FR2436781A1 - 3-Amino-(1h,3h)-quinazoline-2,4-di:one derivs. - useful as anxiolytics and sedatives to treat hypertension - Google Patents

3-Amino-(1h,3h)-quinazoline-2,4-di:one derivs. - useful as anxiolytics and sedatives to treat hypertension

Info

Publication number
FR2436781A1
FR2436781A1 FR7826809A FR7826809A FR2436781A1 FR 2436781 A1 FR2436781 A1 FR 2436781A1 FR 7826809 A FR7826809 A FR 7826809A FR 7826809 A FR7826809 A FR 7826809A FR 2436781 A1 FR2436781 A1 FR 2436781A1
Authority
FR
France
Prior art keywords
amino
anxiolytics
quinazoline
cpds
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7826809A
Other languages
French (fr)
Other versions
FR2436781B1 (en
Inventor
Rene Baronnet
Raymond Callendret
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BERRI BALZAC
Original Assignee
BERRI BALZAC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BERRI BALZAC filed Critical BERRI BALZAC
Priority to FR7826809A priority Critical patent/FR2436781A1/en
Publication of FR2436781A1 publication Critical patent/FR2436781A1/en
Application granted granted Critical
Publication of FR2436781B1 publication Critical patent/FR2436781B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/38—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/28—Nitrogen atoms
    • C07D295/32—Nitrogen atoms acylated with carboxylic or carbonic acids, or their nitrogen or sulfur analogues

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

3-Amino-(1H,3H)-quinazoline-2,4-dione derivs of formula (I) and their acid addition salts are new. R1, R2 are H, 1-4C alkyl or an aromatic or aliphatic acyl group or R1 and R2 together with the N atom for a 5-6 membered heterocyclic group which opt. has a further heteroatom; R3=H or 1-4C alkyl and R4, R5 independently = H, halo, 1-4C alkyl, or 1-4c alkoxy. When R3=H the cpds. may be in teh tautomeric 3-amino-2-hydroxy-3H-quinazolin-4-one form. Anxiolytics and diuretics used to treat hypertension. The cpds. are usually administered orally or rectally in unit doses of 5-30 mg. Toxicity (LD50= 300 mg-1g/kg p.o. or 250-425 mg/kg i.p. for tested cpds.), diuretic and sedative tests are described.
FR7826809A 1978-09-19 1978-09-19 3-Amino-(1h,3h)-quinazoline-2,4-di:one derivs. - useful as anxiolytics and sedatives to treat hypertension Granted FR2436781A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7826809A FR2436781A1 (en) 1978-09-19 1978-09-19 3-Amino-(1h,3h)-quinazoline-2,4-di:one derivs. - useful as anxiolytics and sedatives to treat hypertension

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7826809A FR2436781A1 (en) 1978-09-19 1978-09-19 3-Amino-(1h,3h)-quinazoline-2,4-di:one derivs. - useful as anxiolytics and sedatives to treat hypertension

Publications (2)

Publication Number Publication Date
FR2436781A1 true FR2436781A1 (en) 1980-04-18
FR2436781B1 FR2436781B1 (en) 1981-12-18

Family

ID=9212765

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7826809A Granted FR2436781A1 (en) 1978-09-19 1978-09-19 3-Amino-(1h,3h)-quinazoline-2,4-di:one derivs. - useful as anxiolytics and sedatives to treat hypertension

Country Status (1)

Country Link
FR (1) FR2436781A1 (en)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0370686A2 (en) * 1988-11-23 1990-05-30 Pfizer Inc. A process for preparing quinolone carboxylic acid intermediates
EP0781767A1 (en) * 1995-12-26 1997-07-02 Sumitomo Chemical Company, Limited Process for producing isatoic anhydrides
US20100113774A1 (en) * 2007-03-06 2010-05-06 Roger John Taylor Bicyclic organic compounds suitable for the treatment of inflammatory or allergic conditions
US8080557B2 (en) * 2004-06-30 2011-12-20 Janssen Pharmaceutica, Nv Quinazolinedione derivatives as PARP inhibitors
US8168644B2 (en) 2008-03-27 2012-05-01 Janssen Pharmaceutica Nv Quinazolinone derivatives as tubulin polymerization inhibitors
US8299256B2 (en) 2007-03-08 2012-10-30 Janssen Pharmaceutica Nv Quinolinone derivatives as PARP and TANK inhibitors
US8404713B2 (en) 2007-10-26 2013-03-26 Janssen Pharmaceutica Nv Quinolinone derivatives as PARP inhibitors
US8450486B2 (en) 2003-11-20 2013-05-28 Janssen Pharmaceutica, Nv 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors
US8524714B2 (en) 2003-11-20 2013-09-03 Janssen Pharmaceutica, Nv 7-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors
US8623872B2 (en) 2004-06-30 2014-01-07 Janssen Pharmaceutica, Nv Quinazolinone derivatives as PARP inhibitors
US8889866B2 (en) 2008-03-27 2014-11-18 Janssen Pharmaceutica, Nv Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as PARP and tubulin polymerization inhibitors
US8946221B2 (en) 2004-06-30 2015-02-03 Janssen Pharmaceutica, Nv Phthalazine derivatives as PARP inhibitors

