FR2418799A1 - Extraction of tabersonine - from seeds of plumeroidees using alkaline solvent followed by acidification - Google Patents

Extraction of tabersonine - from seeds of plumeroidees using alkaline solvent followed by acidification

Info

Publication number
FR2418799A1
FR2418799A1 FR7806130A FR7806130A FR2418799A1 FR 2418799 A1 FR2418799 A1 FR 2418799A1 FR 7806130 A FR7806130 A FR 7806130A FR 7806130 A FR7806130 A FR 7806130A FR 2418799 A1 FR2418799 A1 FR 2418799A1
Authority
FR
France
Prior art keywords
seeds
plumeroidees
tabersonine
acidification
extraction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7806130A
Other languages
French (fr)
Other versions
FR2418799B1 (en
Inventor
Jean-Claude Dulin
Alain Heymes
Dominique Louard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Parcor SARL
Original Assignee
Parcor SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parcor SARL filed Critical Parcor SARL
Priority to FR7806130A priority Critical patent/FR2418799A1/en
Publication of FR2418799A1 publication Critical patent/FR2418799A1/en
Application granted granted Critical
Publication of FR2418799B1 publication Critical patent/FR2418799B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Saccharide Compounds (AREA)

Abstract

(-)Tabersonine (I) is extracted from the seeds of Plumeroidees by the following process: (i) the seeds are crushed in suspension in a solvent in which the hydrohalides of (I) are insoluble, at an alkaline pH, (ii) the organic phase is separated, (iii) the liquid is treated with a hydrogen halide gas and (iv) the precipitate is recovered. (I) is an intermediate for the hemisynthesis of vincamine. The process is simple and gives good yields.
FR7806130A 1978-03-03 1978-03-03 Extraction of tabersonine - from seeds of plumeroidees using alkaline solvent followed by acidification Granted FR2418799A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7806130A FR2418799A1 (en) 1978-03-03 1978-03-03 Extraction of tabersonine - from seeds of plumeroidees using alkaline solvent followed by acidification

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7806130A FR2418799A1 (en) 1978-03-03 1978-03-03 Extraction of tabersonine - from seeds of plumeroidees using alkaline solvent followed by acidification

Publications (2)

Publication Number Publication Date
FR2418799A1 true FR2418799A1 (en) 1979-09-28
FR2418799B1 FR2418799B1 (en) 1980-09-05

Family

ID=9205315

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7806130A Granted FR2418799A1 (en) 1978-03-03 1978-03-03 Extraction of tabersonine - from seeds of plumeroidees using alkaline solvent followed by acidification

Country Status (1)

Country Link
FR (1) FR2418799A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102060856A (en) * 2010-12-21 2011-05-18 英杰华纳（厦门）生物工程有限公司 Method for extracting tabersonine from voacanga seeds
CN114989171A (en) * 2022-07-20 2022-09-02 张家港威胜生物医药有限公司 Efficient production process of tabersonine hydrochloride

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102060856A (en) * 2010-12-21 2011-05-18 英杰华纳（厦门）生物工程有限公司 Method for extracting tabersonine from voacanga seeds
CN114989171A (en) * 2022-07-20 2022-09-02 张家港威胜生物医药有限公司 Efficient production process of tabersonine hydrochloride
CN114989171B (en) * 2022-07-20 2024-01-12 威胜生物医药(苏州)股份有限公司 Efficient production process of tabersonine hydrochloride

Also Published As

Publication number Publication date
FR2418799B1 (en) 1980-09-05

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Legal Events

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ST Notification of lapse