FR2798604B1 - Dispositif pour la realisation de reactions chimiques ou biochimiques par cyclage thermique - Google Patents

Dispositif pour la realisation de reactions chimiques ou biochimiques par cyclage thermique

Info

Publication number
FR2798604B1
FR2798604B1 FR9911652A FR9911652A FR2798604B1 FR 2798604 B1 FR2798604 B1 FR 2798604B1 FR 9911652 A FR9911652 A FR 9911652A FR 9911652 A FR9911652 A FR 9911652A FR 2798604 B1 FR2798604 B1 FR 2798604B1
Authority
FR
France
Prior art keywords
thermal cycling
biochemical reactions
performing chemical
chemical
biochemical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9911652A
Other languages
English (en)
Other versions
FR2798604A1 (fr
Inventor
Yves Fouillet
Claude Vauchier
Jean Frederic Clerc
Christine Peponnet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Biodevelopment SAS
Original Assignee
Genset SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9911652A priority Critical patent/FR2798604B1/fr
Application filed by Genset SA filed Critical Genset SA
Priority to EP00949852A priority patent/EP1203096B1/fr
Priority to AT00949852T priority patent/ATE419384T1/de
Priority to AU63109/00A priority patent/AU782726B2/en
Priority to CA002379927A priority patent/CA2379927A1/fr
Priority to DE60041264T priority patent/DE60041264D1/de
Priority to PCT/IB2000/001137 priority patent/WO2001007159A2/fr
Priority to US09/627,647 priority patent/US7015030B1/en
Priority to JP2001512031A priority patent/JP2003505059A/ja
Priority to US09/772,280 priority patent/US6977145B2/en
Publication of FR2798604A1 publication Critical patent/FR2798604A1/fr
Application granted granted Critical
Publication of FR2798604B1 publication Critical patent/FR2798604B1/fr
Priority to US11/197,040 priority patent/US20050282224A1/en
Priority to US11/196,989 priority patent/US20060011478A1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0418—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electro-osmotic flow [EOF]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
FR9911652A 1999-07-28 1999-09-17 Dispositif pour la realisation de reactions chimiques ou biochimiques par cyclage thermique Expired - Fee Related FR2798604B1 (fr)

Priority Applications (12)

Application Number Priority Date Filing Date Title
FR9911652A FR2798604B1 (fr) 1999-09-17 1999-09-17 Dispositif pour la realisation de reactions chimiques ou biochimiques par cyclage thermique
JP2001512031A JP2003505059A (ja) 1999-07-28 2000-07-28 連続流マイクロ流体デバイスにおける生化学的プロトコルの集積化
AU63109/00A AU782726B2 (en) 1999-07-28 2000-07-28 Integration of biochemical protocols in a continuous flow microfluidic device
CA002379927A CA2379927A1 (fr) 1999-07-28 2000-07-28 Integration de protocoles biochimiques dans un dispositif microfluidique a ecoulement continu
DE60041264T DE60041264D1 (de) 1999-07-28 2000-07-28 Durchfluss-Mikroreaktor in dem lokale Temperaturzyklen auf eine fliessende Probe einwirken
PCT/IB2000/001137 WO2001007159A2 (fr) 1999-07-28 2000-07-28 Integration de protocoles biochimiques dans un dispositif microfluidique a ecoulement continu
EP00949852A EP1203096B1 (fr) 1999-07-28 2000-07-28 Dispositif microfluidique dans lequel un changement de température locale agit sur un echantillon en flux continu
AT00949852T ATE419384T1 (de) 1999-07-28 2000-07-28 Durchfluss-mikroreaktor in dem lokale temperaturzyklen auf eine fliessende probe einwirken
US09/627,647 US7015030B1 (en) 1999-07-28 2000-07-28 Microfluidic devices and uses thereof in biochemical processes
US09/772,280 US6977145B2 (en) 1999-07-28 2001-01-29 Method for carrying out a biochemical protocol in continuous flow in a microreactor
US11/197,040 US20050282224A1 (en) 1999-07-28 2005-08-04 Method for carrying out a biochemical protocol in continuous flow in a microreactor
US11/196,989 US20060011478A1 (en) 1999-07-28 2005-08-04 Integration of biochemical protocols in a continuous flow microfluidic device

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9911652A FR2798604B1 (fr) 1999-09-17 1999-09-17 Dispositif pour la realisation de reactions chimiques ou biochimiques par cyclage thermique

Publications (2)

Publication Number Publication Date
FR2798604A1 FR2798604A1 (fr) 2001-03-23
FR2798604B1 true FR2798604B1 (fr) 2001-12-07

Family

ID=9549969

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9911652A Expired - Fee Related FR2798604B1 (fr) 1999-07-28 1999-09-17 Dispositif pour la realisation de reactions chimiques ou biochimiques par cyclage thermique

Country Status (1)

Country Link
FR (1) FR2798604B1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2930457B1 (fr) 2008-04-24 2010-06-25 Commissariat Energie Atomique Procede de fabrication de microcanaux reconfigurables

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5637469A (en) * 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US6210882B1 (en) * 1998-01-29 2001-04-03 Mayo Foundation For Medical Education And Reseach Rapid thermocycling for sample analysis
US6896855B1 (en) * 1998-02-11 2005-05-24 Institut Fuer Physikalische Hochtechnologie E.V. Miniaturized temperature-zone flow reactor

Also Published As

Publication number Publication date
FR2798604A1 (fr) 2001-03-23

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Year of fee payment: 17

ST Notification of lapse

Effective date: 20170531