FR2456522A1 - Insulin compsns. for admin via mucosa - contg. selected acids to increase absorption pref. also contg. a surfactant and a protease inhibitor - Google Patents
Insulin compsns. for admin via mucosa - contg. selected acids to increase absorption pref. also contg. a surfactant and a protease inhibitorInfo
- Publication number
- FR2456522A1 FR2456522A1 FR8010946A FR8010946A FR2456522A1 FR 2456522 A1 FR2456522 A1 FR 2456522A1 FR 8010946 A FR8010946 A FR 8010946A FR 8010946 A FR8010946 A FR 8010946A FR 2456522 A1 FR2456522 A1 FR 2456522A1
- Authority
- FR
- France
- Prior art keywords
- acids
- insulin
- acid
- pref
- contg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Insulin prepns. comprise insulin, a carrier for absorption via mucous membranes, and 0.01-0.5 wt.% of >=1 selected from (a) 1-6C alkanoic acid, (b) lower hydroxy carboxylic acid, (c) inorganic acids selected from HCl, H3PO4, HN3, phosphotungstic acid and HClO4, (d) benzoic, phthalic and pyromellitic acids, (e) monochloro-, dichloro-, trichloro- and sulpho-acetic acids, (f) acrylic and maleic acids, and (g) pyruvic, furoic and picric acids. The carrier is pref. a suppository base. Pref. acids are 1-5C alkanoic acids (esp. acetic), tartaric acid, glycolic acid, HCl, HNO3 and monochloroacetic acid. The prepns. can also contain a surfactant and a protease inhibitor. They are pref. produced by dissolving insulin in an aq. soln. of the acid and incorporating the soln. into the carrier (esp. molten suppository base). The prepns. are esp. useful for rectal, intravaginal or sublingual admin. giving large reductions in blood sugar levels at low insulin concns.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6129279A JPS55153712A (en) | 1979-05-18 | 1979-05-18 | Insulin pharmaceutical preparation and its production |
Publications (1)
Publication Number | Publication Date |
---|---|
FR2456522A1 true FR2456522A1 (en) | 1980-12-12 |
Family
ID=13166964
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR8010946A Withdrawn FR2456522A1 (en) | 1979-05-18 | 1980-05-14 | Insulin compsns. for admin via mucosa - contg. selected acids to increase absorption pref. also contg. a surfactant and a protease inhibitor |
Country Status (3)
Country | Link |
---|---|
JP (1) | JPS55153712A (en) |
DE (1) | DE3018843A1 (en) |
FR (1) | FR2456522A1 (en) |
Cited By (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2587621A1 (en) * | 1985-09-09 | 1987-03-27 | Berlin Chemie Veb | PROCESS FOR THE MANUFACTURE OF PHARMACEUTICAL PREPARATIONS OF PEPTIDES HAVING INCREASED RESORPTION CAPACITY |
EP0273202A2 (en) * | 1986-12-23 | 1988-07-06 | Eugene J. Dr. Van Scott | Use of hydroxycarboxylic acids to enhance therapeutic effects of topical compositions for fungal infections and pigmented spots. |
EP0302772A1 (en) * | 1987-08-03 | 1989-02-08 | Asahi Kasei Kogyo Kabushiki Kaisha | Calcitonin composition for nasal administration |
EP0332222A2 (en) * | 1988-03-11 | 1989-09-13 | Teikoku Seiyaku Co., Ltd. | Intravaginal delivery of biologically active polypeptides |
WO2003105888A1 (en) | 2002-06-18 | 2003-12-24 | Aventis Pharma Deutschland Gmbh | Acidic insulin preparations with improved stability |
US20070292355A1 (en) * | 2002-10-25 | 2007-12-20 | Foamix Ltd. | Anti-infection augmentation foamable compositions and kit and uses thereof |
US7696162B2 (en) | 2001-03-23 | 2010-04-13 | Sanofi-Aventis Deutschland Gmbh | Zinc-free and low-zinc insulin preparations having improved stability |
US8013017B2 (en) | 2001-05-31 | 2011-09-06 | Upsher-Smith Laboratories, Inc. | Dermatological compositions and methods |
US9320705B2 (en) | 2002-10-25 | 2016-04-26 | Foamix Pharmaceuticals Ltd. | Sensation modifying topical composition foam |
US9364519B2 (en) | 2011-09-01 | 2016-06-14 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
US9408893B2 (en) | 2011-08-29 | 2016-08-09 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for use in glycemic control in diabetes type 2 patients |
