FR2429210A1 - Derives de phenyl-4 thiazolyl-2 oxamates utiles dans le traitement de l'asthme - Google Patents

Derives de phenyl-4 thiazolyl-2 oxamates utiles dans le traitement de l'asthme

Info

Publication number
FR2429210A1
FR2429210A1 FR7818500A FR7818500A FR2429210A1 FR 2429210 A1 FR2429210 A1 FR 2429210A1 FR 7818500 A FR7818500 A FR 7818500A FR 7818500 A FR7818500 A FR 7818500A FR 2429210 A1 FR2429210 A1 FR 2429210A1
Authority
FR
France
Prior art keywords
thiazolyl
asthma
phenyl
treatment
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7818500A
Other languages
English (en)
French (fr)
Other versions
FR2429210B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html
Inventor
H Cousse
G Mouzin
J-P Tarayre
S Casadio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre SA
Original Assignee
Pierre Fabre SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre SA filed Critical Pierre Fabre SA
Priority to FR7818500A priority Critical patent/FR2429210A1/fr
Priority to AT79400293T priority patent/ATE407T1/de
Priority to DE7979400293T priority patent/DE2961352D1/de
Priority to EP79400293A priority patent/EP0006368B1/fr
Priority to US06/048,371 priority patent/US4246271A/en
Priority to ES481633A priority patent/ES481633A1/es
Priority to CA000330121A priority patent/CA1231952A/fr
Priority to JP7638779A priority patent/JPS552684A/ja
Publication of FR2429210A1 publication Critical patent/FR2429210A1/fr
Application granted granted Critical
Publication of FR2429210B1 publication Critical patent/FR2429210B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
FR7818500A 1978-06-19 1978-06-19 Derives de phenyl-4 thiazolyl-2 oxamates utiles dans le traitement de l'asthme Granted FR2429210A1 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
FR7818500A FR2429210A1 (fr) 1978-06-19 1978-06-19 Derives de phenyl-4 thiazolyl-2 oxamates utiles dans le traitement de l'asthme
DE7979400293T DE2961352D1 (en) 1978-06-19 1979-05-09 4-phenyl-thiazolyl-2-oxamate derivatives, their preparation and their use in the treatment of asthma
EP79400293A EP0006368B1 (fr) 1978-06-19 1979-05-09 Dérivés de phényl-4 thiazolyl-2 oxamate, procédé pour leur préparation et leur application dans le traitement de l'asthme
AT79400293T ATE407T1 (de) 1978-06-19 1979-05-09 4-phenyl-thiazolyl-2-oxamat derivate, verfahren zu ihrer herstellung und ihre anwendung bei der behandlung von asthma.
US06/048,371 US4246271A (en) 1978-06-19 1979-06-14 4-Phenyl-2-thiazolyl-oxamates useful in the treatment of asthma
ES481633A ES481633A1 (es) 1978-06-19 1979-06-18 Un procedimiento de preparacion de derivados de 4-fenil-2- tiazolil-oxamato.
CA000330121A CA1231952A (fr) 1978-06-19 1979-06-19 Derives de phenyl-4 thiazolyl-2 oxamates
JP7638779A JPS552684A (en) 1978-06-19 1979-06-19 *44phenyll22thiazolyl**oxaminic ester*its manufacture and drug containing it for asthma therapy

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7818500A FR2429210A1 (fr) 1978-06-19 1978-06-19 Derives de phenyl-4 thiazolyl-2 oxamates utiles dans le traitement de l'asthme

Publications (2)

Publication Number Publication Date
FR2429210A1 true FR2429210A1 (fr) 1980-01-18
FR2429210B1 FR2429210B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1980-10-31

Family

ID=9209775

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7818500A Granted FR2429210A1 (fr) 1978-06-19 1978-06-19 Derives de phenyl-4 thiazolyl-2 oxamates utiles dans le traitement de l'asthme

Country Status (8)

Country Link
US (1) US4246271A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0006368B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS552684A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE407T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1231952A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE2961352D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES481633A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2429210A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2828091A1 (de) * 1978-06-27 1980-01-10 Boehringer Sohn Ingelheim 4-substituierte thiazoloxamsaeuren sowie ihre salze und ester
US4321372A (en) * 1980-06-16 1982-03-23 Pfizer Inc. Antiulcer thiazol-2-ylcarbamoyl-carboxylic acids, esters and amides
DE3027527A1 (de) * 1980-07-19 1982-02-18 Basf Ag, 6700 Ludwigshafen Neue oxamidsaeure-derivate, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel
FR2494272A1 (fr) * 1980-11-19 1982-05-21 Fabre Sa Pierre Derives de l'acide thiazolyl-2 oxamique substitues en position 4 par un radical thienyle ou furyle, leur preparation et leur utilisation comme medicaments
DE3135250A1 (de) * 1981-09-05 1983-03-17 Basf Ag, 6700 Ludwigshafen Tricyclische thiazolyloxamate, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel
IT1183061B (it) * 1984-07-31 1987-10-05 Zambon Spa Composti dotati di attivita'antiallergica
DE3503773A1 (de) * 1985-02-05 1986-08-07 Basf Ag, 6700 Ludwigshafen Thiazolylamide, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung unerwuenschten pflanzenwuchses
IT1204960B (it) * 1987-03-25 1989-03-10 Zambon Farmaceutici Spa Composti dotati di attivita' antiallergica
DE3807232A1 (de) * 1988-03-05 1989-09-14 Bayer Ag Substituierte acrylsaeureester
JPH0667836B2 (ja) * 1989-03-01 1994-08-31 東洋紡績株式会社 アミド系化合物からなる抗アレルギー剤
FR2671552B1 (fr) * 1991-01-15 1993-05-07 Pf Medicament Procede de preparation de thiazolyl-2 oxamates d'alkyle.
EP0589985A1 (en) * 1991-06-21 1994-04-06 Boehringer Mannheim Italia S.P.A. 2-amino-4-aryl-thiazoles with antiasthmatic and anti-inflammatory activities on the respiratory tract
JP2510110B2 (ja) * 1992-04-07 1996-06-26 日本航空電子工業株式会社 電子部品用導体の製造方法
US6506777B1 (en) * 1999-06-11 2003-01-14 Merck & Co., Inc. Cyclopentyl modulators of chemokine receptor activity
TWI314928B (en) * 2002-02-28 2009-09-21 Novartis A 5-phenylthiazole derivatives and use as pi3 kinase inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH486481A (de) * 1965-03-05 1970-02-28 Ciba Geigy Verfahren zur Herstellung neuer Nitrothiazolverbindungen

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3966965A (en) * 1973-03-23 1976-06-29 American Home Products Corporation Oxamic acid derivatives for the prevention of immediate type hypersensitivity reactions
US4054666A (en) * 1973-03-23 1977-10-18 American Home Products Corporation Compositions and methods of treating immediate hypersensitivity reactions with thiazolyl oxamic acid derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH486481A (de) * 1965-03-05 1970-02-28 Ciba Geigy Verfahren zur Herstellung neuer Nitrothiazolverbindungen

Also Published As

Publication number Publication date
CA1231952A (fr) 1988-01-26
ES481633A1 (es) 1980-02-16
US4246271A (en) 1981-01-20
JPS6251272B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1987-10-29
ATE407T1 (de) 1981-12-15
EP0006368A1 (fr) 1980-01-09
FR2429210B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1980-10-31
EP0006368B1 (fr) 1981-11-18
JPS552684A (en) 1980-01-10
DE2961352D1 (en) 1982-01-21

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