FR2418225A1 - N-1-Cycloalkyl-2-pyrrolidinyl-methyl 2-methoxy-benzamide derivs. - for treating psychoses and depressive states, prepd. by reaction of 1-cycloalkyl-2-aminomethyl-pyrrolidine with methoxy-benzoic acid deriv. - Google Patents

N-1-Cycloalkyl-2-pyrrolidinyl-methyl 2-methoxy-benzamide derivs. - for treating psychoses and depressive states, prepd. by reaction of 1-cycloalkyl-2-aminomethyl-pyrrolidine with methoxy-benzoic acid deriv.

Info

Publication number
FR2418225A1
FR2418225A1 FR7805579A FR7805579A FR2418225A1 FR 2418225 A1 FR2418225 A1 FR 2418225A1 FR 7805579 A FR7805579 A FR 7805579A FR 7805579 A FR7805579 A FR 7805579A FR 2418225 A1 FR2418225 A1 FR 2418225A1
Authority
FR
France
Prior art keywords
cycloalkyl
methoxy
prepd
aminomethyl
pyrrolidinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7805579A
Other languages
French (fr)
Other versions
FR2418225B1 (en
Inventor
Henry Najer
Jean-Pierre Kaplan
Daniel Charles Leon Obitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to FR7805579A priority Critical patent/FR2418225A1/en
Priority to FR7900259A priority patent/FR2445829A2/en
Priority to IT20541/79A priority patent/IT1113417B/en
Priority to IL56738A priority patent/IL56738A0/en
Priority to SE7901707A priority patent/SE7901707L/en
Priority to AU44603/79A priority patent/AU521027B2/en
Priority to NL7901473A priority patent/NL7901473A/en
Priority to ES478072A priority patent/ES478072A1/en
Priority to PT69289A priority patent/PT69289A/en
Priority to JP2247779A priority patent/JPS54135765A/en
Priority to DK82179A priority patent/DK82179A/en
Priority to NZ189770A priority patent/NZ189770A/en
Priority to NO790647A priority patent/NO790647L/en
Priority to ZA79907A priority patent/ZA79907B/en
Priority to DE19792907378 priority patent/DE2907378A1/en
Priority to FI790657A priority patent/FI790657A/en
Priority to GB7906952A priority patent/GB2016467A/en
Priority to GR58491A priority patent/GR66972B/el
Priority to LU80975A priority patent/LU80975A1/en
Priority to BE0/193729A priority patent/BE874489A/en
Publication of FR2418225A1 publication Critical patent/FR2418225A1/en
Application granted granted Critical
Publication of FR2418225B1 publication Critical patent/FR2418225B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

N-(1-Cycloalkyl-2-pyrrolidinylmethyl)-2-methoxy-5-(sulphamoyl, sulphonyl, sulphinyl, mercapto, chloro or 1-benzamide derivs. of formula (I) and their salts as the racemates or enantiomers are new. In (I), n is 1,2,3 or 4; R is -SO2-NR1R2, -S(O)m-R3, halo or CF3; R1, R2 independently are H or 1-4C alkyl; R3 is 1-4C alkyl and m is 0,1 or 2. Used in treatment of psychosomatic and psychic disorders (depressive states and psychoses) by oral, rectal or parenteral admin. in daily doses of 5-300mg.
FR7805579A 1978-02-27 1978-02-27 N-1-Cycloalkyl-2-pyrrolidinyl-methyl 2-methoxy-benzamide derivs. - for treating psychoses and depressive states, prepd. by reaction of 1-cycloalkyl-2-aminomethyl-pyrrolidine with methoxy-benzoic acid deriv. Granted FR2418225A1 (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
FR7805579A FR2418225A1 (en) 1978-02-27 1978-02-27 N-1-Cycloalkyl-2-pyrrolidinyl-methyl 2-methoxy-benzamide derivs. - for treating psychoses and depressive states, prepd. by reaction of 1-cycloalkyl-2-aminomethyl-pyrrolidine with methoxy-benzoic acid deriv.
FR7900259A FR2445829A2 (en) 1978-02-27 1979-01-05 METHOXY-2 BENZAMIDES AND THEIR THERAPEUTIC APPLICATION
ZA79907A ZA79907B (en) 1978-02-27 1979-02-26 2-methoxybenzamides
SE7901707A SE7901707L (en) 1978-02-27 1979-02-26 2-BETOXYBENZAMIDES
AU44603/79A AU521027B2 (en) 1978-02-27 1979-02-26 "2-methoxybenzamides"
NL7901473A NL7901473A (en) 1978-02-27 1979-02-26 PROCESS FOR THE PREPARATION OF A MEDICINAL PRODUCT WITH AN ACTIVITY RELATING TO THE CENTRAL NERVOUS SYSTEM AND THE MEDICINAL PRODUCT THEREFORE.
ES478072A ES478072A1 (en) 1978-02-27 1979-02-26 2-Methoxybenzamides
PT69289A PT69289A (en) 1978-02-27 1979-02-26 PROCESS FOR PREPARING METHOXY-2 BENZAMIDES
JP2247779A JPS54135765A (en) 1978-02-27 1979-02-26 22methoxybenzamide derivative*its manufacture and medicine containing said derivative
DK82179A DK82179A (en) 1978-02-27 1979-02-26 2-METHOXYBENZAMIDES AND PROCEDURE FOR THEIR PREPARATION
IT20541/79A IT1113417B (en) 1978-02-27 1979-02-26 2-METOSSIBENZAMIDI
NO790647A NO790647L (en) 1978-02-27 1979-02-26 PROCEDURE FOR THE PREPARATION OF 2-METHOXYBENZAMIDES
IL56738A IL56738A0 (en) 1978-02-27 1979-02-26 2-methoxybenzamides,their preparation and pharmaceutical composition containing them
DE19792907378 DE2907378A1 (en) 1978-02-27 1979-02-26 2-METHOXY-BENZAMIDE, METHOD OF MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING IT
NZ189770A NZ189770A (en) 1978-02-27 1979-02-26 2-methoxybenzamide derivatives and pharmaceutical compositions
FI790657A FI790657A (en) 1978-02-27 1979-02-27 2-METHODYBENZAMAMIDER OCH FOERFARANDE FOER DERAS FRAMSTAELLNING
GB7906952A GB2016467A (en) 1978-02-27 1979-02-27 2-Methoxybenzamides
GR58491A GR66972B (en) 1978-02-27 1979-02-27
LU80975A LU80975A1 (en) 1978-02-27 1979-02-27 METHOXY-2 BENZAMIDES
BE0/193729A BE874489A (en) 1978-02-27 1979-02-27 METHOXY-2 BENZAMIDES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7805579A FR2418225A1 (en) 1978-02-27 1978-02-27 N-1-Cycloalkyl-2-pyrrolidinyl-methyl 2-methoxy-benzamide derivs. - for treating psychoses and depressive states, prepd. by reaction of 1-cycloalkyl-2-aminomethyl-pyrrolidine with methoxy-benzoic acid deriv.

Publications (2)

Publication Number Publication Date
FR2418225A1 true FR2418225A1 (en) 1979-09-21
FR2418225B1 FR2418225B1 (en) 1980-09-26

Family

ID=9205108

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7805579A Granted FR2418225A1 (en) 1978-02-27 1978-02-27 N-1-Cycloalkyl-2-pyrrolidinyl-methyl 2-methoxy-benzamide derivs. - for treating psychoses and depressive states, prepd. by reaction of 1-cycloalkyl-2-aminomethyl-pyrrolidine with methoxy-benzoic acid deriv.

Country Status (2)

Country Link
FR (1) FR2418225A1 (en)
ZA (1) ZA79907B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2678266A1 (en) * 1991-06-28 1992-12-31 Delagrange Laboratoires New 2-hydroxy-4-amino-5-(ethylsulphonyl)benzamide derivatives which are useful as anxiolytic agents

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2245628A1 (en) * 1973-09-28 1975-04-25 Ile De France

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2245628A1 (en) * 1973-09-28 1975-04-25 Ile De France

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2678266A1 (en) * 1991-06-28 1992-12-31 Delagrange Laboratoires New 2-hydroxy-4-amino-5-(ethylsulphonyl)benzamide derivatives which are useful as anxiolytic agents

Also Published As

Publication number Publication date
ZA79907B (en) 1980-02-27
FR2418225B1 (en) 1980-09-26

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