FR2401166A1 - 7-Alpha methoxy cephalosporin cpds. - are antimicrobials prepd. from amino cephalosporanic acid and a sulphinyl carboxylic acid - Google Patents

7-Alpha methoxy cephalosporin cpds. - are antimicrobials prepd. from amino cephalosporanic acid and a sulphinyl carboxylic acid

Info

Publication number
FR2401166A1
FR2401166A1 FR7719166A FR7719166A FR2401166A1 FR 2401166 A1 FR2401166 A1 FR 2401166A1 FR 7719166 A FR7719166 A FR 7719166A FR 7719166 A FR7719166 A FR 7719166A FR 2401166 A1 FR2401166 A1 FR 2401166A1
Authority
FR
France
Prior art keywords
sulphinyl
substd
lower alkyl
alkyl
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7719166A
Other languages
French (fr)
Other versions
FR2401166B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Asahi Kasei Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd, Asahi Kasei Kogyo KK filed Critical Asahi Chemical Industry Co Ltd
Priority to FR7719166A priority Critical patent/FR2401166A1/en
Publication of FR2401166A1 publication Critical patent/FR2401166A1/en
Application granted granted Critical
Publication of FR2401166B1 publication Critical patent/FR2401166B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/57—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with a further substituent in position 7, e.g. cephamycines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

7-alpha-Methoxycephalosporin derivs. of formula (I) in which the sulphinyl gp. is in the R form, and their sales and esters, are new. (where R1 = lower alkyl or alkynyl, aryl, aralkyl, heterocyclyl or heterocyclyl lower alkyl, these gps. opt. being substd. by >=1 of halogens, NO2, OH, lower alkenyl, lower alkoxy, azido, amino, substd. amino, carboxy, carboxy lower alkyl, CF3, CN, NH2CONH, SH, CONH2, sulphinyl, sulphonyl, hydrazino, formyl, acetoxy, lower acylamino, lower alkylamino, lower acyl, carbonyl, thio, hydroxyamino, lower alkyl, carbonyl, thio, hydroxyamino, lower alkyl, lower hydroxy alkyl, lower alkoxymethyl, N-oxo, lower carboalkoxy or thiocarbonyl; R2 = 1-3C straight or branched, alkylene chain which may be substd. by CH3; X = H, acetoxy, quat. ammonium carbamoyloxy, lower alkoxy, lower alkylmercapto or heterocyclic mercapto, the heterocyclic mercapto gp. opt. being substd. by the same substituents as for R1; and the R form signifies an optical isomer having the same stereochemical structure as the optical isomer of The two isomers of the sulphinyl gp. of the cpd. R1-SO-R2-COOH (II), which has a positive specific rotatory power in ethanol). (I) are active against Gram positive and negative bacteria and partic. useful against choleoystitis, septicaemia and nephropyelitis.
FR7719166A 1977-06-22 1977-06-22 7-Alpha methoxy cephalosporin cpds. - are antimicrobials prepd. from amino cephalosporanic acid and a sulphinyl carboxylic acid Granted FR2401166A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7719166A FR2401166A1 (en) 1977-06-22 1977-06-22 7-Alpha methoxy cephalosporin cpds. - are antimicrobials prepd. from amino cephalosporanic acid and a sulphinyl carboxylic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7719166A FR2401166A1 (en) 1977-06-22 1977-06-22 7-Alpha methoxy cephalosporin cpds. - are antimicrobials prepd. from amino cephalosporanic acid and a sulphinyl carboxylic acid

Publications (2)

Publication Number Publication Date
FR2401166A1 true FR2401166A1 (en) 1979-03-23
FR2401166B1 FR2401166B1 (en) 1980-06-27

Family

ID=9192422

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7719166A Granted FR2401166A1 (en) 1977-06-22 1977-06-22 7-Alpha methoxy cephalosporin cpds. - are antimicrobials prepd. from amino cephalosporanic acid and a sulphinyl carboxylic acid

Country Status (1)

Country Link
FR (1) FR2401166A1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2283689A1 (en) * 1974-09-09 1976-04-02 Smithkline Corp NEW CEPHAMYCINS, THEIR PREPARATION AND THEIR APPLICATION

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2283689A1 (en) * 1974-09-09 1976-04-02 Smithkline Corp NEW CEPHAMYCINS, THEIR PREPARATION AND THEIR APPLICATION

Also Published As

Publication number Publication date
FR2401166B1 (en) 1980-06-27

Similar Documents

Publication Publication Date Title
PE20030969A1 (en) HETEROCICLIC COMPOUNDS, ACTIVE INHIBITORS OF BETA-LACTAMASES
NO931529L (en) CYCLIC FRUITOPYRANOSULSULPHITES AND SULPHATES WITH ANTI-CONVICTIVE EFFECT
PE59099A1 (en) NEW DERIVATIVES OF HEXANOIC ACID
ES2107789T3 (en) INHIBITION OF HAIR GROWTH.
LV10089A (en) New Vitamin D Derivatives
ES2079774T3 (en) DERIVATIVES OF INDOLOPYROLOCARBAZOLE.
ATE207922T1 (en) CARBAPENEM DERIVATIVES
ES2138983T3 (en) USE OF 2- (N- (2-AMINOETHYL) AMINO) -ACETIC ACID DERIVATIVES FOR THE TREATMENT OF DISEASES CONDITIONED BY NON-ENZYMATIC GLYCOSILATION.
DK0563096T3 (en) New methylene bisphosphonic acid derivatives
KR930016402A (en) Imidazole derivatives having anti-HIV activity
FR2401166A1 (en) 7-Alpha methoxy cephalosporin cpds. - are antimicrobials prepd. from amino cephalosporanic acid and a sulphinyl carboxylic acid
ES8303422A1 (en) 7-Acylaminocephalosporanic acid derivatives
ATE122669T1 (en) ZEARALANOL DERIVATIVES WITH ANABOLYTIC ACTION.
SE8104771L (en) cephalosporin derivatives
PT1021404E (en) AZETIDINONE DERIVATIVES FOR THE TREATMENT OF INFECTIONS BY HCMV
SE7910391L (en) ANTIBACTERIAL AGENTS
FI823199A0 (en) -LACTOR-ANTIBIOTICS, FOERFARANDE FOER DERAS FRAMSTAELLNING OCH DERAS ANVAENDNING SAOSOM CEILING MODEL
KR870004992A (en) Method for preparing cephalosporin derivative
FI833839A (en) FOERFARANDE FOER FRAMSTAELLNING AV TERAPEUTISKT AKTIVA KEFALOSPORINDERIVAT
JPS5111782A (en) 77 aminosefuemujudotaino seizoho
IE40528L (en) Cephalosporin derivatives
KR900007844A (en) 2- [4- (N-cyano sulfamoylmethyl) -1-pyridinium] ethylthio carbapenem
FI910602A0 (en) NYA IMIDAZOLFOERENINGAR, FOERFARANDE FOER DERAS FRAMSTAELLNING CEEKEMEDEL BASERADE PAO DESSA FOERENINGAR SAMT NAOGRA MELLANPRODUKTER.
EP0037797A3 (en) Cephalosporin derivatives, process for their preparation, pharmaceutical compositions containing them and their application
PH18629A (en) Substituted 2,3-alkylene bis (oxy) benzoic acid derivatives

Legal Events

Date Code Title Description
ST Notification of lapse