FR2829934A1 - Use of microcapsules containing ginger oil to improve microcirculation and relieve sensations of swelling and heavy legs by constant topical delivery of the ginger oil - Google Patents

Abstract

Microcapsules containing ginger oil are used to improve microcirculation and relieve sensations of swelling and heavy legs by constant topical delivery of the ginger oil.

Description

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The Cosmetics industry has put on the market a large quantity of finished products, using all kinds of galenic forms such as, for example: O / W and W / O emulsions, milks, ointments, hair lotions, shampoos, soaps, powders, sticks and pencils, sprays, body oils.

These finished products convey and facilitate the cutaneous availability of molecules or mixtures of molecules synthesized industrially by chemical means, by biotechnology or naturally contained in plant or animal extracts.

These molecules carry the desired biological activity which is at the very base of the production and marketing of these finished products.

To deliver these molecules and these products to the cutaneous or capillary level, it is necessary to realize a topical, regular application with, in certain cases, imperatives to be respected, such as, for example, the daily repetitiveness, before or after another application of any complementary product.

To overcome this disadvantage and this constraint, it has been proposed to fix the molecules on clothing and underwear textiles by all kinds of physical or chemical processes (for example US4234627, FR 2789073, EP0436729).

With the prevention or improvement of wrinkles, improving the microcirculation and virtually eliminating the sensation of swelling and heavy leg are among the most sought after cosmetic effects.

The invention that is the subject of this patent application lies in the use of microcapsules containing ginger oil permanently attached to any commercial textile, for example, those of which stockings and tights are made.

This improves the microcirculation and virtually eliminates the sensation of swelling and heavy leg sought. These effects are powerful and long lasting, which will be illustrated later in this patent application.

In combination with ginger oil, it is possible to use other active ingredients, alone or mixed together, such as shea butter, menthol or other similar molecules such as Frescolate, vitamins such as vitamin K1 or phytomenadione.

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Ginger oil contains various compounds whose virtues explain the traditional use that is made of these rhizomes, to relieve stomach pains, haemorrhages and for their stimulating activity of the peripheral blood circulation, activity also demonstrated in analysis. cutaneous blood flow.

The Frescolae, a chemical structure very similar to that of menthol, brings a feeling of lasting freshness that contributes to the feeling of lightness.

Vitamin K1, or phytomenadione, is an essential vitamin for the synthesis of blood coagulation factors. This vitamin is normally brought to the body by green vegetables and vegetable oils. Vitamin K has clinically proven to be active in the treatment of rosacea by strengthening the wall of blood capillaries.

The combination of these three liposoluble active ingredients, in encapsulated form, makes it possible to protect the active complex until the moment of delivery, by breaking the membrane of the capsule in contact with the skin.

The other active ingredient (s) used may enhance the activity of the ginger oil itself, produce synergistic effects or stabilize the composition until the ginger oil is released. the microcapsules.

The encapsulation of ginger oil, alone or in combination with another active ingredient or with other active ingredients, can be carried out according to any conventional method or not, as for example that described in the patent application FR / 00. 06604.

Depending on the properties desired for the final product (for example: stability over time or speed of delivery of the encapsulated product), it is possible to choose or adapt the encapsulation process, to obtain microcapsules whose size varies between 2 and 100 μm.

For those skilled in the art, it is easy to determine the average amount of ginger oil, and those of other active ingredients possibly added to this ginger oil, trapped in the microcapsules, for example, from a aliquot of microcapsules that have been exploded mechanically or chemically before.

The amount of ginger oil in the microcapsule suspension is 65% (w / w).

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 To illustrate this discovery, the following example will describe the improvement of the microcirculation and the virtual elimination of the swelling and heavy leg sensations observed during the reported study.

A sensory study was carried out on 16 female volunteers, to evaluate the effect of a 15% nylon / 85% elastane 85% veil glue, bearing microcapsules containing ginger oil.

For this test, only one leg of the pantyhose was treated by the microcapsules, the volunteer can at any time compare the sensations on his left leg and his right leg.

Volunteers (52 years on average) were selected based on the following criteria: e Frequently feel heavy legs and / or swollen ankles, e Have both leg / ankle sensations, e Not undergoing venotonic medical treatment or venoprotective, The side of the leg with the treated side is randomized (8 on the right, 8 on the left).

suivant : port du 1 er collant de J+l à J+2, port du 2ème collant de J+3 à J+5.

Two tights are given to volunteers for a 5-day trial according to the scheme

next: wearing of the first glue from D + 1 to D + 2, wearing of the second glue from D + 3 to D + 5.

Les panélistes avaient un questionnaire à 12 entrées, réponses OUI ou NON, à remplir le dernier jour de l'essai. Le OUI traduisait le sentiment d'amélioration du critère concerné alors que le NON indiquait une aggravation de ce paramètre. TO 1st day 2nd day 3rd day 4th day 3rd day Wearing tights Do you wear tights? 2 4 '"

The panelists had a 12-entry questionnaire, YES or NO, to complete the last day of the test. The OUI reflected the feeling of improvement of the criterion concerned while the NO indicated a worsening of this parameter.

Results-Criteria: Improvement The answers YES or not for each of the legs, to the 5 following questions are expressed in%, and are reported in the following table:
Percentages of YES

<Tb>
<tb> Swelling <SEP> Pain <SEP> Cramps <SEP> Heaviness
<tb> Ankles <SEP> Leg
<tb> Side <SEP> no <SEP> Treated <SEP> 37.5 <SEP> 43.8 <SEP> 31.3 <SEP> 12.5 <SEP> 37.5
<tb> Grade <SEP> Treated <SEP> 25.0 <SEP> 12.5 <SEP> 12.5 <SEP> 0.0 <SEP> 12.5
<Tb>

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<Tb>
<tb> Differential <SEP>% <SEP> -12.5 <SEP> -31.3 <SEP> -18.8 <SEP> -12.5 <SEP> -25.0
<Tb>
On the 5 criteria, there is a clear difference in favor of YES responses, so going in the direction of improvement, between the leg wearing the treated veil relative to the leg wearing the untreated veil.

