FR2395270A1 - Antidepressant hexa:hydro-benzo:pyrano (3,2-c) pyridine derivs. - useful for treating psychic disturbances, depressive states, etc. - Google Patents

Antidepressant hexa:hydro-benzo:pyrano (3,2-c) pyridine derivs. - useful for treating psychic disturbances, depressive states, etc.

Info

Publication number
FR2395270A1
FR2395270A1 FR7719360A FR7719360A FR2395270A1 FR 2395270 A1 FR2395270 A1 FR 2395270A1 FR 7719360 A FR7719360 A FR 7719360A FR 7719360 A FR7719360 A FR 7719360A FR 2395270 A1 FR2395270 A1 FR 2395270A1
Authority
FR
France
Prior art keywords
halogen
useful
pyrano
antidepressant
hexa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7719360A
Other languages
French (fr)
Other versions
FR2395270B1 (en
Inventor
Philippe Briet
Jean-Jacques Berthelon
Jean-Claude Depin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sante SAS
Original Assignee
LIPHA SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LIPHA SAS filed Critical LIPHA SAS
Priority to FR7719360A priority Critical patent/FR2395270A1/en
Priority to CS783793A priority patent/CS207624B2/en
Priority to ZA00783478A priority patent/ZA783478B/en
Priority to IT24705/78A priority patent/IT1097257B/en
Priority to EP78400025A priority patent/EP0000306B1/en
Priority to YU1438/78A priority patent/YU40338B/en
Priority to IL54953A priority patent/IL54953A/en
Priority to DE7878400025T priority patent/DE2860016D1/en
Priority to NZ187629A priority patent/NZ187629A/en
Priority to IE1239/78A priority patent/IE46999B1/en
Priority to IN456/DEL/78A priority patent/IN151192B/en
Priority to NO782184A priority patent/NO150205C/en
Priority to AR272690A priority patent/AR225732A1/en
Priority to DK281978A priority patent/DK158311C/en
Priority to CA306,057A priority patent/CA1098519A/en
Priority to MX787170U priority patent/MX5090E/en
Priority to HU78LI328A priority patent/HU177341B/en
Priority to US05/918,597 priority patent/US4201783A/en
Priority to ES471060A priority patent/ES471060A1/en
Priority to SU782629397A priority patent/SU931108A3/en
Priority to DD78206246A priority patent/DD137441A5/en
Priority to JP7598478A priority patent/JPS5412399A/en
Priority to AT464478A priority patent/AT356662B/en
Priority to AU37463/78A priority patent/AU519417B2/en
Publication of FR2395270A1 publication Critical patent/FR2395270A1/en
Application granted granted Critical
Publication of FR2395270B1 publication Critical patent/FR2395270B1/fr
Priority to IN858/DEL/80A priority patent/IN151210B/en
Priority to IN859/DEL/80A priority patent/IN151209B/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/12—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 3 and unsubstituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/14—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 6 and unsubstituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Pyridine derivs. of formula (I) and thier salts with therapeutically acceptable mineral or organic acids are new (R is H or opt. unsatd., opt. branched lower alkyl, aralkyl, acyl, dialkylaminoalkyl, alkylcarbonyl,alkoxycarbonyl, haloalkoxycarbonyl or aryl; R1 is H, halogen or lower alkoxy; R2 is H or halogen; R3 is H, halogen, lower alkyl, alkoxy, NO2, NH2 or with R4 and the benzene ring forms a naphthalene nucleus; R4 is H, halogen or combines with R3 as above; R5 is H, lower alkyl or aralkyl). (I) are antidepressants useful in treatment of psychic disturbances, depressive states etc. Daily doses are 1-200 mg. in units of 0.05-100 mg. Toxicity is low e.g. LD50 (mouse, p.o.) ranges from 360 to >3200 mg./kg.
FR7719360A 1977-06-24 1977-06-24 Antidepressant hexa:hydro-benzo:pyrano (3,2-c) pyridine derivs. - useful for treating psychic disturbances, depressive states, etc. Granted FR2395270A1 (en)

Priority Applications (26)

