FR2708200A1 - Process for incorporating an active ingredient in a membrane and products thus obtained - Google Patents

Abstract

Process for incorporating an active ingredient in a membrane and products thus obtained, for the preventive and curative control of sexually transmitted diseases. Application to hygiene and/or protection products, especially gloves, condoms and masks.

Description

PROCe of incorporating an active principle into a membrane and product thus obtained.

The present invention relates to a process for manufacturing an elastomer-based membrane in which an active ingredient is incorporated. The invention also relates, by way of new industrial products, to the articles obtained by the implementation of the process such as gloves, condoms, masks or other hygiene and / or protective products.

There are many products such as protective gloves, condoms, masks or others, for which it is necessary to associate, during their use, an active anti-viral and / or anti-mycotic and / o bactericidal and / or bacteriostatic, so as to reduce the risks of contamination by contact and to protect the cutaneous surfaces or the mucous membranes. To respond to this problem, compositions have been developed which are coated on the surface of the product coming into contact with the skin surface or mucous membrane to be protected.

There are also active principle release devices, in particular medicamentous active principles, which comprise a reservoir or an internal support integrating the active principle and a semi-permeable membrane or capsule which allows the active principle to diffuse at constant speed or not. These devices, an example of which is provided by the patent Fr A-2.II3.778 require most of the time an implantation of the device in the organism and present a significant congestion. -
Other devices consist of a mixture of an excipient and an active principle, the excipient gradually disintegrating over time, thereby causing a release of the active principle.

Also known according to patent Fr-A-87.036I5 a device in which an active principle is incorporated into the solid membrane.

All of these systems have appreciably the disadvantages. They reduce for the most part the contact sensitivity which is necessary in particular when working on very thin membranes. It does not allow to favor a direction of diffusion.

The present invention therefore aims to overcome these drawbacks by proposing a method for manufacturing an elastomer-based membrane incorporating an active product in which the direction of diffusion of the active principle is predetermined at the time of manufacture.

Another bFt of the present invention is to develop a process which allows the diffusion of an active principle from a single membrane without it breaking up over time.

Another object of the present invention is to provide a method for incorporating an active principle into a membrane intended to constitute a glove or a preservative without modifying the pre-existing production lines.

To this end, the present invention relates to a process for manufacturing an elastomer-based membrane incorporating an active principle, consisting in measuring this already finished membrane and VULCANIZING it by soaking in a solution of the active principles. solution, a migration takes place, this solution and the active principle which is found in this solution penetrates, is deposited on the latex molecules, remains on it after drying. (The solutin evaporates, only the active ingredient remains in the membrane.)
Said membrane releasing the active principle on its internal surface and / or on its external surface in contact with a wet environment.

 flans this glove, the active ingredient will tend to diffuse towards the inside of the glove thus forming a protective film. The quantities diffused can reach 72% of the total quantity diffused within the first hour over 24 hours, the quantity diffused will be equal at about 530 of the total amount contained in the membrane. As the diffusion is very important during the first hour, this process turns out to be particularly suitable for the manufacture of gloves or condoms.

Claims (6)

 REVEKDICA? ION  re.  ncipe active remains in the membrane, the liquid or the aqueous solution sevapo  quide or aqueous solution added with the active ingredient, drying the pr:  active, for a while, this membrane becomes throated and swells with li  not soaked in a liquid or an aqueous solution supplemented with a principle  vulcanize or polymerize to make this membrane active. This membra I- Process for incorporating an active principle into an already finished membrane, 2- A method according to claim I characterized in that it performs a drying  ge soaked soaking.  3- Method according to one of claims I and 2, characterized in that the deposit  solutions on the solid support are made by soaking or spraying  or other of said support. 4- Method according to one of claims I to 3 characterized in that the support  solid is a membrane. 5- Method according to one of claims I to 4 characterized in that the prince  active is an: anti viral and / or anti mycotic and / or contraceptive product and  or bactericide or ect .. for example a quaternary ammonium preferably  benzalkonium chloride.  6- Method according to one of claims I to 5 characterized in that the elastic-  tomer can be a natural elastomer; for example latex. Or a Polymer.