DE3000625C2 - - Google Patents

Info

Publication number
DE3000625C2
DE3000625C2 DE3000625A DE3000625A DE3000625C2 DE 3000625 C2 DE3000625 C2 DE 3000625C2 DE 3000625 A DE3000625 A DE 3000625A DE 3000625 A DE3000625 A DE 3000625A DE 3000625 C2 DE3000625 C2 DE 3000625C2
Authority
DE
Germany
Prior art keywords
pyrrolidinol
chlorophenoxy
trans
ethyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE3000625A
Other languages
German (de)
Other versions
DE3000625A1 (en
Inventor
David Allan Walsh
William John Richmond Va. Us Welstead Jun.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AH Robins Co Inc
Original Assignee
AH Robins Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AH Robins Co Inc filed Critical AH Robins Co Inc
Publication of DE3000625A1 publication Critical patent/DE3000625A1/en
Application granted granted Critical
Publication of DE3000625C2 publication Critical patent/DE3000625C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Claims (2)

1. trans-4-(2-Chlorphenoxy)-1-ethyl-3-pyrrolidinol der Formel 1. trans-4- (2-chlorophenoxy) -1-ethyl-3-pyrrolidinol of the formula 2. Pharmazeutische Zubereitung, enthaltend die Verbindung nach Anspruch 1, zusammen mit einem pharmazeutischen Träger.2. Pharmaceutical preparation containing the compound according to claim 1, together with a pharmaceutical carrier.
DE19803000625 1979-01-09 1980-01-09 CIS AND TRANS ISOMERS OF 3-ARYLOXY- 4-HYDROXYPYRROLIDINES AND THEIR DERIVATIVES, METHODS FOR THE PRODUCTION THEREOF AND THEIR USE Granted DE3000625A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US215179A 1979-01-09 1979-01-09

Publications (2)

Publication Number Publication Date
DE3000625A1 DE3000625A1 (en) 1980-07-17
DE3000625C2 true DE3000625C2 (en) 1989-04-20

Family

ID=21699450

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19803000625 Granted DE3000625A1 (en) 1979-01-09 1980-01-09 CIS AND TRANS ISOMERS OF 3-ARYLOXY- 4-HYDROXYPYRROLIDINES AND THEIR DERIVATIVES, METHODS FOR THE PRODUCTION THEREOF AND THEIR USE

Country Status (9)

Country Link
JP (1) JPS5598160A (en)
CA (1) CA1133495A (en)
CH (1) CH643243A5 (en)
DE (1) DE3000625A1 (en)
FR (1) FR2446279B1 (en)
GB (1) GB2040933B (en)
IT (1) IT1127967B (en)
MX (1) MX6634E (en)
SE (1) SE435927B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE45511B1 (en) 1976-09-01 1982-09-08 Ciba Geigy Ag New derivatives of perhydro-aza-heterocycles and processesfor the production thereof
US4547514A (en) * 1983-12-05 1985-10-15 A. H. Robins Company, Incorporated Aryloxy-N-(aminoalkyl)-1-pyrrolidine and piperidine carboxamides and carbothioamides having antiarrhythmic activity
JPS60178860A (en) * 1984-02-24 1985-09-12 Sankyo Co Ltd Preparation of 3-mercaptopyrrolidine or salt thereof
JPS6157552A (en) * 1984-08-29 1986-03-24 Toyama Chem Co Ltd Production of 3-aminopyrrolidine or its salt
DE3813416A1 (en) * 1988-04-21 1989-11-02 Hoechst Ag 3,4-DIHYDROXYPYRROLIDIN-2-ON DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THE AGENTS CONTAINING THEM AND THEIR USE, AND THE NEW INTERMEDIATES WHICH ARE INVOLVED IN THE MANUFACTURE
EP0407701A3 (en) * 1989-05-15 1992-04-22 Fujisawa Pharmaceutical Co., Ltd. Antiretroviral pyrroline and pyrrolidine sulfonic acid derivatives
ES2422603T3 (en) 2007-05-31 2013-09-12 Shionogi & Co Oxyimino compounds and the use of these
JP5501983B2 (en) * 2008-06-11 2014-05-28 塩野義製薬株式会社 Oxycarbamoyl compounds and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1000308A (en) * 1949-05-28 1952-02-11 Basf Ag Process for the production of 3. 4-dioxypyrrolidines
FR1000310A (en) * 1949-06-18 1952-02-11 Basf Ag Process for the production of pyrrolidine derivatives
FR1532221A (en) * 1963-10-22 1968-07-12 Robins Co Inc A H Process for the production of n, n-di (monocarbocyclic aryl) -carbamates of 1- (lower alkyl) -3-pyrrolidyl
CH521338A (en) * 1967-03-13 1972-04-15 Robins Co Inc A H Pyrrolidin thiol derivs antiarrhythmia
US3577415A (en) * 1968-12-23 1971-05-04 Robins Co Inc A H 1-substituted-3-substituted phenoxypyrrolidines
IE45511B1 (en) * 1976-09-01 1982-09-08 Ciba Geigy Ag New derivatives of perhydro-aza-heterocycles and processesfor the production thereof

Also Published As

Publication number Publication date
SE435927B (en) 1984-10-29
GB2040933B (en) 1983-07-20
JPS648621B2 (en) 1989-02-14
CA1133495A (en) 1982-10-12
CH643243A5 (en) 1984-05-30
SE8000085L (en) 1980-08-26
JPS5598160A (en) 1980-07-25
GB2040933A (en) 1980-09-03
IT1127967B (en) 1986-05-28
DE3000625A1 (en) 1980-07-17
FR2446279A1 (en) 1980-08-08
FR2446279B1 (en) 1985-10-31
IT8067020A0 (en) 1980-01-08
MX6634E (en) 1985-09-12

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Legal Events

Date Code Title Description
8128 New person/name/address of the agent

Representative=s name: SCHWABE, H., DIPL.-ING. SANDMAIR, K., DIPL.-CHEM.

8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee