FR2428032A1 - N-Aryl-azolidone cpds. - useful as psychotropic agents and antidepressants (NL 11.12.79) - Google Patents

N-Aryl-azolidone cpds. - useful as psychotropic agents and antidepressants (NL 11.12.79)

Info

Publication number
FR2428032A1
FR2428032A1 FR7817388A FR7817388A FR2428032A1 FR 2428032 A1 FR2428032 A1 FR 2428032A1 FR 7817388 A FR7817388 A FR 7817388A FR 7817388 A FR7817388 A FR 7817388A FR 2428032 A1 FR2428032 A1 FR 2428032A1
Authority
FR
France
Prior art keywords
phenyl
cyclopentylmethoxy
cyclohexylmethoxy
och2ar
substituent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7817388A
Other languages
French (fr)
Other versions
FR2428032B1 (en
Inventor
Colette Douzon
Jean-Francois Ancher
Guy Bourgery
Philippe Dostert
Patrick Guerret
Alain Lacour
Michel Langlois
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Priority to FR7817388A priority Critical patent/FR2428032A1/en
Priority to US06/045,143 priority patent/US4348393A/en
Priority to CA329,220A priority patent/CA1129859A/en
Priority to LU81370A priority patent/LU81370A1/en
Priority to ZA792799A priority patent/ZA792799B/en
Priority to AU47862/79A priority patent/AU525787B2/en
Priority to SE7904970A priority patent/SE446733B/en
Priority to BE0/195621A priority patent/BE876831A/en
Priority to GR59290A priority patent/GR69969B/el
Priority to DE19792923295 priority patent/DE2923295A1/en
Priority to CH540079A priority patent/CH642069A5/en
Priority to NL7904528A priority patent/NL7904528A/en
Priority to ES481909A priority patent/ES481909A0/en
Priority to GB7920102A priority patent/GB2028306B/en
Priority to GB8021771A priority patent/GB2054575B/en
Priority to IT7923395A priority patent/IT1206305B/en
Priority to JP7295479A priority patent/JPS5551064A/en
Publication of FR2428032A1 publication Critical patent/FR2428032A1/en
Priority to US06/119,073 priority patent/US4287351A/en
Priority to SE8001674A priority patent/SE447381B/en
Priority to NL8001539A priority patent/NL8001539A/en
Priority to CH216180A priority patent/CH639962A5/en
Priority to ES490110A priority patent/ES8106509A1/en
Priority to ES490114A priority patent/ES490114A0/en
Priority to ES490113A priority patent/ES490113A0/en
Priority to ES490112A priority patent/ES490112A0/en
Priority to IT8022284A priority patent/IT1206307B/en
Priority to FR8012423A priority patent/FR2458547B2/en
Priority to JP6772281A priority patent/JPS56167666A/en
Application granted granted Critical
Publication of FR2428032B1 publication Critical patent/FR2428032B1/fr
Priority to FR8208858A priority patent/FR2506769A2/en
Priority to US06/388,866 priority patent/US4526786A/en
Priority to US06/388,867 priority patent/US4413001A/en
Priority to US06/389,136 priority patent/US4435415A/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/14—Oxygen atoms

Abstract

Azolidone derivs. of formulae (Ia)-(Ie) and intermediates for their prepn. are claimed. In (Ia) (i) R2 is CH2OCOR3, where R3 is 1-8C alkyl, cyclohexyl, Ph, CH2OMe or CH2OPh, and R is a p-substituent comprising n-BuO, 3-methylbutoxy, cyclopentylmethoxy, cyclohexylmethoxy, 2-cyanoethoxy, OCH2CN or OCH2Ar, where Ar is Ph, m-chlorophenyl, m- or p-fluorophenyl, m-cyanophenyl, m-nitrophenyl, 3-nitro-5-chlorophenyl or 3-nitro-5cyanophenyl; or (ii) R2 is CH2OR6, where R6 is 1-5C alkyl, cycloexhyl, allyl, propargyl or CH2OMe, and R is m-Me or a p-substituent comprising 4-6C alkoxy, (4-7C cycloalkyl)methoxy, 1-methyl-1-cyclopentylmethoxy, 1-cyclopentenylmethoxy, 1-cyclohexenylmethoxy, 2-butenyloxy, 3-methyl-2-butenyloxy, 4-chlorobytoxy, 2-cyanoethoxy, 3-cyanopropoxy, 4-cyanobutoxy, 2-oxopropoxy, 4-oxo 1-cyclohexylmethoxy, 2-morpholinoethoxy, NEt2, 4- or 3-tetrahydropyranyloxy, trans-styryl (opt. m-substd. by Cl, CN or NO2), cis-styryl (opt. m-substd. by NO2), PhC=C, phenethyl, phenyl or OCH2AR', where Ar' is Ph, 3- or 4-Cl-phenyl, 3- or 4-F-phenyl, 3-I-phenyl, 3-Br-phenyl, 3-CF3-phenyl, 3- or 4-NO2-phenyl, 3- or 4-CN-phenyl, 3-Cl-4-F-phenyl, 3-CN,4-F-phenyl, 3-NO2-4-F-phenyl, 3,4-di-Cl-phenyl, 3-Cl-4-NO2-phenyl, 3-Cl-5-NO2-phenyl, 3-CN-5-NO2-phenyl or 3 5-di-Cl-phenyl; or (iii) CH2NR12R13. where NR12R13 is NH2, NHMe, NHEt, NHCHMe2, NME2, pyrrolidino or morpholino, and R is a p-substituent comprising n-BuO, 3-methylbutoxy, cyclopentylmethoxy, cyclopentylmethoxy, cyclohexylmethoxy, OCH2CN, OCH2CH2CN or OCH2Ar", where Ar" is Ph, 3-Cl-phenyl, 4-F-phenyl, 3-CN-phenyl, 3-NO2-phenyl or 3-Cl-5-NO2-phenyl). In (Ib)-(Ie) (i) R'2 is CH2OH and R' is 2-5C alkoxy, cyclopentylmethoxy, cyclohexylmethoxy, 1-cyclohexenylmethoxy, 4-tetrahydropyranylmethoxy, O(CH2)nCN(n=1-4) or OCH2Ar1, where Ar1 is 3- or 4-Cl-phenyl, 3- or 4-F-phenyl, 3-NO2-phenyl, 3-CN-phenyl, 3-CF3-phenyl, 3-Cl-5-NO2-phenyl or 3-CN-4-F-phenyl; or (ii) R'2 is CH2OR16, where R16 is 1-3C alkyl, and R' is 3-methyl-n-butoxy, cyclopentylmethoxy, cyclohexylmethoxy, 4-cyanobutoxy or OCH2Ar2, where Ar2 is 3-CN-phenyl, 3-NO2-phenyl, 3-CN-5-NO2-phenyl or 3-pyridyl; or (iii) R'2 is CH2OCOR 18, where R18 is Me or Et, and R' is cyclohexylmethoxy m-CN-benzyloxy or m-NO2-benzyloxy). Cpds. (Ia)-(Ie) are psychotropic agents and potential antidepressants, e.g. with higher activity than toloxation against reserpine-induced ptosis.
FR7817388A 1978-06-09 1978-06-09 N-Aryl-azolidone cpds. - useful as psychotropic agents and antidepressants (NL 11.12.79) Granted FR2428032A1 (en)

Priority Applications (32)

Application Number Priority Date Filing Date Title
FR7817388A FR2428032A1 (en) 1978-06-09 1978-06-09 N-Aryl-azolidone cpds. - useful as psychotropic agents and antidepressants (NL 11.12.79)
US06/045,143 US4348393A (en) 1978-06-09 1979-06-04 N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones
LU81370A LU81370A1 (en) 1978-06-09 1979-06-06 NOVEL N-ARYL OXAZOLIDINONES, OXAZOLIDINETHIONES, PYRROLIDINONES, PYRROLIDINES AND THIAZOLIDINONES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
ZA792799A ZA792799B (en) 1978-06-09 1979-06-06 Novel n-aryl oxazolidinones,oxazolidinethiones,pyrrolidinones,pyrrolidinines and thiazolidinones,process for their preparation and their application in therapeutics
CA329,220A CA1129859A (en) 1978-06-09 1979-06-06 N-aryle oxazolidinones, oxazolidinethiones and pyrrolidinones, their process of preparation and their application in therapeutics
SE7904970A SE446733B (en) 1978-06-09 1979-06-07 NEW N-ARYLOXAZOLIDINONES, OXAZOLIDINIONS, PYRROLIDINONES, PYRROLIDINES AND TIAZOLIDINONES AND SETTING TO MAKE THE SAME AND COMPOSITIONS THEREOF
AU47862/79A AU525787B2 (en) 1978-06-09 1979-06-07 N-aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones
BE0/195621A BE876831A (en) 1978-06-09 1979-06-07 NEWS N-ARYL OXAZOLIDINONES, OXAZOLIDINETHIONES, PYRROLIDINONES, PYRROLIDINES AND THIAZOLIDINONES, THEIR PREPARATION PROCESS AND THEIR APPLICATION IN THERAPEUTICS
GR59290A GR69969B (en) 1978-06-09 1979-06-07
CH540079A CH642069A5 (en) 1978-06-09 1979-06-08 N-ARYL OXAZOLIDINONES, OXAZOLIDINETHIONES, PYRROLIDINONES, PYRROLIDINES AND THIAZOLIDINONES, PROCESSES FOR THEIR PREPARATION, AND MEDICAMENTS CONTAINING THEM.
NL7904528A NL7904528A (en) 1978-06-09 1979-06-08 NEW N-ARYLOXAZOLIDINONES, OXAZOLIDINETHIONS, PYRRO-LIDINONES, PYRROLIDINES AND THIAZOLIDINONES.
ES481909A ES481909A0 (en) 1978-06-09 1979-06-08 PROCEDURE FOR THE PREPARATION OF NEW ARIL-3 ETER-5 O-XAZOLIDINONAS-2
GB7920102A GB2028306B (en) 1978-06-09 1979-06-08 Aryl oxazolidinones oxazolidinethiones pyrrolidinones pyrrolidines and thiazolidinones their process of proparation and their therapeutic application
GB8021771A GB2054575B (en) 1978-06-09 1979-06-08 N-aryl oxazolidinones and pyrrolidinones and their processes
IT7923395A IT1206305B (en) 1978-06-09 1979-06-08 N-ARYL-OSSAZOLIDINONI, -OSSAZOLIDINTIONI, -PIRROLIDINONI, -PIRROLIDINE AND -TIAZOLIDINONI, THEIR PREPARATION PROCEDURE AND THEIR APPLICATION IN THERAPY.
DE19792923295 DE2923295A1 (en) 1978-06-09 1979-06-08 NEW N-ARYL-OXAZOLIDINONE, -OXAZOLIDINTHIONE, -PYRROLIDINONE, -PYRROLIDINE AND -THIAZOLIDINONE, METHODS FOR THEIR PREPARATION AND MEDICINAL PRODUCTS CONTAINING SUCH COMPOUNDS
JP7295479A JPS5551064A (en) 1978-06-09 1979-06-09 Novel aryloxazolidinone*oxazolidinethione* pyrrolidinone*pyrrolidine and thiazolidinone* their manufacture and their therapeutic application
US06/119,073 US4287351A (en) 1978-06-09 1980-02-06 3-Parahydroxyphenyl-5-methylether-2-oxazolidinone compounds
SE8001674A SE447381B (en) 1978-06-09 1980-03-04 NEW N-ARYLOXAZOLIDINONES AND PYRROLIDINONES
NL8001539A NL8001539A (en) 1978-06-09 1980-03-14 N-Aryl-azolidone cpds. - useful as psychotropic agents and antidepressants (NL 11.12.79)
CH216180A CH639962A5 (en) 1978-06-09 1980-03-19 N-ARYLE OXAZOLIDINONES AND PYRROLIDINONES.
ES490114A ES490114A0 (en) 1978-06-09 1980-03-31 METHOD OF PREPARING NEW ARIL-3 ETER-5 OXAZOLIDINONES-2
ES490112A ES490112A0 (en) 1978-06-09 1980-03-31 PROCEDURE FOR PREPARING OXAZOLIDINATIONAS
ES490113A ES490113A0 (en) 1978-06-09 1980-03-31 PREPARATION METHOD OF NEW ARIL-3 AMINOMETIL-5 OXAZOLIDINONES-2
ES490110A ES8106509A1 (en) 1978-06-09 1980-03-31 N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones
IT8022284A IT1206307B (en) 1978-06-09 1980-05-23 N-ARIL-OSSAZOLIDINONI AND -PIRROLIDINONI, AND PROCEDURES FOR THEIR PREPARATION.
FR8012423A FR2458547B2 (en) 1978-06-09 1980-06-04 NOVEL AZOLONES N-ARYLE, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
JP6772281A JPS56167666A (en) 1978-06-09 1981-05-07 N-aryloxazolidinone, pyrrolidinone and their manufacture
FR8208858A FR2506769A2 (en) 1978-06-09 1982-05-19 Cyano:pentyl:phenyl-methoxymethyl-oxazolidinone - useful as antidepressant
US06/389,136 US4435415A (en) 1978-06-09 1982-06-16 N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones
US06/388,867 US4413001A (en) 1978-06-09 1982-06-16 N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones
US06/388,866 US4526786A (en) 1978-06-09 1982-06-16 N-Substituted phenyl-5-aminomethyl oxazolidinones and their method of use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7817388A FR2428032A1 (en) 1978-06-09 1978-06-09 N-Aryl-azolidone cpds. - useful as psychotropic agents and antidepressants (NL 11.12.79)

Publications (2)

Publication Number Publication Date
FR2428032A1 true FR2428032A1 (en) 1980-01-04
FR2428032B1 FR2428032B1 (en) 1981-10-16

Family

ID=9209330

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7817388A Granted FR2428032A1 (en) 1978-06-09 1978-06-09 N-Aryl-azolidone cpds. - useful as psychotropic agents and antidepressants (NL 11.12.79)

