FR2640139A1 - Application de benzamides substitues comme gastromoteurs - Google Patents

Application de benzamides substitues comme gastromoteurs Download PDF

Info

Publication number
FR2640139A1
FR2640139A1 FR8816433A FR8816433A FR2640139A1 FR 2640139 A1 FR2640139 A1 FR 2640139A1 FR 8816433 A FR8816433 A FR 8816433A FR 8816433 A FR8816433 A FR 8816433A FR 2640139 A1 FR2640139 A1 FR 2640139A1
Authority
FR
France
Prior art keywords
ethyl
product
washed
application
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR8816433A
Other languages
English (en)
French (fr)
Inventor
Jacques Acher
Jean-Claude Monier
Jean-Paul Schmitt
Renee Gardaix-Luthereau
Brenda Costall
Robert Naylor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Delagrange SA
Original Assignee
Laboratoires Delagrange SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Delagrange SA filed Critical Laboratoires Delagrange SA
Priority to FR8816433A priority Critical patent/FR2640139A1/fr
Priority to DK613989A priority patent/DK613989A/da
Priority to JP1322467A priority patent/JPH02237928A/ja
Priority to AT89403431T priority patent/ATE73997T1/de
Priority to DE8989403431T priority patent/DE68901085D1/de
Priority to EP89403431A priority patent/EP0374029B1/fr
Priority to CA002005442A priority patent/CA2005442A1/fr
Priority to US07/450,422 priority patent/US5116857A/en
Publication of FR2640139A1 publication Critical patent/FR2640139A1/fr
Priority to GR920400705T priority patent/GR3004350T3/el
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/28—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/18—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
FR8816433A 1988-12-14 1988-12-14 Application de benzamides substitues comme gastromoteurs Withdrawn FR2640139A1 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
FR8816433A FR2640139A1 (fr) 1988-12-14 1988-12-14 Application de benzamides substitues comme gastromoteurs
DK613989A DK613989A (da) 1988-12-14 1989-12-06 Anvendelse af substituerede benzamider til fremstilling af laegemidler med gastromotorisk virkning
JP1322467A JPH02237928A (ja) 1988-12-14 1989-12-11 置換ベンズアミドより成る胃の自動運動性増進用薬剤
AT89403431T ATE73997T1 (de) 1988-12-14 1989-12-12 Verwendung von substituierten benzamiden zur stimulierung der gastromotorik.
DE8989403431T DE68901085D1 (de) 1988-12-14 1989-12-12 Verwendung von substituierten benzamiden zur stimulierung der gastromotorik.
EP89403431A EP0374029B1 (fr) 1988-12-14 1989-12-12 Application de benzamides substitués comme gastromoteurs
CA002005442A CA2005442A1 (fr) 1988-12-14 1989-12-13 Application de benzamides substitues comme gastromoteurs
US07/450,422 US5116857A (en) 1988-12-14 1989-12-14 Method of increasing gastrointestinal motility with substituted benzamides
GR920400705T GR3004350T3 (enExample) 1988-12-14 1992-04-15

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8816433A FR2640139A1 (fr) 1988-12-14 1988-12-14 Application de benzamides substitues comme gastromoteurs

Publications (1)

Publication Number Publication Date
FR2640139A1 true FR2640139A1 (fr) 1990-06-15

Family

ID=9372914

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8816433A Withdrawn FR2640139A1 (fr) 1988-12-14 1988-12-14 Application de benzamides substitues comme gastromoteurs

Country Status (9)

Country Link
US (1) US5116857A (enExample)
EP (1) EP0374029B1 (enExample)
JP (1) JPH02237928A (enExample)
AT (1) ATE73997T1 (enExample)
CA (1) CA2005442A1 (enExample)
DE (1) DE68901085D1 (enExample)
DK (1) DK613989A (enExample)
FR (1) FR2640139A1 (enExample)
GR (1) GR3004350T3 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6770262B2 (en) * 2000-03-30 2004-08-03 Questcor Pharmaceuticals, Inc. Nasal administration of agents for the treatment of gastroparesis
US6662951B1 (en) * 2000-09-27 2003-12-16 Basic Resources, Inc. Process for extracting and purifying naturally occurring zeolite
US20130213393A1 (en) 2009-12-22 2013-08-22 Evoke Pharma, Inc. Nasal formulations of metoclopramide
US8334281B2 (en) * 2008-12-22 2012-12-18 Evoke Pharma, Inc. Nasal formulations of metoclopramide
EP3554489A4 (en) 2016-12-15 2020-06-17 Evoke Pharma, Inc. TREATMENT FROM MODERATE TO HEAVY GASTROPARESIS

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0236646A1 (fr) * 1985-12-19 1987-09-16 Laboratoires DELAGRANGE, Société Anonyme Nouveaux ortho-anisamides, leur procédé d'obtention et leurs applications thérapeutiques

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL281394A (enExample) * 1961-07-25
CA1082181A (en) * 1976-06-03 1980-07-22 Eric A. Watts Benzamide derivatives
US4188393A (en) * 1977-04-22 1980-02-12 Sandoz Ltd. Treating spastic conditions or relaxing muscles
US4714707A (en) * 1984-01-13 1987-12-22 Rorer Pharmaceutical Corporation Aryl substituted heterocycles for treating gastrointestinal motility dysfunction
WO1986002553A1 (en) * 1984-10-23 1986-05-09 Nastech Pharmaceutical Company, Inc. Novel method of administering anti-nausea and anti-emetic pharmaceutical agents and novel dosage forms containing same
GB8519707D0 (en) * 1985-08-06 1985-09-11 Fordonal Sa Chemical compounds
CZ284687B6 (cs) * 1986-04-30 1999-02-17 Dainippon Pharmaceutical Co., Ltd. Substituovaný benzamidový derivát, způsob jeho výroby a farmaceutický prostředek na jeho bázi
DE3782651T2 (de) * 1987-06-17 1993-03-25 Delagrange Lab Anwendung von n-(2-(diaethylamino)aethyl)-2-methoxy-4((1-h-4,5-dihydro-2-imidazolyl)amino)-5-chlorobenzamid als anxiolytisches und antipsychotisches mittel.
GB8718345D0 (en) * 1987-08-03 1987-09-09 Fordonal Sa N-substituted benzamides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0236646A1 (fr) * 1985-12-19 1987-09-16 Laboratoires DELAGRANGE, Société Anonyme Nouveaux ortho-anisamides, leur procédé d'obtention et leurs applications thérapeutiques

Also Published As

Publication number Publication date
DK613989A (da) 1990-06-15
EP0374029B1 (fr) 1992-03-25
DE68901085D1 (de) 1992-04-30
CA2005442A1 (fr) 1990-06-14
US5116857A (en) 1992-05-26
JPH02237928A (ja) 1990-09-20
DK613989D0 (da) 1989-12-06
ATE73997T1 (de) 1992-04-15
GR3004350T3 (enExample) 1993-03-31
EP0374029A1 (fr) 1990-06-20

Similar Documents

Publication Publication Date Title
EP0706512B1 (fr) Derives d'acetamide et leur utilisation comme modificateurs du comportement de prise alimentaire
EP0099802A1 (fr) Nouveaux dérivés de la thiéno-(3,2-c) pyridine, leur procédé de préparation et leur application thérapeutique
CA2055859A1 (fr) Derives d'oxazolopyridines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2536749A1 (fr) (amino-2 ethyl)-6 benzoxazolinones substituees, leur preparation et leurs applications en therapeutique
FR2522324A1 (fr) Pyrrole-acetamides, leur procede de preparation et composition therapeutique les contenant
FR2591596A1 (fr) Nouvelles 4h-triazolo(4,3-a)(1,4)benzodiazepines, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
EP0151072A2 (fr) Dérivés de l'acide méthylènediphosphonique, procédé d'obtention et compositions pharmaceutiques antirhumatismales les contenant
BE897843A (fr) Derives biologiquement actifs de 2, 5-piperazinediones, procede pour leur preparation et compositions pharmaceutique en contenant
EP0374029B1 (fr) Application de benzamides substitués comme gastromoteurs
EP0000452B1 (fr) Dérivés d'oxadiazole-1,2,4, leur préparation et leur application en thérapeutique.
CA1298301C (fr) Benzamides, leur procede d'obtention et leurs applications therapeutiques
CA1093582A (fr) Procede d'obtention de nouvelles propylenediamines
CH641775A5 (fr) N-(1-methyl 2-pyrrolidinyl methyl) 2,3-dimethoxy 5-methylsulfamoyl benzamide et ses derives, son procede de preparation et composition le renferment.
EP0005422B1 (fr) Dérivés d'acides oméga-dialkylalkanoiques, leurs procédés de préparation ainsi que leur utilisation en thérapeutique
EP0082040B1 (fr) Dérivés de diaza-3,7a cyclohepta(j,k)fluorènes, leur préparation et leur application en thérapeutique
MC1169A1 (fr) Composes tricycliques
CH635844A5 (fr) Thieno(3,2-c) et thieno(2,3-c)pyridines, leur procede de preparation et leur application en therapeutique.
FR2478629A1 (fr) Derives d'acides 2-cyano-ethyl-2-(n-benzoylamino) alcanoiques, leur procede de preparation et leur application en therapeutique
CH632763A5 (en) Triazolothiadiazine derivatives and processes for preparing them
EP0022737B1 (fr) Imines dérivées de l'amino-5 benzodioxole-1,3 utiles comme médicaments et leur préparation
EP0179076A1 (fr) Derives sulfures de l'hydantoine et compositions pharmaceutiques les contenant.
EP0039294B1 (fr) Bis (phénoxyacétates substitués) de N-alkyl-dialcanolamines, procédé d'obtention, et compositions pharmaceutiques les contenant
LU83775A1 (fr) Derives de naphtyridine,leur preparation et leur application en therapeutique
EP0183584A1 (fr) Nouveaux esters dérivés de l'acide 4-hydroxy 3-quinoléine carboxylique substitué en 2 par une chaîne alpha-hydroxylée, leur préparation, leur application comme médicaments et les compositions les renfermant
EP0010030A1 (fr) Nouveaux dérivés d'ortho chloro benzoyl-2 chloro-4 glycylanilide, leur préparation et leur application en tant que médicaments

Legal Events

Date Code Title Description
ST Notification of lapse