FR2715659B1 - 3- (2-aminoethyl) -4- [3- (trifluoromethyl) benzoyl] -3,4-dihydro-2H-1,4-benzoxazine derivatives, their preparation and their therapeutic use. - Google Patents

3- (2-aminoethyl) -4- [3- (trifluoromethyl) benzoyl] -3,4-dihydro-2H-1,4-benzoxazine derivatives, their preparation and their therapeutic use.

Info

Publication number
FR2715659B1
FR2715659B1 FR9401196A FR9401196A FR2715659B1 FR 2715659 B1 FR2715659 B1 FR 2715659B1 FR 9401196 A FR9401196 A FR 9401196A FR 9401196 A FR9401196 A FR 9401196A FR 2715659 B1 FR2715659 B1 FR 2715659B1
Authority
FR
France
Prior art keywords
aminoethyl
dihydro
benzoyl
trifluoromethyl
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR9401196A
Other languages
French (fr)
Other versions
FR2715659A1 (en
Inventor
Pascal George
Jonathan Frost
Patrick Pasau
Corinne Rousselle
Regine Bartsch
Paul Howard Williams
Jean-Claude Muller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to FR9401196A priority Critical patent/FR2715659B1/en
Priority to CN95101657A priority patent/CN1109880A/en
Priority to HU9500310A priority patent/HUT71238A/en
Priority to JP7015892A priority patent/JPH07278123A/en
Priority to NO950378A priority patent/NO304229B1/en
Priority to US08/382,589 priority patent/US5550125A/en
Priority to DE69511127T priority patent/DE69511127D1/en
Priority to CZ95270A priority patent/CZ27095A3/en
Priority to CA002141728A priority patent/CA2141728A1/en
Priority to ZA95834A priority patent/ZA95834B/en
Priority to KR1019950001835A priority patent/KR950032184A/en
Priority to PL95307040A priority patent/PL307040A1/en
Priority to AT95400215T priority patent/ATE182887T1/en
Priority to IL11252895A priority patent/IL112528A/en
Priority to FI950457A priority patent/FI950457A/en
Priority to SK128-95A priority patent/SK12895A3/en
Priority to EP95400215A priority patent/EP0666260B1/en
Priority to RU95101386A priority patent/RU2136670C1/en
Priority to NZ270444A priority patent/NZ270444A/en
Priority to AU11545/95A priority patent/AU687134B2/en
Publication of FR2715659A1 publication Critical patent/FR2715659A1/en
Application granted granted Critical
Publication of FR2715659B1 publication Critical patent/FR2715659B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR9401196A 1994-02-03 1994-02-03 3- (2-aminoethyl) -4- [3- (trifluoromethyl) benzoyl] -3,4-dihydro-2H-1,4-benzoxazine derivatives, their preparation and their therapeutic use. Expired - Lifetime FR2715659B1 (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
FR9401196A FR2715659B1 (en) 1994-02-03 1994-02-03 3- (2-aminoethyl) -4- [3- (trifluoromethyl) benzoyl] -3,4-dihydro-2H-1,4-benzoxazine derivatives, their preparation and their therapeutic use.
CN95101657A CN1109880A (en) 1994-02-03 1995-01-30 3-(2-aminoethyl)-4-[3-(trifluoromethyl) benzoyl]-3,4-dihydro-1,4-benzoxazine derivative and preparation of same
IL11252895A IL112528A (en) 1994-02-03 1995-02-02 3-(2-Aminoethyl)-4-[3-(trifluoromethyl) benzoyl]-3,4-dihydro-2h-1,4-benzoxazine derivatives process for their preparation and their therapeutic application
NO950378A NO304229B1 (en) 1994-02-03 1995-02-02 Benzoxazine derivatives, and drugs and pharmaceutical preparations containing them