Application Number Priority Date Filing Date Title
FR7719360A FR2395270A1 (en) 1977-06-24 1977-06-24 Antidepressant hexa:hydro-benzo:pyrano (3,2-c) pyridine derivs. - useful for treating psychic disturbances, depressive states, etc.
CS783793A CS207624B2 (en) 1977-06-24 1978-06-09 Method of making the substituted lactanes of the hexahydro-benzopyrano-3,2-c pyridin vinegar acids
ZA00783478A ZA783478B (en) 1977-06-24 1978-06-16 Substituted hexahydro benzopyrano(3,2-c)pyridines
IT24705/78A IT1097257B (en) 1977-06-24 1978-06-19 HEXAHYDROBENZOPIRAN OPEN PARENTESI QUADRA 3,2-C CLOSED PARENTESI QUADRA PYRIDINS REPLACED
EP78400025A EP0000306B1 (en) 1977-06-24 1978-06-19 Substituted hexahydrobenzopyrano(3,2-c)pyridines, process for their preparation and medicines containing them
YU1438/78A YU40338B (en) 1977-06-24 1978-06-19 Process for obtaining substituted hexahydro-benzopirano(3,2-c) pyridines
IL54953A IL54953A (en) 1977-06-24 1978-06-19 Lactams of 4a-amino-hexahydrobenzopyrano(3,2-c)pyridine-10-acetic acid,their preparation and pharmaceutical compositions containing them
DE7878400025T DE2860016D1 (en) 1977-06-24 1978-06-19 Substituted hexahydrobenzopyrano(3,2-c)pyridines, process for their preparation and medicines containing them
IE1239/78A IE46999B1 (en) 1977-06-24 1978-06-20 Substituted hexahydro benzopyrano (3,2-c) pyridines, a method of preparing them and medication containing them
IN456/DEL/78A IN151192B (en) 1977-06-24 1978-06-20
NZ187629A NZ187629A (en) 1977-06-24 1978-06-20 Hexahydrobenzopyran (3,2-c) pyridine derivatives and pharmaceutical compositions
DK281978A DK158311C (en) 1977-06-24 1978-06-22 METHOD OF ANALOGUE FOR THE PREPARATION OF HEXAHYDROBENZOPYRANO (3,2-C) PYRIDINES
NO782184A NO150205C (en) 1977-06-24 1978-06-22 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE, SUBSTITUTED HEXA HYDROBENZOPYRANO (3-2-C) PYRIDINES
CA306,057A CA1098519A (en) 1977-06-24 1978-06-22 No translation available
MX787170U MX5090E (en) 1977-06-24 1978-06-22 PROCEDURE FOR THE PREPARATION OF HEXAHIDRO-BENZOPIRANO (3,2-C) SUBSTITUTED PYRIDINES
AR272690A AR225732A1 (en) 1977-06-24 1978-06-22 PROCEDURE FOR PREPARING LACTAMS OF AMINOHEXAHIDROPIRAN (3,2-C) PIRIDINYL-ACETIC SUBSTITUTE
SU782629397A SU931108A3 (en) 1977-06-24 1978-06-23 Process for producing hexahydrobenzopyrano-(3,2-c)pyridines
US05/918,597 US4201783A (en) 1977-06-24 1978-06-23 Antidepressant substituted hexahydro benzopyrano [3,2-c] pyridines
ES471060A ES471060A1 (en) 1977-06-24 1978-06-23 Substituted hexahydrobenzopyrano(3,2-c)pyridines, process for their preparation and medicines containing them.
HU78LI328A HU177341B (en) 1977-06-24 1978-06-23 Process for producing new substituted hexahydro-benzopirano-square bracket-3,2-c-square bracket closed-pyridines
DD78206246A DD137441A5 (en) 1977-06-24 1978-06-23 PROCESS FOR THE PREPARATION OF HEXAHYDROBENZOPYRANO CORNER CLAIM TO 3.2-C SQUARE BRACKET TO PYRIDINES
JP7598478A JPS5412399A (en) 1977-06-24 1978-06-24 Hexahydrobenzopyrano*3*22c*pyridine derivative* its preparation and pharmaceutical compositions containing said derivative
AT464478A AT356662B (en) 1977-06-24 1978-06-26 METHOD FOR PRODUCING NEW SUBSTITUTED HEXAHYDRO-BENZOPYRANO (3,2-C) PYRIDINES, THEIR ACID ADDITON SALTS AND THEIR STEREOISOMERS
AU37463/78A AU519417B2 (en) 1977-06-24 1978-06-26 Substituted hexahydro benzopyran 0[3, 2-c]pyridines
IN859/DEL/80A IN151209B (en) 1977-06-24 1980-12-01
IN858/DEL/80A IN151210B (en) 1977-06-24 1980-12-01

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7719360A FR2395270A1 (en) 1977-06-24 1977-06-24 Antidepressant hexa:hydro-benzo:pyrano (3,2-c) pyridine derivs. - useful for treating psychic disturbances, depressive states, etc.

Publications (2)

Publication Number Publication Date
FR2395270A1 true FR2395270A1 (en) 1979-01-19
FR2395270B1 FR2395270B1 (en) 1980-03-14

Family

ID=9192502

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7719360A Granted FR2395270A1 (en) 1977-06-24 1977-06-24 Antidepressant hexa:hydro-benzo:pyrano (3,2-c) pyridine derivs. - useful for treating psychic disturbances, depressive states, etc.

Country Status (2)

Country Link
FR (1) FR2395270A1 (en)
ZA (1) ZA783478B (en)

Also Published As

Publication number Publication date
ZA783478B (en) 1979-06-27
FR2395270B1 (en) 1980-03-14

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