FR2818138A1 - COMPOSITION, ESPECIALLY COSMETIC, CONTAINING 7-HYDROXY DHEA AND / OR 7-CETO DHEA AND AT LEAST ONE DEPIGMENTING AGENT - Google Patents
COMPOSITION, ESPECIALLY COSMETIC, CONTAINING 7-HYDROXY DHEA AND / OR 7-CETO DHEA AND AT LEAST ONE DEPIGMENTING AGENT Download PDFInfo
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- FR2818138A1 FR2818138A1 FR0016443A FR0016443A FR2818138A1 FR 2818138 A1 FR2818138 A1 FR 2818138A1 FR 0016443 A FR0016443 A FR 0016443A FR 0016443 A FR0016443 A FR 0016443A FR 2818138 A1 FR2818138 A1 FR 2818138A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/415—Aminophenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Abstract
Description
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La présente invention se rapporte à une composition renfermant la 7-hydroxy DHEA et/ou la 7-céto DHEA et au moins un agent dépigmentant, ainsi qu'à l'utilisation de ladite composition, notamment pour prévenir ou traiter les signes du vieillissement cutané actinique. The present invention relates to a composition containing 7-hydroxy DHEA and / or 7-keto DHEA and at least one depigmenting agent, as well as to the use of said composition, in particular for preventing or treating the signs of skin aging actinic.
La DHEA, ou déhydroépiandrostérone, est un stéroïde naturel produit essentiellement par les glandes corticosurrénales. La DHEA exogène, administrée par voie topique ou orale, est connue pour sa capacité à promouvoir la kératinisation de l'épiderme (JP-07 196 467) et à traiter les peaux sèches en augmentant la production endogène et la sécrétion de sébum et en renforçant ainsi l'effet barrière de la peau (US-4,496, 556). Il a également été décrit dans le brevet US-5,843, 932 l'utilisation de la DHEA pour remédier à l'atrophie du derme par inhibition de la perte de collagène et de tissu conjonctif. Enfin, la Demanderesse a mis en évidence la capacité de la DHEA à lutter contre l'aspect papyracé de la peau (FR 00/00349), à moduler la pigmentation de la peau et des cheveux (FR 99/12773) et à lutter contre l'atrophie de l'épiderme (FR 00/06154). Ces propriétés de la DHEA en font un candidat de choix comme actif anti-âge. DHEA, or dehydroepiandrosterone, is a natural steroid produced primarily by the adrenal cortex. Exogenous DHEA, administered topically or orally, is known for its ability to promote keratinization of the epidermis (JP-07 196 467) and to treat dry skin by increasing endogenous production and sebum secretion and by strengthening thus the barrier effect of the skin (US Pat. 4,496,556). It has also been described in US Pat. No. 5,843,932 the use of DHEA to remedy atrophy of the dermis by inhibiting the loss of collagen and connective tissue. Finally, the Applicant has demonstrated the ability of DHEA to fight against the papery appearance of the skin (FR 00/00349), to modulate the pigmentation of the skin and hair (FR 99/12773) and to fight against atrophy of the epidermis (FR 00/06154). These properties of DHEA make it a candidate of choice as an anti-aging active.
Parmi les métabolites de la DHEA, une attention particulière a été portée ces dernières années à ! a 7a-hydroxy DHEA.) ! a en effet été démontré que ce métabolite, qui ne possède pas l'activité hormonale de la DHEA, permettait d'augmenter la prolifération des fibroblastes et la viabilité des kératinocytes humains et présentait des effets antiradicalaires (WO 98/40074). Il a également été mis en évidence sur le rat (WO 00/28996) que la 7a-hydroxy DHEA augmentait l'épaisseur du derme et le contenu en élastine et collagène de la peau. Il a ainsi été suggéré d'utiliser ce métabolite de DHEA pour prévenir et/ou traiter les effets néfastes des UV sur la peau, lutter contre les rides et augmenter la fermeté et la tonicité de la peau. Among the metabolites of DHEA, particular attention has been paid in recent years to! a 7a-hydroxy DHEA.)! has indeed been shown that this metabolite, which does not have the hormonal activity of DHEA, makes it possible to increase the proliferation of fibroblasts and the viability of human keratinocytes and has anti-free radical effects (WO 98/40074). It has also been demonstrated in rats (WO 00/28996) that 7a-hydroxy DHEA increases the thickness of the dermis and the elastin and collagen content of the skin. It has thus been suggested to use this metabolite of DHEA to prevent and / or treat the harmful effects of UV on the skin, fight against wrinkles and increase the firmness and tone of the skin.
La 7a-hydroxy DHEA est, avec le 5-androstène 3ss, 17ss-diol, un métabolite majeur de la DHEA, obtenu par action de la 7a-hydroxylase sur la DHEA. Parmi les métabolites mineurs de la DHEA, on peut citer la 7p-hydroxy DHEA, obtenue par action de la 7p- hydroxylase sur la DHEA et la 7-céto DHEA, qui est elle-même un métabolite de la 7ss- hydroxy DHEA. 7a-hydroxy DHEA is, with 5-androstene 3ss, 17ss-diol, a major metabolite of DHEA, obtained by the action of 7a-hydroxylase on DHEA. Among the minor metabolites of DHEA, mention may be made of 7p-hydroxy DHEA, obtained by the action of 7p-hydroxylase on DHEA and 7-keto DHEA, which is itself a metabolite of 7ss-hydroxy DHEA.
Dans la suite de cette description, l'expression"7-hydroxy DHEA"sera utilisée pour désigner indifféremment la 7a-hydroxy DHEA et la 7p-hydroxy DHEA. In the remainder of this description, the expression "7-hydroxy DHEA" will be used to denote either 7a-hydroxy DHEA and 7p-hydroxy DHEA.
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Il est maintenant apparu à la Demanderesse que l'association de la 7-hydroxy DHEA et/ou de la 7-céto DHEA avec un agent dépigmentant permettait de prévenir ou traiter plus efficacement les signes de vieillissement cutané, en particulier du vieillissement actinique ou photovieillissement. It has now appeared to the Applicant that the combination of 7-hydroxy DHEA and / or 7-keto DHEA with a depigmenting agent makes it possible to more effectively prevent or treat the signs of skin aging, in particular of actinic aging or photoaging. .
La présente invention a donc pour objet une composition renfermant, dans un milieu physiologiquement acceptable : (a) au moins un dérivé de DHEA choisi parmi la 7hydroxy DHEA et la 7-céto DHEA, et (b) au moins un agent dépigmentant. The present invention therefore relates to a composition containing, in a physiologically acceptable medium: (a) at least one DHEA derivative chosen from 7hydroxy DHEA and 7-keto DHEA, and (b) at least one depigmenting agent.
La 7-hydroxy DHEA est de préférence la 7a-OH DHEA. Un procédé de préparation de ce composé est notamment décrit dans les demandes de brevet FR-2 771 105 et WO 94/08588. Toutefois, la 70-OH DHEA convient également à une utilisation dans la présente invention. 7-hydroxy DHEA is preferably 7a-OH DHEA. A process for the preparation of this compound is described in particular in patent applications FR-2 771 105 and WO 94/08588. However, 70-OH DHEA is also suitable for use in the present invention.
La concentration en dérivé de DHEA dans la composition selon l'invention est avantageusement comprise entre 0, 0001% et 10% en poids, de préférence entre 0, 001% et 5% en poids, par rapport au poids total de la composition. The concentration of DHEA derivative in the composition according to the invention is advantageously between 0.001% and 10% by weight, preferably between 0.001% and 5% by weight, relative to the total weight of the composition.
La composition selon la présente invention renferme, en association avec le dérivé de DHEA, au moins un agent dépigmentant. The composition according to the present invention contains, in association with the DHEA derivative, at least one depigmenting agent.
Les agents dépigmentants utilisables selon la présente invention sont des composés qui agissent directement sur la vitalité des mélanocytes épidermiques où se déroule la mélanogénèse et/ou interfèrent avec une des étapes de la biosynthèse de la mélanine soit en inhibant une des enzymes impliquées dans la mélanogénèse, soit en s'intercalant comme analogue structural d'un des composés chimiques de la chaîne de synthèse de la mélanine, chaîne qui peut alors être bloquée et ainsi assurer la dépigmentation. The depigmenting agents which can be used according to the present invention are compounds which act directly on the vitality of the epidermal melanocytes where melanogenesis takes place and / or interfere with one of the stages of melanin biosynthesis either by inhibiting one of the enzymes involved in melanogenesis, either by intercalating as a structural analogue of one of the chemical compounds in the melanin synthesis chain, a chain which can then be blocked and thus ensure depigmentation.
L'agent dépigmentant selon l'invention est avantageusement choisi parmi : la DHEA ;
l'acide kojique ; l'acide ellagique ; l'arbutine et ses dérivés tels que ceux décrits dans les demandes EP-895 779 et EP-524 109 ; l'hydroquinone ; les dérivés d'aminophénol tels que ceux décrits dans les demandes WO 99/10318 et WO 99/32077, et en particulier le N-cholestéryloxycarbonyl-para-aminophénol et le N-éthytoxycarbonyt- para-aminophénol ; les dérivés d'iminophénol, en particulier ceux décrits dans la demande WO 99/22707 ; l'acide L-2-oxothiazolidine-4-carboxylique ou procystéine, ainsi que ses sels et esters ; l'acide ascorbique et ses dérivés, notamment le glucoside The depigmenting agent according to the invention is advantageously chosen from: DHEA;
kojic acid; ellagic acid; arbutin and its derivatives such as those described in applications EP-895,779 and EP-524,109; hydroquinone; aminophenol derivatives such as those described in applications WO 99/10318 and WO 99/32077, and in particular N-cholesteryloxycarbonyl-para-aminophenol and N-ethytoxycarbonyt- para-aminophenol; iminophenol derivatives, in particular those described in application WO 99/22707; L-2-oxothiazolidine-4-carboxylic acid or procysteine, as well as its salts and esters; ascorbic acid and its derivatives, in particular the glucoside
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d'ascorbyle ; et les extraits de plantes, en particulier de réglisse, de mûrier et de scutellaire ; et leurs mélanges, sans que cette liste ne soit limitative. ascorbyle; and plant extracts, in particular licorice, mulberry and skullcap; and their mixtures, without this list being exhaustive.
L'agent dépigmentant représente de préférence de 0. 01% à 5 % et, mieux, de 0.1 % à 1 % en poids, par rapport au poids total de la composition. The depigmenting agent preferably represents from 0.01% to 5% and, better still, from 0.1% to 1% by weight, relative to the total weight of the composition.
La composition selon l'invention est de préférence adaptée à une application topique sur la peau. Elle peut se présenter sous toutes les formes galéniques normalement utilisées pour ce type d'application, notamment sous forme d'une solution aqueuse ou huileuse, d'une émulsion huile-dans-eau ou eau-dans-huile ou multiple, d'une émulsion siliconée, d'une microémulsion ou nanoémulsion, d'un gel aqueux ou huileux ou d'un produit anhydre liquide, pâteux ou solide. The composition according to the invention is preferably suitable for topical application to the skin. It can be in all dosage forms normally used for this type of application, in particular in the form of an aqueous or oily solution, an oil-in-water or water-in-oil or multiple emulsion, a silicone emulsion, a microemulsion or nanoemulsion, an aqueous or oily gel or a liquid, pasty or solid anhydrous product.
Cette composition peut être plus ou moins fluide et avoir l'aspect d'une crème blanche ou colorée, d'une pommade, d'un lait, d'une lotion, d'un sérum, d'une pâte, d'une mousse ou d'un gel. Elle peut éventuellement être appliquée sur la peau sous forme d'aérosol. Elle peut également se présenter sous forme solide, et par exemple sous forme de stick. Elle peut être utilisée comme produit de soin et/ou comme produit de maquillage de la peau. This composition can be more or less fluid and have the appearance of a white or colored cream, an ointment, a milk, a lotion, a serum, a paste, a foam. or a gel. It can optionally be applied to the skin in the form of an aerosol. It can also be in solid form, and for example in the form of a stick. It can be used as a care product and / or as a skin makeup product.
De façon connue, la composition de l'invention peut contenir également les adjuvants habituels dans les domaines cosmétique et dermatologique, tels que les gélifiants hydrophiles ou lipophiles, les actifs hydrophiles ou lipophiles, les conservateurs, les
antioxydants, les solvants, les parfums, les charges, les filtres, les pigments, les absorbeurs d'odeur et les matières colorantes. Les quantités de ces différents adjuvants sont celles classiquement utilisées dans les domaines considérés, et par exemple de 0,01 à 20 % du poids total de la composition. Ces adjuvants, selon leur nature, peuvent être introduits dans la phase grasse ou dans la phase aqueuse. Ces adjuvants, ainsi que leurs concentrations, doivent être tels qu'ils ne nuisent pas aux propriétés avantageuses des dérivés de DHEA, ni des agent dépigmentants selon l'invention. In a known manner, the composition of the invention may also contain the adjuvants customary in the cosmetic and dermatological fields, such as hydrophilic or lipophilic gelling agents, hydrophilic or lipophilic active agents, preservatives,
antioxidants, solvents, perfumes, fillers, filters, pigments, odor absorbers and coloring materials. The amounts of these various adjuvants are those conventionally used in the fields under consideration, and for example from 0.01 to 20% of the total weight of the composition. These adjuvants, depending on their nature, can be introduced into the fatty phase or into the aqueous phase. These adjuvants, as well as their concentrations, must be such that they do not harm the advantageous properties of the DHEA derivatives, nor of the depigmenting agents according to the invention.
Lorsque la composition selon l'invention est une émulsion, la proportion de la phase grasse peut aller de 5 à 80 % en poids, et de préférence de 5 à 50 % en poids par rapport au poids total de la composition. Les matières grasses, les émulsionnants et les coémulsionnants utilisés dans la composition sous forme d'émulsion sont choisis parmi ceux classiquement utilisés dans le domaine considéré. L'émulsionnant et le When the composition according to the invention is an emulsion, the proportion of the fatty phase can range from 5 to 80% by weight, and preferably from 5 to 50% by weight relative to the total weight of the composition. The fats, emulsifiers and coemulsifiers used in the composition in the form of an emulsion are chosen from those conventionally used in the field under consideration. The emulsifier and
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coémulsionnant sont de préférence présents, dans la composition, en une proportion allant de 0, 3 à 30 % en poids, et de préférence de 0, 5 à 20 % en poids par rapport au poids total de la composition. coemulsifiers are preferably present in the composition in a proportion ranging from 0.3 to 30% by weight, and preferably from 0.5 to 20% by weight relative to the total weight of the composition.
Comme matières grasses utilisables dans invention, on peut utiliser les huiles et notamment les huiles minérales (huile de vaseline), les huiles d'origine végétale (huile d'avocat, huile de soja), les huiles d'origine animale (lanoline), les huiles de synthèse (perhydrosqualène), les huiles siliconées (cyclométhicone) et les huiles fluorées (perfluoropolyéthers). On peut aussi utiliser comme matières grasses des alcools gras tels que l'alcool cétylique, des acides gras, des cires et des gommes et en particulier les gommes de silicone. As fats which can be used in the invention, oils and in particular mineral oils (petroleum jelly oil), oils of vegetable origin (avocado oil, soybean oil), oils of animal origin (lanolin) can be used, synthetic oils (perhydrosqualene), silicone oils (cyclomethicone) and fluorinated oils (perfluoropolyethers). Fatty alcohols such as cetyl alcohol, fatty acids, waxes and gums and in particular silicone gums can also be used as fats.
