FR2405236A1 - 5, 6, 7-TRIMETHOXY-NAPHTALENE AND HYDRONAPHTALENE- (2) -CARBOXYLIC ACIDS AND DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS A MEDICINAL PRODUCT - Google Patents

5, 6, 7-TRIMETHOXY-NAPHTALENE AND HYDRONAPHTALENE- (2) -CARBOXYLIC ACIDS AND DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS A MEDICINAL PRODUCT

Info

Publication number
FR2405236A1
FR2405236A1 FR7817452A FR7817452A FR2405236A1 FR 2405236 A1 FR2405236 A1 FR 2405236A1 FR 7817452 A FR7817452 A FR 7817452A FR 7817452 A FR7817452 A FR 7817452A FR 2405236 A1 FR2405236 A1 FR 2405236A1
Authority
FR
France
Prior art keywords
hydronaphtalene
naphtalene
trimethoxy
derivatives
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7817452A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Degussa GmbH
Deutsche Gold und Silber Scheideanstalt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa GmbH, Deutsche Gold und Silber Scheideanstalt filed Critical Degussa GmbH
Publication of FR2405236A1 publication Critical patent/FR2405236A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Ces composés répondant à la formule générale I, dans laquelle le noyau hydrogéné peut également contenir une ou deux doubles liaisons, R1 est un groupe hydroxy, alcoxy en C1-C6, un atome d'halogène, un groupe alcanoyloxy en C2 -C6 , amino, alkylamino en C1 -C6 ou di-(alkyle en C1 -C6 )-amino, les deux groupes alkyle peuyent également former dans ce dernier cas un noyau hétérocyclique; l'invention comprend également les sels de ces composés et d'acides acceptables pour l'usage pharmaceutique. Ces composés ont entre autres des propriétés hypolipémiques justifiant leur utilisation en thérapeutique pour traiter l'hyperlipémie, l'hypercholestérolémie et l'artériosclérose.These compounds corresponding to the general formula I, in which the hydrogen nucleus can also contain one or two double bonds, R1 is a hydroxy group, C1-C6 alkoxy, a halogen atom, a C2 -C6 alkanoyloxy group, amino , C1 -C6 alkylamino or di- (C1 -C6 alkyl) -amino, the two alkyl groups can also form in the latter case a heterocyclic ring; the invention also includes salts of these compounds and of acids acceptable for pharmaceutical use. These compounds have among other things hypolipemic properties justifying their use in therapy for treating hyperlipemia, hypercholesterolemia and arteriosclerosis.

FR7817452A 1977-06-13 1978-06-12 5, 6, 7-TRIMETHOXY-NAPHTALENE AND HYDRONAPHTALENE- (2) -CARBOXYLIC ACIDS AND DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS A MEDICINAL PRODUCT Withdrawn FR2405236A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2453577 1977-06-13

Publications (1)

Publication Number Publication Date
FR2405236A1 true FR2405236A1 (en) 1979-05-04

Family

ID=10213176

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7817452A Withdrawn FR2405236A1 (en) 1977-06-13 1978-06-12 5, 6, 7-TRIMETHOXY-NAPHTALENE AND HYDRONAPHTALENE- (2) -CARBOXYLIC ACIDS AND DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS A MEDICINAL PRODUCT

Country Status (4)

Country Link
BE (1) BE868023A (en)
DE (1) DE2824409A1 (en)
FR (1) FR2405236A1 (en)
GB (1) GB2001956A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8508588D0 (en) * 1985-04-02 1985-05-09 Akzo Nv Indene & napthalene derivatives
US7115767B2 (en) * 2003-07-18 2006-10-03 Abbott Laboratories Tetraline derivatives as ghrelin receptor modulators

Also Published As

Publication number Publication date
BE868023A (en) 1978-12-11
DE2824409A1 (en) 1978-12-21
GB2001956A (en) 1979-02-14

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Legal Events

Date Code Title Description
RE Withdrawal of published application