FR2834210A1 - The use of an extract of Bocoa prouacensis in cosmetic composition to fight against intrinsic and/or actinic aging of the skin - Google Patents

Abstract

The cosmetic use of an extract of Bocoa prouacensis (ironwood) to ward against aging of the skin. An Independent claim is also included for a composition comprising the Bocoa prouacensis extract.

Description

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 COSMETIC COMPOSITION FOR COMBATING SKIN AGING.

 The invention relates to the field of cosmetics and aims to provide a new cosmetic composition that can fight against skin aging containing an extract, especially water soluble, Bocoa prouacensis.

 The term "cosmetic composition capable of combating cutaneous aging" means any cosmetic composition capable of preventing and / or limiting the appearance of the signs of skin aging such as fine lines, wrinkles and dry skin. It also means any cosmetic composition capable, when the skin already has signs of skin aging, to correct and / or reduce these signs of aging.

 There are two types of skin aging, intrinsic or chronological aging induced by genetically programmed processes and actinic aging related to solar exposures. This last type of aging is also called heliodermia.

 Skin aging is characterized by the thinning of skin thickness, with a loss of 6% of the thickness of the skin from birth every ten years (Robert et al., 2001, J. Med. and Chir Derm, vol 28, pages 27-35). In fact, the proliferation of keratinocytes in the epidermis slows down over time, which causes tissue thinning and an alteration of the barrier function.

 In the dermis, fibroblast metabolism also slows with age and their ability to

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 in synthesizing the extracellular matrix decreases causing atrophy of the dermis (Benoît et al., 2000, IFSCC Magazine, vol 3, pages 11-17).

 This quantitative modification is accompanied by a qualitative modification of the composition of this extracellular matrix. The amount of collagen declines with age (Shuster et al., 1975, Brit J. Dermatol., Vol.

93, pp. 639-43). Indeed, the synthesis of fibrillar collagens (type I and III in particular) decreases slightly with age but less so for type III collagen. The synthesis of elastin and fibronectin increases with age (Robert et al., 2001, J.

Med. Esth. and Chir. Derm., Vol. 28, pp. 27-35).

At the same time, the effective concentration of proteoglycans and glycosaminoglycans in the dermis decreases, this fact is particularly clear for hyaluronic acid which becomes undetectable from the age of 60 (Alirezai and Meynadier, 1997, New Dermatol., Vol 16, pages 41-47). This qualitative modification of the composition of the cutaneous extracellular matrix modifies the mechanical properties of the skin, the elasticity of which decreases and becomes less resistant to pressure. This modification is also manifested by a loss of tissue hydration.

 The qualitative change in the composition of the cutaneous extracellular matrix is aggravated and accelerated by age-related catabolic activity. Indeed, all cells of the body are able to produce proteolytic enzymes that can attack some of the constituents of the extracellular matrix such as collagen and elastin fibers. These enzymes are respectively called collagenases and elastases.

During chronological aging, an increase in the elastase activity of fibroblasts could be

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 evidence in vitro (Pelletier-Lebon et al., 1989, Cutaneous development, aging and repair, vol 18, pages 341-345, Fidia Research Series, Liviana Press). This increase appears to be an intrinsic process in the regulation of genes and their transcripts.

 The increase in the activity of these proteases causes an increase in the release of peptides that can act on the cells and modify their phenotype.

For example, the elastin receptor activated by elastin peptides increases the production of elastases by fibroblasts (Archilla-Marcos and Robert, 1993, Clin Physiol Biochem, Vol 10, pages 86-91). ).

 Actinic aging is induced by the accumulation of free radicals derived from oxygen in the skin. This excess of free radicals can no longer be neutralized by the endogenous anti-free radical defenses and leads to chemical modifications of the cellular and extracellular constituents (Benoît et al., 2000, IFSCC Magazine, vol 3, pages 11-17). During actinic aging, important enzymatic modifications condition the degradation of the extracellular matrix of the dermis. In fact, the reactions induced by the free radicals derived from oxygen degrade the collagen whose molecules are cut off and release polynuclear activating peptides, the latter accentuating the degradation of the connective tissue (Alirezai and Meynadier, 1997, Nouv Dermatol 16, pages 41-47). In addition, the elastatic activity of the skin increases as a result of UV irradiation (Labat-Robert et al., 2000, J. Photochem, Photobiol., Vol 57, pages 113-118).