Country Status (3)

Country Link
JP (2) JPS5551064A (en)
FR (1) FR2428032A1 (en)
ZA (1) ZA792799B (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2458547A2 (en) * 1978-06-09 1981-01-02 Delalande Sa Antidepressant aryl derivs of azolone(s) - prepd. e.g. from hydroxymethyl-nitrobenzyl-oxy:phenyl oxazolidine thione
FR2500450A1 (en) * 1981-02-25 1982-08-27 Delalande Sa NOVEL AMINOMETHYL-5-OXAZOLIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC USE THEREOF
FR2506769A2 (en) * 1978-06-09 1982-12-03 Delalande Sa Cyano:pentyl:phenyl-methoxymethyl-oxazolidinone - useful as antidepressant
DE3320394A1 (en) * 1982-06-08 1983-12-08 Delalande S.A., 92400 Courbevoie, Hauts-de-Seine OPTICALLY ACTIVE N-ARYLATED OXAZOLIDINONE (2) DERIVATIVES, THE USE THEREOF AS SPECIFIC AND REVERSIBLE INHIBITORS OF MONOAMINOOXYDASE OF THE B-TYPE AND METHOD FOR THE PRODUCTION THEREOF
FR2603279A1 (en) * 1986-09-03 1988-03-04 Rech Ind 5:Amino ethyl 2:oxazolidinone(s)
EP0259228A1 (en) * 1986-09-03 1988-03-09 Delalande S.A. 5-Aminomethyl-2-oxazolidinone derivatives, their preparation and their therapeutical use
FR2609029A1 (en) * 1986-12-30 1988-07-01 Delalande Sa 5-Aminoethylated derivatives of oxazolidin-2-one, process for their preparation and their application in therapeutics

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS608277A (en) * 1983-06-07 1985-01-17 ザ・デュポン・メルク・ファーマシュウティカル・カンパニー Aminomethyloxooxazolidinylbenzene derivative
WO2007116960A1 (en) * 2006-04-06 2007-10-18 Research Foundation Itsuu Laboratory Oxazolidinone derivative having carbocyclic ring

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1602544A (en) * 1968-10-29 1970-12-21 Acetylenic 2-oxazolidinones
FR2330318A1 (en) * 1975-11-07 1977-06-03 Ciba Geigy Ag AGENT AND METHOD FOR INFLUENCING THE GROWTH OF PLANTS, AND NEW DERIVATIVES OF 1-PHENYL 2-OXO-PYRROLIDINE-4-CARBOXYLIC ACID

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1252101A (en) * 1969-03-18 1971-11-03

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1602544A (en) * 1968-10-29 1970-12-21 Acetylenic 2-oxazolidinones
FR2330318A1 (en) * 1975-11-07 1977-06-03 Ciba Geigy Ag AGENT AND METHOD FOR INFLUENCING THE GROWTH OF PLANTS, AND NEW DERIVATIVES OF 1-PHENYL 2-OXO-PYRROLIDINE-4-CARBOXYLIC ACID

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2458547A2 (en) * 1978-06-09 1981-01-02 Delalande Sa Antidepressant aryl derivs of azolone(s) - prepd. e.g. from hydroxymethyl-nitrobenzyl-oxy:phenyl oxazolidine thione
FR2506769A2 (en) * 1978-06-09 1982-12-03 Delalande Sa Cyano:pentyl:phenyl-methoxymethyl-oxazolidinone - useful as antidepressant
FR2500450A1 (en) * 1981-02-25 1982-08-27 Delalande Sa NOVEL AMINOMETHYL-5-OXAZOLIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC USE THEREOF
DE3320394A1 (en) * 1982-06-08 1983-12-08 Delalande S.A., 92400 Courbevoie, Hauts-de-Seine OPTICALLY ACTIVE N-ARYLATED OXAZOLIDINONE (2) DERIVATIVES, THE USE THEREOF AS SPECIFIC AND REVERSIBLE INHIBITORS OF MONOAMINOOXYDASE OF THE B-TYPE AND METHOD FOR THE PRODUCTION THEREOF
FR2603279A1 (en) * 1986-09-03 1988-03-04 Rech Ind 5:Amino ethyl 2:oxazolidinone(s)
EP0259228A1 (en) * 1986-09-03 1988-03-09 Delalande S.A. 5-Aminomethyl-2-oxazolidinone derivatives, their preparation and their therapeutical use
FR2609029A1 (en) * 1986-12-30 1988-07-01 Delalande Sa 5-Aminoethylated derivatives of oxazolidin-2-one, process for their preparation and their application in therapeutics

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FR2428032B1 (en) 1981-10-16
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JPS635391B2 (en) 1988-02-03
JPS5551064A (en) 1980-04-14
JPS56167666A (en) 1981-12-23

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