US08/382,589 US5550125A (en) 1994-02-03 1995-02-02 3-(2-aminomethyl)-4-[3-trifluoromethyl)benzoyl]-3-4 dihydro-2h-1,4-benzoxazine derivatives and their therapeutic application
DE69511127T DE69511127D1 (en) 1994-02-03 1995-02-02 3- (2-aminoethyl) -4-3- (trifluoromethyl) benzoyl-3,4-dihydro-2H-1,4-benzoxazine derivatives, their preparation and use in therapy
CZ95270A CZ27095A3 (en) 1994-02-03 1995-02-02 Derivatives of 3-(2-aminoethyl)-4-/3-(trifluoromethyl)benzoyl/-3,4-dihydro-2h-1,4-benzoxazine, process of their preparation and pharmaceutical compositions containing thereof
CA002141728A CA2141728A1 (en) 1994-02-03 1995-02-02 3-(2-aminoethyl)-4-¬3-(trifluoromethyl)benzoyl|-3, 4-dihydro-2h-1,4- benzoxazine derivatives, process for their preparation and their therapeutic application
ZA95834A ZA95834B (en) 1994-02-03 1995-02-02 3-(2-aminoethyl)-4-[3-(trifluoromethyl)benzoyl]-3, 4-dihydro-2H-1, 4-benzoxazine derivatives process for their preparation and their therapeutic application:
KR1019950001835A KR950032184A (en) 1994-02-03 1995-02-02 3- (2-aminoethyl) -4- [3- (trifluoromethyl) benzoyl] -3, 4-dihydro-2H-1, 4-benzoxazine derivatives, preparation method thereof and therapeutic application thereof
HU9500310A HUT71238A (en) 1994-02-03 1995-02-02 3-(2-amino-ethyl)-4-[3-(trifluoro-methyl)-benzoyl]-3,4-dihydro-2h-1,4-benzoxazine derivatives, process for producing them and pharmaceutical compositions containing them
AT95400215T ATE182887T1 (en) 1994-02-03 1995-02-02 3-(2-AMINOETHYL)-4-3-(TRIFLUOROMETHYL)BENZOYL-3 4-DIHYDRO-2H-1,4-BENZOXAZINE DERIVATIVES, THEIR PREPARATION AND USE IN THERAPY
JP7015892A JPH07278123A (en) 1994-02-03 1995-02-02 3-(2-aminomethyl)-4-(3-(trifluoromethyl)benzoyl)-3,4-dihydro2h-1,4-benzoxazine derivative, its production, and its application in medical treatment
FI950457A FI950457A (en) 1994-02-03 1995-02-02 3- (2-Aminoethyl) -4- (3-trifluoromethyl) benzoyl) -3,4-dihydro-2H-1,4-benzoxazine derivatives, preparation and therapeutic use thereof
SK128-95A SK12895A3 (en) 1994-02-03 1995-02-02 3-(2-aminoethyl)-4-(3-trifluoromethyl-benzoyl)-3,4-dihydro-2h- -1,4-benzoxazine derivatives, method of their preparation and pharmaceutical composition containing of these derivatives
EP95400215A EP0666260B1 (en) 1994-02-03 1995-02-02 3-(2-aminoethyl)-4-3-(trifluoromethyl)benzoyl-3,4-dihydro-2H-1,4-benzoxazine derivatives, their preparation and use in therapy
RU95101386A RU2136670C1 (en) 1994-02-03 1995-02-02 Derivatives of 3-(2-aminoethyl)-4-[3-(trifluoromethyl)benzoyl]- -3,4-dihydro-2h-1,4-benzoxazine, method of their synthesis and pharmaceutical composition containing on said
NZ270444A NZ270444A (en) 1994-02-03 1995-02-02 3-aminoethyl-4-benzoyl-1,4-benzoxazine derivatives and medicaments
AU11545/95A AU687134B2 (en) 1994-02-03 1995-02-02 3-(2-aminoethyl)-4-{3-(trifluoromethyl)benzoyl}-3,4-dihydro- 2H-1,4-benzoxazine derivatives, process for their preparation and their therapeutic application
PL95307040A PL307040A1 (en) 1994-02-03 1995-02-02 Derivatives of 3-(2-aminoethyl)-4-[3-(trifluoromethyl) benzoil]-3,4-dihydro-2h-1,4-bnzoxazine, method of obtaining them and their medicinal application

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9401196A FR2715659B1 (en) 1994-02-03 1994-02-03 3- (2-aminoethyl) -4- [3- (trifluoromethyl) benzoyl] -3,4-dihydro-2H-1,4-benzoxazine derivatives, their preparation and their therapeutic use.

Publications (2)

Publication Number Publication Date
FR2715659A1 FR2715659A1 (en) 1995-08-04
FR2715659B1 true FR2715659B1 (en) 1996-03-22

Family

ID=9459715

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9401196A Expired - Lifetime FR2715659B1 (en) 1994-02-03 1994-02-03 3- (2-aminoethyl) -4- [3- (trifluoromethyl) benzoyl] -3,4-dihydro-2H-1,4-benzoxazine derivatives, their preparation and their therapeutic use.

Country Status (1)

Country Link
FR (1) FR2715659B1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1287584B (en) * 1962-07-04 1969-01-23 Thomae Gmbh Dr K Process for the preparation of 2, 3-dihydro-1, 4-benzoxazine derivatives
US4636563A (en) * 1985-09-16 1987-01-13 American Home Products Corporation Antipsychotic γ-carbolines
FR2619111B1 (en) * 1987-08-07 1991-01-11 Synthelabo (PIPERIDINYL-4) METHYL-2 TETRAHYDRO-1,2,3,4 9H-PYRIDO (3,4-B) INDOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Also Published As

Publication number Publication date
FR2715659A1 (en) 1995-08-04

Similar Documents

Publication Publication Date Title
DE59703261D1 (en) Substituted oxazolidinones and their use as antibacterial drugs
ATE232865T1 (en) 1,4-DIAZABICYCLO(3.2.2)NONAN-4-CARBOXYLATE AND CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE
EA200101156A1 (en) DRUG COMPOSITIONS OF A NEW TYPE ON THE BASIS OF POSSESSING HOLYNTHERGIC ACTION OF COMPOUNDS AND β-MIMETIC
AU8296987A (en) Pharmaceutical composition comprising fluticasone propionate
FR2710915B1 (en) Piperidine derivatives, their preparation and their therapeutic use.
HUP9901184A3 (en) Antibacterial benzoxazine and pyrido-oxazine derivatives, intermediates, pharmaceutical compositions containing these compounds, preparation and use thereof
ATE250570T1 (en) PHENYLAMINOALKYLCARBOXYLIC ACID DERIVATIVES AND MEDICAL COMPOSITIONS CONTAINING SAME
FR2713234B1 (en) New derivatives of triphenodioxazine, their preparation and their use as pigments.
DE60128100D1 (en) ANALGICAL DRUG
ATE184005T1 (en) OXAZOLIDINONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
FR2715659B1 (en) 3- (2-aminoethyl) -4- [3- (trifluoromethyl) benzoyl] -3,4-dihydro-2H-1,4-benzoxazine derivatives, their preparation and their therapeutic use.
PL339073A1 (en) Derivatives of benzoxazine and benzothiazine and their application in therapeutic agents
DE60024108D1 (en) LEUKOTRIEN RECEPTOR
FR2715655B1 (en) 3- (2-aminoethyl) -4-benzoyl-3,4-dihydro-2H-1,4-benzoxazine derivatives, their preparation and their therapeutic use.
AU2979899A (en) Treatment of viral disease in swine
WO2002028858A3 (en) Hexahydropyrazino `1'2' : 1, 6!- pyrido `3, 4-b! indole-1, 4-dione derivatives for the treatment of cardiovascular disorders and erectile disfunction
FR2716193B1 (en) 1 [2- (1h-inden-3-yl) ethyl] -4- (naphthalen-1-yl) piperazine derivatives, their preparation and their therapeutic use.
NO984651L (en) Use of benzone-offset derivatives for the manufacture of drugs for the treatment of central nervous system diseases
FR2701479B1 (en) New heterocyclic derivatives of 4-aminomethyl piperidine, their preparation and their therapeutic use.
FR2669631B1 (en) NEW OXAZOLIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE.
FR2714055B1 (en) Derivatives of 5- (arylalkyl) -1,3-dioxane substituted in position 2, their preparation and their use in therapy.
FR2700546B1 (en) Imidazo [2,1-b] benzoxazole-3-acetamide derivatives, their preparation and their therapeutic use.
FR2714056B1 (en) 2- (aminoalkyl) -5- (arylalkyl) -1,3-dioxane derivatives, their preparation and their therapeutic use.
FR2717479B1 (en) News 3- (omega-benzoylpiperidino) alcoyl) -4H-Benzopyran-4-ones, their preparation and their therapeutic application.
ATE251137T1 (en) INDOLE DERIVATIVES AND ROOT-FORMING AGENTS CONTAINING THESE AS ACTIVE INGREDIENTS

Legal Events

Date Code Title Description
TP Transmission of property
CD Change of name or company name