FR2679248A1 - Bioreacteur et dispositif pour la culture de cellules animales. - Google Patents
Bioreacteur et dispositif pour la culture de cellules animales. Download PDFInfo
- Publication number
- FR2679248A1 FR2679248A1 FR9109159A FR9109159A FR2679248A1 FR 2679248 A1 FR2679248 A1 FR 2679248A1 FR 9109159 A FR9109159 A FR 9109159A FR 9109159 A FR9109159 A FR 9109159A FR 2679248 A1 FR2679248 A1 FR 2679248A1
- Authority
- FR
- France
- Prior art keywords
- bioreactor according
- bioreactor
- turnstiles
- culture chamber
- cell culture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241001465754 Metazoa Species 0.000 title description 2
- 238000004113 cell culture Methods 0.000 claims abstract description 27
- 239000012528 membrane Substances 0.000 claims abstract description 20
- 210000004102 animal cell Anatomy 0.000 claims abstract description 19
- 210000004027 cell Anatomy 0.000 claims abstract description 18
- 239000001963 growth medium Substances 0.000 claims description 22
- 239000002609 medium Substances 0.000 claims description 19
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 14
- 239000002207 metabolite Substances 0.000 claims description 13
- 239000012526 feed medium Substances 0.000 claims description 12
- 239000007789 gas Substances 0.000 claims description 12
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 10
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 10
- 239000011707 mineral Substances 0.000 claims description 10
- 239000001301 oxygen Substances 0.000 claims description 10
- 229910052760 oxygen Inorganic materials 0.000 claims description 10
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 7
- 239000001569 carbon dioxide Substances 0.000 claims description 7
- 239000000523 sample Substances 0.000 claims description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
- 210000004748 cultured cell Anatomy 0.000 claims description 3
- 230000001105 regulatory effect Effects 0.000 claims description 3
- 230000001788 irregular Effects 0.000 claims description 2
- 229910052757 nitrogen Inorganic materials 0.000 claims description 2
- 238000009530 blood pressure measurement Methods 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 239000008267 milk Substances 0.000 claims 1
- 210000004080 milk Anatomy 0.000 claims 1
- 235000013336 milk Nutrition 0.000 claims 1
- 238000001914 filtration Methods 0.000 abstract description 2
- 239000007788 liquid Substances 0.000 description 7
- 238000013019 agitation Methods 0.000 description 5
- 235000015097 nutrients Nutrition 0.000 description 5
- 238000002156 mixing Methods 0.000 description 3
- 239000003507 refrigerant Substances 0.000 description 3
- 238000000108 ultra-filtration Methods 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 239000004809 Teflon Substances 0.000 description 2
- 229920006362 Teflon® Polymers 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- MCMNRKCIXSYSNV-UHFFFAOYSA-N Zirconium dioxide Chemical compound O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 238000009833 condensation Methods 0.000 description 2
- 230000005494 condensation Effects 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- NJXPYZHXZZCTNI-UHFFFAOYSA-N 3-aminobenzonitrile Chemical compound NC1=CC=CC(C#N)=C1 NJXPYZHXZZCTNI-UHFFFAOYSA-N 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 229910052681 coesite Inorganic materials 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 229910052906 cristobalite Inorganic materials 0.000 description 1
- 239000013530 defoamer Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000008246 gaseous mixture Substances 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 150000001247 metal acetylides Chemical class 0.000 description 1
- 239000012982 microporous membrane Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 150000004767 nitrides Chemical class 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 238000005373 pervaporation Methods 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229910052682 stishovite Inorganic materials 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 229910052905 tridymite Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/02—Stirrer or mobile mixing elements
Landscapes
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9109159A FR2679248A1 (fr) | 1991-07-19 | 1991-07-19 | Bioreacteur et dispositif pour la culture de cellules animales. |
