FR2403799A2 - Prepn. of injectable aspirin solns. - by mixing aspirin with arginine or lysine, glutamic acid, betaine and water - Google Patents

Prepn. of injectable aspirin solns. - by mixing aspirin with arginine or lysine, glutamic acid, betaine and water

Info

Publication number
FR2403799A2
FR2403799A2 FR7729075A FR7729075A FR2403799A2 FR 2403799 A2 FR2403799 A2 FR 2403799A2 FR 7729075 A FR7729075 A FR 7729075A FR 7729075 A FR7729075 A FR 7729075A FR 2403799 A2 FR2403799 A2 FR 2403799A2
Authority
FR
France
Prior art keywords
parts
aspirin
betaine
arginine
glutamic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
FR7729075A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UNION PHARMA SCIENT APPL
Original Assignee
UNION PHARMA SCIENT APPL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UNION PHARMA SCIENT APPL filed Critical UNION PHARMA SCIENT APPL
Priority to FR7729075A priority Critical patent/FR2403799A2/en
Publication of FR2403799A2 publication Critical patent/FR2403799A2/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
    • A61K31/621—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate having the hydroxy group in position 2 esterified, e.g. benorylate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Abstract

An aq. injectable solution is prepared extemporaneously from a first container having 20-100 pts. wt. of acetylsalicyclic acid (I) and a second container in which are (a) 1000 pts. wt. of water suitable for injection, (b) 105-150 parts of arginine or lysine, and (c) 10-100 parts of glutamic acid and of betaine. Pref. (c) contains about twice as much glutamic acid as betaine. (I) is pref. sterilised by gamma and/or beta radiation of 2.5-4 megarads per unit, and a prepared solution contains 20-100 parts (I), 1000 parts water, 118 parts anhydrous arginine base, 20 parts goutamic acid and 8 parts anhydrous betaine base.
FR7729075A 1977-09-27 1977-09-27 Prepn. of injectable aspirin solns. - by mixing aspirin with arginine or lysine, glutamic acid, betaine and water Pending FR2403799A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7729075A FR2403799A2 (en) 1977-09-27 1977-09-27 Prepn. of injectable aspirin solns. - by mixing aspirin with arginine or lysine, glutamic acid, betaine and water

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7729075A FR2403799A2 (en) 1977-09-27 1977-09-27 Prepn. of injectable aspirin solns. - by mixing aspirin with arginine or lysine, glutamic acid, betaine and water

Publications (1)

Publication Number Publication Date
FR2403799A2 true FR2403799A2 (en) 1979-04-20

Family

ID=9195827

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7729075A Pending FR2403799A2 (en) 1977-09-27 1977-09-27 Prepn. of injectable aspirin solns. - by mixing aspirin with arginine or lysine, glutamic acid, betaine and water

Country Status (1)

Country Link
FR (1) FR2403799A2 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004049095A2 (en) * 2002-11-25 2004-06-10 Jallal Messadek Betaine and salicylic acid compositions
US7608640B2 (en) 1999-03-02 2009-10-27 Jallal Messadek Glycine betaine and its use
US7780990B2 (en) 2005-02-15 2010-08-24 Jallal Messadek Combination therapeutic compositions and method of use
US7786077B2 (en) 2005-04-27 2010-08-31 Jallal Messadek Insulins combinations
US8318805B2 (en) 2004-11-10 2012-11-27 Jallal Messadek Modulation of nitric oxide synthases by betaines
US8343947B2 (en) 2003-07-15 2013-01-01 Jallal Messadek Therapeutic treatment
WO2023198294A1 (en) 2022-04-14 2023-10-19 Hyloris Developments Sa Acetyl salicylic acid composition for intravenous administration, its storage, production and use

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5144623A (en) * 1974-10-14 1976-04-16 Green Cross Corp CHUSHAYOASECHIRUSARICHIRUSANENNO SEIHO

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5144623A (en) * 1974-10-14 1976-04-16 Green Cross Corp CHUSHAYOASECHIRUSARICHIRUSANENNO SEIHO

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CA1976 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7608640B2 (en) 1999-03-02 2009-10-27 Jallal Messadek Glycine betaine and its use
WO2004049095A2 (en) * 2002-11-25 2004-06-10 Jallal Messadek Betaine and salicylic acid compositions
WO2004049095A3 (en) * 2002-11-25 2004-12-23 Jallal Messadek Betaine and salicylic acid compositions
US8343947B2 (en) 2003-07-15 2013-01-01 Jallal Messadek Therapeutic treatment
US8318805B2 (en) 2004-11-10 2012-11-27 Jallal Messadek Modulation of nitric oxide synthases by betaines
US7780990B2 (en) 2005-02-15 2010-08-24 Jallal Messadek Combination therapeutic compositions and method of use
US7786077B2 (en) 2005-04-27 2010-08-31 Jallal Messadek Insulins combinations
WO2023198294A1 (en) 2022-04-14 2023-10-19 Hyloris Developments Sa Acetyl salicylic acid composition for intravenous administration, its storage, production and use
WO2023198704A1 (en) 2022-04-14 2023-10-19 Hyloris Developments Sa Acetyl salicylic acid composition for intravenous administration, its storage, production and use

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