant des plastifiants comme des hydrates de carbone. La substance active est incorporée dans le gel ainsi formé, qu'il s'agit de sécher. C'est à ce stade que ce procédé rencontre des difficultés : le séchage se fait en chauffant et dure trop longtemps pour la stabilité des substances sensibles, notamment la présence d'eau dans le gel dégrade souvent les composants actifs et fait courir un risque de contamination bactérienne, d'autant que les applications visées par ce brevet sont pharmaceutiques. In the patent PCT / FR 96/00055, gels or polymeric films are produced from gliadin or wheat prolamine by adding plasticizers to them such as carbohydrates. The active substance is incorporated into the gel thus formed, which has to be dried. It is at this stage that this process encounters difficulties: the drying is done by heating and lasts too long for the stability of the sensitive substances, in particular the presence of water in the gel often degrades the active components and creates a risk of bacterial contamination, especially as the applications covered by this patent are pharmaceutical.
La demanderesse a essayé avec succès de parer ces difficultés dans sa demande n 0101624, en obtenant de bon résultats, sans palier cependant les effets allergiques ulcériques pour la voie orale, du gluten contenu dans ces formulations. The Applicant has successfully tried to overcome these difficulties in Application No. 0101624, by obtaining good results, without however mitigating the ulcerative allergic effects for the oral route, of the gluten contained in these formulations.
Sachant en outre que pour la cosmétique topique ces formules à bases notamment de prolamines végétales sont inutilisables. Knowing further that for topical cosmetics these formulas based in particular on vegetable prolamins cannot be used.
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La présente invention concerne une composition diététique et cosmétique à base de polymères naturels alimentaires contenant des principes actifs, son mode d'obtention palliant aux inconvénients des techniques actuelles, et rendant ainsi possible leurs utilisations, en facilitant leurs mises en oeuvre et en augmentant leurs performances en terme de bio-disponibilité et de stabilité des actifs. The present invention relates to a dietary and cosmetic composition based on natural food polymers containing active principles, its method of obtaining overcomes the drawbacks of current techniques, and thus making their uses possible, by facilitating their use and increasing their performance. in terms of bio-availability and stability of the active ingredients.
Description sommaire de l'invention
La composition à usage diététique et cosmétique à base de polymères naturels réticulés tels que les dits polymères contient des principes actifs qui sont introduits dans le gel polymérique avant sa réticulation. L'invention s'est donnée pour but d'obtenir une composition dans laquelle les actifs sont préservés ou immobilisés très rapidement. Brief description of the invention
The composition for dietetic and cosmetic use based on crosslinked natural polymers such as said polymers contains active principles which are introduced into the polymer gel before its crosslinking. The object of the invention is to obtain a composition in which the active ingredients are preserved or immobilized very quickly.
Parmi les polymères capables de répondre au besoins de l'invention on peut les choisir dans deux familles principales et non limitatives : - Les protéines animales ou végétales comme les gélatines et les collagènes marin, bovin, porcin, les protéines végétales de haut poids moléculaire, par exemples de soja, de lupin. Among the polymers capable of meeting the needs of the invention, they can be chosen from two main and nonlimiting families: - Animal or vegetable proteins such as gelatins and marine, bovine, porcine collagens, high molecular weight vegetable proteins, for example soy, lupine.
L'agent réticulant sera pour cette famille de protéines choisies de préférence parmi les substances tannantes comme les tanins ou poly phénols de fruits tels que les oligomères procyanoliques, les flavonoides. De façon moins courante on pourra faire appel à des réticulations chimiques, tel que PPC Phenol ou enzymatique appartenant à la famille des polymérases - Les polyoses ou polysaccharides du type chondroitine sulfate d'origine bovine, porcine, marine, les gommes telle que gomme guar, l'agar agar, l'hémi cellulose, la chitine, les mannanes, poly galacturonate, le xanthane, polyose membranaire. The crosslinking agent will be for this family of proteins preferably chosen from tanning substances such as tannins or polyphenols from fruits such as procyanolic oligomers, flavonoids. Less commonly, chemical crosslinks may be used, such as PPC Phenol or enzymatic belonging to the polymerase family - Polyoses or polysaccharides of the chondroitin sulfate type from bovine, porcine, marine origin, gums such as guar gum, agar agar, hemi cellulose, chitin, mannan, poly galacturonate, xanthan, membrane polyosis.