Comme émulsionnants et coémulsionnants utilisables dans l'invention, on peut citer par exemple les esters d'acide gras et de polyéthylène glycol tels que le stéarate de PEG-100, le stéarate de PEG-50 et le stéarate de PEG-40 ; les esters d'acide gras et de polyol tels que le stéarate de glycéryle, le tristéarate de sorbitane et les stéarates de sorbitane oxyéthylénés disponibles sous les dénominations commerciales Tween ! 20 ou Tween'60, par exemple ; et leurs mélanges. As emulsifiers and coemulsifiers which can be used in the invention, mention may, for example, be made of fatty acid and polyethylene glycol esters such as PEG-100 stearate, PEG-50 stearate and PEG-40 stearate; fatty acid and polyol esters such as glyceryl stearate, sorbitan tristearate and oxyethylenated sorbitan stearates available under the trade names Tween! 20 or Tween'60, for example; and their mixtures.
Comme gélifiants hydrophiles, on peut citer en particulier les polymères carboxyvinyliques (carbomer), les copolymères acryliques tels que les copolymères d'acrylates/alkylacrylates, les polyacrylamides, les polysaccharides, les gommes naturelles et les argiles, et, comme gélifiants lipophiles, on peut citer les argiles modifiées comme les bentones, les sels métalliques d'acides gras et la silice hydrophobe. As hydrophilic gelling agents, mention may in particular be made of carboxyvinyl polymers (carbomers), acrylic copolymers such as acrylate / alkyl acrylate copolymers, polyacrylamides, polysaccharides, natural gums and clays, and, as lipophilic gelling agents, cite modified clays such as bentones, metal salts of fatty acids and hydrophobic silica.
La composition selon l'invention comprend une quantité efficace de dérivé de DHEA et une quantité efficace d'agent dépigmentant, suffisante pour obtenir l'effet recherché, dans un milieu physiologiquement acceptable. The composition according to the invention comprises an effective amount of DHEA derivative and an effective amount of depigmenting agent, sufficient to obtain the desired effect, in a physiologically acceptable medium.
La composition selon l'invention trouve notamment une application dans la prévention et le traitement des signes du vieillissement cutané, en particulier du vieillissement actinique. The composition according to the invention finds in particular an application in the prevention and the treatment of the signs of skin aging, in particular of actinic aging.
La présente invention concerne donc également l'utilisation cosmétique de la composition mentionnée ci-dessus pour prévenir ou traiter les signes du vieillissement cutané, en particulier du vieillissement actinique. The present invention therefore also relates to the cosmetic use of the composition mentioned above for preventing or treating the signs of skin aging, in particular of actinic aging.
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L'invention sera maintenant illustrée par l'exemple non limitatif suivant. Dans cet exemple, les quantités sont indiquées en pourcentage pondéral.
The invention will now be illustrated by the following nonlimiting example. In this example, the quantities are indicated in percentage by weight.
Exemple 1 : Lotion dépigmentante
Acide kojique 1, 00 % 7a-OH DHEA 0, 10 % Acide capryloyl salicylique 2, 00 % Ethanol 48, 00 % Eau 9, 30 % Polyéthylène glycol (PEG-8) 39, 50 % Conservateur 0, 10 % Exemple 2 : Gel dépigmentant Acide kojique 2, 00 % 7a-OH DHEA 1, 00 % Acide capryloyl salicylique 2, 00 % Ethanol 45, 50 % Eau 8, 00 % Polyéthylène glycol (PEG-8) 36, 40 % Conservateur 0, 10 % Gélifiant (Polyacrylamide + isoparaffine en C13-C14 + laureth-7) 5, 00 %EXAMPLE 1 Depigmenting Lotion
Kojic acid 1, 00% 7a-OH DHEA 0, 10% Capryloyl salicylic acid 2, 00% Ethanol 48, 00% Water 9, 30% Polyethylene glycol (PEG-8) 39, 50% Preservative 0, 10% Example 2: Depigmenting gel Kojic acid 2.00% 7a-OH DHEA 1.00% Capryloyl salicylic acid 2.00% Ethanol 45.50% Water 8.00% Polyethylene glycol (PEG-8) 36.40% Preservative 0.10% Gelling agent (Polyacrylamide + C13-C14 isoparaffin + laureth-7) 5.00%
Claims (13)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0016443A FR2818138B1 (en) | 2000-12-15 | 2000-12-15 | COMPOSITION, ESPECIALLY COSMETIC, CONTAINING 7-HYDROXY DHEA AND / OR 7-CETO DHEA AND AT LEAST ONE DEPIGMENTING AGENT |
| AU2002221995A AU2002221995A1 (en) | 2000-12-15 | 2001-11-20 | Composition containing 7-hydroxy dhea and/or 7-keto dhea and at least a depigmentation composition |
| PCT/FR2001/003633 WO2002047647A1 (en) | 2000-12-15 | 2001-11-20 | Composition containing 7-hydroxy dhea and/or 7-keto dhea and at least a depigmentation composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0016443A FR2818138B1 (en) | 2000-12-15 | 2000-12-15 | COMPOSITION, ESPECIALLY COSMETIC, CONTAINING 7-HYDROXY DHEA AND / OR 7-CETO DHEA AND AT LEAST ONE DEPIGMENTING AGENT |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2818138A1 true FR2818138A1 (en) | 2002-06-21 |
| FR2818138B1 FR2818138B1 (en) | 2003-02-14 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR0016443A Expired - Fee Related FR2818138B1 (en) | 2000-12-15 | 2000-12-15 | COMPOSITION, ESPECIALLY COSMETIC, CONTAINING 7-HYDROXY DHEA AND / OR 7-CETO DHEA AND AT LEAST ONE DEPIGMENTING AGENT |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU2002221995A1 (en) |
| FR (1) | FR2818138B1 (en) |
| WO (1) | WO2002047647A1 (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0723775A1 (en) * | 1995-01-26 | 1996-07-31 | L'oreal | Use of dehydroepi-androsterone in cosmetic or dermatologic composition |
| WO1997003676A1 (en) * | 1995-07-21 | 1997-02-06 | Cabo Soler Jose | Novel pharmaceutical formulation of dehydroepiandrosterone for percutaneous topical application |
| FR2771105A1 (en) * | 1997-11-20 | 1999-05-21 | Vitasterol | 7 alpha-hydroxylation of dehydroepiandrosterone and pregnelone by bioconversion using Fusarium moniliforme |
-
2000
- 2000-12-15 FR FR0016443A patent/FR2818138B1/en not_active Expired - Fee Related
-
2001
- 2001-11-20 WO PCT/FR2001/003633 patent/WO2002047647A1/en not_active Application Discontinuation
- 2001-11-20 AU AU2002221995A patent/AU2002221995A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0723775A1 (en) * | 1995-01-26 | 1996-07-31 | L'oreal | Use of dehydroepi-androsterone in cosmetic or dermatologic composition |
| WO1997003676A1 (en) * | 1995-07-21 | 1997-02-06 | Cabo Soler Jose | Novel pharmaceutical formulation of dehydroepiandrosterone for percutaneous topical application |
| FR2771105A1 (en) * | 1997-11-20 | 1999-05-21 | Vitasterol | 7 alpha-hydroxylation of dehydroepiandrosterone and pregnelone by bioconversion using Fusarium moniliforme |
Non-Patent Citations (1)
| Title |
|---|
| DATABASE WPI Derwent World Patents Index; AN 1997-145203 * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002221995A1 (en) | 2002-06-24 |
| WO2002047647A1 (en) | 2002-06-20 |
| FR2818138B1 (en) | 2003-02-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |
Effective date: 20070831 |