The results are to the detriment of the untreated side and all the criteria vary in the same direction indicating a coherence of sensations felt.

The difference between the 2 legs is much more important in the swelling of the ankle and leg, feelings of heaviness, cramps and pain, which are felt much more strongly for the leg with untreated veil The percentages show a differential from -12% to -31%.

Pourcentages de OUI

Results-Criteria: Positive Sensation The answers by YES or NO to the 7 criteria of positive sensations resulting in a satisfaction expressed globally, are reported in the following table (A Differential):

Percentages of YES

<Tb>
<tb> Freshness <SEP> Comfort <SEP> Good <SEP> Lightness <SEP> Improvement <SEP> Feeling <SEP> Satisfaction
<tb> be <SEP> J1 <SEP> to <SEP> J5 <SEP> new <SEP> overall
<tb> Treated <SEP> 50.0 <SEP> 81.3 <SEP> 81.3 <SEP> 68.8 <SEP> 50.0 <SEP> 62.5 <SEP> 81.3
<tb> No <SEP> Treated <SEP> 6.3 <SEP> 62.5 <SEP> 62.5 <SEP> 31.3 <SEP> 18.8 <SEP> 31.3 <SE> 62.5
<tb>#<SEP>%<SEP> 43.7 <SEP> 18.8 <SEP> 18.8 <SEP> 37.5 <SEP> 31.2 <SEP> 31.2 <SEP> 18.8
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On these 7 criteria, there is a clear difference in favor of YES responses, so going in the direction of improvement, between the leg wearing the treated veil relative to the leg wearing the untreated veil.

The results are in favor of the treated side and all the criteria vary in the same direction indicating a coherence of sensations felt.

The difference between the two legs on the sensations of freshness and lightness are very strongly felt with the veil treated: + 43.7% and + 37.5%.

The comfort, the well-being, stand out with + 18, 8%.

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A new sensation was reported by 62.5% of panellists, 31.2% more than for the untreated side.

Thus, the improvement observed between J1 and J5 is very in favor of the treated veil: + 31.2%.

Together, the different criteria allow panelists to post overall satisfaction at 81.3%.

The opinions expressed show a differential ranging from 18.8% to 43.7%.

In conclusion, this sensory study conducted on 16 panelists selected to complain frequently of heavy leg sensation and swollen ankles, having worn for 5 days a pantyhose whose one leg was treated with ginger oil found that all the panelists established a difference of sensation between the treated veil leg compared to the untreated side for the 12 criteria investigated.

Regarding the criteria for improving their initial state, a large majority is in favor of the treated veil since on average 12.5% of them feel a swelling of the legs on the treated side against 43.8% of the untreated side , a differential of -31.3%.

Cramps are improved by 12.5% and the feeling of heaviness of the legs is decreased by 25.0%.

As regards the criteria of positive sensations, the treated veil brings + 43,7% of freshness, + 37,5% of lightness, the comfort and the well-being are increased by + 18, 8%.

In addition, 62.5% of the panelists perceive a new sensation that accompanies an improvement in the feeling of J1 to J5.

The overall results show a very broad consensus on the superiority of the veil treated with ginger oil with overall satisfaction expressed by 81.3% of panelists.

Slightly higher results were obtained when in Ginger Oil, other products were added, such as shea butter, menthol or other similar molecules such as Frescolate, vitamins such as

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 vitamin KI or phytomenadione, these products being added alone or mixed together, with ginger oil.

This patent application therefore describes the use of ginger oil incorporated into microcapsules, fixed by any means whatsoever, on any textile used for the manufacture of clothing and undergarments, in particular on stockings or on tights in order to obtain a significant improvement of the microcirculation and the virtual elimination of swelling and heavy leg sensations.

The microcapsules range in size from 2 to 100 μm and the amount of ginger oil in the microsphere solution varies between 35 and 65% (w / w).

Ginger oil is, or is not, associated or related to or mixed with any other molecule (s) or product (s), alone or in combination with each other, in the microcapsules, such as, for example, example, shea butter, menthol or other similar molecules such as Frescolat, vitamins such as vitamin K1 or phytomenadione.

The microcapsules containing the ginger oil, alone or associated, or bound, or mixed with any other molecule or product, are used or not with other active or molecules or products fixed or deposited in any way on the fabric used.

Claims (7)

 1. Use of ginger oil in microcapsules to achieve a significant improvement in microcirculation and the near elimination of swelling and heavy leg sensations over time by the constant topical delivery of ginger oil. 2. Microcapsules according to claim 1, characterized in that their size may vary between 2 and 100 μm. 3. Microcapsules according to any one of claims 1 to 2 characterized in that the amount of ginger oil in the microcapsule solution varies between 35 and 65%. 4. Microcapsules according to one of claims 1 or 3 characterized in that they contain other molecules associated or related to ginger oil, in particular, shea butter, menthol or other similar molecules such as Frescolat, vitamins like vitamin Kl or phytomenadione. 5. Use of microcapsules according to one of claims 1 to 4 by fixing, by any means whatsoever, these microcapsules on any textile used for the manufacture of clothing or undergarments. 6. Use of microcapsules according to claim 5, characterized in that the clothes or undergarments are stockings or tights. 7. Use of the microcapsules according to one of claims 1 to 4, with other active agents or molecules or products fixed or deposited in any manner whatsoever on the fabric used according to one of claims 5 to 6.