FR2758462A1 - Injection or sampling syringe - Google Patents

Abstract

A medical syringe, e.g. for giving injections or taking blood samples, consists of a body (17) with a needle (11) which is covered by a sleeve (3). The body and sleeve can be moved relative to one another between one position in which the needle is retracted inside the sleeve, and another in which the needle is extended from the end for use. The syringe body is moved relative to the sleeve by a slider (31) attached to the body moving in a slot in the sleeve, while the needle is of variable wall thickness and more rigid where it joins the syringe body than at its tip.

Description

 The invention relates to a medical device comprising a hollow needle for pricking a body, through its cutaneous surface, this needle comprising a posterior end through which it is adapted to be linked to a support for the injection (or even the removal) of a substance, such as a syringe, and an anterior end through which it stings.

In this context, one aspect of the invention relates to a medical device for transcutaneous local anesthesia, this device comprising
a syringe for injecting a local anesthetic substance, the syringe comprising a body and a piston displaceable in this body,
- And a hollow needle linked to the syringe body and having a free end (hereinafter called the anterior end).

 Local anesthesia of the skin and subcutaneous tissues (hereinafter referred to as AL) is a prerequisite for the practice of numerous technical gestures in medicine, surgery, anesthesia-resuscitation, radiology, etc.

 Its realization is currently uniformly codified and frozen for many years.

This realization is simple, but typically requires to date the deconditioning of five to six components
- an anesthetic drug injected locally,
- at least one "re-sterilizable" or single-use syringe,
- and a set of three to four needles of different sizes (outside diameters).

 The invention aims, for the practice of a LA, to improve the current conditions for carrying out these LAs, and in particular the safety conditions, both for the patient to be numb and for the medical staff.

 One solution of the invention consists in proposing that the medical device presented above for currently performing a LA, further comprises a sheath having with the body of the syringe relative mobility, the sheath and the syringe body being arranged one with respect to the other so that in a (first) state of protection of the needle, the sheath contains said needle and a part of the syringe and, in a (second) state of penetration of the needle, the needle is taken out of the sheath by an opening of the latter located opposite the needle, the sheath then always containing a part of the syringe.

 Note that such a device could be used for other medical applications than a LA, for example a drug injection in the body of a patient or a sample of body fluid, the present device meeting the current demand for safety. increased.

 Although other solutions exist (sheath having, on the anterior side - needle side -, longitudinal slits defining elastic articulated lamellae deforming towards the outside, in the manner of flaps, when one presses on the end of the sheath facing the needle), the invention further provides, for a simple, reliable, effective and always favorable to the "comfort" of the patient, that the sheath and the syringe body be sliding relatively one to the other, along an axis parallel to that of the needle (mounted on the syringe).

 If such a general solution is adopted, an additional characteristic of the invention then recommends to link a part of the body of the syringe to a push-button system movable in two opposite and maneuverable directions, from outside the sheath, to induce in particular a projection of the needle out of the sheath during the operation of said pusher in one direction.

 Furthermore, it may be advisable to adapt a sheath which is non-deformable (rigid), in particular along the axis of the needle, and which is also devoid of mobile part.

 By one and / or the other of these characteristics, a solution is provided to the problem of the conditions of exit of the needle from the sheath (or even re-entry into the sheath), which conditions must advantageously be rapid, while being simple to make, reliable and safe.

 In connection with this, another characteristic of the invention moreover advises that the push-button system comprises a cursor linked to the body of the syringe through a slot in the sleeve, to define a slide directed essentially parallel to the sliding axis. relative between the sheath and the body of the syringe.

 Note also the advantage of using a sheath with an anterior end (needle side) which is tapered, favoring the conditions of engagement, or withdrawal, of the needle vis-à-vis the patient's body.

 Besides the way in which the relative mobility of the sheath relative to the body of the syringe will be ensured, another characteristic of the invention relates to the conditions for producing a hollow needle, of the type defined at the beginning of the text, which is in particular adaptable to the body of the syringe of the LA device presented above.

 Indeed, the use of current needles has in some cases disadvantages.

 For example, in the case of LAs, it has already been indicated that such interventions typically require deconditioning and the use of a set of three to four needles of different calibers.

 Thus, the thinnest and shortest needle, which is the least aggressive, is commonly used for the first puncture and the first injection, at the location of the epidermis (most superficial cutaneous plane). The following, progressively longer and of progressively larger sizes (outside diameter), serve to extend the anesthesia on the surface as well as in depth, step by step, through the cutaneous and possibly subcutaneous tissues.

 One or two larger needles, called trocars, are then used to collect the anesthetic.

 This practice can be considered to have drawbacks related to the safety of the intervention, but also to its quality (speed, number of manipulations), as well as its ease of implementation.

 Also, to resolve at least some of these difficulties, which are also found in applications other than LA (in particular maternity or radiology services), another characteristic of the invention recommends the use of '' a hollow needle which is more rigid towards its posterior end (end of connection to the injection or sampling support, such as the syringe) than towards its anterior end (where the needle pricks).

 To preserve good circulation conditions of the liquid substance in the needle (flow rate, pressure, ...), it is also advised that this variation in stiffness of the needle along its axis of elongation is obtained by a variation of its external caliber.

 To obtain this, a first solution consists in making the needle in one piece, with a substantially conical shape (or more or less frustoconical, since the needles are generally bevelled at their anterior end).

 However, such a "conical" needle may prove difficult to manufacture, or even too expensive.

 Also, an alternative solution proposed by the invention is that the variation in external caliber is progressive, per section, from one end to the other.

 If such a solution is chosen, it is then recommended, for simplicity of manufacture and for the quality of the needle, that the latter comprises several rods, arranged substantially parallel to the axis of elongation of the needle, all or part of these rods then containing at least one substantially axial passage for the circulation of the liquid substance.

 To optimize the variation in needle stiffness, the rods in question may have different axial lengths.

For the association of the stems, two solutions were more particularly retained
The first provides that each rod is axially hollow and that the rods (of different outside diameters between them) are arranged one after the other, along the axis of the needle.

 This solution has an advantage linked to the concentricity in the arrangement of the rods and makes possible a telescopic embodiment.

 In the second solution, the rods, which have different lengths but which may be of the same diameter, are joined laterally to each other while extending in a general direction substantially parallel to the axis of the needle.

Over their lengths, all or part of these needles can have a constant outside and / or inside diameter, as is the case in the previous solution.

 But this second solution has, compared to the first, an advantage as to the seal between the rods since, in the second solution, it can be provided that only one of the rods is tubular (hollow) for the circulation of the substance liquid, the other rods being full, with the function essentially of gradually increasing the rigidity of the needle, without particular discomfort for the patient.

 In this solution, it is moreover advised that, among the rods, only the longest one is tubular and therefore contains the entire passage used for the circulation of the liquid substance, the other rods, shorter, therefore having no passage for this substance.

 Note also that if several rods are used to vary the outside gauge of the needle, each rod will preferably have a chamfer at the change (s) in external diameter, thus facilitating the penetration of the needle into the body of the patient.

 Another characteristic of the invention also relates to the packaging of this hollow needle device.

 However, this is an important question, directly related to ease of use, security, speed, and even reliability of intervention.

A packaging solution proposed by the invention consists, in order to carry out an injection
- permanently attach the needle to the syringe body,
- And to pre-fill this syringe body with the product to be injected, the assembly thus defined being, with the sheath (needle retracted), placed inside a sterile protective packaging.

A more detailed description of the invention will now be provided, with reference to the accompanying drawings, in which
FIG. 1 is a schematic view assumed in longitudinal section of a first possible embodiment of a medical device according to the invention, the device being in the "safety" position, needle inside the sheath,
FIG. 2 shows the device of FIG. 1, according to the same schematic view, but in the needle out position, ready to prick,
FIG. 3 shows a possible embodiment of the slot of the sheath, in an enlarged and partial view according to arrow III in FIG. 1,
FIG. 4 shows more particularly a detail of the cursor, in section, according to section IV - IV of FIG. 2,
FIG. 5 shows in enlarged and still schematic view, in longitudinal section, the syringe of FIG. 1,
FIG. 6 shows in the same view as FIG. 5, the sheath of the device of FIG. 1,
FIGS. 7 and 8 show according to the same views as FIGS. 1 and 2, an alternative embodiment of a device according to the invention,
- Figures 9, 10, 11 and 12 show three alternative embodiments of a hollow needle capable of being used on a device of the previous figures.

FIG. 13 shows the production of a sheath with an offset opening, as well as a fixing of the offset needle on the syringe body,
- And Figure 14 shows the device of Figure 1 in a packaging package.

 In what follows, we will only deal with the case of the use of a medical device for local anesthesia (LA), identified 1 in particular in FIGS. 1 and 2, even if other applications of this device are possible. , in particular if a deep needle prick is necessary (penetration length of the needle beyond one centimeter).

 The device 1 comprises a rigid carrying sheath, of plastic material, 3.

 In this case, the sheath 3 which is rigid (plastic or glass for example) has the coarse shape of a tubular pen widely open at 4 (Figure 6) at its rear end 3a where it has an outer perimeter corolla 5. A its opposite anterior end 3b, the sheath 3 is tapered, this end (end piece 6) which can be full, being traversed by a passage 7 coaxial with the sheath (axis 9) and of sufficient diameter to allow free passage to the needle 11 d '' a syringe 13.

 The anterior end 3b allows the approach of the skin to be pricked. It can be fitted with a safety shutter 15.

 Note that the side wall of the plug 6 which defines the passage 7 participates in the maintenance of the needle 11 or in its axial guidance, as will be seen below.

 The hollow interior of the sheath 3 (which may be, on its non-tapered part, a hollow cylinder of circular section, or more or less oval), contains a part of the syringe 13, which comprises a syringe body 17 (pre- filled in FIGS. 1 and 14 with a liquid substance 19), and a piston 21 consisting of a piston element 23 which can be moved in leaktight manner inside the body 19, under the operation of an associated control rod 25 (see figure 5).

 For the operation of the pusher 25, the body 17 is equipped with an outer perimeter flange 27, at its rear end opposite to that where the needle 11 is mounted.

 The syringe 13 and the sheath 3 are arranged coaxially, in such a way that the syringe body can axially slide tightly inside (after having been introduced therein via the opening 4) in order to pass from the situation of FIG. 1 to that of FIG. 2 where a relative axial translational movement between the sheath and the syringe body has taken place with deeper penetration of the second into the first, the needle 11 (possibly after withdrawal of the cover 15) emerging now out of the tapered front part 3b.

 In FIG. 2, it will also be noted that it has been assumed that part of the liquid 19 has already been injected, by axial operation of the pusher 25 in the direction of the arrow 29.

 For the operation of deeper axial engagement of the body 17 inside the sheath 3, provision could be made to simply use, by an appropriate arrangement of the user's fingers, the two flanges 5, 27, their bringing together causing the translation desired.

 Although these two flanges, typical of syringes, can be used in this way, it has however been planned here to use as a push-button system of the needle 11, the assembly constituted by a slider 31 and a slot 33 parallel to the axis 9.

 The slider 31 comprises a fin 35 fixed on one side to the outside of the syringe body 17. This fin 35 passes through the slot 33 in which it is intended to be closely guided in translation.

 Outside the sheath, the fin 35 is provided with a digital maneuvering tip 37 (see FIGS. 4 and 5).

 The axial length 11 of the slot 33 determines the outward and return stroke of the syringe body in the sheath and corresponds to the useful length (and not total) of the needle 11 (length 12 in FIG. 2).

 As can be seen in Figure 3, the longitudinal edges of the slot 33 may not be smooth, but provided with a series of small grooves perpendicular to the axis 9 or forming a series of undulations 39, as on Figure 3, with a spacing for example of about one to two millimeters.

 The fin 35 can be provided, for its part, with a flexible lamella system 41 (FIG. 4), to define, with the irregularities in the slot, a notch system implying a priori displacement by small constant and controlled jolts. of the cursor 31, by simple push in one direction or the other.

 A rear notch 43 and / or anterior notch 43 ′, for example more marked than the others (39), can be provided to favor retaining the needle in the retracted position (FIG. 1), this notch being however passable by a slightly greater push by a finger on the cursor in the appropriate direction.

 Of course, any notched system associating a cursor with the walls of a slot for a stepwise movement in one direction and / or the other of the cursor in the slot, should be suitable.

Such a device, applied to the realization of an LA, can be used as follows
First of all, provision may be made to condition, in a package as marked 45 in FIG. 14, the device 1 in its state shown in FIG. 1, that is to say with the needle 11 fully retracted to the inside the sheath and the syringe body 17 pre-filled with the necessary dose of local anesthetic substance, 19.

 Note that so-called "galenic" conditions relating to the requirements of drug storage and chemical stability, may however sometimes not allow "direct" pre-filling of the syringe. One could on the other hand then provide that the drug is in a sort of percutable cartridge 46 reproducing the bulb effect, this cartridge being able to be accommodated in the syringe. The cartridge would then be open on a sort of striker 48 formed frontally on the piston 23 and acting from the pushing action of this piston.