L'agent réticulant de cette famille sera une solution saline de type NaCI ou une solution d'enzymes du type polymérase telle que par exemple la glucosyl transférase ou enzyme mano transférase correspondant au substrat. The crosslinking agent of this family will be a saline solution of the NaCl type or a solution of enzymes of the polymerase type such as for example the glucosyl transferase or enzyme mano transferase corresponding to the substrate.
Parmi les actifs susceptibles d'être incorporés dans ces polymères, ce sont tous ceux qui rencontrent des bio-disponibilités mauvaises ou insuffisantes, comme certaines vitamines, ferments, oligo-éléments mal assimilés par l'organisme comme le phosphore, le calcium, le magnésium, comme certains actifs irritants ou ulcériques comme l'aspirine. Among the active ingredients likely to be incorporated into these polymers, these are all those which encounter bad or insufficient bioavailability, such as certain vitamins, enzymes, trace elements poorly assimilated by the body such as phosphorus, calcium, magnesium. , like some irritating or ulcerative active ingredients like aspirin.
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La demanderesse s'est particulièrement préoccupée pour son invention des enzymes propices aux défenses immunitaires telles que la superoxydismutase, la catalase, peroxydase seules ou en combinaisons, le cytochrome. The Applicant is particularly concerned for its invention of enzymes conducive to immune defenses such as superoxydismutase, catalase, peroxidase alone or in combination, cytochrome.
Le procédé d'obtention de la dite compositions consiste : i) à réaliser avec le polymère un gel aqueux ii) à introduire l'actif sous agitation afin de le solubiliser ou de le mettre en suspension dans le gel iii) à disperser le gel en fines particules dans un bain contenant l'agent de réticulation, suivant le cas par l'usage d'un agitateur broyeur, par jets sous pression. iv) A séparer par filtration ou centrifugation les particules ou fils réticulés obtenus en iii), v) A les mélanger avec des produits osmoseurs comme le dextrose vi) A sécher dans une étuve ventilé réglée en température en fonction de la thermo sensibilité de l'actif
Une variante peut être utilisée dans certains cas :
On procède i) et ii) comme précédemment et ensuite : iii) à mélanger le gel dans l'osmoseur intimement. iv) A verser sur le mélange intime la substance de réticulation v) A sécher comme précédemment. The process for obtaining said compositions consists of: i) making an aqueous gel with the polymer ii) introducing the active ingredient with stirring in order to dissolve it or to suspend it in the gel iii) dispersing the gel into fine particles in a bath containing the crosslinking agent, as the case may be by the use of a milling agitator, by pressurized jets. iv) to separate by filtration or centrifugation the crosslinked particles or wires obtained in iii), v) to mix them with osmosis products such as dextrose vi) to dry in a ventilated oven regulated in temperature according to the thermosensitivity of the active
A variant can be used in certain cases:
Proceed i) and ii) as above and then: iii) mix the gel in the reverse osmosis unit. iv) Pour the cross-linking substance over the intimate mixture v) Dry as above.
Le produit finalement obtenu dans les deux variantes est une poudre. The product finally obtained in the two variants is a powder.
L'avantage de l'osmoseur consiste à bloquer l'activité de l'eau dans le gel du polymère par addition et mélange de produits dépresseurs ou osmoseurs tels que des sucres. The advantage of the reverse osmosis is to block the activity of water in the polymer gel by adding and mixing depressant or reverse osmosis products such as sugars.
On obtient ainsi le blocage de l'activité de l'eau (Aw) par addition dans le gel polymérique de produits dépresseurs ou osmoseurs en quantités comprises entre de 1,5 à 15 fois la quantité d'eau en poids contenue dans le gel polymérique réticulé. L'expérience montre que pour une Aw égale ou inférieure à 0,7 il n'y a pas d'apparition ou de développement de moisissures, de levures, de bactéries. The blocking of the water activity (Aw) is thus obtained by adding depressant or osmosis products to the polymer gel in quantities of between 1.5 and 15 times the amount of water by weight contained in the polymer gel. reticle. Experience shows that for an Aw equal to or less than 0.7 there is no appearance or development of molds, yeasts, bacteria.
Pour certaines utilisations comme en diététique la poudre obtenue peut être très facilement dispersée dans de l'eau en se délitant rapidement tout en conservant les particules actives enfermant les actifs en suspension. De même une telle suspension permet d'introduire dans des compositions cosmétiques les particules d'actifs incorporés. For certain uses such as in dietetics, the powder obtained can be very easily dispersed in water by disintegrating quickly while retaining the active particles enclosing the active agents in suspension. Likewise, such a suspension makes it possible to introduce into cosmetic compositions the particles of incorporated active agents.
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Manières de réaliser l'invention
L'invention bien que simple dans sa description sera bien comprise à l'aide des exemples qui illustrent ses multiples applications et ses avantages :
Exemple 1 Formulation nutraceutique pour un comprimé de 500 mg lOmg d'extrait sec de fruit (cucurbitacés par exemple) contenant de la SOD, dosée en activité à 20 unités/mg, de la catalase dosée à 40 unités/mg et de la peroxydase, mélangée à 30 mg de gélatine marine gélifiée au préalable par addition d'eau et en chauffant. Le gel est ensuite pulvérisé par pression au travers de buses dans un bain de tannins purifiés de raisin dilués dans de l'eau à raison de 10g/litre d'eau. On observe la réticulation qui intervient instantanément dans le bain. On recueille sur toile tamisante inox le réticulat. Ways to realize the invention
The invention, although simple in its description, will be well understood with the aid of the examples which illustrate its multiple applications and its advantages:
Example 1 Nutraceutical formulation for a 500 mg 10 mg tablet of dry fruit extract (cucurbits for example) containing SOD, dosed at activity at 20 units / mg, catalase dosed at 40 units / mg and peroxidase, mixed with 30 mg of marine gelatin gelled beforehand by adding water and heating. The gel is then sprayed by pressure through nozzles in a bath of purified grape tannins diluted in water at a rate of 10 g / liter of water. We observe the crosslinking which occurs instantly in the bath. The reticulate is collected on a stainless steel sieve canvas.
Enfin 460 mg de dextrose anhydre sont rajoutés par malaxage soit 15 fois le poids d'eau contenue dans le réticulat. On obtient une poudre fine par séchage à température ambiante, laquelle est comprimée à 500 mg/unité. Finally 460 mg of anhydrous dextrose are added by mixing, ie 15 times the weight of water contained in the reticulate. A fine powder is obtained by drying at room temperature, which is compressed to 500 mg / unit.
Exemple 2
A la place du dextrose de l'exemple 1 le dépresseur est constitué en un mélange en pourcentage de : 23% de saccharose, 16% de dextrose, 5% de sorbitol, 5% de chlorure de sodium, 1% d'acide citrique, 50% d'alcool éthylique. Example 2
In place of the dextrose of Example 1, the depressant is made up of a percentage mixture of: 23% sucrose, 16% dextrose, 5% sorbitol, 5% sodium chloride, 1% citric acid, 50% ethyl alcohol.
Dans ce cas la quantité de dépresseurs représente le dixième de la quantité d'eau du gel préparé comme dans l'exemple 1. In this case, the amount of depressants represents one tenth of the amount of water in the gel prepared as in Example 1.
Exemple 3 Essais in vivo avec la poudre obtenue dans l'exemple 1 : en l'introduisant dans la nourriture de chiens d'effort, 150mg/jour et en mesurant l'augmentation effective de l'activité SOD endogène sur les isolats érythrocytaires du sang au bout de 3 jours. On observe une meilleure récupération des animaux. Example 3 In Vivo Tests with the Powder Obtained in Example 1: By Introducing It Into Dog Food for Exercise Dogs, 150 mg / Day and Measuring the Effective Increase in Endogenous SOD Activity on Erythrocyte Isolates from the Blood after 3 days. Better recovery of the animals is observed.