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0370686A2 (en) * 1988-11-23 1990-05-30 Pfizer Inc. A process for preparing quinolone carboxylic acid intermediates
EP0370686A3 (en) * 1988-11-23 1990-12-12 Pfizer Inc. A process for preparing quinolone carboxylic acid intermediates
EP0781767A1 (en) * 1995-12-26 1997-07-02 Sumitomo Chemical Company, Limited Process for producing isatoic anhydrides
US5795984A (en) * 1995-12-26 1998-08-18 Sumitomo Chemical Company Limited Process for producing isatoic anhydrides
US5973145A (en) * 1995-12-26 1999-10-26 Sumitomo Chemical Company, Limited Process for producing isatoic anhydrides
US5981749A (en) * 1995-12-26 1999-11-09 Sumitomo Chemical Company Limited Process for producing isatoic anhydrides
US8524714B2 (en) 2003-11-20 2013-09-03 Janssen Pharmaceutica, Nv 7-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors
US8450486B2 (en) 2003-11-20 2013-05-28 Janssen Pharmaceutica, Nv 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors
US8080557B2 (en) * 2004-06-30 2011-12-20 Janssen Pharmaceutica, Nv Quinazolinedione derivatives as PARP inhibitors
US10150757B2 (en) 2004-06-30 2018-12-11 Janssen Pharmaceutica Nv Quinazolinone derivatives as PARP inhibitors
US9522905B2 (en) 2004-06-30 2016-12-20 Janssen Pharmaceutica Nv Quinazolinone derivatives as PARP inhibitors
US9255080B2 (en) 2004-06-30 2016-02-09 Janssen Pharmaceutica Nv Quinazolinedione derivatives as PARP inhibitors
US8946221B2 (en) 2004-06-30 2015-02-03 Janssen Pharmaceutica, Nv Phthalazine derivatives as PARP inhibitors
US8623872B2 (en) 2004-06-30 2014-01-07 Janssen Pharmaceutica, Nv Quinazolinone derivatives as PARP inhibitors
US8633211B2 (en) * 2007-03-06 2014-01-21 Novartis Ag Bicyclic organic compounds suitable for the treatment of inflammatory or allergic conditions
US20100113774A1 (en) * 2007-03-06 2010-05-06 Roger John Taylor Bicyclic organic compounds suitable for the treatment of inflammatory or allergic conditions
US8778966B2 (en) 2007-03-08 2014-07-15 Janssen Pharmaceutica, Nv Quinolinone derivatives as PARP and tank inhibitors
US8299256B2 (en) 2007-03-08 2012-10-30 Janssen Pharmaceutica Nv Quinolinone derivatives as PARP and TANK inhibitors
US8404713B2 (en) 2007-10-26 2013-03-26 Janssen Pharmaceutica Nv Quinolinone derivatives as PARP inhibitors
US8889866B2 (en) 2008-03-27 2014-11-18 Janssen Pharmaceutica, Nv Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as PARP and tubulin polymerization inhibitors
US9150540B2 (en) 2008-03-27 2015-10-06 Janssen Pharmaceutica Nv Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as parp and tubulin polymerization inhibitors
US9598396B2 (en) 2008-03-27 2017-03-21 Janssen Pharmaceutica Nv Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as PARP and tubulin polymerization inhibitors
US8168644B2 (en) 2008-03-27 2012-05-01 Janssen Pharmaceutica Nv Quinazolinone derivatives as tubulin polymerization inhibitors

Also Published As

Publication number Publication date
FR2436781B1 (en) 1981-12-18

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