US9439857B2 (en) | 2007-11-30 | 2016-09-13 | Foamix Pharmaceuticals Ltd. | Foam containing benzoyl peroxide |
US9492412B2 (en) | 2002-10-25 | 2016-11-15 | Foamix Pharmaceuticals Ltd. | Penetrating pharmaceutical foam |
US9526764B2 (en) | 2008-10-17 | 2016-12-27 | Sanofi-Aventis Deutschland Gmbh | Combination of an insulin and a GLP-1-agonist |
US9539208B2 (en) | 2002-10-25 | 2017-01-10 | Foamix Pharmaceuticals Ltd. | Foam prepared from nanoemulsions and uses |
US9549898B2 (en) | 2007-12-07 | 2017-01-24 | Foamix Pharmaceuticals Ltd. | Oil and liquid silicone foamable carriers and formulations |
US9572775B2 (en) | 2009-07-29 | 2017-02-21 | Foamix Pharmaceuticals Ltd. | Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses |
US9622947B2 (en) | 2002-10-25 | 2017-04-18 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
US9636405B2 (en) | 2003-08-04 | 2017-05-02 | Foamix Pharmaceuticals Ltd. | Foamable vehicle and pharmaceutical compositions thereof |
US9662298B2 (en) | 2007-08-07 | 2017-05-30 | Foamix Pharmaceuticals Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
US9668972B2 (en) | 2002-10-25 | 2017-06-06 | Foamix Pharmaceuticals Ltd. | Nonsteroidal immunomodulating kit and composition and uses thereof |
US9675700B2 (en) | 2009-10-02 | 2017-06-13 | Foamix Pharmaceuticals Ltd. | Topical tetracycline compositions |
US9682021B2 (en) | 2006-11-14 | 2017-06-20 | Foamix Pharmaceuticals Ltd. | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses |
US9707176B2 (en) | 2009-11-13 | 2017-07-18 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical composition comprising a GLP-1 agonist and methionine |
US9713643B2 (en) | 2002-10-25 | 2017-07-25 | Foamix Pharmaceuticals Ltd. | Foamable carriers |
US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
US9849142B2 (en) | 2009-10-02 | 2017-12-26 | Foamix Pharmaceuticals Ltd. | Methods for accelerated return of skin integrity and for the treatment of impetigo |
US9884017B2 (en) | 2009-04-28 | 2018-02-06 | Foamix Pharmaceuticals Ltd. | Foamable vehicles and pharmaceutical compositions comprising aprotic polar solvents and uses thereof |
US9950039B2 (en) | 2014-12-12 | 2018-04-24 | Sanofi-Aventis Deutschland Gmbh | Insulin glargine/lixisenatide fixed ratio formulation |
US9981013B2 (en) | 2010-08-30 | 2018-05-29 | Sanofi-Aventis Deutschland Gmbh | Use of AVE0010 for the treatment of diabetes mellitus type 2 |
US10029011B2 (en) | 2009-11-13 | 2018-07-24 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical composition comprising a GLP-1 agonist, an insulin and methionine |
US10159713B2 (en) | 2015-03-18 | 2018-12-25 | Sanofi-Aventis Deutschland Gmbh | Treatment of type 2 diabetes mellitus patients |
US10322085B2 (en) | 2002-10-25 | 2019-06-18 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
US10350166B2 (en) | 2009-07-29 | 2019-07-16 | Foamix Pharmaceuticals Ltd. | Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses |
US10398641B2 (en) | 2016-09-08 | 2019-09-03 | Foamix Pharmaceuticals Ltd. | Compositions and methods for treating rosacea and acne |
US10434147B2 (en) | 2015-03-13 | 2019-10-08 | Sanofi-Aventis Deutschland Gmbh | Treatment type 2 diabetes mellitus patients |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56138110A (en) * | 1980-03-28 | 1981-10-28 | Teijin Ltd | Suppository containing citric acid or salt thereof |
JPS56138112A (en) * | 1980-03-31 | 1981-10-28 | Teijin Ltd | Suppository containing ascorbic acid or sodium ascorbate |
JPS56138115A (en) * | 1980-03-31 | 1981-10-28 | Teijin Ltd | Suppository containing acidic amino acid or derivative thereof |
JPS5780315A (en) * | 1980-11-09 | 1982-05-19 | Kyoto Yakuhin Kogyo Kk | Absorption promotor for accelerating rectum absorption, base comprising it, and pharmaceutical preparation to be medicated to rectum |
JPS6321704Y2 (en) * | 1981-06-02 | 1988-06-15 | ||
