FR2705571A1 - Combination of a fatty oil and one or more aromatic essential oils - Google Patents

Combination of a fatty oil and one or more aromatic essential oils Download PDF

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FR2705571A1
FR2705571A1 FR9306393A FR9306393A FR2705571A1 FR 2705571 A1 FR2705571 A1 FR 2705571A1 FR 9306393 A FR9306393 A FR 9306393A FR 9306393 A FR9306393 A FR 9306393A FR 2705571 A1 FR2705571 A1 FR 2705571A1
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fatty oil
oil
aromatic essential
combination
essential oil
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Perez Adrien Guy
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Birds (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention relates to a combination of two natural products, one being taken systematically as base and in the larger proportion, and is a fatty oil of vegetable or animal origin, the other is an aromatic essential oil extracted from a plant, namely Melaleuca alternifolia, which may be replaced by - or combined with - another aromatic essential oil of equivalent biochemical composition or which is traditionally known for its similar therapeutic effects, in particular on localised dental complaints: gingival abscesses or any other periodontal pathologies displaying infectious or inflammatory features.

Description

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L'objet de l'invention est la fabrication et l'utilisation dans l'art dentaire d'une association de produits naturels ayant des effets adjuvants antibactériens , antalgiques et anti inflammatoires localisés.  The object of the invention is the manufacture and use in dentistry of a combination of natural products having adjuvant antibacterial, analgesic and anti-inflammatory localized effects.

Actuellement les praticiens de la chirurgie dentaire peuvent difficilement soigner immédiatemnt une dent infectée (parulie) , ils font précéder leurs soins de prise d'antibiotiques et d'anti-inflammatoires ce qui retarde leur intervention ( durée de la prise en moyenne 10 jours) , et présente l'inconvénient de l'accoutumance ( adaptation enzymatique) parles germes pathogènes à l'origine de l'abcès. Currently dental practitioners can hardly care for an infected tooth immediately (parulia), they precede their care with taking antibiotics and anti-inflammatories which delays their intervention (duration of taking on average 10 days), and has the disadvantage of habituation (enzymatic adaptation) by the pathogenic germs causing the abscess.

Par ailleurs certains patients peuvent difficilement supporter les effets secondaires des antibiotiques .Le produit peut supprimer ces inconvénients importants : les résultats obtenus (en moyenne, et suivant les tests réalisés, régression de l'infection en 48 heures) , sont donc plus rapides que ceux obtenus par les antibiotiques classiques. seuls. Il ne présente aucun effet secondaire, il est très facile d'emploi. In addition, some patients can hardly bear the side effects of antibiotics. The product can eliminate these significant drawbacks: the results obtained (on average, and according to the tests carried out, regression of the infection in 48 hours), are therefore faster than those obtained by conventional antibiotics. alone. It has no side effects, it is very easy to use.

L'action antibactérienne à large spectre d'un des deux composants est reconnue et prouvée( Gram+: staph. ,Gram- : coti, proteus,Kleb.,..)  The broad spectrum antibacterial action of one of the two components is recognized and proven (Gram +: staph., Gram-: coti, proteus, Kleb., ..)

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@ Le produit objet de l'invention est compose de ceux huiles,

Figure img00020001

l'une dite"grasse"(lipidique) l'autre dite "esssentielle" (aromatique). @ The product which is the subject of the invention is composed of those oils,
Figure img00020001

one called "fatty" (lipid) the other called "essential" (aromatic).

1)- L'huile grasse est d'origine végétale ('vierge') ou animale (poisson) : olive, carthamme, soja,germe de blé, tournesol etc.. ou toute autre huile végétale ou animale de préférence riche en acides gras essentiels (A.G.E.) .  1) - The fatty oil is of vegetable ('virgin') or animal (fish) origin: olive, carthamme, soya, wheat germ, sunflower etc. or any other vegetable or animal oil preferably rich in fatty acids essential (AGE).

