FR2420523A1 - Antiulcer compsns. contg. carboxylic acids, esters or alcohols - including new terpenoid cpds. - Google Patents
Antiulcer compsns. contg. carboxylic acids, esters or alcohols - including new terpenoid cpds.Info
- Publication number
- FR2420523A1 FR2420523A1 FR7808581A FR7808581A FR2420523A1 FR 2420523 A1 FR2420523 A1 FR 2420523A1 FR 7808581 A FR7808581 A FR 7808581A FR 7808581 A FR7808581 A FR 7808581A FR 2420523 A1 FR2420523 A1 FR 2420523A1
- Authority
- FR
- France
- Prior art keywords
- cpds
- decaprenyl
- compsns
- contg
- antiulcer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/17—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds
- C07C29/172—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds with the obtention of a fully saturated alcohol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/03—Monocarboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Anti-ulcer compsns. contg. cpds. of formulae R-Z (Ia), RCOOR2 (Ib), H-(CH2-C(Me)(A)-CHB-CH2)nCH2COOR3 (Ic), R4CH2COOR5 (Id) or R6OH (Ie), are new, (where R is a satd. or unsatd. aliphatic gp. opt. substd. by OH or epoxy; Z is OH or COOR1; R1 is H, alkyl or R2; R2 is phytyl, isophytyl, dihydrophytyl, decaprenyl or solanesyl; n is an integer; A+B is a pair of H atoms or a bond, each A+B being independently a pair of H atoms or a bond when n =2 (sic); R3 is alpha-tocopheryl; R4 is phytyl, solanesyl or decaprenyl; R5 is H or alkyl; R6 is solanesyl, decaprenyl, isodecaprenyl, dihydrophytyl or hydrogenated decaprenyl). Several new cpds. of type (I) are specifically claimed. Cpds. (I) have high anti-ulcer activity and low toxicity (LD50 >=4 g kg); many have higher preventive and curative activity than gefarnate.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7808581A FR2420523A1 (en) | 1978-03-23 | 1978-03-23 | Antiulcer compsns. contg. carboxylic acids, esters or alcohols - including new terpenoid cpds. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7808581A FR2420523A1 (en) | 1978-03-23 | 1978-03-23 | Antiulcer compsns. contg. carboxylic acids, esters or alcohols - including new terpenoid cpds. |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2420523A1 true FR2420523A1 (en) | 1979-10-19 |
FR2420523B1 FR2420523B1 (en) | 1981-12-11 |
Family
ID=9206228
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7808581A Granted FR2420523A1 (en) | 1978-03-23 | 1978-03-23 | Antiulcer compsns. contg. carboxylic acids, esters or alcohols - including new terpenoid cpds. |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2420523A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1260509A1 (en) * | 2001-05-25 | 2002-11-27 | Derma Developpement S.A.R.L. | Uses of tocopherol esters |
FR2825089A1 (en) * | 2001-05-25 | 2002-11-29 | Derma Dev | Compositions containing tocopherol mono- and polyunsaturated fatty acid esters having a beneficial effect on the skin |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1981M (en) * | 1961-05-24 | 1963-08-26 | Angeli Inst Spa | Anti-ulcer drug based on esters of farnesyl-acetic acid. |
FR2278334A1 (en) * | 1974-07-18 | 1976-02-13 | Eisai Co Ltd | ESTERS OF ALIPHATIC CARBOXYLIC ACIDS OF VITAMIN E, THEIR PREPARATION PROCESS AND THEIR APPLICATION |
FR2332009A1 (en) * | 1975-11-18 | 1977-06-17 | Sankyo Co | NEW POLYPRENYL DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATIONS |
-
1978
- 1978-03-23 FR FR7808581A patent/FR2420523A1/en active Granted
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1981M (en) * | 1961-05-24 | 1963-08-26 | Angeli Inst Spa | Anti-ulcer drug based on esters of farnesyl-acetic acid. |
FR2278334A1 (en) * | 1974-07-18 | 1976-02-13 | Eisai Co Ltd | ESTERS OF ALIPHATIC CARBOXYLIC ACIDS OF VITAMIN E, THEIR PREPARATION PROCESS AND THEIR APPLICATION |
FR2332009A1 (en) * | 1975-11-18 | 1977-06-17 | Sankyo Co | NEW POLYPRENYL DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATIONS |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1260509A1 (en) * | 2001-05-25 | 2002-11-27 | Derma Developpement S.A.R.L. | Uses of tocopherol esters |
FR2825088A1 (en) * | 2001-05-25 | 2002-11-29 | Derma Dev | NOVEL TOCOPHEROL ESTERS, PROCESSES FOR OBTAINING SAME AND USES THEREOF |
FR2825089A1 (en) * | 2001-05-25 | 2002-11-29 | Derma Dev | Compositions containing tocopherol mono- and polyunsaturated fatty acid esters having a beneficial effect on the skin |
Also Published As
Publication number | Publication date |
---|---|
FR2420523B1 (en) | 1981-12-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |