FR2637083B1 - Procede et dispositif de determination du ph et de la concentration cellulaire dans un milieu de culture de cellules - Google Patents

Procede et dispositif de determination du ph et de la concentration cellulaire dans un milieu de culture de cellules

Info

Publication number
FR2637083B1
FR2637083B1 FR8812657A FR8812657A FR2637083B1 FR 2637083 B1 FR2637083 B1 FR 2637083B1 FR 8812657 A FR8812657 A FR 8812657A FR 8812657 A FR8812657 A FR 8812657A FR 2637083 B1 FR2637083 B1 FR 2637083B1
Authority
FR
France
Prior art keywords
determining
culture medium
cell
cell culture
concentration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR8812657A
Other languages
English (en)
Other versions
FR2637083A1 (fr
Inventor
Isabelle Geahel
Yves Dordet
Jean Hache
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bertin Technologies SAS
Original Assignee
Bertin et Cie SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bertin et Cie SA filed Critical Bertin et Cie SA
Priority to FR8812657A priority Critical patent/FR2637083B1/fr
Priority to PCT/FR1989/000492 priority patent/WO1990003567A1/fr
Priority to AU44055/89A priority patent/AU4405589A/en
Publication of FR2637083A1 publication Critical patent/FR2637083A1/fr
Application granted granted Critical
Publication of FR2637083B1 publication Critical patent/FR2637083B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/53—Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke
    • G01N21/532—Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke with measurement of scattering and transmission
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G01N21/80—Indicating pH value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/2803—Investigating the spectrum using photoelectric array detector
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/031—Multipass arrangements
    • G01N2021/0314—Double pass, autocollimated path
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/08—Optical fibres; light guides
    • G01N2201/084—Fibres for remote transmission
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/122—Kinetic analysis; determining reaction rate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/127—Calibration; base line adjustment; drift compensation
    • G01N2201/12746—Calibration values determination
    • G01N2201/12753—Calibration values determination and storage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Sustainable Development (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
FR8812657A 1988-09-28 1988-09-28 Procede et dispositif de determination du ph et de la concentration cellulaire dans un milieu de culture de cellules Expired - Lifetime FR2637083B1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FR8812657A FR2637083B1 (fr) 1988-09-28 1988-09-28 Procede et dispositif de determination du ph et de la concentration cellulaire dans un milieu de culture de cellules
PCT/FR1989/000492 WO1990003567A1 (fr) 1988-09-28 1989-09-27 PROCEDE ET DISPOSITIF DE DETERMINATION DU pH ET DE LA CONCENTRATION CELLULAIRE DANS UN MILIEU DE CULTURE DE CELLULES
AU44055/89A AU4405589A (en) 1988-09-28 1989-09-27 Method and device for determining the ph and the cell concentration in a cell culture medium

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8812657A FR2637083B1 (fr) 1988-09-28 1988-09-28 Procede et dispositif de determination du ph et de la concentration cellulaire dans un milieu de culture de cellules

Publications (2)

Publication Number Publication Date
FR2637083A1 FR2637083A1 (fr) 1990-03-30
FR2637083B1 true FR2637083B1 (fr) 1990-11-30

Family

ID=9370475

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8812657A Expired - Lifetime FR2637083B1 (fr) 1988-09-28 1988-09-28 Procede et dispositif de determination du ph et de la concentration cellulaire dans un milieu de culture de cellules

Country Status (3)

Country Link
AU (1) AU4405589A (fr)
FR (1) FR2637083B1 (fr)
WO (1) WO1990003567A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ532039A (en) * 2001-10-15 2004-12-24 Dsm Ip Assets B Apparatus and method for detecting undesired residues in a sample
CN110376190B (zh) * 2019-08-19 2020-05-19 世翱（上海）生物医药科技有限公司 一种基于光谱的细胞培养悬液pH值检测方法
JP2024500604A (ja) * 2020-12-24 2024-01-10 テルモ株式会社 細胞培養システム

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4561779A (en) * 1983-01-07 1985-12-31 Rikagaku Kenkyusho Instrument for measuring concentration of substance in suspension
US4812392A (en) * 1984-12-27 1989-03-14 Sumitomo Electric Industries, Ltd. Method and apparatus for incubating cells
FR2583164B1 (fr) * 1985-06-06 1988-10-14 Trapil Transports Petroliers P Procede et dispositif pour determiner la couleur et la turbidite d'un fluide

Also Published As

Publication number Publication date
WO1990003567A1 (fr) 1990-04-05
AU4405589A (en) 1990-04-18
FR2637083A1 (fr) 1990-03-30

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