FR2770402A1 - Ultrasound-conducting gel with antimicrobial activity - Google Patents

Abstract

Ultrasound-conducting gel with antimicrobial activity comprises (by weight) 0.06-2% antiseptic, 0.33-1.33% Carbopol 940, 0.33-1.33% glycerol, 0.03-0.33% formaldehyde, 0.33-1.33% triethanolamine and a trace amount of Patent blue, the balance being water. The antiseptic is a 20% chlorohexidine solution. The composition is prepared by adding 50-200 g Carbopol 940 to 10-20 L distilled water while stirring, allowing the mixture to stand, for between 30 minutes and upto several hours, adding a few drops of Patent blue, 50-200 g glycerol and 5-50 ml formaldehyde, adding 10-250 ml of 20% chlorhexidine solution and 50-200 g triethanolamine, and sterilising the product at 50-200 deg C, preferably at 115-116 deg C for 30 minutes or at 121-123 deg C for 15 minutes.

Description

 DESCRIPTION. Previously, the ultrasound conduction gel for ultrasound, doppler, and electrocardiographic examinations should not have antiseptic properties.

.From February 6, 1996, the circular relating to article L-655-5 of the public health code notes that infectious dermatoses have been found following the use of gels conditioned in properly occluded cans.

Consequently, recommendations made by the national homologation committee were given in order to avoid these incidents:
-condition the gel in 250 ml cans and not in 5 liter cans,
- absolute necessity to put any can at the end of the day
started even if it was not fully used,
-use sterile gel in individual packaging in 5 cases
-existence of a recent operating scar
- skin wound
-operative ultrasound
-puncture and or biopsy
-endovaginal or endorectal examination.

-disinfect the ultrasound probe with a product based on
glutaraldehyde in which the probe is to be immersed.

In practice, we realize that few practitioners observe these
recommendations which are restrictive and costly.

In order to respond to the problem, a new gel was invented which
exhibits satisfactory antimicrobial preservation.

This new gel, thanks to these antimicrobial properties allows a
use of gel without change from what was done
previously; therefore:
- ease of use in all circumstances;
-Antiseptic safety to eliminate any risk
infectious dermatoses;
-conditioning possible in canisters or economy
use and uselessness of throwing away the excess gel at the end of the day;
-no need to systematically disinfect the probe;
- moreover, this gel does not alter conduction and does not damage
respondents.

'. This gel is made in the following way
For 15 liters of gel
- pour into a container between 10 and 20 free
15 liters on average in which we gradually insert
stirring with a 75 gr turbine of "carbopol 94011.

 - let stand for 30 minutes in several heltres.

-then pour traces of patent blue
(few drops).

-in the solution while operating the turbine,
75 g of glycerin and 15 ml of formalin are poured in.

- we add 40mil of an antiseptic chosen in
the biguanide amidine class: 20% chlorhexidine.

 -We finish by adding 97gr of triethanolamide.

-the solution is sterilized by autoclaving between
50 and 200 is ideally 115-1160 for 30 minutes.
or 121-1230 for 15 minutes.

During our numerous tests, the concentrations announced seem to be
the best to optimize the product: however, it should be emphasized
that all of the components can be used in quantities
variables: we can estimate that:
-the "carbopol 940" can be used for
quantities ranging from 50 to 200 gr (i.e. 0.33 to 1.33%).

-glycerin in quantities ranging from 50 to 200gr
(i.e. 0.33 to 1.33%).

-trihnolamide in amounts ranging from 50 to
200 gr (i.e. 0.33 to 1.33 Z).

- formalin in quantities ranging from 5 to 50 ml
(i.e. 3.03 to 0.33%).

-chlorhexidine: the pure weight can range from 2
at 50gr (i.e. 0.06 to 2%).

 The gel in an occluded bottle can be stored for 2 years.

 When the bottle is opened, it can be kept for 45 days.

Claims (7)

Claims. 1-Ultrasonic conduction gel with antimicrobial activity characterized in that its composition is as follows:  -antiseptic from 0.06 to 2%  - "carbopol940" from 0.33 to 1.33%  -glycerin from 0.33 to 1.33%  -phormol from 0.03 to 0.33%  -triethanolamide from 0.33 to 1.33%  - patented blue traces  -QSP 100% distilled water The percentage by weight being defined relative to the total weight of the composition. 2-conduction gel according to claim 1 characterized in that the antiseptic is chosen from the class of anidines-biguanides. 3-conduction gel according to one of claims 1 or 2 characterized in that the antiseptic is chlorhexidine. 4-Conduction gel according to one of claims 1 to 3 characterized in that its composition is as follows:  -chlorhexidine 20% = 40ml  - "carbopol 940" = 75 g  -glycerin = 75 g  -phormol = 15 ml  -triethanolamide = 97 g  - patented blue traces  -QSP distilled water. 5-A method of preparing an ultrasound conduction gel according to one of claims 1 to 4 characterized in that one pours into a container of 10 to 20 1 of distilled water in which while stirring with a turbine on pours from 50 to 200 g of "carbopol 940"; it is left to stand for 30 minutes to several hours. Then, complete with a few drops of patent blue, 50 to 200 g of glycerin and 5 to 50 ml of phormol. 10 to 250 ml of 20% chlorhexidine are then added and then 50 to 200 g of triethanolarnide. 6-A method according to claim 5 characterized in that the sterilization step is carried out between 50 and 2000 7-A method according to claim 6 characterized in that the sterilization is carried out at 115 - 116 for 30 min or 121 - 123 for 15 min 8-Use of the ultrasound conduction gel according to one of the claims I to 4 during ultrasound, electrocardiography or doppler examinations. 9-This gel can keep its antiseptic properties for 45 days in an open bottle and 2 years in a closed bottle.