Exemple 4 Complémentation alimentaire ou nutaceutique Avec une poudre telle que celle obtenue dans l'exemple 1, on complémente un yaourt à raison de 80 mg de poudre. Example 4 Food or Nutritional Supplementation With a powder such as that obtained in Example 1, a yogurt is added at the rate of 80 mg of powder.
Exemple 5 Emulsion cosmétique : On rajoute au cours de la préparation d'une crème anti-age 2% de poudre tel qu'obtenue à l'exemple 1. Example 5 Cosmetic emulsion: During the preparation of an anti-aging cream, 2% of powder is added as obtained in Example 1.
Claims (10)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0202864A FR2836827B1 (en) | 2002-03-07 | 2002-03-07 | DIETETIC AND COSMETIC COMPOSITION BASED ON RETICULATED NATURAL POLYMERS IMMOBILIZING ASSETS |
PCT/FR2003/000704 WO2003073869A1 (en) | 2002-03-07 | 2003-03-05 | Dietary and cosmetic composition based on crosslinked natural polymers immobilizing active principles |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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FR0202864A FR2836827B1 (en) | 2002-03-07 | 2002-03-07 | DIETETIC AND COSMETIC COMPOSITION BASED ON RETICULATED NATURAL POLYMERS IMMOBILIZING ASSETS |
Publications (2)
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FR2836827A1 true FR2836827A1 (en) | 2003-09-12 |
FR2836827B1 FR2836827B1 (en) | 2010-10-01 |
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FR0202864A Expired - Fee Related FR2836827B1 (en) | 2002-03-07 | 2002-03-07 | DIETETIC AND COSMETIC COMPOSITION BASED ON RETICULATED NATURAL POLYMERS IMMOBILIZING ASSETS |
Country Status (2)
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WO (1) | WO2003073869A1 (en) |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4670247A (en) * | 1983-07-05 | 1987-06-02 | Hoffman-Laroche Inc. | Process for preparing fat-soluble vitamin active beadlets |
EP0261616A2 (en) * | 1986-09-25 | 1988-03-30 | BASF Corporation | Method for rapid crosslinking of a protein |
EP0618001A1 (en) * | 1993-03-31 | 1994-10-05 | Rhone-Poulenc Nutrition Animale | Process for preparing active agents containing spherules |
EP0982038A1 (en) * | 1998-08-24 | 2000-03-01 | Basf Aktiengesellschaft | Stable powdery vitamin and carotenoide containing compositions and process to prepare them |
EP0988859A1 (en) * | 1998-09-03 | 2000-03-29 | Basf Aktiengesellschaft | Active substance preparations and a process for producing the same |
WO2002062394A2 (en) * | 2001-02-07 | 2002-08-15 | Innoform Sa | Vegetable polymer-based composition that immobilises active agents |
-
2002
- 2002-03-07 FR FR0202864A patent/FR2836827B1/en not_active Expired - Fee Related
-
2003
- 2003-03-05 WO PCT/FR2003/000704 patent/WO2003073869A1/en active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4670247A (en) * | 1983-07-05 | 1987-06-02 | Hoffman-Laroche Inc. | Process for preparing fat-soluble vitamin active beadlets |
EP0261616A2 (en) * | 1986-09-25 | 1988-03-30 | BASF Corporation | Method for rapid crosslinking of a protein |
EP0618001A1 (en) * | 1993-03-31 | 1994-10-05 | Rhone-Poulenc Nutrition Animale | Process for preparing active agents containing spherules |
EP0982038A1 (en) * | 1998-08-24 | 2000-03-01 | Basf Aktiengesellschaft | Stable powdery vitamin and carotenoide containing compositions and process to prepare them |
EP0988859A1 (en) * | 1998-09-03 | 2000-03-29 | Basf Aktiengesellschaft | Active substance preparations and a process for producing the same |
WO2002062394A2 (en) * | 2001-02-07 | 2002-08-15 | Innoform Sa | Vegetable polymer-based composition that immobilises active agents |
Also Published As
Publication number | Publication date |
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WO2003073869A1 (en) | 2003-09-12 |
FR2836827B1 (en) | 2010-10-01 |
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