SU1011126A1 (en) * | 1981-07-14 | 1983-04-15 | Всесоюзный научно-исследовательский и испытательный институт медицинской техники | Method of treating diabetes mellitus |
JPS5838210A (en) * | 1981-08-31 | 1983-03-05 | Taiho Yakuhin Kogyo Kk | Preparation for rectal administration |
JPH0623092B2 (en) * | 1984-03-19 | 1994-03-30 | 太陽化学株式会社 | Suppository pharmaceutical composition |
JPS61138863A (en) * | 1984-12-11 | 1986-06-26 | Honda Motor Co Ltd | Engine body of internal-conbustion engine |
JPH048302Y2 (en) * | 1985-10-22 | 1992-03-03 | ||
JPS62158207A (en) * | 1986-01-06 | 1987-07-14 | Showa Yakuhin Kako Kk | Composition for rectal administration |
CA2050425A1 (en) * | 1990-09-03 | 1992-03-04 | Yoshiaki Uda | Pharmaceutical composition and its mucous use |
KR101152470B1 (en) | 2003-08-13 | 2012-06-01 | 바이오콘 리미티드 | - micro-particle fatty acid salt solid dosage formulations for therapeutic agents |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL45481C (en) * | 1900-01-01 | |||
JPS5315412A (en) * | 1976-07-27 | 1978-02-13 | Ono Pharmaceut Co Ltd | Suppository for diabetics |
FR2455897A1 (en) * | 1979-05-10 | 1980-12-05 | Kyoto Pharma Ind | FATTY ACID ADJUVANT FOR PROMOTING THE ABSORPTION OF PHARMACOLOGICALLY ACTIVATED SUBSTANCES BY RECTUM, BASIC COMPOSITION FOR RECTAL ADMINISTRATION COMPRISING THIS ADJUVANT AND PHARMACEUTICAL COMPOSITION COMPRISING THIS ADJUVANT |
-
1979
- 1979-05-18 JP JP6129279A patent/JPS55153712A/en active Granted
-
1980
- 1980-05-14 FR FR8010946A patent/FR2456522A1/en not_active Withdrawn
- 1980-05-16 DE DE19803018843 patent/DE3018843A1/en not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL45481C (en) * | 1900-01-01 | |||
JPS5315412A (en) * | 1976-07-27 | 1978-02-13 | Ono Pharmaceut Co Ltd | Suppository for diabetics |
FR2455897A1 (en) * | 1979-05-10 | 1980-12-05 | Kyoto Pharma Ind | FATTY ACID ADJUVANT FOR PROMOTING THE ABSORPTION OF PHARMACOLOGICALLY ACTIVATED SUBSTANCES BY RECTUM, BASIC COMPOSITION FOR RECTAL ADMINISTRATION COMPRISING THIS ADJUVANT AND PHARMACEUTICAL COMPOSITION COMPRISING THIS ADJUVANT |
Non-Patent Citations (1)
Title |
---|
CA1978 * |
Cited By (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2587621A1 (en) * | 1985-09-09 | 1987-03-27 | Berlin Chemie Veb | PROCESS FOR THE MANUFACTURE OF PHARMACEUTICAL PREPARATIONS OF PEPTIDES HAVING INCREASED RESORPTION CAPACITY |
EP0273202A2 (en) * | 1986-12-23 | 1988-07-06 | Eugene J. Dr. Van Scott | Use of hydroxycarboxylic acids to enhance therapeutic effects of topical compositions for fungal infections and pigmented spots. |
EP0273202A3 (en) * | 1986-12-23 | 1990-06-06 | Eugene J. Dr. Van Scott | Additives enhancing topical actions of therapeutic agents |
EP0302772A1 (en) * | 1987-08-03 | 1989-02-08 | Asahi Kasei Kogyo Kabushiki Kaisha | Calcitonin composition for nasal administration |
US5059587A (en) * | 1987-08-03 | 1991-10-22 | Toyo Jozo Company, Ltd. | Physiologically active peptide composition for nasal administration |
EP0332222A2 (en) * | 1988-03-11 | 1989-09-13 | Teikoku Seiyaku Co., Ltd. | Intravaginal delivery of biologically active polypeptides |
EP0332222A3 (en) * | 1988-03-11 | 1991-03-06 | Teikoku Seiyaku Co., Ltd. | Intravaginal delivery of biologically active polypeptides |
US5824646A (en) * | 1988-03-11 | 1998-10-20 | Teikoku Seiyaku Co., Ltd. | Intravaginal delivery of biologically active polypeptides |
US7696162B2 (en) | 2001-03-23 | 2010-04-13 | Sanofi-Aventis Deutschland Gmbh | Zinc-free and low-zinc insulin preparations having improved stability |
US9456970B2 (en) | 2001-05-31 | 2016-10-04 | Upsher-Smith Laboratories, Inc. | Dermatological compositions and methods |
US8013017B2 (en) | 2001-05-31 | 2011-09-06 | Upsher-Smith Laboratories, Inc. | Dermatological compositions and methods |
US7713930B2 (en) | 2002-06-18 | 2010-05-11 | Sanofi-Aventis Deutschland Gmbh | Acidic insulin preparations having improved stability |
WO2003105888A1 (en) | 2002-06-18 | 2003-12-24 | Aventis Pharma Deutschland Gmbh | Acidic insulin preparations with improved stability |
US7476652B2 (en) | 2002-06-18 | 2009-01-13 | Sanofi-Aventis Deutschland Gmbh | Acidic insulin preparations having improved stability |
HRP20041200B1 (en) * | 2002-06-18 | 2013-05-31 | Sanofi-Aventis Deutschland Gmbh | Acidic insulin preparations with improved stability |
EP2305288A3 (en) * | 2002-06-18 | 2013-12-11 | Sanofi-Aventis Deutschland GmbH | Acidic insulin preparations with improved stability |
US10322085B2 (en) | 2002-10-25 | 2019-06-18 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
US10117812B2 (en) | 2002-10-25 | 2018-11-06 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
US9668972B2 (en) | 2002-10-25 | 2017-06-06 | Foamix Pharmaceuticals Ltd. | Nonsteroidal immunomodulating kit and composition and uses thereof |
US20070292355A1 (en) * | 2002-10-25 | 2007-12-20 | Foamix Ltd. | Anti-infection augmentation foamable compositions and kit and uses thereof |
US9320705B2 (en) | 2002-10-25 | 2016-04-26 | Foamix Pharmaceuticals Ltd. | Sensation modifying topical composition foam |
US9492412B2 (en) | 2002-10-25 | 2016-11-15 | Foamix Pharmaceuticals Ltd. | Penetrating pharmaceutical foam |
US9713643B2 (en) | 2002-10-25 | 2017-07-25 | Foamix Pharmaceuticals Ltd. | Foamable carriers |
US9539208B2 (en) | 2002-10-25 | 2017-01-10 | Foamix Pharmaceuticals Ltd. | Foam prepared from nanoemulsions and uses |
US10821077B2 (en) | 2002-10-25 | 2020-11-03 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
US11033491B2 (en) | 2002-10-25 | 2021-06-15 | Vyne Therapeutics Inc. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
US9622947B2 (en) | 2002-10-25 | 2017-04-18 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
US9636405B2 (en) | 2003-08-04 | 2017-05-02 | Foamix Pharmaceuticals Ltd. | Foamable vehicle and pharmaceutical compositions thereof |
US9682021B2 (en) | 2006-11-14 | 2017-06-20 | Foamix Pharmaceuticals Ltd. | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses |
US9662298B2 (en) | 2007-08-07 | 2017-05-30 | Foamix Pharmaceuticals Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
US10369102B2 (en) | 2007-08-07 | 2019-08-06 | Foamix Pharmaceuticals Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
US11103454B2 (en) | 2007-08-07 | 2021-08-31 | Vyne Therapeutics Inc. | Wax foamable vehicle and pharmaceutical compositions thereof |
US9439857B2 (en) | 2007-11-30 | 2016-09-13 | Foamix Pharmaceuticals Ltd. | Foam containing benzoyl peroxide |
US9549898B2 (en) | 2007-12-07 | 2017-01-24 | Foamix Pharmaceuticals Ltd. | Oil and liquid silicone foamable carriers and formulations |
US9795564B2 (en) | 2007-12-07 | 2017-10-24 | Foamix Pharmaceuticals Ltd. | Oil-based foamable carriers and formulations |
US11433025B2 (en) | 2007-12-07 | 2022-09-06 | Vyne Therapeutics Inc. | Oil foamable carriers and formulations |
US10117909B2 (en) | 2008-10-17 | 2018-11-06 | Sanofi-Aventis Deutschland Gmbh | Combination of an insulin and a GLP-1 agonist |
US9526764B2 (en) | 2008-10-17 | 2016-12-27 | Sanofi-Aventis Deutschland Gmbh | Combination of an insulin and a GLP-1-agonist |
US10363216B2 (en) | 2009-04-28 | 2019-07-30 | Foamix Pharmaceuticals Ltd. | Foamable vehicles and pharmaceutical compositions comprising aprotic polar solvents and uses thereof |
US9884017B2 (en) | 2009-04-28 | 2018-02-06 | Foamix Pharmaceuticals Ltd. | Foamable vehicles and pharmaceutical compositions comprising aprotic polar solvents and uses thereof |
US10588858B2 (en) | 2009-04-28 | 2020-03-17 | Foamix Pharmaceuticals Ltd. | Foamable vehicles and pharmaceutical compositions comprising aprotic polar solvents and uses thereof |
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US11219631B2 (en) | 2009-07-29 | 2022-01-11 | Vyne Pharmaceuticals Inc. | Foamable compositions, breakable foams and their uses |
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US10092588B2 (en) | 2009-07-29 | 2018-10-09 | Foamix Pharmaceuticals Ltd. | Foamable compositions, breakable foams and their uses |
US10821187B2 (en) | 2009-10-02 | 2020-11-03 | Foamix Pharmaceuticals Ltd. | Compositions, gels and foams with rheology modulators and uses thereof |
US10463742B2 (en) | 2009-10-02 | 2019-11-05 | Foamix Pharmaceuticals Ltd. | Topical tetracycline compositions |
US10137200B2 (en) | 2009-10-02 | 2018-11-27 | Foamix Pharmaceuticals Ltd. | Surfactant-free water-free foamable compositions, breakable foams and gels and their uses |
US10967063B2 (en) | 2009-10-02 | 2021-04-06 | Vyne Therapeutics Inc. | Surfactant-free, water-free formable composition and breakable foams and their uses |
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US10086080B2 (en) | 2009-10-02 | 2018-10-02 | Foamix Pharmaceuticals Ltd. | Topical tetracycline compositions |
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US10265404B2 (en) | 2009-10-02 | 2019-04-23 | Foamix Pharmaceuticals Ltd. | Compositions, gels and foams with rheology modulators and uses thereof |
US10322186B2 (en) | 2009-10-02 | 2019-06-18 | Foamix Pharmaceuticals Ltd. | Topical tetracycline compositions |
US9849142B2 (en) | 2009-10-02 | 2017-12-26 | Foamix Pharmaceuticals Ltd. | Methods for accelerated return of skin integrity and for the treatment of impetigo |
US10946101B2 (en) | 2009-10-02 | 2021-03-16 | Vyne Therapeutics Inc. | Surfactant-free water-free foamable compositions, breakable foams and gels and their uses |
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US9675700B2 (en) | 2009-10-02 | 2017-06-13 | Foamix Pharmaceuticals Ltd. | Topical tetracycline compositions |
US10610599B2 (en) | 2009-10-02 | 2020-04-07 | Foamix Pharmaceuticals Ltd. | Topical tetracycline compositions |
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US10029011B2 (en) | 2009-11-13 | 2018-07-24 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical composition comprising a GLP-1 agonist, an insulin and methionine |
US10028910B2 (en) | 2009-11-13 | 2018-07-24 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical composition comprising a GLP-1-agonist and methionine |
US9707176B2 (en) | 2009-11-13 | 2017-07-18 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical composition comprising a GLP-1 agonist and methionine |
US9981013B2 (en) | 2010-08-30 | 2018-05-29 | Sanofi-Aventis Deutschland Gmbh | Use of AVE0010 for the treatment of diabetes mellitus type 2 |
US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
US9408893B2 (en) | 2011-08-29 | 2016-08-09 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for use in glycemic control in diabetes type 2 patients |
US9364519B2 (en) | 2011-09-01 | 2016-06-14 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
US9987332B2 (en) | 2011-09-01 | 2018-06-05 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
US9950039B2 (en) | 2014-12-12 | 2018-04-24 | Sanofi-Aventis Deutschland Gmbh | Insulin glargine/lixisenatide fixed ratio formulation |
US10434147B2 (en) | 2015-03-13 | 2019-10-08 | Sanofi-Aventis Deutschland Gmbh | Treatment type 2 diabetes mellitus patients |
US10159713B2 (en) | 2015-03-18 | 2018-12-25 | Sanofi-Aventis Deutschland Gmbh | Treatment of type 2 diabetes mellitus patients |
US10849847B2 (en) | 2016-09-08 | 2020-12-01 | Foamix Pharamaceuticals Ltd. | Compositions and methods for treating rosacea and acne |
US11324691B2 (en) | 2016-09-08 | 2022-05-10 | Journey Medical Corporation | Compositions and methods for treating rosacea and acne |
US10398641B2 (en) | 2016-09-08 | 2019-09-03 | Foamix Pharmaceuticals Ltd. | Compositions and methods for treating rosacea and acne |
Also Published As
Publication number | Publication date |
---|---|
JPS55153712A (en) | 1980-11-29 |
JPS5643443B2 (en) | 1981-10-13 |
DE3018843A1 (en) | 1980-11-20 |
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