FR2646346A1 - Composition for the topical deposition of a permeable and light-reflecting continuous film - Google Patents
Composition for the topical deposition of a permeable and light-reflecting continuous film Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
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Abstract
Description
La présente invention concerne une nouvelle composition pour le dépôt topique d'un film continu perméable et réfléchissant la lumière ainsi qu'un procédé de préparation d'une telle composition. The present invention relates to a new composition for the topical deposition of a continuous permeable and light-reflecting film and to a process for preparing such a composition.
La nouvelle composition conforme à la présente invention est particulièrement utile pour la protection contre le rayonnement, et plus particuliérement, pour la protection du derme humain ou animal contre certains rayonnements pouvant entraîner des désordres et, notamment, dans le rayonnement solaire, certaines gammes d'ultraviolets. The new composition in accordance with the present invention is particularly useful for protection against radiation, and more particularly, for the protection of the human or animal dermis against certain radiations which can cause disorders and, in particular, in solar radiation, certain ranges of ultraviolet.
Dans ce qui suit, et pour fixer les idées, on se référera à l'exemple le plus courant de la protection du derme contre les ultraviolets et autres gammes du rayonnement agressif solaire ou artificiel. In what follows, and to fix the ideas, we will refer to the most common example of the protection of the dermis against ultraviolet rays and other ranges of aggressive solar or artificial radiation.
Pendant des siècles la protection a été assurée en recourant à des dispositifs créant une zone d'ombre ou à des vêtements. Depuis quelques décennies l'usage de produits protecteurs que l'on applique sur ie derme s' est largement répandu.Ces produits, généralement sous forme de cremes ou de laits, contiennent des filtres, c'est-à-dire des molécules qui opposent aux rayons un barrage sélectif. L'efficacité de ces produits n'est pas toujours correctement répartie dans les gammes de longueur d'onde à arrêter, et fort souvent elle est particulièrement douteuse, et ceci d'autant plus qu'elle diminue rapidement avec le temps, ce qui nécessite des applications de plus en plus fréquentes. Protection has been provided for centuries by the use of shading devices or clothing. For a few decades the use of protective products which are applied to the dermis has become widespread. These products, generally in the form of creams or milks, contain filters, that is to say molecules which oppose on the shelves a selective barrage. The effectiveness of these products is not always correctly distributed in the wavelength ranges to be stopped, and very often it is particularly questionable, all the more so since it decreases rapidly over time, which requires more and more frequent applications.
Les compositions de l'art antérieur comprennent, le plus souvent un nombre non négligeable de composants et plus leur nombre est élevé, plus les risques de désordres augmentent. En effet, on a constaté de très nombreux cas de phototoxicité et de photoallergie avec les produits classiques, renforcés par la présence de stabilisants, de filtres, d'émulgateurs et autres agents tensioactifs qui induisent des pénétrations déclenchant de tels phénomènes, souvent aggravés par la présence d'eau dans les compositions. The compositions of the prior art generally include a non-negligible number of components and the higher their number, the more the risks of disorders increase. Indeed, there have been very many cases of phototoxicity and photoallergy with conventional products, reinforced by the presence of stabilizers, filters, emulsifiers and other surfactants which induce penetrations triggering such phenomena, often aggravated by the presence of water in the compositions.
Par ailleurs le recours de plus en plus étendu à des produits organiques, fréquemment de synthèse, entraîne des réactions entre composants eux-mêmes, et entre composants et peau qui sont également à l'origine de tels désordres.Furthermore, the increasingly widespread use of organic products, which are frequently synthesized, leads to reactions between components themselves, and between components and skin which are also at the origin of such disorders.
On notera également que les filtres entrant dans de telles compositions absorbent l'énergie lumineuse ce qui n'est pas non plus la solution la plus recommandable. It will also be noted that the filters used in such compositions absorb light energy, which is not the most recommendable solution either.
Il s'avère donc nécessaire de définir des compositions chimiquement et biologiquement aussi inertes que possible, tant entre composants entre eux qu'entre composants et peau.Il faut également des compositions qui assurent une véritable protection sans absorption d'énergie lumineuse, tout en présentant la perméabilité indispensable à une bonne condition du derme. On notera que, contrairement à bien des composés organiques, un très grand nombre de composés minéraux ou organométalliques présentent cette inertie chimique et biologique, et une toxicité nulle. Par ailleurs, on rencontre dans cette catégorie de composés des produits qui sont naturellement à l'état de particules réfléchissantes, ou peuvent aisément y être mis.La présente invention a donc pour but d'apporter une solution à ces divers problèmes, grâce à l'incorporation de particules inertes réfléchissantes dans une composition ne comportant ni eau ni filtre, ni additifs classiques, mais à base d'huile de silicone et de composants minéraux dont le rôle est de donner corps à des compositions stables, d'application topique aisée, pour former un film protecteur perméable, ne donnant pas lieu à dégradation rapide, assurant une bonne réflexion à la lumière, sans altérer de façon significative l'aspect de la peau. It is therefore necessary to define compositions which are chemically and biologically as inert as possible, both between components and between components and skin. It is also necessary to provide compositions which provide real protection without absorption of light energy, while having the permeability essential to a good condition of the dermis. It will be noted that, unlike many organic compounds, a very large number of mineral or organometallic compounds exhibit this chemical and biological inertness, and zero toxicity. In addition, we find in this category of compounds products which are naturally in the state of reflective particles, or can easily be put there. The present invention therefore aims to provide a solution to these various problems, thanks to the incorporation of inert reflective particles in a composition comprising neither water nor filter, nor conventional additives, but based on silicone oil and mineral components whose role is to give body to stable compositions, of easy topical application, to form a permeable protective film, not giving rise to rapid degradation, ensuring good light reflection, without significantly altering the appearance of the skin.
Pour ce faire, l'invention fait appel à des particules réfléchissantes qui renvoient le rayonnement incident, associées à un support qui leur enlève leur aspect brillant, et ne laisse pas à la peau un aspect nacré, voire pailleté ou clinquant. L'invention repose donc essentiellement sur la combinaison de particules réfléchissantes, noyées dans un support fluide plus ou moins visqueux, qui donne à l'ensemble un aspect transparent et relativement mat, ne modifiant pas l'aspect du derme ou même l'améliorant, si l'on ajoute à la combinaison des additifs cosmétiques classiques, tels que des pigments. To do this, the invention uses reflective particles which return the incident radiation, associated with a support which removes their shiny appearance from them, and does not leave the skin with a pearly, even glittery or tinsel appearance. The invention is therefore essentially based on the combination of reflective particles, embedded in a more or less viscous fluid support, which gives the whole a transparent and relatively matte appearance, not modifying the appearance of the dermis or even improving it, if conventional cosmetic additives, such as pigments, are added to the combination.
Selon une forme préférée de l'invention, on utilise des microparticules cristallines et notamment minérales, telles que du mica ou d'autres microparticules organométalliques ou éventuellement organiques, notamment polymères. Ces particules peuvent être utilisées en quantités d'autant plus faibles que leur granulométrie est également faible, dès lors que le but essentiel est de couvrir la plus grande part de la surface du derme, en une couche la plus fine possible-, pour ne pas modifier l'aspect de la peau et entraîner les craquelures ou les boulochages que pourraient provoquer des couches plus épaisses et/ou des particules plus grosses et/ou plus rondes ou plus sphériques. Ces particules sont de dimensions, de préférence, de l'ordre de 3 à 100 micromètres. According to a preferred form of the invention, crystalline and in particular mineral microparticles are used, such as mica or other organometallic or optionally organic microparticles, in particular polymers. These particles can be used in quantities which are all the smaller as their particle size is also low, as soon as the essential aim is to cover the largest part of the surface of the dermis, in the thinnest possible layer, so as not to change the appearance of the skin and cause cracking or pilling that could be caused by thicker layers and / or larger and / or rounder or more spherical particles. These particles are preferably of the order of 3 to 100 micrometers in size.
Parmi les particules réfléchissantes les plus adéquates, on peut citer celles à base de métaux d'oxydes métalliques, de silicates et autres composés métalliques physiologiquement acceptables, tels que l'oxyde de titane les "bentones" et autres composés du magnésium, de l'aluminium, du potassium, du chrome, ainsi que des composés organométalliques en particulier, de ces mêmes métaux, de divers polymères et copolymères tels que des polyuréthanes, des polymères vinyliques, certains polyéthers, notamment vinyliques. Ces produits peuvent être, de préférence, en micropaillettes ou en sphérules. Among the most suitable reflecting particles, mention may be made of those based on metals of metal oxides, silicates and other physiologically acceptable metallic compounds, such as titanium oxide "bentones" and other compounds of magnesium, aluminum, potassium, chromium, as well as organometallic compounds in particular, of these same metals, of various polymers and copolymers such as polyurethanes, vinyl polymers, certain polyethers, in particular vinyls. These products can preferably be in micropaillettes or spherules.
Les dosages de ces produits réfléchissants dans la composition totale peuvent aller de 5 à 60% en poids. The dosages of these reflective products in the total composition can range from 5 to 60% by weight.
Leur association avec des huiles silicones permet d'obtenir un produit de préférence anhydre (ce qui réduit et même supprime les pénétrations), qui ne s'écaille pas avec le temps et peut, si on le désire, n'avoir aucun aspect brillant. Their combination with silicone oils makes it possible to obtain a preferably anhydrous product (which reduces and even eliminates penetrations), which does not flake over time and can, if desired, have no shiny appearance.
La masse du produit est galéniquement nouvelle, ce n'est ni une solution, ni une émulsion, ni une suspension. Elle présente des propriétés physiques voisines de celles d'une pâte assez onctueuse, ou d'une boue argileuse, mais lors de l'application topique elle s'étale très aisément jusqu'à l'obtention d'un film très mince. De préférence, le pH du produit est de l'ordre de 6,5 à 9,5. Pour obtenir cette nouvelle matière, selon un mode de réalisation préféré de l'invention, des microparticules sont'noyées dans un liquide présentant une bonne adhérence à la peau et, en particulier, des huiles telles que des huiles silicones notamment polysiloxanes.Ce type de liquide peut être constitué par un mélange, dont au moins l'un des czmposants est volatil, mais participe à l'étalement du produit et à la répartition des particules, et au moins un autre composant sert à la fixation des particules tout en modifiant leur aspect brillant ou nacré pour redonner à la peau un aspect naturel ou, comme on l'a dit plus haut, pour l'améliorer.The mass of the product is galenically new, it is neither a solution, nor an emulsion, nor a suspension. It has physical properties close to those of a fairly smooth paste, or a clayey mud, but during topical application it spreads very easily until a very thin film is obtained. Preferably, the pH of the product is of the order of 6.5 to 9.5. To obtain this new material, according to a preferred embodiment of the invention, microparticles are embedded in a liquid having good adhesion to the skin and, in particular, oils such as silicone oils, in particular polysiloxanes. liquid can consist of a mixture, at least one of the components of which is volatile, but participates in the spreading of the product and in the distribution of the particles, and at least one other component is used for fixing the particles while modifying their shiny or pearly appearance to give the skin a natural appearance or, as mentioned above, to improve it.
Dans les exemples qui suivent, on donnera d'autres caractéristiques plus détaillées, notamment en ce qui concerne le rôle que peuvent jouer des tiers composants dans les compositions conformes à l'invention. In the examples which follow, other more detailed characteristics will be given, in particular as regards the role that third components can play in the compositions according to the invention.
En ce qui concerne le procédé, il consiste essentiellement dans la préparation d'une masse généralement fluide dans laquelle on va incorporer ensuite les microparticules réfléchissantes. As regards the method, it essentially consists in the preparation of a generally fluid mass in which the reflective microparticles are then incorporated.
Exemples 1,2 et 3
On se base sur la pondérale suivante (pourcentages en poids)
EX. 1 EX. 2 EX.3
Phényltriméthicone 20 8 23
Stéarate de magnésium 4 4 4
Bentonite 0,5 0,5 0,5
Mica 42 12 57,5
Cyclométhicone 33,3 75,3 14,8
Silice micronisée 0,2 0,2 0,2
Le phényltriméthicone est un polyphénylméthylsiloxane relativement peu volatil. On peut utiliser par exemple le produit commercial connu sous le nom DOW 556 de la SociétéDOW
CHEMICAL. On y ajoute, sous agitation douce, à une température de 700C, le stéarate de magnésium (que l'on peut d'ailleurs remplacer par tout ester d'acide gras d'un métal alcalin ou alcalino terreux) ainsi que la bentonite pulvérulente (telle que la marque "Bentone 27", ainsi que tout autre "bentone" lipophile ou rendu lipophile). On notera-que l'ester d'acide gras améliore le toucher et, s'il est choisi ae façon adéquate, il améliore la viscosité et le blanchiment du mélange. La bentonite lipophile participe à la définition de la viscosité. Son dosage doit être précis car la dispersion obtenue en cours de cette première base opératoire peut se décomposer si le dosage est trop fort ou trop faible.Examples 1,2 and 3
We use the following weight (percentages by weight)
EX. 1 EX. 2 EX.3
Phenyltrimethicone 20 8 23
Magnesium stearate 4 4 4
Bentonite 0.5 0.5 0.5
Mica 42 12 57.5
Cyclomethicone 33.3 75.3 14.8
Micronized silica 0.2 0.2 0.2
Phenyltrimethicone is a relatively low volatility polyphenylmethylsiloxane. One can use for example the commercial product known under the name DOW 556 from the company Dow
CHEMICAL. Magnesium stearate (which can also be replaced by any fatty acid ester of an alkali or alkaline earth metal) as well as pulverulent bentonite ( such as the mark "Bentone 27", as well as any other lipophilic or lipophilic "bentone"). It will be noted that the fatty acid ester improves the feel and, if chosen appropriately, it improves the viscosity and the bleaching of the mixture. Lipophilic bentonite participates in the definition of viscosity. Its dosage must be precise because the dispersion obtained during this first operating base can decompose if the dosage is too strong or too weak.
Sans chauffe supplémentaire, au cours d'une seconde phase opératoire, on ajoute le mica, du cyclométhicone (polydiméthylcyclosiloxane tel que celui connu sous le nom de "DOW 344" de la Société DOW CORNING) et la silice micronisée. Without additional heating, during a second operating phase, mica, cyclomethicone (polydimethylcyclosiloxane such as that known under the name "DOW 344" from the company Dow Corning) and micronized silica are added.
Le cyclométhicone peut être introduit aussi lors de la première phase.Cyclomethicone can also be introduced during the first phase.
Le mica est de préférence suffisamment fin, comme cela a été souligné plus haut, par exemple passant à 95% au tamis à d'ouverture de maille 0,074 mm. The mica is preferably sufficiently fine, as has been pointed out above, for example passing 95% through a sieve with a mesh opening of 0.074 mm.
La cyclométhicone présente un point d'ébullition plus bas, et surtout une tension de vapeur plus importante que le phényltriméthicone (Point d'ébullition à 1760C pour le L'DOT 344). La Silice micronisée peut être remplacée par d'autres composés lipophiles qui fixent un éventuel excédent d'huile silicone qui ne serait pas volatilisé. Cyclomethicone has a lower boiling point, and above all a higher vapor pressure than phenyltrimethicone (Boiling point at 1760C for L'DOT 344). Micronized Silica can be replaced by other lipophilic compounds which fix a possible excess of silicone oil which would not be volatilized.
On continue l'agitation douce, mais ample, pendant le refroidissement jusqu'à l'ambiante. La concentration en polyphénylméthylsiloxane est liée à la quantité de mica, à raison de préférence de 1 pour 1,5 à l pour 2,5 en poids. We continue the gentle, but ample agitation, during the cooling down to the ambient. The polyphenylmethylsiloxane concentration is linked to the amount of mica, preferably from 1 to 1.5 to 1 to 2.5 by weight.
Les produits obtenus ont cet aspect intermédiaire entre pâte et crème d'apparence mate, très légèrement nacrée, qui appliquée sur la peau, ne modifie pas son aspect. The products obtained have this intermediate appearance between dough and cream of mat appearance, very slightly pearly, which applied to the skin, does not modify its appearance.
On notera l'absence d'eau, de filtre, et de tous les additifs classiques (stabilisants, tensioactifs et autres). La composition est essentiellement minérale et ne comporte qu'une quantité minoritaire d'organométalliques. Note the absence of water, filter, and all conventional additives (stabilizers, surfactants and others). The composition is essentially mineral and contains only a minority amount of organometallic.
Il est évident que l'on peut ajouter des pigments ou colorants auxdites compositions si l'on veut pouvoir également 1'i1tiliser comme une crème cosmétique classique. It is obvious that pigments or dyes can be added to said compositions if it is also desired to be able to use it like a conventional cosmetic cream.
EXEMPLE 4. EXAMPLE 4.
On procède, comme dans le cas des exemples 1 à 3, avec la composition suivante (pourcentages en poids)
Cyclométhicone 35,5
Palmitate de magnésium 4
Microperles de polythacrylate
de méthyle 41
Phényltriméticone 18,5
Bentonite micronisée 1
On utilise ici à la place du mica de l'exemple 1 des perles polymères dont la dimension est de préférence de l'ordre de la dizaine de micromètres (de 5 à 20 micromètres comme pour les exemples 1 à 3).The procedure is, as in the case of Examples 1 to 3, with the following composition (percentages by weight)
Cyclomethicone 35.5
Magnesium palmitate 4
Polythacrylate microbeads
methyl 41
Phenyltrimeticone 18.5
Micronized bentonite 1
Polymer beads are used here instead of the mica of Example 1, the size of which is preferably of the order of ten micrometers (from 5 to 20 micrometers as in Examples 1 to 3).
La pâte crème obtenue une fois appliquée est assez voisine par ses propriétés de celle de l'exemple 1. The cream paste obtained once applied is fairly similar in its properties to that of Example 1.
EXEMPLE 5. EXAMPLE 5.
On procède, comme dans le cas des exemples 1 à 4, avec la composition suivante (pourcentages en poids)
Cyclométhicone 35,4
Stéarate de magnésium 4
Oxyde de titane 41
Phényltriméthicone 19,5
Alumine micronisée 0,1
La pâte crème résultante est également très voisine de celle des exemples 1 et 4.The procedure is as in Examples 1 to 4, with the following composition (percentages by weight)
Cyclomethicone 35.4
Magnesium stearate 4
Titanium oxide 41
Phenyltrimethicone 19.5
Micronized alumina 0.1
The resulting cream paste is also very close to that of Examples 1 and 4.
Avec les produits obtenus conformément à l'invention, on a mené une série d'essais qui ont prouvé l'innocuité et l'efficacité en faisant varier le temps et la notion d'exposition. On en conclut, grosso modo, que les produits conformes à l'invention donnent au sujet une résistance au moins deux à trois fois plus longue aux effets des rayonnements qu'avec les produits du commerce. With the products obtained in accordance with the invention, a series of tests was carried out which proved the safety and the effectiveness by varying the time and the notion of exposure. It is concluded, roughly speaking, that the products according to the invention give the subject a resistance at least two to three times longer to the effects of radiation than with commercial products.
Les essais in vitro ont consisté à mesurer le taux de réflexion des rayonnements. Selon les produits on a constaté que pour l'ensemble infrarouge-visible-ultraviolet, on obtenait toujours des taux majoritaires de réflexion (de 50 à 70% en moyenne) et plus élevés encore pour les ultraviolets et en particulier des CUVA. En ce qui concerne les essais in vivo, on a pratiqué selon la norme allemande DIN 67501 (modifiée en novembre 1984). The in vitro tests consisted in measuring the rate of reflection of the radiations. According to the products, it has been found that for the infrared-visible-ultraviolet assembly, the majority of reflection rates are always obtained (from 50 to 70% on average) and even higher for ultraviolet rays and in particular for CUVA. Regarding the in vivo tests, we practiced according to the German standard DIN 67501 (modified in November 1984).
Sur 10 sujets hommes et 10 sujets femmes allongés en décubitus ventral, on a appliqué dans la partie supérieure du dos des bandes adhésives opaques aux rayons ultraviolets ménageant des carrés de peau à irradier de 1,5 cm2. On 10 male and 10 female subjects lying in the prone position, adhesive bands opaque to ultraviolet rays leaving 1.5 cm2 squares of skin to be irradiated were applied to the upper back.
La source étant une lampe de type OSRAM VITALUX 300 WT à une distance de 60 cm. La durée moyenne d'irradiation de la peau non protégée pour le seuil d'érythème est en moyenne de 2,8 minutes. The source is an OSRAM VITALUX 300 WT lamp at a distance of 60 cm. The average duration of irradiation of unprotected skin for the erythema threshold is on average 2.8 minutes.
L'application du produit a été effectuée à raison de 150 mg + 15 mg pour 100 cm2. Vingt minutes plus tard, on a commencé l'exposition et on a recouvert successivement les zones exposées à des temps en progression géométrique
1,4 environ) c'est-à-dire en minutes : 0,35 ; 0,50 ; 0,70 1;0 ; 1,4 ; 2,0 ; 2,8 ; 4,0 ; 5,6 ; 8,0 ; 11,2 ; 16,0 ; 22 32 ; 45 ; 64 ; 90 etc...The application of the product was carried out at a rate of 150 mg + 15 mg per 100 cm2. Twenty minutes later, we started the exhibition and we successively covered the areas exposed to times in geometric progression
About 1.4), that is to say in minutes: 0.35; 0.50; 0.70 1; 0; 1.4; 2.0; 2.8; 4.0; 5.6; 8.0; 11.2; 16.0; 22 32; 45; 64; 90 etc ...
En fin d'exposition on a dégagé les champs et laissé reposer hors rayonnement pendant 24 heures. On a calculé les indices de protection Qi qui sont le rapport entre, tl durée d'exposition nécessaire pour atteindre l'érythème pour la peau protégée, et t0 la durée de même nature pour une peau non protégée. On a également utilisé la norme DIN 675010 dont l'indice de protection est 3,7 + 0,3. At the end of the exposure, the fields were cleared and left to stand out for 24 hours. Protection indices Qi have been calculated which are the ratio between, tl duration of exposure necessary to reach erythema for protected skin, and t0 the duration of the same nature for unprotected skin. We also used the standard DIN 675010 whose protection index is 3.7 + 0.3.
Les indices de protection obtenus avec les cinq produits des exemples ci-dessus pour les vingt sujets étaient respectivement de 6,1 à 8,0 de 5,4 à 7,2 de 6,9 à 8,3 de 6,8 à 8,1 et de 6,4 à 8,2 avec des moyennes respectives de 7,14, de 6,57, de 7,69 de 7,00 et de 7,04. Si l'on compare aux 3,7 du produit témoin de la norme allemande, on constate une considérable augmentation. The protection indices obtained with the five products of the examples above for the twenty subjects were respectively from 6.1 to 8.0 from 5.4 to 7.2 from 6.9 to 8.3 from 6.8 to 8 , 1 and from 6.4 to 8.2 with respective averages of 7.14, 6.57, 7.69, 7.00 and 7.04. If we compare to the 3.7 of the control product of the German standard, we see a considerable increase.
On notera que la plupart des composants utilisés sont presque tous minéraux ou organométalliques. Il est évident qu'il est également possible d'obtenir des produits conformes à l'invention avec un résultat similaire en utilisant d'autres composés même non minéraux, les composants compatibles avec un excipient minéral n'offrant pas la même gamme étendue que dans le cas des excipients et composants organiques. It should be noted that most of the components used are almost all mineral or organometallic. It is obvious that it is also possible to obtain products in accordance with the invention with a similar result by using other compounds, even non-mineral compounds, the components compatible with a mineral excipient not offering the same wide range as in the case of excipients and organic components.
Claims (10)
Priority Applications (1)
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FR8905551A FR2646346B1 (en) | 1989-04-26 | 1989-04-26 | COMPOSITION FOR THE TOPICAL DEPOSITION OF A PERMEABLE CONTINUOUS AND LIGHT-REFLECTING FILM |
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FR8905551A FR2646346B1 (en) | 1989-04-26 | 1989-04-26 | COMPOSITION FOR THE TOPICAL DEPOSITION OF A PERMEABLE CONTINUOUS AND LIGHT-REFLECTING FILM |
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FR2646346A1 true FR2646346A1 (en) | 1990-11-02 |
FR2646346B1 FR2646346B1 (en) | 1994-08-12 |
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FR8905551A Expired - Fee Related FR2646346B1 (en) | 1989-04-26 | 1989-04-26 | COMPOSITION FOR THE TOPICAL DEPOSITION OF A PERMEABLE CONTINUOUS AND LIGHT-REFLECTING FILM |
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Cited By (12)
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EP0523294A1 (en) * | 1991-07-16 | 1993-01-20 | Tayca Corporation | Paraffin hydrocarbon dispersion of titanium dioxide fine-particles |
EP0585239A4 (en) * | 1991-02-05 | 1993-12-06 | Sun Smart Inc | Visibly transparent uv sunblock agents and methods of making same. |
EP0669124A1 (en) * | 1994-02-28 | 1995-08-30 | Rohm And Haas Company | Ultraviolet radiation absorbing composition |
EP0680746A1 (en) | 1994-05-04 | 1995-11-08 | Spirig Ag Pharmazeutische Präparate | Sunscreen composition |
US5531985A (en) * | 1991-02-05 | 1996-07-02 | Sunsmart, Inc. | Visibly transparent UV sunblock compositions and cosmetic products containing the same |
FR2737111A1 (en) * | 1995-07-28 | 1997-01-31 | Oreal | FLEXIBLE PASTE COMPOSITION AND PROCESS FOR PREPARING THE SAME |
FR2737112A1 (en) * | 1995-07-28 | 1997-01-31 | Oreal | USE OF THE ASSOCIATION OF TWO PARTICULAR OILS IN A PARTICULARLY COSMETIC COMPOSITION, AND COMPOSITION OBTAINED |
EP0761201A1 (en) * | 1995-08-24 | 1997-03-12 | Rohm And Haas Company | Ultraviolet radiation absorption composition |
FR2751542A1 (en) * | 1996-07-29 | 1998-01-30 | Oreal | COMPOSITION FOR PROTECTING SKIN OR HAIR CONTAINING NANOPIGMENTS AND AN ELASTOMERIC SOLID ORGANOPOLYSILOXANE ASSOCIATED WITH A FATTY PHASE |
US5733531A (en) * | 1991-02-05 | 1998-03-31 | Sunsmart, Inc. | Composite UV sunblock compositions |
EP0898955A2 (en) * | 1997-08-09 | 1999-03-03 | MERCK PATENT GmbH | Sunscreen agent showing ultra-spectral protection |
FR2934496A1 (en) * | 2008-07-30 | 2010-02-05 | Rhodia Poliamida E Especialidades Ltda | Polymer composition, useful e.g. for stimulating biological tissues such as cellulite skin and as textile article in the form of e.g. yarn and fibers, comprises combination of two additives comprising organic additives and inorganic filler |
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EP0585239A4 (en) * | 1991-02-05 | 1993-12-06 | Sun Smart Inc | Visibly transparent uv sunblock agents and methods of making same. |
US5531985A (en) * | 1991-02-05 | 1996-07-02 | Sunsmart, Inc. | Visibly transparent UV sunblock compositions and cosmetic products containing the same |
US5587148A (en) * | 1991-02-05 | 1996-12-24 | Sunsmart, Inc. | Visibly transparent UV sunblock agents and methods of making same |
US5733531A (en) * | 1991-02-05 | 1998-03-31 | Sunsmart, Inc. | Composite UV sunblock compositions |
EP0523294A1 (en) * | 1991-07-16 | 1993-01-20 | Tayca Corporation | Paraffin hydrocarbon dispersion of titanium dioxide fine-particles |
EP0669124A1 (en) * | 1994-02-28 | 1995-08-30 | Rohm And Haas Company | Ultraviolet radiation absorbing composition |
US5663213A (en) * | 1994-02-28 | 1997-09-02 | Rohm And Haas Company | Method of improving ultraviolet radiation absorption of a composition |
EP0680746A1 (en) | 1994-05-04 | 1995-11-08 | Spirig Ag Pharmazeutische Präparate | Sunscreen composition |
EP0756865A1 (en) * | 1995-07-28 | 1997-02-05 | L'oreal | Composition in form of a supple paste and preparation process |
EP0756864A1 (en) * | 1995-07-28 | 1997-02-05 | L'oreal | Use of the association of two particular oils in a cosmetic composition, and the composition obtained thereby |
FR2737112A1 (en) * | 1995-07-28 | 1997-01-31 | Oreal | USE OF THE ASSOCIATION OF TWO PARTICULAR OILS IN A PARTICULARLY COSMETIC COMPOSITION, AND COMPOSITION OBTAINED |
FR2737111A1 (en) * | 1995-07-28 | 1997-01-31 | Oreal | FLEXIBLE PASTE COMPOSITION AND PROCESS FOR PREPARING THE SAME |
US6780402B1 (en) | 1995-07-28 | 2004-08-24 | L'oreal | Make-up compositions containing phenylated silicone oils, which are resistant to transfer and migration |
EP0761201A1 (en) * | 1995-08-24 | 1997-03-12 | Rohm And Haas Company | Ultraviolet radiation absorption composition |
FR2751542A1 (en) * | 1996-07-29 | 1998-01-30 | Oreal | COMPOSITION FOR PROTECTING SKIN OR HAIR CONTAINING NANOPIGMENTS AND AN ELASTOMERIC SOLID ORGANOPOLYSILOXANE ASSOCIATED WITH A FATTY PHASE |
EP0823249A1 (en) * | 1996-07-29 | 1998-02-11 | L'oreal | Composition for the protection of the skin or hair containing nanopigments andsolid organopolysiloxan elastomer in a fatty phase |
EP0898955A2 (en) * | 1997-08-09 | 1999-03-03 | MERCK PATENT GmbH | Sunscreen agent showing ultra-spectral protection |
EP0898955A3 (en) * | 1997-08-09 | 2001-11-21 | MERCK PATENT GmbH | Sunscreen agent showing ultra-spectral protection |
FR2934496A1 (en) * | 2008-07-30 | 2010-02-05 | Rhodia Poliamida E Especialidades Ltda | Polymer composition, useful e.g. for stimulating biological tissues such as cellulite skin and as textile article in the form of e.g. yarn and fibers, comprises combination of two additives comprising organic additives and inorganic filler |
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