FR2400032A1 - 5-Hydroxy-macro:lactone derivs. and glucopyranosyl ether(s) - intermediates for macrolide antibiotics - Google Patents
5-Hydroxy-macro:lactone derivs. and glucopyranosyl ether(s) - intermediates for macrolide antibioticsInfo
- Publication number
- FR2400032A1 FR2400032A1 FR7834348A FR7834348A FR2400032A1 FR 2400032 A1 FR2400032 A1 FR 2400032A1 FR 7834348 A FR7834348 A FR 7834348A FR 7834348 A FR7834348 A FR 7834348A FR 2400032 A1 FR2400032 A1 FR 2400032A1
- Authority
- FR
- France
- Prior art keywords
- intermediates
- macrolide antibiotics
- derivs
- glucopyranosyl
- lactone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Saccharide Compounds (AREA)
Abstract
Macrolides of formula (I) are new (Bond a is single or double. Bond b is single or double, or is an oxiran-2,3-yl.gp. The dotted lines complete a 16- or 17-membered ring. 2 is either H (Cpds. (Ia)) or the gp. (II). (Cpds. (Ib)). A is carbonyl or RO . R is H, acyl or forosaminyl. R1 is aldehyde gp. protected as cyclic acetal or thioacetal. R2=H or acyl. R3= lower alkyl. R4=H, CH2OH or mycinosyloxymethyl. R5=CH3 or CH3O. R6=H or CH3). (I) are intermediates for new macrolide antibiotics. New sugar residues or other substits. can be introduced easily without formation of an intramolecular cyclic acetal. In an example 6-(1,3-dioxolan-2-yl)methyl-3,5-dihydroxy-14-hydroxymethyl-4,8,12- -trimethyl-9-oxo-10,12-heptadecadien-15-olide was prepd. from the corresp. 5-(3,6-dideoxy-3-Me2N-beta-D-glucopyranosloxy) by reaction with m-Cl-perbenzoic acid and Ac2O.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2561977A JPS53111089A (en) | 1977-03-09 | 1977-03-09 | Novel macrolide compound and its preparation |
JP2561877A JPS53111088A (en) | 1977-03-09 | 1977-03-09 | Novel macrolactone derivative and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2400032A1 true FR2400032A1 (en) | 1979-03-09 |
FR2400032B1 FR2400032B1 (en) | 1982-06-11 |
Family
ID=26363262
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7834348A Granted FR2400032A1 (en) | 1977-03-09 | 1978-12-06 | 5-Hydroxy-macro:lactone derivs. and glucopyranosyl ether(s) - intermediates for macrolide antibiotics |
Country Status (2)
Country | Link |
---|---|
DE (1) | DE2858223C2 (en) |
FR (1) | FR2400032A1 (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2243948A1 (en) * | 1973-09-19 | 1975-04-11 | Toyo Jozo Kk |
-
1978
- 1978-03-06 DE DE19782858223 patent/DE2858223C2/de not_active Expired
- 1978-12-06 FR FR7834348A patent/FR2400032A1/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2243948A1 (en) * | 1973-09-19 | 1975-04-11 | Toyo Jozo Kk |
Non-Patent Citations (2)
Title |
---|
EXBK/ * |
EXBK/77 * |
Also Published As
Publication number | Publication date |
---|---|
FR2400032B1 (en) | 1982-06-11 |
DE2858223C2 (en) | 1989-04-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |