FR2808194B1 - USE OF HYDROPHILIC PARTICLES WITH OR WITHOUT ION LIGANDS FOR IMPROVING THE IMMUNOMODULATOR PROPERTIES OF A SUBSTANCE OTHER THAN AN ANTIGEN, AND THE PHARMACEUTICAL COMPOSITIONS THUS OBTAINED - Google Patents

USE OF HYDROPHILIC PARTICLES WITH OR WITHOUT ION LIGANDS FOR IMPROVING THE IMMUNOMODULATOR PROPERTIES OF A SUBSTANCE OTHER THAN AN ANTIGEN, AND THE PHARMACEUTICAL COMPOSITIONS THUS OBTAINED

Info

Publication number
FR2808194B1
FR2808194B1 FR0005304A FR0005304A FR2808194B1 FR 2808194 B1 FR2808194 B1 FR 2808194B1 FR 0005304 A FR0005304 A FR 0005304A FR 0005304 A FR0005304 A FR 0005304A FR 2808194 B1 FR2808194 B1 FR 2808194B1
Authority
FR
France
Prior art keywords
antigen
substance
improving
pharmaceutical compositions
hydrophilic particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0005304A
Other languages
French (fr)
Other versions
FR2808194A1 (en
Inventor
Roger Kravtzoff
Didier Betbeder
Michel Major
Olivier Balland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biovector Therapeutics SA
Original Assignee
Biovector Therapeutics SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0005304A priority Critical patent/FR2808194B1/en
Application filed by Biovector Therapeutics SA filed Critical Biovector Therapeutics SA
Priority to EP01931773A priority patent/EP1276468A1/en
Priority to AU2001258476A priority patent/AU2001258476A1/en
Priority to CA002406949A priority patent/CA2406949A1/en
Priority to JP2001577935A priority patent/JP2004508290A/en
Priority to PCT/FR2001/001289 priority patent/WO2001080836A1/en
Publication of FR2808194A1 publication Critical patent/FR2808194A1/en
Priority to US10/281,371 priority patent/US20040081686A1/en
Application granted granted Critical
Publication of FR2808194B1 publication Critical patent/FR2808194B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
FR0005304A 2000-04-26 2000-04-26 USE OF HYDROPHILIC PARTICLES WITH OR WITHOUT ION LIGANDS FOR IMPROVING THE IMMUNOMODULATOR PROPERTIES OF A SUBSTANCE OTHER THAN AN ANTIGEN, AND THE PHARMACEUTICAL COMPOSITIONS THUS OBTAINED Expired - Fee Related FR2808194B1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
FR0005304A FR2808194B1 (en) 2000-04-26 2000-04-26 USE OF HYDROPHILIC PARTICLES WITH OR WITHOUT ION LIGANDS FOR IMPROVING THE IMMUNOMODULATOR PROPERTIES OF A SUBSTANCE OTHER THAN AN ANTIGEN, AND THE PHARMACEUTICAL COMPOSITIONS THUS OBTAINED
AU2001258476A AU2001258476A1 (en) 2000-04-26 2001-04-26 Use of particulate vectors in immunomodulation
CA002406949A CA2406949A1 (en) 2000-04-26 2001-04-26 Use of particulate vectors in immunomodulation
JP2001577935A JP2004508290A (en) 2000-04-26 2001-04-26 Use of granular vectors in immunomodulation
EP01931773A EP1276468A1 (en) 2000-04-26 2001-04-26 Use of particulate vectors in immunomodulation
PCT/FR2001/001289 WO2001080836A1 (en) 2000-04-26 2001-04-26 Use of particulate vectors in immunomodulation
US10/281,371 US20040081686A1 (en) 2000-04-26 2002-10-25 Use of particle vectors in immunomodulation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0005304A FR2808194B1 (en) 2000-04-26 2000-04-26 USE OF HYDROPHILIC PARTICLES WITH OR WITHOUT ION LIGANDS FOR IMPROVING THE IMMUNOMODULATOR PROPERTIES OF A SUBSTANCE OTHER THAN AN ANTIGEN, AND THE PHARMACEUTICAL COMPOSITIONS THUS OBTAINED

Publications (2)

Publication Number Publication Date
FR2808194A1 FR2808194A1 (en) 2001-11-02
FR2808194B1 true FR2808194B1 (en) 2004-05-07

Family

ID=8849602

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0005304A Expired - Fee Related FR2808194B1 (en) 2000-04-26 2000-04-26 USE OF HYDROPHILIC PARTICLES WITH OR WITHOUT ION LIGANDS FOR IMPROVING THE IMMUNOMODULATOR PROPERTIES OF A SUBSTANCE OTHER THAN AN ANTIGEN, AND THE PHARMACEUTICAL COMPOSITIONS THUS OBTAINED

Country Status (1)

Country Link
FR (1) FR2808194B1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2704145B1 (en) * 1993-04-21 1995-07-21 Pasteur Institut Particulate vector and pharmaceutical composition containing it.
JP2002509116A (en) * 1998-01-16 2002-03-26 ザ・ジョーンズ・ホプキンス・ユニバーシティ Genetic immunity by simultaneous transport of nucleic acids and cytokines in a single solvent

Also Published As

Publication number Publication date
FR2808194A1 (en) 2001-11-02

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ST Notification of lapse

Effective date: 20101230