FR2418225A1 - N-1-Cycloalkyl-2-pyrrolidinyl-methyl 2-methoxy-benzamide derivs. - for treating psychoses and depressive states, prepd. by reaction of 1-cycloalkyl-2-aminomethyl-pyrrolidine with methoxy-benzoic acid deriv. - Google Patents
N-1-Cycloalkyl-2-pyrrolidinyl-methyl 2-methoxy-benzamide derivs. - for treating psychoses and depressive states, prepd. by reaction of 1-cycloalkyl-2-aminomethyl-pyrrolidine with methoxy-benzoic acid deriv.Info
- Publication number
- FR2418225A1 FR2418225A1 FR7805579A FR7805579A FR2418225A1 FR 2418225 A1 FR2418225 A1 FR 2418225A1 FR 7805579 A FR7805579 A FR 7805579A FR 7805579 A FR7805579 A FR 7805579A FR 2418225 A1 FR2418225 A1 FR 2418225A1
- Authority
- FR
- France
- Prior art keywords
- cycloalkyl
- methoxy
- prepd
- aminomethyl
- pyrrolidinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
N-(1-Cycloalkyl-2-pyrrolidinylmethyl)-2-methoxy-5-(sulphamoyl, sulphonyl, sulphinyl, mercapto, chloro or 1-benzamide derivs. of formula (I) and their salts as the racemates or enantiomers are new. In (I), n is 1,2,3 or 4; R is -SO2-NR1R2, -S(O)m-R3, halo or CF3; R1, R2 independently are H or 1-4C alkyl; R3 is 1-4C alkyl and m is 0,1 or 2. Used in treatment of psychosomatic and psychic disorders (depressive states and psychoses) by oral, rectal or parenteral admin. in daily doses of 5-300mg.
Priority Applications (20)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7805579A FR2418225A1 (en) | 1978-02-27 | 1978-02-27 | N-1-Cycloalkyl-2-pyrrolidinyl-methyl 2-methoxy-benzamide derivs. - for treating psychoses and depressive states, prepd. by reaction of 1-cycloalkyl-2-aminomethyl-pyrrolidine with methoxy-benzoic acid deriv. |
FR7900259A FR2445829A2 (en) | 1978-02-27 | 1979-01-05 | METHOXY-2 BENZAMIDES AND THEIR THERAPEUTIC APPLICATION |
PT69289A PT69289A (en) | 1978-02-27 | 1979-02-26 | PROCESS FOR PREPARING METHOXY-2 BENZAMIDES |
IL56738A IL56738A0 (en) | 1978-02-27 | 1979-02-26 | 2-methoxybenzamides,their preparation and pharmaceutical composition containing them |
NZ189770A NZ189770A (en) | 1978-02-27 | 1979-02-26 | 2-methoxybenzamide derivatives and pharmaceutical compositions |
SE7901707A SE7901707L (en) | 1978-02-27 | 1979-02-26 | 2-BETOXYBENZAMIDES |
NO790647A NO790647L (en) | 1978-02-27 | 1979-02-26 | PROCEDURE FOR THE PREPARATION OF 2-METHOXYBENZAMIDES |
DE19792907378 DE2907378A1 (en) | 1978-02-27 | 1979-02-26 | 2-METHOXY-BENZAMIDE, METHOD OF MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING IT |
DK82179A DK82179A (en) | 1978-02-27 | 1979-02-26 | 2-METHOXYBENZAMIDES AND PROCEDURE FOR THEIR PREPARATION |
ES478072A ES478072A1 (en) | 1978-02-27 | 1979-02-26 | 2-Methoxybenzamides |
NL7901473A NL7901473A (en) | 1978-02-27 | 1979-02-26 | PROCESS FOR THE PREPARATION OF A MEDICINAL PRODUCT WITH AN ACTIVITY RELATING TO THE CENTRAL NERVOUS SYSTEM AND THE MEDICINAL PRODUCT THEREFORE. |
IT20541/79A IT1113417B (en) | 1978-02-27 | 1979-02-26 | 2-METOSSIBENZAMIDI |
ZA79907A ZA79907B (en) | 1978-02-27 | 1979-02-26 | 2-methoxybenzamides |
AU44603/79A AU521027B2 (en) | 1978-02-27 | 1979-02-26 | "2-methoxybenzamides" |
JP2247779A JPS54135765A (en) | 1978-02-27 | 1979-02-26 | 22methoxybenzamide derivative*its manufacture and medicine containing said derivative |
GR58491A GR66972B (en) | 1978-02-27 | 1979-02-27 | |
BE0/193729A BE874489A (en) | 1978-02-27 | 1979-02-27 | METHOXY-2 BENZAMIDES |
GB7906952A GB2016467A (en) | 1978-02-27 | 1979-02-27 | 2-Methoxybenzamides |
FI790657A FI790657A (en) | 1978-02-27 | 1979-02-27 | 2-METHODYBENZAMAMIDER OCH FOERFARANDE FOER DERAS FRAMSTAELLNING |
LU80975A LU80975A1 (en) | 1978-02-27 | 1979-02-27 | METHOXY-2 BENZAMIDES |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7805579A FR2418225A1 (en) | 1978-02-27 | 1978-02-27 | N-1-Cycloalkyl-2-pyrrolidinyl-methyl 2-methoxy-benzamide derivs. - for treating psychoses and depressive states, prepd. by reaction of 1-cycloalkyl-2-aminomethyl-pyrrolidine with methoxy-benzoic acid deriv. |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2418225A1 true FR2418225A1 (en) | 1979-09-21 |
FR2418225B1 FR2418225B1 (en) | 1980-09-26 |
Family
ID=9205108
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7805579A Granted FR2418225A1 (en) | 1978-02-27 | 1978-02-27 | N-1-Cycloalkyl-2-pyrrolidinyl-methyl 2-methoxy-benzamide derivs. - for treating psychoses and depressive states, prepd. by reaction of 1-cycloalkyl-2-aminomethyl-pyrrolidine with methoxy-benzoic acid deriv. |
Country Status (2)
Country | Link |
---|---|
FR (1) | FR2418225A1 (en) |
ZA (1) | ZA79907B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2678266A1 (en) * | 1991-06-28 | 1992-12-31 | Delagrange Laboratoires | New 2-hydroxy-4-amino-5-(ethylsulphonyl)benzamide derivatives which are useful as anxiolytic agents |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2245628A1 (en) * | 1973-09-28 | 1975-04-25 | Ile De France |
-
1978
- 1978-02-27 FR FR7805579A patent/FR2418225A1/en active Granted
-
1979
- 1979-02-26 ZA ZA79907A patent/ZA79907B/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2245628A1 (en) * | 1973-09-28 | 1975-04-25 | Ile De France |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2678266A1 (en) * | 1991-06-28 | 1992-12-31 | Delagrange Laboratoires | New 2-hydroxy-4-amino-5-(ethylsulphonyl)benzamide derivatives which are useful as anxiolytic agents |
Also Published As
Publication number | Publication date |
---|---|
ZA79907B (en) | 1980-02-27 |
FR2418225B1 (en) | 1980-09-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |