FR2446279B1 - CIS- AND TRANS-3-ARYLOXY-4-HYDROXYPYRROLIDINES AND DERIVATIVES THEREOF, ESPECIALLY USEFUL IN VETERINARY MEDICINE AS ANTIDEPRESSANTS - Google Patents

CIS- AND TRANS-3-ARYLOXY-4-HYDROXYPYRROLIDINES AND DERIVATIVES THEREOF, ESPECIALLY USEFUL IN VETERINARY MEDICINE AS ANTIDEPRESSANTS

Info

Publication number
FR2446279B1
FR2446279B1 FR8000272A FR8000272A FR2446279B1 FR 2446279 B1 FR2446279 B1 FR 2446279B1 FR 8000272 A FR8000272 A FR 8000272A FR 8000272 A FR8000272 A FR 8000272A FR 2446279 B1 FR2446279 B1 FR 2446279B1
Authority
FR
France
Prior art keywords
hydroxypyrrolidines
antidepressants
aryloxy
cis
trans
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8000272A
Other languages
French (fr)
Other versions
FR2446279A1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AH Robins Co Inc
Original Assignee
AH Robins Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AH Robins Co Inc filed Critical AH Robins Co Inc
Publication of FR2446279A1 publication Critical patent/FR2446279A1/en
Application granted granted Critical
Publication of FR2446279B1 publication Critical patent/FR2446279B1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
FR8000272A 1979-01-09 1980-01-08 CIS- AND TRANS-3-ARYLOXY-4-HYDROXYPYRROLIDINES AND DERIVATIVES THEREOF, ESPECIALLY USEFUL IN VETERINARY MEDICINE AS ANTIDEPRESSANTS Expired FR2446279B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US215179A 1979-01-09 1979-01-09

Publications (2)

Publication Number Publication Date
FR2446279A1 FR2446279A1 (en) 1980-08-08
FR2446279B1 true FR2446279B1 (en) 1985-10-31

Family

ID=21699450

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8000272A Expired FR2446279B1 (en) 1979-01-09 1980-01-08 CIS- AND TRANS-3-ARYLOXY-4-HYDROXYPYRROLIDINES AND DERIVATIVES THEREOF, ESPECIALLY USEFUL IN VETERINARY MEDICINE AS ANTIDEPRESSANTS

Country Status (9)

Country Link
JP (1) JPS5598160A (en)
CA (1) CA1133495A (en)
CH (1) CH643243A5 (en)
DE (1) DE3000625A1 (en)
FR (1) FR2446279B1 (en)
GB (1) GB2040933B (en)
IT (1) IT1127967B (en)
MX (1) MX6634E (en)
SE (1) SE435927B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE45511B1 (en) 1976-09-01 1982-09-08 Ciba Geigy Ag New derivatives of perhydro-aza-heterocycles and processesfor the production thereof
US4547514A (en) * 1983-12-05 1985-10-15 A. H. Robins Company, Incorporated Aryloxy-N-(aminoalkyl)-1-pyrrolidine and piperidine carboxamides and carbothioamides having antiarrhythmic activity
JPS60178860A (en) * 1984-02-24 1985-09-12 Sankyo Co Ltd Preparation of 3-mercaptopyrrolidine or salt thereof
JPS6157552A (en) * 1984-08-29 1986-03-24 Toyama Chem Co Ltd Production of 3-aminopyrrolidine or its salt
DE3813416A1 (en) * 1988-04-21 1989-11-02 Hoechst Ag 3,4-DIHYDROXYPYRROLIDIN-2-ON DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THE AGENTS CONTAINING THEM AND THEIR USE, AND THE NEW INTERMEDIATES WHICH ARE INVOLVED IN THE MANUFACTURE
EP0407701A3 (en) * 1989-05-15 1992-04-22 Fujisawa Pharmaceutical Co., Ltd. Antiretroviral pyrroline and pyrrolidine sulfonic acid derivatives
JP5323063B2 (en) 2007-05-31 2013-10-23 塩野義製薬株式会社 Oxyimino compounds and uses thereof
EP2346820B1 (en) 2008-06-11 2013-02-13 Shionogi & Co., Ltd. Oxycarbamoyl compounds and the use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1000308A (en) * 1949-05-28 1952-02-11 Basf Ag Process for the production of 3. 4-dioxypyrrolidines
FR1000310A (en) * 1949-06-18 1952-02-11 Basf Ag Process for the production of pyrrolidine derivatives
FR1532221A (en) * 1963-10-22 1968-07-12 Robins Co Inc A H Process for the production of n, n-di (monocarbocyclic aryl) -carbamates of 1- (lower alkyl) -3-pyrrolidyl
CH521338A (en) * 1967-03-13 1972-04-15 Robins Co Inc A H Pyrrolidin thiol derivs antiarrhythmia
US3577415A (en) * 1968-12-23 1971-05-04 Robins Co Inc A H 1-substituted-3-substituted phenoxypyrrolidines
IE45511B1 (en) * 1976-09-01 1982-09-08 Ciba Geigy Ag New derivatives of perhydro-aza-heterocycles and processesfor the production thereof

Also Published As

Publication number Publication date
FR2446279A1 (en) 1980-08-08
DE3000625C2 (en) 1989-04-20
IT8067020A0 (en) 1980-01-08
SE435927B (en) 1984-10-29
JPS648621B2 (en) 1989-02-14
MX6634E (en) 1985-09-12
CH643243A5 (en) 1984-05-30
JPS5598160A (en) 1980-07-25
DE3000625A1 (en) 1980-07-17
SE8000085L (en) 1980-08-26
IT1127967B (en) 1986-05-28
CA1133495A (en) 1982-10-12
GB2040933B (en) 1983-07-20
GB2040933A (en) 1980-09-03

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Legal Events

Date Code Title Description
ST Notification of lapse