FR2659351B1 - DELIPID POLYSACCHARIDE COMPOUND, PREPARATION METHOD, COMPOSITIONS COMPRISING SAME. - Google Patents

DELIPID POLYSACCHARIDE COMPOUND, PREPARATION METHOD, COMPOSITIONS COMPRISING SAME.

Info

Publication number
FR2659351B1
FR2659351B1 FR9002957A FR9002957A FR2659351B1 FR 2659351 B1 FR2659351 B1 FR 2659351B1 FR 9002957 A FR9002957 A FR 9002957A FR 9002957 A FR9002957 A FR 9002957A FR 2659351 B1 FR2659351 B1 FR 2659351B1
Authority
FR
France
Prior art keywords
compound
weight
delipid
compositions
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9002957A
Other languages
French (fr)
Other versions
FR2659351A1 (en
Inventor
Hans Binz
Lucien Dussourd D Hinterland
Gerard Normier
Alain Le Pape
Michel Favaron
Souhail Delassan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Priority to FR9002957A priority Critical patent/FR2659351B1/en
Priority to AU72637/91A priority patent/AU646842B2/en
Priority to CA002037741A priority patent/CA2037741A1/en
Priority to DK91400648.1T priority patent/DK0446143T3/en
Priority to EP91400648A priority patent/EP0446143B1/en
Priority to AT91400648T priority patent/ATE116662T1/en
Priority to ES91400648T priority patent/ES2068527T3/en
Priority to DE69106406T priority patent/DE69106406T2/en
Priority to JP3069255A priority patent/JPH04220401A/en
Publication of FR2659351A1 publication Critical patent/FR2659351A1/en
Application granted granted Critical
Publication of FR2659351B1 publication Critical patent/FR2659351B1/en
Priority to US08/369,430 priority patent/US5601799A/en
Priority to GR950400672T priority patent/GR3015538T3/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/06—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/16—Antibodies; Immunoglobulins; Fragments thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/26—Klebsiella (G)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Polymers & Plastics (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Radiology & Medical Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Materials Engineering (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Polysaccharide D 25 compound partially delipidated and its derivatives, characterised in that at least 85 % by weight, preferably 90 %, of the compound is in aqueous solution in monomeric form. Reference is made in particular to the polysaccharide compound of molecular weight 30 kD extracted from membrane proteoglycan of the bacteria Klebsiella pneumoniae. The content of palmitic fatty acids which are bonded to it in esterified form does not excees 0.01 % by weight of the compound and the content of palmitic fatty acids which are associated with it in free form does not exceed 0.1 % by weight of the compound.
FR9002957A 1990-03-08 1990-03-08 DELIPID POLYSACCHARIDE COMPOUND, PREPARATION METHOD, COMPOSITIONS COMPRISING SAME. Expired - Fee Related FR2659351B1 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
FR9002957A FR2659351B1 (en) 1990-03-08 1990-03-08 DELIPID POLYSACCHARIDE COMPOUND, PREPARATION METHOD, COMPOSITIONS COMPRISING SAME.
AU72637/91A AU646842B2 (en) 1990-03-08 1991-03-06 Lipid-free polysaccharide compound, preparation process, compositions containing it
CA002037741A CA2037741A1 (en) 1990-03-08 1991-03-07 Delipidated polysaccharide composition, method for preparing same
EP91400648A EP0446143B1 (en) 1990-03-08 1991-03-08 Polysaccharidic delipidated compounds, process for their preparation and compositions containing them
AT91400648T ATE116662T1 (en) 1990-03-08 1991-03-08 DELIPIDATED POLYSACCHARIDE, METHOD FOR PRODUCING AND COMPOSITIONS CONTAINING SAME.
ES91400648T ES2068527T3 (en) 1990-03-08 1991-03-08 SLOW POLYACCHARIDIC COMPOUND, PREPARATION PROCEDURE, COMPOSITIONS THAT UNDERSTAND IT.
DK91400648.1T DK0446143T3 (en) 1990-03-08 1991-03-08 Degreased polysaccharide derivatives, processes for their preparation and preparations containing them
DE69106406T DE69106406T2 (en) 1990-03-08 1991-03-08 Delipidated polysaccharide, process for its preparation and compositions containing it.
JP3069255A JPH04220401A (en) 1990-03-08 1991-03-08 Polysaccharide compound having lipid removed
US08/369,430 US5601799A (en) 1990-03-08 1995-01-06 Partially delipidated D25 polysaccaride composition for imaging and diagnosis
GR950400672T GR3015538T3 (en) 1990-03-08 1995-03-23 Polysaccharidic delipidated compounds, process for their preparation and compositions containing them.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9002957A FR2659351B1 (en) 1990-03-08 1990-03-08 DELIPID POLYSACCHARIDE COMPOUND, PREPARATION METHOD, COMPOSITIONS COMPRISING SAME.

Publications (2)

Publication Number Publication Date
FR2659351A1 FR2659351A1 (en) 1991-09-13
FR2659351B1 true FR2659351B1 (en) 1994-12-02

Family

ID=9394527

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9002957A Expired - Fee Related FR2659351B1 (en) 1990-03-08 1990-03-08 DELIPID POLYSACCHARIDE COMPOUND, PREPARATION METHOD, COMPOSITIONS COMPRISING SAME.

Country Status (11)

Country Link
US (1) US5601799A (en)
EP (1) EP0446143B1 (en)
JP (1) JPH04220401A (en)
AT (1) ATE116662T1 (en)
AU (1) AU646842B2 (en)
CA (1) CA2037741A1 (en)
DE (1) DE69106406T2 (en)
DK (1) DK0446143T3 (en)
ES (1) ES2068527T3 (en)
FR (1) FR2659351B1 (en)
GR (1) GR3015538T3 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2655267B1 (en) * 1989-12-04 1992-04-03 Roussel Uclaf NOVEL GALACTANE SULPHATE DERIVATIVE EXTRACTED FROM KLEBSIELLA, PREPARATION METHOD, APPLICATION AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME.
US5406950A (en) * 1993-12-23 1995-04-18 Mallinckrodt Medical, Inc. Inhalable contrast agent
FR2717483B1 (en) * 1994-03-16 1996-06-07 Pf Medicament Preparation of a polysaccharide compound D25 defatted and purified and injectable composition comprising it.
FR2734160B1 (en) * 1995-05-18 1997-08-01 Pf Medicament USE OF A COMPOUND COMPRISING A GLYCANIC STRUCTURE FOR THE BLOCKING OF ANTIBODIES AND METHOD FOR OBTAINING SUCH A PRODUCT
CA2279147C (en) 1999-07-29 2003-02-18 Graminia Developments Ltd. Liquid for producing marker vapour, a method of producing marker vapour and a method of inspection with marker vapour
CA2438448C (en) * 2003-08-27 2008-11-18 Quality Fabricating & Machining Ltd. Leak detector
US9820986B2 (en) 2005-03-04 2017-11-21 Taiwan Hopaz Chems, Mfg. Co., Ltd. Glycopeptide compositions
RU2401839C2 (en) * 2006-02-14 2010-10-20 Кусиро Индастриал Текнолоджи Сентер Proteoglycan synthesis method
JP6688498B2 (en) * 2014-10-16 2020-04-28 地方独立行政法人青森県産業技術センター Degradation method and degradation product of proteoglycan

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4285936A (en) * 1979-12-10 1981-08-25 The United States Of America As Represented By The Secretary Of The Army Method for producing a vaccine against bacterial infections caused by pseudomonas aeruginosa
DE3224788A1 (en) * 1981-07-17 1983-02-03 South African Inventions Development Corp., Scientia, Pretoria,Transvaal CARRIER-TIED IMMUNOGENIC MATERIAL
US4873088A (en) * 1983-09-06 1989-10-10 Liposome Technology, Inc. Liposome drug delivery method and composition
FR2598434B1 (en) * 1986-05-12 1988-09-16 Pf Medicament NEW IMMUNOMODULATORS OBTAINED BY HEMISYNTHESIS FROM A BACTERIAL POLYSACCHARIDE ISOLATED FROM AN UNCAPSULATED MUTANT STRAIN OF KLEBSIELLA PNEUMONIAE
FR2614306B1 (en) * 1987-04-22 1989-07-28 Pf Medicament NOVEL D.25 DERIVATIVE, PROCESS FOR THE PREPARATION THEREOF, USE AS AN IMMUNOSTIMULATING AGENT AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME.
FR2650506B1 (en) * 1989-07-11 1991-11-08 Roussel Uclaf GALACTANNE EXTRACT OF KLEBSIELLA, PROCESS FOR OBTAINING AND APPLICATION AS A MEDICAMENT

Also Published As

Publication number Publication date
EP0446143B1 (en) 1995-01-04
EP0446143A3 (en) 1992-02-12
AU7263791A (en) 1991-09-12
GR3015538T3 (en) 1995-06-30
EP0446143A2 (en) 1991-09-11
DE69106406T2 (en) 1995-05-24
ES2068527T3 (en) 1995-04-16
ATE116662T1 (en) 1995-01-15
CA2037741A1 (en) 1991-09-09
DE69106406D1 (en) 1995-02-16
AU646842B2 (en) 1994-03-10
US5601799A (en) 1997-02-11
FR2659351A1 (en) 1991-09-13
JPH04220401A (en) 1992-08-11
DK0446143T3 (en) 1995-03-13

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Legal Events

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ST Notification of lapse