FR2424278A1 - Thieno-pyridine(s) prepn. - form hydroxy tetra:hydro thieno pyridine(s), useful as intermediates for platelet aggregation inhibitors - Google Patents

Thieno-pyridine(s) prepn. - form hydroxy tetra:hydro thieno pyridine(s), useful as intermediates for platelet aggregation inhibitors

Info

Publication number
FR2424278A1
FR2424278A1 FR7812037A FR7812037A FR2424278A1 FR 2424278 A1 FR2424278 A1 FR 2424278A1 FR 7812037 A FR7812037 A FR 7812037A FR 7812037 A FR7812037 A FR 7812037A FR 2424278 A1 FR2424278 A1 FR 2424278A1
Authority
FR
France
Prior art keywords
thieno
pyridine
intermediates
platelet aggregation
aggregation inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7812037A
Other languages
French (fr)
Other versions
FR2424278B1 (en
Inventor
Robert Boigegrain
Jean-Pierre Maffrand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Parcor SARL
Original Assignee
Parcor SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parcor SARL filed Critical Parcor SARL
Priority to FR7812037A priority Critical patent/FR2424278A1/en
Publication of FR2424278A1 publication Critical patent/FR2424278A1/en
Application granted granted Critical
Publication of FR2424278B1 publication Critical patent/FR2424278B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Thienopyridines of formulae (I) and (II) are prepd. by reaction of hydroxy tetrahydro thieno pyridines (III) and (IV) witn N-bromo succinimide and dequaternisation. In the formulae, R is H, halo or 1-4C alkyl and R' is 1-8C alkyl or aralkyl opt. substd. on the phenyl ring by halo or by lower alkyl or alkoxy. (I) and (II) are intermediates for the preparation of known tetrahydrothiene platelet aggregation inhibitors. Process is easy to carry out on an industrial scale and gives good yields of prod.
FR7812037A 1978-04-24 1978-04-24 Thieno-pyridine(s) prepn. - form hydroxy tetra:hydro thieno pyridine(s), useful as intermediates for platelet aggregation inhibitors Granted FR2424278A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7812037A FR2424278A1 (en) 1978-04-24 1978-04-24 Thieno-pyridine(s) prepn. - form hydroxy tetra:hydro thieno pyridine(s), useful as intermediates for platelet aggregation inhibitors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7812037A FR2424278A1 (en) 1978-04-24 1978-04-24 Thieno-pyridine(s) prepn. - form hydroxy tetra:hydro thieno pyridine(s), useful as intermediates for platelet aggregation inhibitors

Publications (2)

Publication Number Publication Date
FR2424278A1 true FR2424278A1 (en) 1979-11-23
FR2424278B1 FR2424278B1 (en) 1980-10-24

Family

ID=9207505

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7812037A Granted FR2424278A1 (en) 1978-04-24 1978-04-24 Thieno-pyridine(s) prepn. - form hydroxy tetra:hydro thieno pyridine(s), useful as intermediates for platelet aggregation inhibitors

Country Status (1)

Country Link
FR (1) FR2424278A1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495691B1 (en) 2001-07-06 2002-12-17 Brantford Chemicals Inc. Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives
WO2003004502A1 (en) * 2001-07-06 2003-01-16 Brantford Chemicals Inc. Process for the preparation of tetrahydrothieno [3,2-c] pyridine derivatives
US7060831B2 (en) 2003-12-23 2006-06-13 Apotex Pharmachem Inc. Process for the preparation of tetrahydrothieno[3,2-c] pyridine derivatives
AU2018332501B2 (en) * 2017-09-13 2023-09-21 Atrogi Ab Heteroaryl substituted beta-hydroxyethylamines for use in treating hyperglycaemia

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2312498A1 (en) * 1975-05-30 1976-12-24 Parcor PROCESS FOR THE PREPARATION OF THIENO (3,2-C) PYRIDINE AND DERIVATIVES THEREOF

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2312498A1 (en) * 1975-05-30 1976-12-24 Parcor PROCESS FOR THE PREPARATION OF THIENO (3,2-C) PYRIDINE AND DERIVATIVES THEREOF

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495691B1 (en) 2001-07-06 2002-12-17 Brantford Chemicals Inc. Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives
WO2003004502A1 (en) * 2001-07-06 2003-01-16 Brantford Chemicals Inc. Process for the preparation of tetrahydrothieno [3,2-c] pyridine derivatives
US7060831B2 (en) 2003-12-23 2006-06-13 Apotex Pharmachem Inc. Process for the preparation of tetrahydrothieno[3,2-c] pyridine derivatives
AU2018332501B2 (en) * 2017-09-13 2023-09-21 Atrogi Ab Heteroaryl substituted beta-hydroxyethylamines for use in treating hyperglycaemia

Also Published As

Publication number Publication date
FR2424278B1 (en) 1980-10-24

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