Ces huiles riches d'acides gras chargés en phospholipides présentent des avantages majeurs : d'une part, grâce à leur structure bio-chimique elles se lient immédiatement aux molécules aromatiques , d'autre part elles facilitent l'absorbtion de ces dernières (effet 'transporteur') par les parois cellulaires des muqueuses gingivales , les A.G.E. facilitant la reconstitution de celles-ci par leur action anti-oxydante (présence de tocophénol) ; par ailleurs, les constituants des molécules lipidiques suppriment une éventuelle causticité des molécules aromatiques pour l'épithélium buccal.  These oils rich in fatty acids loaded with phospholipids have major advantages: on the one hand, thanks to their bio-chemical structure they bind immediately to aromatic molecules, on the other hand they facilitate the absorption of the latter (effect ' transporter ') through the cell walls of the gingival mucosa, EFAs facilitating the reconstitution of these by their antioxidant action (presence of tocophenol); moreover, the constituents of the lipid molecules suppress a possible causticity of the aromatic molecules for the buccal epithelium.

2)- L'huile essentielle (aromatique) à utiliser de préférence : elle est extraite des feuilles d'une plante nommée Melaleuca alternifolia (terpinène-4- Olifera) originaire d'extrême orient , à feuilles alternées à terpinol-4- de la famille des myrtacées .. 2) - The essential oil (aromatic) to be used preferably: it is extracted from the leaves of a plant called Melaleuca alternifolia (terpinene-4- Olifera) originating in the Far East, with leaves alternating with terpinol-4- of the myrtaceae family ..

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Ses principes actifs sont ( pourcentages moyens pouvant varier suivant les récoltes) :

Figure img00030001

- Monoterpènes :q pi nène(3%) ,j$ pinène (0,4% - 1 %), myrcène (0,5%-1 J5%t c et y terpinènes (7%-8% et 14%-18% ), paracymène (3%-16% ) ,limonène bzz- 3%) , J terpi no 1 ène (3% - Sesquiterpènes : 8 caryophyllène (1 J2%) aromadendrène (2,75 %) , allo-aromadendrène (0,4%) , viridiflorène (1%),
Figure img00030002

0 et ≈cadinéne t,5- . Its active ingredients are (average percentages which may vary depending on the harvest):
Figure img00030001

- Monoterpenes: q pi nene (3%), j $ pinene (0.4% - 1%), myrcene (0.5% -1 J5% tc and y terpinenes (7% -8% and 14% -18%) ), paracymene (3% -16%), limonene bzz- 3%), J terpi no 1 ene (3% - Sesquiterpenes: 8 caryophyllene (1 J2%) aromadendrene (2.75%), allo-aromadendrene (0, 4%), viridiflorene (1%),
Figure img00030002

0 and ≈cadinene t, 5-.

-Alcools monoterpéniques (45-50) : terpinène(45%-50%) ci.. terpi nec 1 (3 J5%-5%) J terpineol p-cymenol-8 (0,1%) ; trans et cis thujanol -4 (tr).

Figure img00030003

- Alcools sesquiterpeniques : globulol , J viridif1orol . - Oxydes terpeniques : 1,4 -cineole , 1,8-cineole (5,9) , epoxycargophyllène II. - Monoterpene alcohols (45-50): terpinene (45% -50%) ci .. terpi nec 1 (3 J5% -5%) J terpineol p-cymenol-8 (0.1%); trans and cis thujanol -4 (tr).
Figure img00030003

- Sesquiterpenic alcohols: globulol, J viridif1orol. - Terpenic oxides: 1,4-cineole, 1,8-cineole (5,9), epoxycargophyllene II.

Le produit objet de l'invention est l'association de 50% à 70% d'une huile grasse ,si possible riche en acides gras polyinsaturés; avec 50% à 30% d'huile essentielle de Melaleuca alternifolia ; cette proportion pouvant varier suivant les teneurs des différents principes actifs , cette huile essentielle peut être remplacée par toute autre ou être associée à d'autres si elles présentent des caractéristiques bio-chimiques similaires et/ou si elles ont traditionnellement le même type d'action thérapeutique adjuvante. The product which is the subject of the invention is the combination of 50% to 70% of a fatty oil, if possible rich in polyunsaturated fatty acids; with 50% to 30% essential oil of Melaleuca alternifolia; this proportion being able to vary according to the contents of the various active ingredients, this essential oil can be replaced by any other or be associated with others if they have similar bio-chemical characteristics and / or if they have traditionally the same type of action adjuvant therapy.

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Le mélange homogène est obtenu par simple malaxage des deux produits dans un environnement technique respectant les normes admises dans la production de produits cosmétiques ou alimentaires.  The homogeneous mixture is obtained by simple mixing of the two products in a technical environment respecting the standards accepted in the production of cosmetic or food products.

L'utilisation s'opère à l'aide d'un coton tige(ou le bout du doigt) que l'on humecte du produit et que l'on frotte sur la zone de la gencive infectée pendant quelques minutes; cette opération doit être renouvelée plusieurs fois par jour(au moins trois fois ) pour obtenir un résultat significatif et rapide. The use is carried out using a cotton swab (or the tip of the finger) which one moistens with the product and which one rubs on the area of the infected gum for a few minutes; this operation must be repeated several times a day (at least three times) to obtain a significant and rapid result.

Le produit non absorbé par la muqueuse gingivale peut être avalé sans inconvénient, les actions secondaires de l'huile essentielle de melaleuca alternifolia étant positives pour l'organisme et ne présentent ni contre -indication connue , ni toxicité , aux doses physiologiques employées . Cette composition peut agir indirectement sur la flore intestinale en la protégeant des entéro-bactéries parfois responsables de parodontolyses .  The product not absorbed by the gingival mucosa can be swallowed without drawback, the secondary actions of the essential oil of melaleuca alternifolia being positive for the organism and have no known contraindication or toxicity at the physiological doses used. This composition can act indirectly on the intestinal flora by protecting it from entero-bacteria sometimes responsible for periodontolysis.

Présentation et conditionnement:
Compte tenu de son utilisation limitée dans le temps(8 jours maximum) et des faibles quantités employées quotidiennement le produitpourra être conditionné en flacon de 10 ml. de couleur marron (protection de la lumière) , Presentation and packaging:
Taking into account its limited use in time (8 days maximum) and the small quantities used daily, the product can be packaged in a 10 ml bottle. brown in color (light protection),

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obligatoirement en verre à fermeture hermétique.  must be made of hermetically sealed glass.

La conservation du produit ne dépassera pas 6 mois , la température ambiante n'a pas d'influence sur ses qualités mais à la longue il peut se produire une oxydation de l'hune grasse et une perte aromatique de l'huile essentielle , l'étanchéité de la fermeture n'étant jamais totale.The conservation of the product will not exceed 6 months, the ambient temperature has no influence on its qualities but in the long term there may occur an oxidation of the oily skin and an aromatic loss of the essential oil, the sealing of the closure is never complete.

Claims (3)

REVENDICATIONS: 1-Produit naturel associant une huile grasse et une huile essentielle , celle-ci traditionnellement connue pour son efficacité thérapeutique anti infectieuse, adjuvant ou non d'antibiotiques, agissant localement sur le parodonte et notamment sur les parulies . CLAIMS: 1-Natural product combining a fatty oil and an essential oil, the latter traditionally known for its therapeutic anti-infectious efficacy, adjuvant or not of antibiotics, acting locally on the periodontium and in particular on the warblers. 2- Composition selon la revendication 1 , caractérisée en ce qu'elle renferme une huile grasse d'origine végétale ou animale en quantité majoritaire , et une huile essentielle ou aromatique appelée mélaleuca alternifolia qui sera utilisée prioritairement mais qui peut être remplacée par une ou d'autres huiles essentielles équivalentes. 2- Composition according to claim 1, characterized in that it contains a fatty oil of plant or animal origin in majority amount, and an essential or aromatic oil called melaleuca alternifolia which will be used primarily but which can be replaced by one or d '' other equivalent essential oils. 3- Composition selon les revendications 1 et 2 qui peut agir indirectement sur la flore intestinale en la protégeant des entéro-bactéries parfois responsables de parodontolyses .3- Composition according to claims 1 and 2 which can act indirectly on the intestinal flora by protecting it from entero-bacteria sometimes responsible for periodontolysis.
FR9306393A 1993-05-24 1993-05-24 Combination of a fatty oil and one or more aromatic essential oils Pending FR2705571A1 (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996009834A1 (en) * 1994-09-27 1996-04-04 Joan Louise Hibberd Treatment of periodontal and acute gingival infections
FR2737120A1 (en) * 1995-07-27 1997-01-31 Bionatec Sarl Prodn. of solid granules for crunching or swallowing, preventing evapn. of essential oils - by spraying binder onto crystallised core substance, powdering with core substance, drying, sieving and impregnating with essential oil
WO1999048511A1 (en) * 1998-03-24 1999-09-30 Farmila - Farmaceutici Milano S.R.L. Antifungal and antibacterial compositions containing melaleuca essential oil
WO2008135796A2 (en) * 2007-05-08 2008-11-13 Panayiotis Miltiadous Liquid vegetable tooth paste in spray or drop
CN107432896A (en) * 2017-08-21 2017-12-05 南宁学院 One kind decayed tooth spraying and preparation method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3407860A1 (en) * 1983-03-03 1984-09-06 Ramot University Authority For Applied Research And Industrial Development Ltd., Tel Aviv COMPOSITIONS FOR DENTAL AND ORAL HYGIENE AND THEIR USE
FR2618670A1 (en) * 1987-07-28 1989-02-03 Philip Gerard Medicinal preparation based on essential oils, as well as toothpaste and chewing gum containing it
US4925655A (en) * 1988-03-04 1990-05-15 Robell Research Powder composition for forming a mouthwash
US4971788A (en) * 1989-01-27 1990-11-20 Medicontrol Corporation Oral cavity and dental microemulsion products

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3407860A1 (en) * 1983-03-03 1984-09-06 Ramot University Authority For Applied Research And Industrial Development Ltd., Tel Aviv COMPOSITIONS FOR DENTAL AND ORAL HYGIENE AND THEIR USE
FR2618670A1 (en) * 1987-07-28 1989-02-03 Philip Gerard Medicinal preparation based on essential oils, as well as toothpaste and chewing gum containing it
US4925655A (en) * 1988-03-04 1990-05-15 Robell Research Powder composition for forming a mouthwash
US4971788A (en) * 1989-01-27 1990-11-20 Medicontrol Corporation Oral cavity and dental microemulsion products

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
C.F. CARSON E.A.: "ANTIMICOBIAL ACTIVITY OF THE ESSENTIAL OIL OF MELALEUCA ALTERNIFOLIA", LETTERS IN APPLIED MICROBIOLOGY, vol. 16, no. 2, February 1993 (1993-02-01), pages 49 - 55 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996009834A1 (en) * 1994-09-27 1996-04-04 Joan Louise Hibberd Treatment of periodontal and acute gingival infections
FR2737120A1 (en) * 1995-07-27 1997-01-31 Bionatec Sarl Prodn. of solid granules for crunching or swallowing, preventing evapn. of essential oils - by spraying binder onto crystallised core substance, powdering with core substance, drying, sieving and impregnating with essential oil
WO1999048511A1 (en) * 1998-03-24 1999-09-30 Farmila - Farmaceutici Milano S.R.L. Antifungal and antibacterial compositions containing melaleuca essential oil
WO2008135796A2 (en) * 2007-05-08 2008-11-13 Panayiotis Miltiadous Liquid vegetable tooth paste in spray or drop
WO2008135796A3 (en) * 2007-05-08 2009-07-30 Panayiotis Miltiadous Liquid vegetable tooth paste in spray or drop
CN107432896A (en) * 2017-08-21 2017-12-05 南宁学院 One kind decayed tooth spraying and preparation method thereof

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