FR2684002A1 - Treatment of AIDS by means of aqueous compositions in which the base, which is unavoidable at the present time, consists, before potentiation, of organosilicon derivatives - Google Patents

Abstract

The invention relates to compositions intended for the treatment of AIDS, consisting of aqueous solutions containing organosilicon derivatives possessing silanol functions, the solutions being stabilised with one or more organic acids. These compositions constitute an unavoidable base, which is potentiated by the addition of organic and inorganic sulphur-containing derivatives, and/or of mother tinctures such as those of stinging and sucking insects or homeopathic dilutions thereof.

Description

 The AIDS virus is a very special virus that differs from all the others; in all cases, it results in the death of patients affected by this virus, in the current state of knowledge.

 This explains why various compositions claimed for the treatment of virus diseases (Le Ribault, Nardou, Bonnaval-Lamothe, European Patent No. 0228978 issued on 04-27-1991) have no effect on the treatment of AIDS.

 The present invention relates to the treatment of AIDS with compositions consisting of aqueous solutions containing organosilicon derivatives having silanol functions, stabilized by one or more organic acids.

 These compositions constitute an essential base, which is potentiated by the addition of organic and mineral sulfur derivatives (excluding thiosulfates) such as penicillin, sulfites or bisulfites alkali or magnesium, oa list is not exhaustive) , or / and mother tinctures such as those of biting and sucking insects or their homeopathic dilutions.

ou

dans lesquels:
- n est un nombre entier compris entre 1 et 1000, mais de préférence entre 1 et 50
- p,q,r sont des nombres entiers compris entre 0 et 1000, mais de préférence entre 0 etc0;
- R et R' des groupements qui peuvent être aliphatiques linéaires ou ramifiés, cycianiques, saturés ou non, hétéroaliphatiques, linéaires ou ramifiés, cycliques saturés ou non, aromatiques, hétéroaromatiques, arylaliphatiques ou hétéroarylaliphatiques, qui peuvent être également fonctionnels, ou une combinaison de ces diverses possibilités;
- R peut aussi être un groupe hydroxyle ou être remplacé par OR ou OSiR3 (R étant défini comme ci-avant); - z signifie R, H ou OSiR3;;
- ' correspond à R et plus particulièrement méthyle, ou encore à OR, OH ou OSiR3;
- R" est égal à R, R' où z est constitué d'une chaîne polysiloxanique bi- ou trifonctionnelle dans laquelle les substituants sont R, OH, ou OM- (M étant un atome de potassium, de sodium ou de lithium).1 / The organosilicon compounds are compounds of formula

or

wherein:
- n is an integer between 1 and 1000, but preferably between 1 and 50
- p, q, r are whole numbers between 0 and 1000, but preferably between 0 and 0;
- R and R 'groups which may be linear or branched aliphatic, cycianic, saturated or unsaturated, heteroaliphatic, linear or branched, cyclic saturated or unsaturated, aromatic, heteroaromatic, arylaliphatic or heteroarylaliphatic, which may also be functional, or a combination of these various possibilities;
- R can also be a hydroxyl group or be replaced by OR or OSiR3 (R being defined as above); - z means R, H or OSiR3 ;;
- 'corresponds to R and more particularly methyl, or also to OR, OH or OSiR3;
- R "is equal to R, R 'where z consists of a bi- or trifunctional polysiloxane chain in which the substituents are R, OH, or OM- (M being a potassium, sodium or lithium atom).

It is possible to use the organosilicon compounds which are sold commercially such as potassium methylsiliconate 51 T (Rhodorsil) sold by the Company
RHONE-POULENC, 18, Avenue d'Alsace, 92400 COURBEVOIE or those obtained by hydrolysis of precursors such as silazanes, alkoxysilanes or chlorosilanes for example.

 The organosilicon derivative will be used in a concentration varying from 10 to 10-2 mol / l.

 20 / These derivatives are stabilized by the addition of one or more organic acids (or their salts, particularly the alkaline salts) such as salicyclic acid, citric acid, propionic acid, aspartic acid, glutaric acid, glutamic acid, ascorbic acid, the list is not exhaustive.

 The organic acid (s) or its (their) alkaline salts is (are) used in concentration varying from 10-7 to 10-2 mol / l.

 3 / The sulfur derivatives used are organic or mineral derivatives such as penicillin, a bisulfite or an alkali or magnesium sulfite, the list not being limiting.

These various sulfur derivatives are sold commercially, in particular by
Prolabo, 65, Boulevard Richard Lenoir, 75011 Paris.