| PCT/FR1992/000691 WO1993002179A1 (fr) | 1991-07-19 | 1992-07-16 | Bioreacteur et dispositif pour la culture de cellules animales |
| DE69213695T DE69213695T2 (de) | 1991-07-19 | 1992-07-16 | Bioreaktor und vorrichtung zur kultivierung von tierischen zellen |
| DK92916487T DK0549782T3 (en, 2012) | 1991-07-19 | 1992-07-16 | |
| EP92916487A EP0549782B1 (fr) | 1991-07-19 | 1992-07-16 | Bioreacteur et dispositif pour la culture de cellules animales |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9109159A FR2679248A1 (fr) | 1991-07-19 | 1991-07-19 | Bioreacteur et dispositif pour la culture de cellules animales. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2679248A1 true FR2679248A1 (fr) | 1993-01-22 |
| FR2679248B1 FR2679248B1 (en, 2012) | 1994-07-13 |
Family
ID=9415321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR9109159A Granted FR2679248A1 (fr) | 1991-07-19 | 1991-07-19 | Bioreacteur et dispositif pour la culture de cellules animales. |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0549782B1 (en, 2012) |
| DE (1) | DE69213695T2 (en, 2012) |
| DK (1) | DK0549782T3 (en, 2012) |
| FR (1) | FR2679248A1 (en, 2012) |
| WO (1) | WO1993002179A1 (en, 2012) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0789072A3 (en) * | 1995-08-15 | 1998-05-13 | Becton, Dickinson and Company | Growth environment assembly and method of use therof |
| FR2955591A1 (fr) * | 2010-01-26 | 2011-07-29 | Centre Nat Rech Scient | Dispositif de controle et de regulation de la pression partielle en oxygene et son utilisation dans des essais in vitro permettant de respecter la " physioxie " |
| WO2012115586A1 (en) * | 2011-02-24 | 2012-08-30 | Ge Healthcare Bio-Sciences Ab | Bioreactor with feed and harvest flow through filter assembly |
| CN111801410A (zh) * | 2017-12-20 | 2020-10-20 | 尤尼沃尔塞尔斯技术股份公司 | 生物反应器及相关方法 |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10120835C2 (de) * | 2001-04-27 | 2003-04-10 | Sifin Inst Fuer Immunpraeparat | Verfahren zur Herstellung von monoklonalen Antikörpern |
| DE102004032318B4 (de) * | 2004-07-02 | 2015-08-20 | Technische Hochschule Mittelhessen | Herstellung einer konzentrierten Lösung aus biologischen Substanzen |
| CN101043832A (zh) | 2004-10-22 | 2007-09-26 | 株式会社资生堂 | 嘴唇的分类方法，化妆方法，分类图谱及化妆用器具 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4178209A (en) * | 1977-11-14 | 1979-12-11 | Monsanto Company | Continuous cell culture method and apparatus |
| DE3539609A1 (de) * | 1985-11-08 | 1987-05-14 | Diessel Gmbh & Co | Vorrichtung zur begasung einer fluessigkeit |
| US5002890A (en) * | 1988-11-29 | 1991-03-26 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Spiral vane bioreactor |
| FR2640638B1 (fr) * | 1988-12-20 | 1991-02-15 | Commissariat Energie Atomique | Bioreacteur et dispositif pour la culture de cellules animales |
-
1991
- 1991-07-19 FR FR9109159A patent/FR2679248A1/fr active Granted
-
1992
- 1992-07-16 WO PCT/FR1992/000691 patent/WO1993002179A1/fr active IP Right Grant
- 1992-07-16 DK DK92916487T patent/DK0549782T3/da active
- 1992-07-16 DE DE69213695T patent/DE69213695T2/de not_active Expired - Fee Related
- 1992-07-16 EP EP92916487A patent/EP0549782B1/fr not_active Expired - Lifetime
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0789072A3 (en) * | 1995-08-15 | 1998-05-13 | Becton, Dickinson and Company | Growth environment assembly and method of use therof |
| FR2955591A1 (fr) * | 2010-01-26 | 2011-07-29 | Centre Nat Rech Scient | Dispositif de controle et de regulation de la pression partielle en oxygene et son utilisation dans des essais in vitro permettant de respecter la " physioxie " |
| WO2012115586A1 (en) * | 2011-02-24 | 2012-08-30 | Ge Healthcare Bio-Sciences Ab | Bioreactor with feed and harvest flow through filter assembly |
| US9428724B2 (en) | 2011-02-24 | 2016-08-30 | Ge Healthcare Bio-Sciences Ab | Bioreactor with feed and harvest flow through filter assembly |
| CN111801410A (zh) * | 2017-12-20 | 2020-10-20 | 尤尼沃尔塞尔斯技术股份公司 | 生物反应器及相关方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE69213695T2 (de) | 1997-03-20 |
| EP0549782B1 (fr) | 1996-09-11 |
| DE69213695D1 (de) | 1996-10-17 |
| EP0549782A1 (fr) | 1993-07-07 |
| FR2679248B1 (en, 2012) | 1994-07-13 |
| WO1993002179A1 (fr) | 1993-02-04 |
| DK0549782T3 (en, 2012) | 1997-03-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |