FR2436774A1 - N-Alkylamino-benzophenone preparation - by reacting amino-benzophenone with alkylation agent, base, quat. ammonium catalyst etc. to give pharmaceutical intermediate (J5 28.3.80) - Google Patents

N-Alkylamino-benzophenone preparation - by reacting amino-benzophenone with alkylation agent, base, quat. ammonium catalyst etc. to give pharmaceutical intermediate (J5 28.3.80)

Info

Publication number
FR2436774A1
FR2436774A1 FR7826918A FR7826918A FR2436774A1 FR 2436774 A1 FR2436774 A1 FR 2436774A1 FR 7826918 A FR7826918 A FR 7826918A FR 7826918 A FR7826918 A FR 7826918A FR 2436774 A1 FR2436774 A1 FR 2436774A1
Authority
FR
France
Prior art keywords
benzophenone
quat
alkylamino
base
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7826918A
Other languages
French (fr)
Other versions
FR2436774B1 (en
Inventor
Gilbert Mouzin
Henri Cousse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre SA
Original Assignee
Pierre Fabre SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre SA filed Critical Pierre Fabre SA
Priority to FR7826918A priority Critical patent/FR2436774A1/en
Priority to CA335,380A priority patent/CA1129886A/en
Priority to ES484245A priority patent/ES484245A1/en
Priority to IT50292/79A priority patent/IT1162396B/en
Priority to JP12155679A priority patent/JPS5543099A/en
Publication of FR2436774A1 publication Critical patent/FR2436774A1/en
Application granted granted Critical
Publication of FR2436774B1 publication Critical patent/FR2436774B1/fr
Granted legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B61/00—Other general methods
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Process for the prepn. of N-alkylamino-benzophenone of formula (I) by reaction of an amino-benzophenone (II) with an alkylating agent, in the presence of a base, a quat. ammonium cpd. as catalyst and in an organic solvent. R is opt. branched, 1-5C alkyl and the two X groups independently-H or halo. Used as intermediates for medicaments, such as 2-benzoyl-4-chloro-glycinanilides (French application 77-18511) and diazepam. Process gives selective and quantitative alkylation in a single reaction stage to yield pure prods. Known processes have numerous stage, are non-selective (giving dialkyl cpds.) and give poor yields of purified (I).
FR7826918A 1978-09-20 1978-09-20 N-Alkylamino-benzophenone preparation - by reacting amino-benzophenone with alkylation agent, base, quat. ammonium catalyst etc. to give pharmaceutical intermediate (J5 28.3.80) Granted FR2436774A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
FR7826918A FR2436774A1 (en) 1978-09-20 1978-09-20 N-Alkylamino-benzophenone preparation - by reacting amino-benzophenone with alkylation agent, base, quat. ammonium catalyst etc. to give pharmaceutical intermediate (J5 28.3.80)
CA335,380A CA1129886A (en) 1978-09-20 1979-09-11 Process for the preparation of n-alkylaminobenzophenones
ES484245A ES484245A1 (en) 1978-09-20 1979-09-18 Preparation of nnalkylaminobenzophenone
IT50292/79A IT1162396B (en) 1978-09-20 1979-09-19 PROCEDURE FOR PREPARING N-ALCHYLAMINO-BENZOPHENONES USEFUL IN THE PREPARATION OF MEDICATIONS
JP12155679A JPS5543099A (en) 1978-09-20 1979-09-20 Preparation of nnalkylaminobenzophenone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7826918A FR2436774A1 (en) 1978-09-20 1978-09-20 N-Alkylamino-benzophenone preparation - by reacting amino-benzophenone with alkylation agent, base, quat. ammonium catalyst etc. to give pharmaceutical intermediate (J5 28.3.80)

Publications (2)

Publication Number Publication Date
FR2436774A1 true FR2436774A1 (en) 1980-04-18
FR2436774B1 FR2436774B1 (en) 1982-12-03

Family

ID=9212811

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7826918A Granted FR2436774A1 (en) 1978-09-20 1978-09-20 N-Alkylamino-benzophenone preparation - by reacting amino-benzophenone with alkylation agent, base, quat. ammonium catalyst etc. to give pharmaceutical intermediate (J5 28.3.80)

Country Status (5)

Country Link
JP (1) JPS5543099A (en)
CA (1) CA1129886A (en)
ES (1) ES484245A1 (en)
FR (1) FR2436774A1 (en)
IT (1) IT1162396B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0044091A2 (en) * 1978-09-25 1982-01-20 Pierre Fabre S.A. Process for the preparation of N-alkylamino-benzophenones

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2081393A1 (en) * 1969-12-23 1971-12-03 Pharmacia Ab

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2081393A1 (en) * 1969-12-23 1971-12-03 Pharmacia Ab

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
C.R. ACAD.SC. PARIS, tôme 285, Série C, pages 199 - 201 (septembre 1971) *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0044091A2 (en) * 1978-09-25 1982-01-20 Pierre Fabre S.A. Process for the preparation of N-alkylamino-benzophenones
EP0044091A3 (en) * 1978-09-25 1982-03-31 Fabre Sa Pierre Process for the preparation of n-alkylamino-benzophenones

Also Published As

Publication number Publication date
ES484245A1 (en) 1980-05-16
FR2436774B1 (en) 1982-12-03
CA1129886A (en) 1982-08-17
IT7950292A0 (en) 1979-09-19
IT1162396B (en) 1987-03-25
JPS5543099A (en) 1980-03-26

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