 These derivatives are used in concentrations varying from 10-7 to 10.2 mol / l.

 40 / Macerations in alcohol at 600, for twenty-one days, of biting and sucking insects such as the mosquito Culex Pipiens, the bug Cimex Lectularius, the flea Pulex Irritans, the louse Pédiculus Capitis, are prepared according to the protocol used in homeopathy to obtain the mother tinctures of these various insects.

 It is also possible to use, from these mother tinctures, usual homeopathic dilutions of 5 CH to 30 CH.

 The mother tinctures of biting and sucking insects are used at a rate of 0.001 ml to 0.1 ml per liter.

 When using 5CH homeopathic dilutions of these mother tinctures, 2 to 100 grains of 5CH homeopathic preparations are used per liter.

 The compositions being made up, the pH is adjusted between 3.5 and 8 and preferably between 5 and 7.

EXAMPLE 1
Mister D. Lab ... D, 26 years old, did a first blood test in September 1989, he is then HIV negative. A second examination, carried out a month later, reveals that Mr. D. Lab ... is then HIV positive. n at this time presents a picture with frequent diarrhea, otolaryngological and bronchial infections as well as chronic gengivitis.

He then begins treatment with a solution prepared as follows:
- 1 g of citric acid is introduced into a 1 liter beaker and 700 ml of distilled water are added.

 2.2 ml of a potassium methylsiliconate solution containing 51% dry extract are poured slowly over this solution, with vigorous stirring.

 Then add 20 grains of Culex Pipiens 5CH and shake vigorously.

 It is made up to 1000 ml after having brought the pH to 4.7 with potassium hydrogen carbonate.

 The inside of the forearms is dabbed with a cotton pad soaked in the previous solution (the organosilicon compound present in the solution has the property of easily crossing the epidermis and the dermis [Gueyne, Duffaut, Quilichini Therapy, 1962,17,417]).

 Then apply a cotton pad (about 6cm / 6cm) soaked in the same solution to the patient's chest. This compress is covered with a plastic sheet of 15 cm / l5cm approximately), to maintain humidity. It is maintained for 8 to 10 hours a day (preferably at night). The treatment is continued every day, changing the compress to avoid possible skin irritation.

 The course of the disease is monitored clinically and biologically.

 Clinically, after three months, the diarrhea disappeared. The gingivitis has regressed and there is progressive healing of the lesions. On the other hand, infectious episodes of the respiratory tract no longer manifest themselves.

 The general condition of the patient is satisfactory. The winter of 1990-1991 took place without any notable pathological incident In August 1991, he presented a brief gastroenteritis following the injection of shellfish.

From the biological point of view, the different assessments are summarized in the following table: 01/07/90 T4 = 553 T8 = 735 Td / r8 = 0.75 total lymph 1730 29/08/90 T4 = 1024 T8 = 1280 T4 / T8 = 0.8 total lymph 3006 11/16/90 T4 = 638 T8 = 589 T4 / T8 = 1.08 total lymph 1838 05/22/91 T4 = 1023 T8 975 T4 / T8 = 1.05 lymph .total 2624 11/02/91 T4 = 1080 T8 = 987 T4 / T8 = l, l lymph.total 2872
This observation shows a normalization of blood parameters and a clinical improvement directly attributable to the application of the treatment: in fact, the patient was not subjected to any other treatment and, in the absence of any treatment, such
results have never been observed.

The one year hindsight we have does not allow a definitive conclusion
especially the fact that the patient remains HIV positive.

EXAMPLE 2
Mr. B. Cos ..., 28 years old, learns in March 1991, that he is HIV positive and that he
has significant blood changes. Clinically it has no
typical table if not a slight asthenia and a weight loss of 5 kg which can be
just as well due to a new, more tiring job than to the illness itself.

He then begins treatment with a solution prepared as follows:
1 g of citric acid is introduced into a 1 liter beaker and 700 ml are added.
distilled water.

Slowly poured onto this solution, with vigorous stirring, 2.2 ml of a
potassium methylsiliconate solution 51% dry extract.

5 ml of a normal solution of sodium hydrogen sulfite are then added and
shakes vigorously.

Make up to 1000 ml after bringing the pH to 4.7 with
potassium hydrogen carbonate.

 The patient is followed clinically and biologically from March to October 1991.

 The clinical condition is satisfactory, with weight gain of 3 kg.

 The asthenia has eased.

The biological results are summarized in the following table: 01/03/91 T4 = 364 T3 = 616 Td / r8 0.59 Total lymph 1256 02/05/91 T4 = 1062 T8 = 1040 Td / rs = 1.03 Lymph .total 2685 10/30/91 T4 = 1150 T8 = 1052 "TJr8 = 1.10 Lymph.total 2786
The evolution seems rather favorable and encourages the continuation of the treatment.

Claims (10)

1 - Compositions intended for the treatment of AIDS characterized in that the base, essential to date, consists of aqueous solutions containing organosilicon derivatives having silanol functions stabilized by one or more organic acids (or their alkaline salts), the pH being adjusted between 3.5 and 8 and preferably between Set7. 2 - Compositions intended for the treatment of AIDS according to claim 1, in which the organosilicon derivatives have the formula:

 or

 wherein:  - n is an integer between 1 and 1000 but preferably between 1 and 50;  - p, q, r are whole numbers between 0 and 1000 but preferably between 0 and 50;  - R and R 'are groups which can be linear or branched aliphatic, or cyclic, saturated or unsaturated, linear or branched heteroaliphatic, cyclic  saturated or unsaturated, aromatic, heteroaromatic, arylaliphatic or heteroarylaliphatic, which may also be functional, or a combination of  these various possibilities.  potassium, sodium or lithium).  trifunctional in which the substituents are R, OH, or OM- (M being an atom of  R "is equal to R, R 'where z consists of a bi- or polysiloxane chain OSiR3;  - l: 'corresponds to R and more particularly methyl, or alternatively to OR, OH or  being defined as above); - z signifies R, H or OSiR3;  - R can also be a hydroxyl group or be replaced by OR or OSiR3 (R 3 - Compositions intended for the treatment of AIDS according to claim 1, consisting of organosilicon derivatives defined according to claim 2, in which the organosilicon derivatives are used at a concentration between 10 to 10-2 mol / liter. 4 - Compositions intended for the treatment of AIDS according to claim 1, consisting of organosilicon derivatives according to claims 2 and 3, in which the aqueous base solutions of organosilicon derivatives are stabilized by addition of one or more organic acids (or their salts , especially alkaline salts) such as, for example, salicylic acid, citric acid, propionic acid, aspartic acid, glutaric acid, glutamic acid, ascorbic acid. 5 - Compositions intended for the treatment of AIDS according to claim 1, constituted according to claims 2, 3 and 4, in which the aqueous base solutions of the organosilicon derivatives are stabilized by organic acids which are used at a concentration between 10-7 mol / liter and 10-2 mole / liter. 6 - Compositions intended for the treatment of AIDS according to claim 1, constituted according to claims 2, 3, 4 and 5, in which the aqueous base solutions of the organosilicon derivatives are potentiated by the addition of an organic or mineral sulfur derivative. 7 - Compositions intended for the treatment of AIDS according to claim 1, constituted according to claims 2, 3, 4, 5 and 6, in which the aqueous base solution of the organosilicon derivatives is potentiated by the addition of an organic sulfur derivative such than penicillin and / or a bisulfite or an alkali or magnesium sulfite, several different additions can be made. 8 - Compositions intended for the treatment of AIDS according to claim 1, constituted according to claims 2, 3, 4, 5, 6 and, 7 in which the aqueous base solution of the organosilicon derivatives is potentiated by addition of a sulfur derivative defined in claim 7 in which the sulfur derivative (s) are used at a concentration between 10: 1 moles and 10-2 moles / l. 9 - Compositions intended for the treatment of AIDS according to claim 1, constituted according to claims 2, 3, 4 and 5, in which the aqueous base solution of the organosilicon derivatives is potentiated by the addition of mother tincture (s) biting and sucking insects, used at the rate of 0.001 to 0.1 ml per liter of solution, or of corresponding homeopathic dilutions used, by way of nonlimiting example, at the rate of 2 to 100 grains of dilution 5 CH per liter of solution. 10) Compositions intended for the treatment of AIDS according to claim 1, constituted according to claims 2,3,4,5,6,7, and 8, in which the aqueous base solution of the organosilicon derivatives is potentiated on the one hand by l 'addition of an organic sulfur derivative such as penicillin and / or a bisulfite or an alkali or magnesium sulfite, several different additions can be made and, on the other hand, by the addition of dye (s ) mother (s) of biting and sucking insects, used at a rate of 0.001 to 0.1 ml per liter of solution, or of corresponding homeopathic dilutions used, by way of nonlimiting example, at a rate of 2 to 100 grains of 5 CH dilution per liter of solution.