 Thus, a cosmetic composition useful for combating cutaneous aging must contain

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 inhibitors of proteases and more particularly inhibitors of collagenases and elastases, and anti-radical active agents.

1
Le Bocoa prouacensis est également appelé boco ou arbre de fer . Cet arbre de la famille des Caesalpiniaceae est un arbre de forêt primaire présentant une croissance exponentielle lente, un bois d'une très grande densité (d'où son nom de bois de fer) et une longévité remarquable. La répartition géographique des populations de Bocoa prouacensis couvre le tiers nord du département de la Guyane ainsi que la région nord-est du Surinam voisin. Il s'agit d'une donc d'une espèce remarquable endémique du bouclier des Guyanes. The work of the Applicant has made it possible to demonstrate that a water-soluble extract of Bocoa prouacensis exhibited both an anticollagenase activity and an anti-radical activity which make this extract a useful component for combating cutaneous aging.

1
Bocoa prouacensis is also called boco or iron tree. This tree of the Caesalpiniaceae family is a primary forest tree with slow exponential growth, very dense wood (hence the name ironwood) and remarkable longevity. The geographical distribution of the populations of Bocoa prouacensis covers the northern third of the department of Guyana as well as the northeastern region of neighboring Surinam. It is therefore a remarkable species endemic to the Guiana Shield.

 The density, the mechanical properties and the low mineralization of the heartwood's duramen make it a valuable material in cabinet making, marquetry, violin making and jewelery. In addition, the leaves of Bocoa prouacensis are traditionally used by Samaracas for their fortifying, stimulating, defatigating or even aphrodisiac properties. The leaves come in particular in the preparation of a decoction used in bath or shower by Samaracas.

 The cosmetic composition that is the subject of the present invention contains an extract of Bocoa prouacensis.

 Advantageously, this extract is an extract derived from leaves of Bocoa prouacensis. Preferably, it is a water-soluble extract.

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- matières sèches = 22 g/l, - polyphénols = 1250 mg/ml - pH = 5, 9. The water-soluble and more particularly the hydroglycolic extract of Bocoa prouacensis used in the composition according to the invention has a limpid liquid appearance, a dark amber color and a strong odor. It has the following analytical characteristics:

- dry matter = 22 g / l, - polyphenols = 1250 mg / ml - pH = 5, 9.

 The cosmetic composition that is the subject of the present invention contains, on the order of 0.1 to 10% by weight and preferably from 0.5 to 5% by weight, of water-soluble extract of Bocoa prouacensis.

 The cosmetic composition that is the subject of the present invention may advantageously also contain at least one compound or plant extract capable of increasing the hydration and / or elasticity of the skin. These compounds or plant extracts are advantageously chosen from the group consisting of Pequi oil (Caryoca brasiliens or Caryoca corieaceum), a water-soluble extract of Mourera fluviatilis, a hydrosoluble extract of anthyllis (Anthyllis vulneraria), a water-soluble extract of Pinus Lambertiana, an extract of hops, shea butter.

 The fruit tree of the common name of Péqui (Caryoca brasiliens or Caryoca corieaceum) belongs to the family Caryocaceae which includes 20 species scattered in the Amazon of North and North-West Brazil. Péqui oil is obtained by cold pressing the pulp of the fruit of Pequi. The fatty acids mainly present in this oil are monounsaturated fatty acids of the oleic type. This oil, like all vegetable oils, brings softness, body and texture to cosmetic creams and lotions. In addition, it protects the skin against

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 dehydration. It is for this activity that it is preferentially used in the composition object of the present invention.

 A water-soluble extract of Mourera fluviatilis (aquatic plant growing in the tumultuous waters of the Guyanese rivers) usable in the cosmetic composition according to the invention is described in the French patent application No. 01/06328. This extract acts specifically on epidermal horny layers and exerts both a hygroscopic regulating effect, a substantive hydroregulatory effect, a dehydrating retarding effect and a hydration prolongation effect. In the context of the present invention, it makes it possible to slow the skin dehydration induced by aging.

 The hydrosoluble anthyllis extract (Anthyllis vulneraria) described in the French patent application No. 01/14057 can be used in the cosmetic composition according to the invention since this extract makes it possible to increase the synthesis of glycosaminoglycans and proteoglycans and thus stimulates the molecules responsible for moisturizing the skin.

 Pinus Lambertiana is a New Zealand pine with a trunk and leaf extract rich in cyclidol (D-pintol). It is a sugar constituting a major oligosaccharide that contributes to the survival of certain species subjected to salt stress. This sugar also has membrane stabilizing properties which give the water-soluble extract of Pinus Lambertiana moisturizing properties at the cutaneous level used in the composition according to the invention.

 The hop extract that can be used in the cosmetic composition according to the invention makes it possible to provide an unsaponifiable fraction, consisting of all the natural elements of the plant extracted after saponification. This extract is therefore rich in tocopherol,

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 phytosterols, terpene alcohols and carotenoids.

Phytosterols are precursors of vitamin D which contributes to the improvement of cell growth and differentiation. Since vitamin D is unstable and degraded by oxygen and especially by light, it is preferable to use its precursors, phytosterols. Therefore, the hop extract has the following properties: stimulation of cutaneous metabolism, acceleration of regeneration processes and fight against senescence and skin dryness. In the same way, the shea butter that is usable in the cosmetic composition according to the invention is rich in unsaponifiables and phytosterols. Therefore, it protects the skin against skin aging and has a trophic action by improving the appearance of dry and aged skin.

 The composition object of the present invention may also contain any plant extract rich in flavonoids and / or tannins. Indeed, the flavonoids interact with the collagen and elastin fibers and protect them very effectively from the proteolytic degradation present during cutaneous aging. In addition, the rich tannins of plant extracts give them stimulating, antioxidant and protective activities. An antioxidant activity is particularly useful for combating skin aging. By way of example and in a non-exhaustive manner, mention may be made, as a tannin-rich plant extract which may be used in the context of the present invention, of the glycolic extract of wild cardena (Dipsacus sylvestris Mill.). The wild carden also known as Wolf-comb M, Baignoire de Venus or or Cabaret-des-oiseaux is a biennial herbaceous plant of 60 to 150 cm found throughout Europe along roadsides and ditches.

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 The hydroglycolic extract of wild carden is obtained by digestion in the hydroglycolic mixture from the aerial part of the finely ground plant, then it is decolourised, clarified, standardized and preserved.

 The plant extracts rich in flavonoids that can be used are advantageously chosen from the group consisting of a water-soluble extract of rosemary (Rosmarinus officinalis) and a hydrosoluble extract of galangal (Alpinia officinarum).

 A water-soluble extract of rosemary (Rosmarinus officinalis) is obtained from the leaves of this common plant in the Mediterranean region. This extract contains flavonoids, ursolic acid and rosmarinic acid.

 The galangal (Alpinia officinarum) of the family Zingiberaceae is a shrub native to eastern Asia whose black and gnarled rhizome resembles that of ginger. The hydrosoluble galangal extract that may be used in the composition of the invention is a galangal rhizome extract containing flavonoids described in French Patent Application No. 01/12270. This galangal extract is rich in phytosterols and flavonoids (1.5 g / l rutin equivalent) such as galangine and kaempferol and essential oils such as borneol, cineole, caryophyllene and geraniol.

 The compositions according to the invention may also comprise one or more formulating agents or additives of known and conventional use in cosmetic and dermatological compositions, such as, by way of example and without limitation, softeners, colorants, film-forming active agents, surfactants, perfumes, preservatives, emulsifiers, oils, glycols, sebum-absorbing agents (talc), vitamins such as vitamin E, UV filters, etc.

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 to this knowledge of cosmetics, the skilled person will know which formulating agents add to the compositions of the invention and in what quantities depending on the desired properties.

 It should be noted that the addition of UV filters in the cosmetic composition according to the invention makes it possible to fight against actinic aging induced by UV. The UV filters that can be used in the cosmetic composition according to the invention can be chemical or mineral filters. Advantageously, the UV filters that can be used in the cosmetic composition according to the invention are the filters described in French Patent Application No. 00/08758.

 In addition, vitamin E, also known as tocopherol acetate, usable in the composition according to the invention prevents skin aging. Indeed, this vitamin is a natural anti-oxidant that protects the skin from the harmful effects of free radicals produced in particular by UVB rays by blocking lipid peroxidation. It also improves the skin's elasticity and the skin's ability to retain water, which leads to a reduction in wrinkles and a rough appearance.

 The compositions according to the invention may be in any form known to those skilled in the field of cosmetology and dermatology with no other pharmaceutical restriction than the application on the face and on the body. Advantageously, the compositions according to the invention are in the form of a gel, a lotion, a cream, an emulsion, a milk, a spray, etc.

 The present invention also relates to the cosmetic use of an extract of Bocoa prouacensis

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 to fight against skin aging and the use of an extract of Bocoa prouacensis for the preparation of a cosmetic or dermatological composition for the care of the skin. The anti-radical activity of the extract of Bocoa prouacensis allows its use or the use of a composition containing it to fight against actinic aging. The anticollagenase activity of Bocoa prouacensis extract allows its use or the use of a composition containing it to combat intrinsic aging.

 Other advantages and characteristics of the invention will appear on reading the following examples concerning the anti-radical and anticollagenase activity of the hydroglycolic extract of Bocoa prouacensis and some examples of formulation which are given for illustrative purposes and can not be used. interpreted as limiting the scope of the invention.

 I. Preparation and characteristics of the extract.

 The water-soluble extract of Bocoa prouacensis used in the compositions of the invention can be obtained as follows: i) Solubilization in a water / alcohol medium.

Preferably water (75%) / alcohol (25%). ii) Heat treatment for 1 to 4 hours between 40 and 80 C. iii) Separation of soluble and insoluble phases by filtration, decantation or centrifugation. iv) 0.45 μm membrane sterilizing filtration.

 The plant / extract ratio is 0.6 to 0.8 l of assets.

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 Analytical characterization: the extract comprises from 800 to 2000 μm / ml total polyphenols of which: - flavone (apigenin) 15 to 25%, and - flavonol (kaempferol) 20 to 25%.

 The bacteriological characteristics of the extract are: - Total mesophilic flora <100 germs / g - No pathological germ present.

 The extract is stored preferably at 4 ° C. It is soluble in an aqueous medium and in ethanol (60/40 ethanol / in (v / v)). It is stable at temperatures above 60 C for at least two hours and is compatible with a pH of 6 or less.

 The extract is not irritating according to the irritation tests of the skin and the eyes. It does not cause sensitivity or allergy reactions according to the Magnusson and Kligman test. It is not phototoxic and non-mutagenic according to the Ames test.

 II. Anti-radical activity of the water-soluble extract of Bocoa prouacensis.

 1. Principle of the dosage.

 DiPhenyl picrylhydrazyl hydrate (DPPH, Sigma D9132) is a free radical, absorbing in violet at 517 nm.

 An anti-radical product causes a disappearance of the purple coloring.

 2. Experimental protocol. at. Preparation of solutions.

 The DPPH solution is prepared by dissolving 4.8 mg of DPPH in 200 ml of methanol (Prolabo Rectapur 20846.292).

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 The samples to be tested are diluted to obtain a total concentration of about 50 μg / ml. The test samples are 2% Bocoa prouacensis extract, 5% Bocoa prouacensis extract and 10% Bocoa prouacensis extract.

 The control control is a sample whose anti-radical activity is known. This is helioxin diluted 1/20 in distilled water. b. Assay.

 2.5 ml of DPPH solution are added to hemolysis tubes and then: - either 200 μl of the dilute solution of the product to be tested, or 200 μl of distilled water (for the blank), or 200 μl of control witness.

 The mixtures are stirred and then waited for 20 minutes before reading the optical densities at 517 nm against the air in a spectrophotometer. c. Results.

The result is provided as a percentage of anti-radical activity according to the following formula:% activity = [(OD white-DO product) / OD white] x 100
Table 1 below presents the results obtained.

Table 1: Effect of different concentrations of extract of
Bocoa prouacensis on anti-radical activity.

<Tb>
<Tb>

<SEP> anti-radical activity
<tb> Extract <SEP> from <SEP> Bocoa <SEP> prouacensis <SEP> to <SEP> 2% <SEP> 36%
<tb> Extract <SEP> from <SEP> Bocoa <SEP> prouacensis <SEP> to <SEP> 5% <SEP> 73%
<tb> Extract <SEP> from <SEP> Bocoa <SEP> prouacensis <SEP> to <SEP> 10% <SEP> 82%
<Tb>

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The water-soluble extract of Bocoa prouacensis has an anti-radical activity and this effect is dose-dependent.

 III. Anti-collagenase activity of the water soluble extract of Bocoa prouacensis.

1. Principle of the dosage.

One collagenase unit hydrolyzed 1 pmol of FALGPA (Furylacryloyl-Leu-Gly-Pro-Ala, Sigma F 5135) per minute at 25 ° C at pH 7.5 in the presence of calcium ions. This hydrolysis reaction results in a decrease in absorbance at 324 nm.

 If a product has anticollagenase activity, the reaction on the FALGPA substrate is inhibited and the absorbance does not decrease.

 2. Experimental protocol. at. Preparation of solutions.

 The buffer solution is obtained by dissolving, in 1 l of distilled water, 8.96 g of tricine (Sigma T 7911), 23.4 g of sodium chloride (Merck 1 06404.1000) and 1.47 g of calcium chloride. (Cooper 93,042).

 The FALGPA substrate solution at 0.105 mM is obtained by mixing 5 mg of FALGPA in 100 ml of buffer solution. The resulting solution is stirred for at least 30 minutes and then aliquoted into approximately 15 ml fractions which are frozen.

 The collagenase solution (Sigma C 7657) is a solution at 5 U / ml frozen in 200 μl aliquots.

 The test samples are 2% Bocoa prouacensis extract, 5% Bocoa prouacensis extract and 10% Bocoa prouacensis extract. b. Assay.

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 The FALGPA substrate solution and the collagenase solution are thawed.

 In a quartz tank, 2 ml of FALGPA substrate solution are placed with - either 400 μl of sample to be tested, or 400 μl of distilled water (for the blank).

 The mixtures are stirred and the optical densities at 324 nm are read in a spectrophotometer.

 The addition of 20 μl of collagenase solution triggers the reaction. Optical densities should be read 10 min after this addition. c. Results.

The result is provided as a percentage of anti-collagenase activity of the samples tested according to the following formula:% activity = [(ADO white-ADO sample) / ADO white] x 100 with ADO = [OD (at t0) -DO (at tlO min)] / 10
Table 2 below presents the results obtained.

Table 2: Effect of different concentrations of extract of
Bocoa prouacensis on anti-collagenase activity.

<Tb>
<Tb>

<SEP> anti-collagenase activity
<tb> Extract <SEP> from <SEP> Bocoa <SEP> prouacensis <SEP> to <SEP> 2% <SEP> 29%
<tb> Extract <SEP> from <SEP> Bocoa <SEP> prouacensis <SEP> to <SEP> 5% <SEP> 50%
<tb> Extract <SEP> from <SEP> Bocoa <SEP> prouacensis <SEP> to <SEP> 10% <SEP> 61%
<Tb>

The water-soluble extract of Bocoa prouacensis has anti-collagenase activity and this effect is dose-dependent.

 IV. Examples of quantitative formulas for the composition of the invention

 1) Face cream.

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% GLYCERINE 4,0 AGENT SÉQUESTRANT 0,1 CONSERVATEURS 1,0 AGENTS EPAISSISSANTS 1,0 TALC 2,5 ALCOOL GRAS 1,0 EMULSIONNANT 6,5 TRIGLYCÉRIDES 1,0 ESTER D'ACIDE GRAS 5,0 SUCRES 6,0 HUILES DE SILICONE 5,5 EXTRAIT D'ALOES 1,0 FILTRES SOLAIRES UVA/UVB 5,0 EXTRAIT DE BOCOA PROUACENSIS 3,0 EXTRAIT DE MOURERA FLUVIATILIS2,0 HUILE DE PEQUI 2,0 BEURRE DE KARITÉ 2,0 EXTRAIT DE HOUBLON 1,0 EXTRAIT DE PINUS LAMBERTIANA 1,0 PARFUM 0,5 EAU PURIFIÉE q. s. p. 100 2) Gel visage.

% GLYCOL 2,0 AGENT EPAISSISSANT NEUTRALISÉ 1,0 AGENT SÉQUESTRANT 0,1 CONSERVATEURS 0,7 ALCOOL ETHYLIQUE 5,0 EXTRAIT DE BOCOA PROUACENSIS 3,0 EXTRAIT DE MOURERA FLUVIATILIS 2,0 EXTRAIT DE CARDERE 2,0 EXTRAIT DE ROMARIN 2,0

% GLYCERIN 4.0 SEQUESTING AGENT 0.1 PRESERVATIVES 1.0 THICKENING AGENTS 1.0 TALC 2.5 FATTY ALCOHOL 1.0 EMULSIFIER 6.5 TRIGLYCERIDES 1.0 ESTER FATTY ACID 5.0 SUGARS 6.0 OILS SILICONE 5.5 ALOE EXTRACT 1.0 UVA / UVB SOLAR FILTERS 5.0 BOCOA PROUACENSIS EXTRACT 3.0 MOURERA EXTRACT FLUVIATILIS2.0 PEQUI OIL 2.0 SHEA BUTTER 2.0 HOP EXTRACT 1.0 PINUS LAMBERTIANA EXTRACT 1.0 PERFUME 0.5 PURIFIED WATER qs 100 2) Face gel.

% GLYCOL 2.0 THICKENING AGENT NEUTRALIZED 1.0 SEQUESTING AGENT 0.1 PRESERVATIVES 0.7 ETHYL ALCOHOL 5.0 BOCOA PROUACENSIS EXTRACT 3.0 MOURERA EXTRACT FLUVIATILIS 2.0 CARDERE EXTRACT 2.0 ROSEMARY EXTRACT 2, 0

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% PROPYLÈNE GLYCOL 2,0 BUTYLEN GLYCOL 4,0 AGENT SEQUESTRANT 0,1 CONSERVATEUR 0,6 C. M. C 0,4 EXTRAIT DE BOCOA PROUACENSIS 4,0 EXTRAIT DE MOURERA FLUVIATILIS 2,0 EXTRAIT DE CARDERE 2,0 EXTRAIT DE PINUS LAMBERTIANA 2,0 EXTRAIT DE HOUBLON 2,0 EXTRAIT DE ROMARIN 2,0 PARFUM 0,2 SOLUBILISANT 0,8 EAU FLORALE 20,0 EAU PURIFIÉE q. s. p. 100EXTRACT OF ANTHYLIS 1.0 SOLUBILIZER 1.0 PERFUME 0.5 PURIFIED WATER qs 100 3) Face serum.

% PROPYLENE GLYCOL 2.0 BUTYLEN GLYCOL 4.0 SEQUESTRANT AGENT 0.1 PRESERVATIVE 0.6 CM C 0.4 EXTRACT OF BOCOA PROUACENSIS 4.0 EXTRACT FROM MOURERA FLUVIATILIS 2.0 CARDERE EXTRACT 2.0 PINUS LAMBERTIANA EXTRACT 2 , 0 HOPPER EXTRACT 2.0 ROSEMARY EXTRACT 2.0 PERFUME 0.2 SOLUBILIZING 0.8 FLORAL WATER 20.0 PURIFIED WATER qs 100

Claims (10)

1) Cosmetic composition containing a water-soluble extract of Bocoa prouacensis.  2) Cosmetic composition according to claim 1, characterized in that said extract is an extract from leaves of Bocoa prouacensis.  3) Cosmetic composition according to any one of claims 1 or 2, characterized in that it contains from about 0.1 to 10% by weight and preferably from 0.5 to 5% by weight of extract water soluble Bocoa prouacensis.  4) Cosmetic composition according to any one of claims 1 to 3, characterized in that it contains at least one compound or plant extract capable of increasing the hydration and / or elasticity of the skin.  5) Cosmetic composition according to any one of claims 1 to 4, characterized in that it contains at least one plant extract rich in flavonoids and / or tannins.  6) Cosmetic composition according to any one of the preceding claims, characterized in that it comprises one or more formulating agents or additives such as softeners, colorants, film-forming active agents, surfactants, perfumes, preservatives, emulsifiers , oils, glycols, sebum absorbers, vitamins and UV filters. <Desc / Clms Page number 18>  7) Cosmetic use of an extract of Bocoa prouacensis to fight against skin aging.  8) Use of an extract of Bocoa prouacensis for the preparation of a cosmetic or dermatological composition for the care of the skin.  9) Use according to one of claims 7 or 8, characterized in that said extract of Bocoa prouacensis or the composition containing it are intended to fight against actinic aging.  10) Use according to one of claims 7 or 8, characterized in that said extract of Bocoa prouacensis or the composition containing it are intended to fight against intrinsic aging.