FR2420523A1 - Antiulcer compsns. contg. carboxylic acids, esters or alcohols - including new terpenoid cpds. - Google Patents

Antiulcer compsns. contg. carboxylic acids, esters or alcohols - including new terpenoid cpds.

Info

Publication number
FR2420523A1
FR2420523A1 FR7808581A FR7808581A FR2420523A1 FR 2420523 A1 FR2420523 A1 FR 2420523A1 FR 7808581 A FR7808581 A FR 7808581A FR 7808581 A FR7808581 A FR 7808581A FR 2420523 A1 FR2420523 A1 FR 2420523A1
Authority
FR
France
Prior art keywords
cpds
decaprenyl
compsns
contg
antiulcer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7808581A
Other languages
French (fr)
Other versions
FR2420523B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nisshin Seifun Group Inc
Original Assignee
Nisshin Seifun Group Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nisshin Seifun Group Inc filed Critical Nisshin Seifun Group Inc
Priority to FR7808581A priority Critical patent/FR2420523A1/en
Publication of FR2420523A1 publication Critical patent/FR2420523A1/en
Application granted granted Critical
Publication of FR2420523B1 publication Critical patent/FR2420523B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/17—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds
    • C07C29/172—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds with the obtention of a fully saturated alcohol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/03—Monocarboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Anti-ulcer compsns. contg. cpds. of formulae R-Z (Ia), RCOOR2 (Ib), H-(CH2-C(Me)(A)-CHB-CH2)nCH2COOR3 (Ic), R4CH2COOR5 (Id) or R6OH (Ie), are new, (where R is a satd. or unsatd. aliphatic gp. opt. substd. by OH or epoxy; Z is OH or COOR1; R1 is H, alkyl or R2; R2 is phytyl, isophytyl, dihydrophytyl, decaprenyl or solanesyl; n is an integer; A+B is a pair of H atoms or a bond, each A+B being independently a pair of H atoms or a bond when n =2 (sic); R3 is alpha-tocopheryl; R4 is phytyl, solanesyl or decaprenyl; R5 is H or alkyl; R6 is solanesyl, decaprenyl, isodecaprenyl, dihydrophytyl or hydrogenated decaprenyl). Several new cpds. of type (I) are specifically claimed. Cpds. (I) have high anti-ulcer activity and low toxicity (LD50 >=4 g kg); many have higher preventive and curative activity than gefarnate.
FR7808581A 1978-03-23 1978-03-23 Antiulcer compsns. contg. carboxylic acids, esters or alcohols - including new terpenoid cpds. Granted FR2420523A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7808581A FR2420523A1 (en) 1978-03-23 1978-03-23 Antiulcer compsns. contg. carboxylic acids, esters or alcohols - including new terpenoid cpds.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7808581A FR2420523A1 (en) 1978-03-23 1978-03-23 Antiulcer compsns. contg. carboxylic acids, esters or alcohols - including new terpenoid cpds.

Publications (2)

Publication Number Publication Date
FR2420523A1 true FR2420523A1 (en) 1979-10-19
FR2420523B1 FR2420523B1 (en) 1981-12-11

Family

ID=9206228

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7808581A Granted FR2420523A1 (en) 1978-03-23 1978-03-23 Antiulcer compsns. contg. carboxylic acids, esters or alcohols - including new terpenoid cpds.

Country Status (1)

Country Link
FR (1) FR2420523A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1260509A1 (en) * 2001-05-25 2002-11-27 Derma Developpement S.A.R.L. Uses of tocopherol esters
FR2825089A1 (en) * 2001-05-25 2002-11-29 Derma Dev Compositions containing tocopherol mono- and polyunsaturated fatty acid esters having a beneficial effect on the skin

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1981M (en) * 1961-05-24 1963-08-26 Angeli Inst Spa Anti-ulcer drug based on esters of farnesyl-acetic acid.
FR2278334A1 (en) * 1974-07-18 1976-02-13 Eisai Co Ltd ESTERS OF ALIPHATIC CARBOXYLIC ACIDS OF VITAMIN E, THEIR PREPARATION PROCESS AND THEIR APPLICATION
FR2332009A1 (en) * 1975-11-18 1977-06-17 Sankyo Co NEW POLYPRENYL DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATIONS

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1981M (en) * 1961-05-24 1963-08-26 Angeli Inst Spa Anti-ulcer drug based on esters of farnesyl-acetic acid.
FR2278334A1 (en) * 1974-07-18 1976-02-13 Eisai Co Ltd ESTERS OF ALIPHATIC CARBOXYLIC ACIDS OF VITAMIN E, THEIR PREPARATION PROCESS AND THEIR APPLICATION
FR2332009A1 (en) * 1975-11-18 1977-06-17 Sankyo Co NEW POLYPRENYL DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATIONS

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1260509A1 (en) * 2001-05-25 2002-11-27 Derma Developpement S.A.R.L. Uses of tocopherol esters
FR2825088A1 (en) * 2001-05-25 2002-11-29 Derma Dev NOVEL TOCOPHEROL ESTERS, PROCESSES FOR OBTAINING SAME AND USES THEREOF
FR2825089A1 (en) * 2001-05-25 2002-11-29 Derma Dev Compositions containing tocopherol mono- and polyunsaturated fatty acid esters having a beneficial effect on the skin

Also Published As

Publication number Publication date
FR2420523B1 (en) 1981-12-11

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