FR2425448A2 - Acetal derivs. of benzopyran glycoside(s) - useful as capillary protectors, antiinflammatory agents and aldose reductase inhibitors - Google Patents

Acetal derivs. of benzopyran glycoside(s) - useful as capillary protectors, antiinflammatory agents and aldose reductase inhibitors

Info

Publication number
FR2425448A2
FR2425448A2 FR7813807A FR7813807A FR2425448A2 FR 2425448 A2 FR2425448 A2 FR 2425448A2 FR 7813807 A FR7813807 A FR 7813807A FR 7813807 A FR7813807 A FR 7813807A FR 2425448 A2 FR2425448 A2 FR 2425448A2
Authority
FR
France
Prior art keywords
cpds
benzopyran
useful
reductase inhibitors
aldose reductase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7813807A
Other languages
French (fr)
Other versions
FR2425448B2 (en
Inventor
F Fauran
C Feniou
J Mosser
A Thibault
C Andre
G Prat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meda Pharma SAS
Original Assignee
Laboratoires Sarget
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Sarget filed Critical Laboratoires Sarget
Priority to FR7813807A priority Critical patent/FR2425448A2/en
Priority to PT68117A priority patent/PT68117A/en
Priority to US05/911,634 priority patent/US4211772A/en
Priority to ES470431A priority patent/ES470431A1/en
Priority to IT24118/78A priority patent/IT1158740B/en
Priority to CH600678A priority patent/CH634080A5/en
Priority to NL7806022A priority patent/NL7806022A/en
Priority to LU79753A priority patent/LU79753A1/en
Publication of FR2425448A2 publication Critical patent/FR2425448A2/en
Application granted granted Critical
Publication of FR2425448B2 publication Critical patent/FR2425448B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/07—Benzo[b]pyran-4-ones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

New acetals (I) formed between benzopyran glycosides (II) and certain carbonyl cpds. (III) are claimed. Cpds. (III) comprise 5-8C cycloalkanones, 2-adamantanone, 1-decalone, 2-decalone, and cpds. of formula R1COR2 (where R1 and R2 are H, alkyl or opt. substd. phenyl, but are not both H). Cpds. (I) reduce capillary fragility and have anti-inflammatory activity. They also act as aldose reductase inhibitors at lower concns. than their parent glycosides (II), and are thus useful for treating diabetic cataracts. A typical cpd. (I) is rutin acetonide. In an example, this is prepd. by reacting rutin with acetone in DMF in the presence of methyl chloroformate.
FR7813807A 1977-06-02 1978-05-10 Acetal derivs. of benzopyran glycoside(s) - useful as capillary protectors, antiinflammatory agents and aldose reductase inhibitors Granted FR2425448A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
FR7813807A FR2425448A2 (en) 1978-05-10 1978-05-10 Acetal derivs. of benzopyran glycoside(s) - useful as capillary protectors, antiinflammatory agents and aldose reductase inhibitors
PT68117A PT68117A (en) 1977-06-02 1978-05-31 NOVEL PROCESS FOR THE PREPARATION OF BENZOPYRANIC GLYCOSIDE DERIVATIVES
ES470431A ES470431A1 (en) 1977-06-02 1978-06-01 Benzopyran glycoside acetals and ketals
IT24118/78A IT1158740B (en) 1977-06-02 1978-06-01 BENZOPYRANIC GLYCOSIDES DERIVATIVES, THEIR PROCEDURE OF OBTAINING AND THEIR USE IN HUMAN THERAPEUTICS
US05/911,634 US4211772A (en) 1977-06-02 1978-06-01 Benzopyran glycoside acetals and ketals
CH600678A CH634080A5 (en) 1977-06-02 1978-06-01 NOVEL ACETALS FORMED BETWEEN A BENZOPYRANIC GLYCOSIDE.
NL7806022A NL7806022A (en) 1977-06-02 1978-06-02 BENZPYRANGLYCOSIDE DERIVATIVES.
LU79753A LU79753A1 (en) 1977-06-02 1978-06-02 METHOD FOR PREPARING DERIVATIVES OF BENZOPYRANNIC GLYCOSIDES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7813807A FR2425448A2 (en) 1978-05-10 1978-05-10 Acetal derivs. of benzopyran glycoside(s) - useful as capillary protectors, antiinflammatory agents and aldose reductase inhibitors

Publications (2)

Publication Number Publication Date
FR2425448A2 true FR2425448A2 (en) 1979-12-07
FR2425448B2 FR2425448B2 (en) 1981-01-02

Family

ID=9208082

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7813807A Granted FR2425448A2 (en) 1977-06-02 1978-05-10 Acetal derivs. of benzopyran glycoside(s) - useful as capillary protectors, antiinflammatory agents and aldose reductase inhibitors

Country Status (1)

Country Link
FR (1) FR2425448A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1006429B (en) * 1956-10-16 1957-04-18 Dr Max Hering Process for the production of water-soluble condensation products of rutin

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1006429B (en) * 1956-10-16 1957-04-18 Dr Max Hering Process for the production of water-soluble condensation products of rutin

Also Published As

Publication number Publication date
FR2425448B2 (en) 1981-01-02

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