 The packaging 45 may consist, as illustrated in FIG. 13, in a tear-away flexible plastic envelope 47, closely surrounding a more rigid casing 49 enclosing the device 1 in its state of FIG. 1. Preferably, this will be a packaging. unique sterile, suitable for aseptic conditions.

 The housing 49 may be a housing in two separable parts, mounted tiltable with respect to each other via a hinge (not shown).

 To use the device 1, the casing 47 is first removed, then the housing 49 is opened to take hold of the device.

 After disinfection of the skin area to be anesthetized (not shown), the safety shutter 15 is removed.

 The carrying sheath 3 is grasped by the non-dominant hand of the user, thumb on the cursor 31.

 The device is in its position in FIG. 1.

 The front end 3b of the sheath is then approached and pressed against the skin, perpendicular or substantially tangential to it.

 At this stage, it will be noted that to facilitate a tangential approach, there is shown in FIG. 13 an alternative embodiment in which the parts comparable with those of FIG. 1 bear the same reference, with a "prime" sign.

 Thus, it can be seen that the passage 7 '(formed in the tapered anterior end 3'b of the sheath 3') is offset (axis 10) relative to the central axis 9 'of the syringe 13' whose body 17 'is itself provided with a hollow front end 17 ′ offset (axis 10) on which is fixed the rear end of the needle 11' (which of course extends itself along said axis 10) .

 As for the truncated cone 3 ′ b, it is no longer a cone of revolution as in FIG. 1, but a skewed cone, with an axis 10 parallel to the axis 9 ′, but not confused with it .

 To return to the conditions of use of the device of the invention, once the front end of the sheath is properly pressed against the skin, a pressure of the thumb on the slider 31 releases the needle / syringe pair from the safety catch 43.

 The thumb then continues its light pressure forward on the cursor which takes a first step (arrow 51 in Figure 1).

 The distal free end of the needle 11 then emerges from the sheath, a priori under the effect of a small sharp blow, and thus penetrates the skin painlessly, for example to a depth of one to two millimeters.

 The dominant hand, which holds the syringe 13, then begins injecting a small amount of anesthetic product.

 As the needle is preferably (as will be seen below) with progressive rigidity, this rigidity manifests itself as it leaves the sheath, this allowing both the needle to be held in the puncture axis and a possible directional readjustment.

 By progressive advance of the cursor, and step by step, the anesthesia is performed on the surface or in depth, using if necessary all the useful length 12 of the needle.

 The retraction of this needle into the sheath is done by reverse operation of the thumb on the cursor.

 Anesthesia can be supplemented on this occasion by an additional injection of anesthetic product.

 Once out of the skin, the needle 11 is fully retracted into the sheath, preferably up to the rear safety catch 43, which is crossed by a new pressure of the finger.

 We can then plan to throw the device as it is, without risk.

 Another embodiment of the protective sheath is illustrated in FIGS. 7 and 8.

 In these figures, we find the syringe 13 of Figure 1, but this syringe is here arranged inside a sheath 30 still widely open at its rear end 30a where it is provided with an outer perimeter flange 50, but which, on the front side, is provided with two wings 32, 34, articulated in rotation each at 36 (thinned area) on the fixed front part 38 of the sleeve, so as to be able to pivot between a close position, as in FIG. 7, where the two flaps 32, 34 extend parallel to the longitudinal axis 9 of the device 1 and surround the needle 11 over its entire length 13, and a position where the two flaps are folded perpendicular to the axis 9, towards the exterior, as in Figure 8, by opening an opening 70 for the needle.

 The two wings or flaps 32, 34 may have a substantially semi-cylinder shape, these flaps being separated by two opposite axial slots defining them and having a length at least slightly greater than 13.

 For the opening and closing of the flaps 32, 34, a cursor 40 can be provided, so as to slide around the sheath 30. To open, the cursor must be placed in the "rear" position, as in FIG. 8, where it is located between the hinges 36 and the rear end 30a of the sheath having caused the opening by external deployment of the flaps, under the action of two filaments 42, 44, linked to it at one end and respectively to one and the other of the shutters, at the other end.

 In the rear position of the slider (Figure 8), the wires 42, 44 are stretched.

 To close the shutters, it suffices to move the cursor 40 along arrow 46, as far as beyond the hinges 36, in the direction of the front end 30b, until reaching the position of FIG. 7, the cursor 40 causing in passing the folding of the flaps along the needle.

 Preferably, stops 48 block the translation of the cursor before the end 30b.

 In such an implementation hypothesis, the packaging of the device 1 ′ in FIGS. 7 and 8 will of course take place in the state of the device in FIG. 7 (closed flaps and needle 11 protected inside the sheath). It is only at the time of pricking the skin that the needle will be discovered, as in FIG. 8, the needle being able to be protected again as soon as it is removed from the patient's body, by repositioning the sheath in its state of figure 7.

 For possible additional details concerning the production of a tilting shutter system, reference may be made, if necessary, to DE-U-9108771.6 (pages 4 to 7), the content of which is introduced in the present description, by reference.

 Let us now turn to the preferred embodiment of the needle 11, four possible embodiments of which have been shown successively in FIGS. 9, 10, 11 and 12, respectively under the references lla, llb, lîc and lld.

 Note now that only in Figure 9 the needle has been shown mounted on the syringe body 17, the attachment of the needle can be effected by crimping the syringe body, or by any other known means.

 In FIG. 9, it is a conical needle, or more exactly frustoconical, intended to be fixed by its widest base ll'a to the syringe body, the narrowest anterior end 11a being, conventionally, beveled.

 Of course, this is a hollow needle having an internal passage 110 coaxial with the needle (axis 111).

 At its thinnest end (il), the needle 11a can have a diameter of approximately 0.4 to 0.5 mm (gauge from 25 to 27 gauges), with a short bevel, until it reaches approximately 1.1 mm (or about 19 Gauges) at the posterior end ll'a.

 In FIG. 10, the needle llb comprises three sections 112, 113, 114, each of constant diameter but different from the others, the three sections being arranged one after the other, end to end, of the section of larger diameter 114 to the section of smaller diameter 112, the attachment to the syringe body being provided on the side of the free end 114a of the section of larger diameter 114, while the opposite free end 112a has a typical short bevel, 116 .

 At each change in diameter, the two corresponding adjacent sections are connected to each other (for example welded) in a sealed manner and preferably this connection has the shape of a chamfer such as 118 and 120 favorable for the penetration of the needle.

 The axial internal channel 110 of the needle ilb naturally extends over the entire length of the needle to open at the two ends, after having traversed the entire axial length of each of the sections 112, 113 and 114.

 In FIG. 11, there are three tubular sections each of constant but different caliber depending on the sections 122, 124 and 126, the sections being mounted telescopically, from the smallest to the largest, so as to be able, for example, to adapt the length 13 of the needle and therefore the penetration depth of each of the sections.

 In FIG. 12, there are again three sections 128, 130 and 132; but these three sections are joined laterally substantially in a triangle, while each extending parallel to the general axis 111 of the needle îîd.

 In such an implementation hypothesis, it seems preferable that only the longer section (in this case 128) has the internal passage 110 reserved for the liquid to be circulated in the needle, the other sections being either full or blocked at their ends. One can imagine that the three sections were crimped together, from two solid rods, and a hollow rod, each of constant diameter, the difference in length between the sections making it possible to vary the stiffness of the needle on its length.

 A bevel will preferably be provided at the anterior end of each section.

 One can also imagine that the production of a needle with several sections is made from a raw material from a wire drawing and welding chain which directly produces a multichannel conduit (2, 3 or 4 channels). Therefore, the needle will be obtained by cutting and pruning the channels.

 Note that such a needle embodiment with rigidity that is all the more important the closer it is to its end for fixing to the syringe body, will make it possible to use a single needle on the AL device presented above. , this single needle then preferably being permanently fixed to said body, of manufacture.

 Having only one needle will limit handling, therefore the risk of aseptic errors for the patient and the risk of injury and contamination for the operator and the personnel responsible for cleaning and storage.

 Note that this characteristic could be applied to other syringe devices than a device for AL.

 For a deep AL, the length of the needle used may reach approximately 50 to 90 mm, of useful length, or up to 110 to 130 mm of total length (l3). It should also be noted that the use of a pre-filled syringe (or with a percutable cartridge), as advised above, avoids manipulation and potential aseptic errors when withdrawing the liquid to be injected into a standard syringe, empty.

 However, in certain applications other than for local anesthesia (LA), one could nevertheless envisage packaging a device in a kit comparable to that of FIG. 1 or of FIG. 7, that is to say by conditioning side by side. side (in their disassembled state) a sheath, a syringe (empty) and at least one needle typical of the prior art or corresponding to one of the embodiments presented above, this (each) needle being adapted to be fixed classic way on the tip of the syringe body, when

Claims (19)

 1.- Medical device for intervention through a skin surface, comprising  - an injection or sampling syringe (13), the syringe comprising a body (17, 17 ') and a piston (21) movable in the body,  - And a needle (11) linked to the syringe, characterized in that it further comprises a sheath (3, 3 ', 30) the sheath and the body (17, 17') of the syringe having relative mobility and being arranged relative to each other so that, in a first state of protection of the needle, the sheath contains said needle (11, lla, llb, ...) and a part of the syringe ( 13), and that, in a second state of penetration of the needle, this needle (11, pila, ...) has come out of the sheath through an opening (7, 70) thereof situated opposite the needle, the sheath then always containing part of the syringe.  2.- Medical device for local anesthesia, including  - an injection syringe (13), the syringe comprising a body (17, 17 ') and a piston (21) movable in the body,  - And a needle (11) linked to the syringe, characterized in that it further comprises a sheath (3, 3 ', 30) the sheath and the body (17, 17') of the syringe having relative mobility and being arranged relative to each other so that, in a first state of protection of the needle, the sheath contains said needle (11, lla, llb, ...) and a part of the syringe ( 13), and that, in a second state of penetration of the needle, this needle (11, lla, ...) has come out of the sheath through an opening (7, 70) thereof situated opposite the needle, the sheath then always containing part of the syringe.  3.- Device according to claim 1 or 2, characterized in that the sheath (3, 3 ', 30) and the body (17, 17') of the syringe are sliding relatively to each other, according to a axis parallel to that of the needle linked to the syringe.  4.- Device according to any one of claims 1 to 3, characterized in that the sheath (3, 3 ') is non-deformable along the axis (9, 10) of the needle (11, 11') mounted on the syringe body and is devoid of a movable part relative to a fixed part of itself.  5.- Device according to one of claims 1 to 4, characterized in that a part of the body (17) of the syringe is linked to a pusher system (31, 27) movable in two different directions and operable from the 'outside of the sheath (3), to induce a projection of the needle out of said sheath, during the operation of the pusher in one direction.  6.- Device according to claim 5, characterized in that the pusher system comprises a cursor (31) linked to the body (17) of the syringe through a slot (33) of the sheath (3), to define a directed slide essentially parallel to the axis (9) of relative sliding between the sheath and the body of the syringe.  7.- Device according to any one of the preceding claims, characterized in that the needle is fixed permanently to the body (17) of the syringe.  8.- Device according to any one of the preceding claims, characterized in that said needle, which is hollow, comprises a posterior end by which it is fixed to the body (17) of the syringe, and an anterior end by which it stings, said needle being more rigid towards its posterior end than towards its anterior end.  9.- Device according to any one of the preceding claims, characterized in that the needle (11, lla, llb, ...) has a length and an external gauge which varies over this length.  10.- Device according to any one of the preceding claims, characterized in that the needle has a length and an external gauge which varies in sections, gradually, from one end to the other of the needle.  11.- Device according to any one of the preceding claims, characterized in that the needle has a longitudinal axis and comprises several rods (112, 113, 114; 122, 124, 126; 118, 130, 132) arranged substantially parallel at said axis, all or part of these rods containing at least one substantially axial passage (110) for the circulation of a substance through the needle.  12.- Device according to claim 11, characterized in that the rods (128, 130, 132) have different axial lengths between them.  13.- Device according to claim 11 or claim 12, characterized in that each rod (112, 113, 114; 122, 124, 126) is axially hollow and the rods, which have different diameters between them, are arranged at following each other, along the axis of the needle.  14.- Device according to claim 13, characterized in that the rods (122, 124, 126) are telescopic.  15.- Device according to claim 11 or claim 12, characterized in that the rods (128, 130, 132) are joined laterally to each other.  16.- Device according to any one of claims 12 or 15, characterized in that  - among the rods (128, 130, 132), the needle (lad) comprises a rod (128) which is the longest axially, which is tubular and which encloses the whole of said passage (110),  - And the other rods (130, 132), shorter, have no passage for the circulation of said substance.  17.- Device according to any one of claims 9 to 14, characterized in that the needle has a chamfer at the change of rod.  18.- Device according to any one of claims 1 to 9, characterized in that the needle (lia) consists of a single piece, substantially in a truncated cone.  19.- Packaging of a device according to any one of the preceding claims, characterized in that  - the conditioned needle (11) is permanently fixed to the body (17) of the syringe,  - And the conditioned syringe body contains a substance to be injected (19), following a pre-filling or via a cartridge (46).