FR2412548A1 - PROCESS FOR PREPARING OCTAHYDROPYRROLO (1,2-A) PYRAZINE - Google Patents

PROCESS FOR PREPARING OCTAHYDROPYRROLO (1,2-A) PYRAZINE

Info

Publication number
FR2412548A1
FR2412548A1 FR7832776A FR7832776A FR2412548A1 FR 2412548 A1 FR2412548 A1 FR 2412548A1 FR 7832776 A FR7832776 A FR 7832776A FR 7832776 A FR7832776 A FR 7832776A FR 2412548 A1 FR2412548 A1 FR 2412548A1
Authority
FR
France
Prior art keywords
pyrazine
pyrrolo
dichlorhydratee
nonanyl
diaza
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7832776A
Other languages
French (fr)
Other versions
FR2412548B1 (en
Inventor
A P Skoldinov
A M Likhosherstov
V P Peresada
N V Kaverina
M I Shmarian
A G Petukhov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INST FARMAKOLOGII AKADEMII
Original Assignee
INST FARMAKOLOGII AKADEMII
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by INST FARMAKOLOGII AKADEMII filed Critical INST FARMAKOLOGII AKADEMII
Publication of FR2412548A1 publication Critical patent/FR2412548A1/en
Application granted granted Critical
Publication of FR2412548B1 publication Critical patent/FR2412548B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

L'INVENTION CONCERNE LES PROCEDES CHIMIQUES. LE PROCEDE FAISANT L'OBJET DE L'INVENTION EST DU TYPE COMPRENANT UNE REDUCTION D'UN DERIVE DE LA PYRROLO 1,2-A PYRAZINE, ET EST CARACTERISE EN CE QU'A TITRE DE DERIVE DE PYRROLO 1,2-A PYRAZINE ON UTILISE LE DIHYDRO-3,4 PYRROLO 1,2-A PYRAZINE ET QU'ON LA REDUIT PAR HYDROGENATION CATALYTIQUE A UNE TEMPERATURE DE 100 A 180C ET SOUS UNE PRESSION DE 100 A 180ATMOSPHERES EN PRESENCE D'UN CATALYSEUR AU NICKEL, AU PLATINE OU AU PALLADIUM, EN OBTENANT UN MELANGE REACTIONNEL CONTENANT LE PRODUIT VISE ET EN ISOLANT ENSUITE CE DERNIER. LE COMPOSE EN QUESTION TROUVE DES APPLICATIONS EN TANT QUE MATIERE PREMIERE POUR LA SYNTHESE DE SUBSTANCES PHYSIOLOGIQUEMENT ACTIVES, EN PARTICULIER POUR LA PREPARATION D'UN VASODILATATEUR CORONARIEN TEL QUE LA BETA-N-DIAZA-1,4 BICYCLO 4,3,0-NONANYL) PROPIONYL -10 CHLORO-2-PHENOTHIAZINE DICHLORHYDRATEE, ET D'UN NEUROLEPTIQUE TEL QUE LA GAMMA N-DIAZA-1,4 BICYCLO 4,3,0 NONANYL PROPYL-PARA-FLUOROPHENYLCETONE DICHLORHYDRATEE.THE INVENTION CONCERNS CHEMICAL PROCESSES. THE PROCESS WHICH IS THE OBJECT OF THE INVENTION IS OF THE TYPE INCLUDING A REDUCTION OF A DERIVATIVE OF PYRROLO 1,2-A PYRAZINE, AND IS CHARACTERIZED AS A DERIVATIVE OF PYRROLO 1,2-A PYRAZINE ON USE 3,4-DIHYDRO PYRROLO 1,2-A PYRAZINE AND REDUCE IT BY CATALYTIC HYDROGENATION TO A TEMPERATURE OF 100 TO 180C AND UNDER A PRESSURE OF 100 TO 180ATMOSPHERES IN THE PRESENCE OF A NICKEL, PLATINUM OR CATALYST. AT THE PALLADIUM, BY OBTAINING A REACTIONAL MIXTURE CONTAINING THE CONCERNED PRODUCT AND THEN INSULATING THE LATTER. THE COMPOUND IN QUESTION FINDS APPLICATIONS AS A RAW MATERIAL FOR THE SYNTHESIS OF PHYSIOLOGICALLY ACTIVE SUBSTANCES, IN PARTICULAR FOR THE PREPARATION OF A CORONARY VASODILATOR SUCH AS BETA-N-DIAZA-1,4 BICYCLO 4,3,0-NONANYL ) PROPIONYL -10 CHLORO-2-PHENOTHIAZINE DICHLORHYDRATEE, AND A NEUROLEPTIC SUCH AS GAMMA N-DIAZA-1,4 BICYCLO 4,3,0 NONANYL PROPYL-PARA-FLUOROPHENYLCETONE DICHLORHYDRATEE.

FR7832776A 1977-12-22 1978-11-21 PROCESS FOR PREPARING OCTAHYDROPYRROLO (1,2-A) PYRAZINE Granted FR2412548A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU772558067A SU810697A1 (en) 1977-12-22 1977-12-22 Process for preparing octahydropyrroco 1,2-pyrazine

Publications (2)

Publication Number Publication Date
FR2412548A1 true FR2412548A1 (en) 1979-07-20
FR2412548B1 FR2412548B1 (en) 1982-05-28

Family

ID=20739338

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7832776A Granted FR2412548A1 (en) 1977-12-22 1978-11-21 PROCESS FOR PREPARING OCTAHYDROPYRROLO (1,2-A) PYRAZINE

Country Status (8)

Country Link
JP (1) JPS5823879B2 (en)
DD (1) DD139261A1 (en)
DE (1) DE2844549A1 (en)
FR (1) FR2412548A1 (en)
GB (1) GB2010831B (en)
HU (1) HU175980B (en)
SU (1) SU810697A1 (en)
YU (1) YU243378A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378846A (en) * 1993-06-11 1995-01-03 Russian-American Institute For New Drug Development 1,2,3,4-tetrahydropyrrolo-[1,2-a]-pyrazine derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2655512A (en) * 1950-06-22 1953-10-13 Quaker Oats Co Preparation of 2-acylpyrroles from 2-acylfurans

Also Published As

Publication number Publication date
DE2844549A1 (en) 1979-07-05
JPS5823879B2 (en) 1983-05-18
GB2010831B (en) 1982-06-16
SU810697A1 (en) 1984-03-30
HU175980B (en) 1980-11-28
FR2412548B1 (en) 1982-05-28
GB2010831A (en) 1979-07-04
JPS5488294A (en) 1979-07-13
YU243378A (en) 1982-10-31
DD139261A1 (en) 1979-12-19

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